Xiaoyaosan inhibits neuronal apoptosis by regulating the miR-200/NR3C1 signaling in the prefrontal cortex of chronically stressed rats

Al-Harbi, 2012, Treatment-resistant depression: therapeutic trends, challenges, and future directions, Patient Prefer. Adherence, 6, 369, 10.2147/PPA.S29716 Antoniuk, 2019, Chronic unpredictable mild stress for modeling depression in rodents: meta-analysis of model reliability, Neurosci. Biobehav. Rev., 99, 101, 10.1016/j.neubiorev.2018.12.002 Arango-Lievano, 2015, Neurotrophic-priming of glucocorticoid receptor signaling is essential for neuronal plasticity to stress and antidepressant treatment, Proc. Natl. Acad. Sci. U. S. A., 112, 15737, 10.1073/pnas.1509045112 Baum, 1999, Health psychology: mapping biobehavioral contributions to health and illness, Annu. Rev. Psychol., 50, 137, 10.1146/annurev.psych.50.1.137 Belgardt, 2015, The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes, Nat. Med., 21, 619, 10.1038/nm.3862 Belzung, 2015, Depression: from psychopathology to pathophysiology, J. Curr. Opin. Neurobiol., 30, 24, 10.1016/j.conb.2014.08.013 Boulle, 2016, Behavioral and neurochemical characterization of TrkB-dependent mechanisms of agomelatine in glucocorticoid receptor-impaired mice, Eur. Neuropsychopharmacol., 26, 65, 10.1016/j.euroneuro.2015.11.003 Boyle, 2005, Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior, Proc. Natl. Acad. Sci. U. S. A., 102, 473, 10.1073/pnas.0406458102 Burk, 2008, A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells, EMBO Rep., 9, 582, 10.1038/embor.2008.74 Cao, 2010, Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway, J. Ethnopharmacol., 131, 122, 10.1016/j.jep.2010.06.009 Cao, 2016, MicroRNAs: key regulators in the central nervous system and their implication in neurological diseases, Int. J. Mol. Sci., 17, 842, 10.3390/ijms17060842 Caughlan, 2004, Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases, Toxicol. Sci., 78, 125, 10.1093/toxsci/kfh038 Chen, 2017, Paeoniflorin exerts neuroprotective effects against glutamate‑induced PC12 cellular cytotoxicity by inhibiting apoptosis, Int. J. Mol. Med., 40, 825, 10.3892/ijmm.2017.3076 Chen, 2008, Effects of the Chinese traditional prescription Xiaoyaosan decoction on chronic immobilization stress-induced changes in behavior and brain BDNF, TrkB, and NT-3 in rats, Cell. Mol. Neurobiol., 28, 745, 10.1007/s10571-007-9169-6 Collaborators, 2022, Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019, Lancet Psychiatry Dwivedi, 2018, MicroRNAs in depression and suicide: recent insights and future perspectives, J. Affect. Disord., 240, 146, 10.1016/j.jad.2018.07.075 Fan, 2019, Neuroprotective effects of curcumin on IL-1β-induced neuronal apoptosis and depression-like behaviors caused by chronic stress in rats, Front. Cell Neurosci., 12, 516, 10.3389/fncel.2018.00516 Hao, 2021, Xiaoyaosan Improves Antibiotic-Induced Depressive-Like and Anxiety-Like Behavior in Mice Through Modulating the Gut Microbiota and Regulating the NLRP3 Inflammasome in the Colon, Front. Pharmacol., 12, 773, 10.3389/fphar.2021.619103 Herrman, 2022, Time for united action on depression: a Lancet–World Psychiatric Association Commission, Lancet, 399, 957, 10.1016/S0140-6736(21)02141-3 Issler, 2014, MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity, Neuron, 83, 344, 10.1016/j.neuron.2014.05.042 Jiao, 2019, Influence of Xiaoyaosan on depressive-like behaviors in chronic stress-depressed rats through regulating tryptophan metabolism in hippocampus, Neuropsychiatr. Dis. Treat., 15, 21, 10.2147/NDT.S185295 Jing, 2015, Effect of Xiaoyaosan on major depressive disorder, Chin. Med., 10, 18, 10.1186/s13020-015-0050-0 Li, 2020, MicroRNA-382-5p Targets Nuclear Receptor Subfamily 3 Group C Member 1 to Regulate Depressive-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Rats, Neuropsychiatr. Dis. Treat., 16, 2053, 10.2147/NDT.S243920 Li, 2015, Baicalin decreases SGK1 expression in the hippocampus and reverses depressive-like behaviors induced by corticosterone, Neuroscience, 311, 130, 10.1016/j.neuroscience.2015.10.023 Li, 2018, Repression of the glucocorticoid receptor aggravates acute ischemic brain injuries in adult mice, Int. J. Mol. Sci., 19, 2428, 10.3390/ijms19082428 Liu, 2015, Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional Chinese medicine formula Xiaoyaosan: a 1H NMR-based metabolomics approach, J. Affect. Disord., 185, 156, 10.1016/j.jad.2015.05.005 Liu, 2019, Paeoniflorin attenuates impairment of spatial learning and hippocampal long-term potentiation in mice subjected to chronic unpredictable mild stress, Psychopharmacology (Berl.), 236, 2823, 10.1007/s00213-019-05257-5 Liu, 2020, Plasma metabolomics of depressed patients and treatment with Xiaoyaosan based on mass spectrometry technique, J. Ethnopharmacol., 246, 10.1016/j.jep.2019.112219 Liu, 2016, Increased miR-132 level is associated with visual memory dysfunction in patients with depression, Neuropsychiatr. Dis. Treat., 12, 2905, 10.2147/NDT.S116287 Ma, 2019, Xiaoyaosan Ameliorates Chronic Immobilization Stress-Induced Depression-Like Behaviours and Anorexia in Rats: the Role of the Nesfatin-1-Oxytocin-Proopiomelanocortin Neural Pathway in the Hypothalamus, Front. Psychiatry, 10, 910, 10.3389/fpsyt.2019.00910 MacQueen, 2011, The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?, Mol. Psychiatry, 16, 252, 10.1038/mp.2010.80 Mao, 2012, Protective Effects of Paeoniflorin Against Corticosterone-induced Neurotoxicity in PC12 Cells, Phytother. Res., 26, 969, 10.1002/ptr.3673 McKlveen, 2013, Role of prefrontal cortex glucocorticoid receptors in stress and emotion, Biol. Psychiatry, 74, 672, 10.1016/j.biopsych.2013.03.024 Molasy, 2017, MicroRNAs in glaucoma and neurodegenerative diseases, J. Hum. Genet., 62, 105, 10.1038/jhg.2016.91 Numakawa, 2009, Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-γ signaling for glutamate release via a glutamate transporter, Proc. Natl. Acad. Sci. U. S. A., 106, 647, 10.1073/pnas.0800888106 Pandey, 2015, Transactivation of P53 by cypermethrin induced miR-200 and apoptosis in neuronal cells, Toxicol. Res. (Camb.), 4, 1578, 10.1039/C5TX00200A Pandey, 2015, Critical role of the miR-200 family in regulating differentiation and proliferation of neurons, J. Neurochem., 133, 640, 10.1111/jnc.13089 Park, 2013, Neurotrophin regulation of neural circuit development and function, Nat. Rev. Neurosci., 14, 7, 10.1038/nrn3379 Price, 2010, Neurocircuitry of mood disorders, Neuropsychopharmacology, 35, 192, 10.1038/npp.2009.104 Reichardt, 2000, Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock, Mol. Cell. Biol., 20, 9009, 10.1128/MCB.20.23.9009-9017.2000 Santomauro, 2021, Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic, Lancet, 398, 1700, 10.1016/S0140-6736(21)02143-7 Satyanarayanan, 2019, miR-200a-3p modulates gene expression in comorbid pain and depression: molecular implication for central sensitization, Brain Behav. Immun., 82, 230, 10.1016/j.bbi.2019.08.190 Song, 2020, Effects of Xiaoyaosan on depressive-like behaviors in rats with chronic unpredictable mild stress through HPA axis induced astrocytic activities, Front. Psychiatry, 959 Teng, 2005, ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin, J. Neurosci., 25, 5455, 10.1523/JNEUROSCI.5123-04.2005 Venzala, 2012, Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors, Psychopharmacology (Berl.), 224, 313, 10.1007/s00213-012-2754-5 Vollmayr, 2013, Learned helplessness: unique features and translational value of a cognitive depression model, Cell Tissue Res., 354, 171, 10.1007/s00441-013-1654-2 Walf, 2007, The use of the elevated plus maze as an assay of anxiety-related behavior in rodents, Nat. Protoc., 2, 322, 10.1038/nprot.2007.44 Wang, 2017, microRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors, Prog. Neuropsychopharmacol. Biol. Psychiatry, 79, 417, 10.1016/j.pnpbp.2017.07.024 Wang, 2020, Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats, Metab. Brain Dis., 35, 959, 10.1007/s11011-020-00571-w Wang, 2012, MicroRNAs in learning, memory, and neurological diseases, Learn. Mem., 19, 359, 10.1101/lm.026492.112 Webster, 2002, Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders, Mol. Psychiatry, 7, 985, 10.1038/sj.mp.4001139 Wei, 2020, Sex differences in the association of body mass index with symptoms and cognitive deficits in Chinese patients with chronic schizophrenia, Transl. Psychiatry, 10, 1, 10.1038/s41398-020-0717-x Xiao, 2005, Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats, Life Sci., 78, 413, 10.1016/j.lfs.2005.04.069 Yuan, 2020, An integrated pharmacology-based analysis for antidepressant mechanism of Chinese herbal formula Xiao-Yao-San, Front. Pharmacol., 11, 284, 10.3389/fphar.2020.00284 Zhang, 2012, Chinese herbal formula Xiao Yao san for treatment of depression: a systematic review of randomized controlled trials, Evid. Based Complement. Alternat. Med., 2012 Zhong, 2019, Paeoniflorin ameliorates chronic stress-induced depression-like behaviors and neuronal damages in rats via activation of the ERK-CREB pathway, Front. Psychiatry, 9, 772, 10.3389/fpsyt.2018.00772 Zhou, 2019, Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain, J. Neuroinflammation, 16, 1, 10.1186/s12974-019-1476-6 Zhou, 2021, Xiaoyaosan alleviates hippocampal glutamate-induced toxicity in the CUMS rats via NR2B and PI3K/Akt signaling pathway, Front. Pharmacol., 12 Zhu, 2021, Xiaoyaosan Exerts Therapeutic Effects on the Colon of Chronic Restraint Stress Model Rats via the Regulation of Immunoinflammatory Activation Induced by the TLR4/NLRP3 Inflammasome Signaling Pathway, Evid. Based Complement. Alternat. Med., 2021 Zhu, 2019, Xiaoyaosan improves depressive-like behavior in rats with chronic immobilization stress through modulation of the gut microbiota, Biomed. Pharmacother., 112, 10.1016/j.biopha.2019.108621