XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

Acosta-Alvear, 2007, XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks, Mol. Cell, 27, 53, 10.1016/j.molcel.2007.06.011

Ayabe, 2000, Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria, Nat. Immunol., 1, 113, 10.1038/77783

Ayabe, 2002, Activation of Paneth cell α-defensins in mouse small intestine, J. Biol. Chem., 277, 5219, 10.1074/jbc.M109410200

Barker, 2007, Identification of stem cells in small intestine and colon by marker gene Lgr5, Nature, 449, 1003, 10.1038/nature06196

Barmada, 2004, A genome scan in 260 inflammatory bowel disease-affected relative pairs, Inflamm. Bowel Dis., 10, 513, 10.1097/00054725-200409000-00004

Barrett, 2005, Haploview: analysis and visualization of LD and haplotype maps, Bioinformatics, 21, 263, 10.1093/bioinformatics/bth457

Bertolotti, 2001, Increased sensitivity to dextran sodium sulfate colitis in IRE1β-deficient mice, J. Clin. Invest., 107, 585, 10.1172/JCI11476

Birney, 2007, Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project, Nature, 447, 799, 10.1038/nature05874

Calfon, 2002, IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA, Nature, 415, 92, 10.1038/415092a

Cohen, 2004, Multiple rare alleles contribute to low plasma levels of HDL cholesterol, Science, 305, 869, 10.1126/science.1099870

Franke, 2007, Systematic association mapping identifies NELL1 as a novel IBD disease gene, PLoS ONE, 2, e691, 10.1371/journal.pone.0000691

Gabriel, 2002, The structure of haplotype blocks in the human genome, Science, 296, 2225, 10.1126/science.1069424

Garabedian, 1997, Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice, J. Biol. Chem., 272, 23729, 10.1074/jbc.272.38.23729

Garrett, 2007, Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system, Cell, 131, 33, 10.1016/j.cell.2007.08.017

Gorlov, 2008, Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms, Am. J. Hum. Genet., 82, 100, 10.1016/j.ajhg.2007.09.006

Halfvarson, 2003, Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics, Gastroenterology, 124, 1767, 10.1016/S0016-5085(03)00385-8

Hampe, 1999, A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort, Am. J. Hum. Genet., 64, 808, 10.1086/302294

Hampe, 2007, A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1, Nat. Genet., 39, 207, 10.1038/ng1954

Heazlewood, 2008, Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis, PLoS Med., 5, e54, 10.1371/journal.pmed.0050054

Iwakoshi, 2003, Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1, Nat. Immunol., 4, 321, 10.1038/ni907

Kobayashi, 2005, Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract, Science, 307, 731, 10.1126/science.1104911

Kojouharoff, 1997, Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice, Clin. Exp. Immunol., 107, 353, 10.1111/j.1365-2249.1997.291-ce1184.x

Krawczak, 2006, PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships, Community Genet., 9, 55

Lee, 2003, Proteasome inhibitors disrupt the unfolded protein response in myeloma cells, Proc. Natl. Acad. Sci. USA, 100, 9946, 10.1073/pnas.1334037100

Lee, 2003, XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response, Mol. Cell. Biol., 23, 7448, 10.1128/MCB.23.21.7448-7459.2003

Lee, 2005, XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands, EMBO J., 24, 4368, 10.1038/sj.emboj.7600903

Libioulle, 2007, Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4, PLoS Genet., 3, e58, 10.1371/journal.pgen.0030058

Lin, 2007, IRE1 signaling affects cell fate during the unfolded protein response, Science, 318, 944, 10.1126/science.1146361

Lodes, 2004, Bacterial flagellin is a dominant antigen in Crohn disease, J. Clin. Invest., 113, 1296, 10.1172/JCI200420295

Madison, 2002, Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine, J. Biol. Chem., 277, 33275, 10.1074/jbc.M204935200

Mathew, 2008, New links to the pathogenesis of Crohn disease provided by genome-wide association scans, Nat. Rev. Genet., 9, 9, 10.1038/nrg2203

Nenci, 2007, Epithelial NEMO links innate immunity to chronic intestinal inflammation, Nature, 446, 557, 10.1038/nature05698

Nikolaus, 2007, Diagnostics of inflammatory bowel disease, Gastroenterology, 336, 1670, 10.1053/j.gastro.2007.09.001

Reimold, 2001, Plasma cell differentiation requires the transcription factor XBP-1, Nature, 412, 300, 10.1038/35085509

Ron, 2007, Signal integration in the endoplasmic reticulum unfolded protein response, Nat. Rev. Mol. Cell Biol., 8, 519, 10.1038/nrm2199

Shaffer, 2004, XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation, Immunity, 21, 81, 10.1016/j.immuni.2004.06.010

Shkoda, 2007, Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation, Gastroenterology, 132, 190, 10.1053/j.gastro.2006.10.030

Song, 1999, Expression of the neutrophil chemokine KC in the colon of mice with enterocolitis and by intestinal epithelial cell lines: effects of flora and proinflammatory cytokines, J. Immunol., 162, 2275, 10.4049/jimmunol.162.4.2275

Strober, 2002, The immunology of mucosal models of inflammation, Annu. Rev. Immunol., 20, 495, 10.1146/annurev.immunol.20.100301.064816

Tashiro, 2007, Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from Streptomyces sp, J. Antibiot. (Tokyo), 60, 547, 10.1038/ja.2007.69

Urano, 2000, Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1, Science, 287, 664, 10.1126/science.287.5453.664

van de Wal, 2003, Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells, Gastroenterology, 124, 1420, 10.1016/S0016-5085(03)00219-1

Vermeire, 2004, Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis, Gut, 53, 980, 10.1136/gut.2003.034033

Wehkamp, 2005, Reduced Paneth cell α-defensins in ileal Crohn's disease, Proc. Natl. Acad. Sci. USA, 102, 18129, 10.1073/pnas.0505256102

Wilson, 1999, Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense, Science, 286, 113, 10.1126/science.286.5437.113

Wu, 2006, From acute ER stress to physiological roles of the unfolded protein response, Cell Death Differ., 13, 374, 10.1038/sj.cdd.4401840

Zaph, 2007, Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis, Nature, 446, 552, 10.1038/nature05590