Wound healing effects of new 15-hydroxyprostaglandin dehydrogenase inhibitors

Martin, 1997, Wound healing for perfect skin regeneration, Science, 276, 75, 10.1126/science.276.5309.75 Werner, 2003, Regulation of wound healing by growth factors and cytokines, Physiol. Rev., 83, 835, 10.1152/physrev.2003.83.3.835 Pierce, 1988, In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins, J. Exp. Med., 167, 974, 10.1084/jem.167.3.974 Arnold, 1991, Angiogenesis in wound healing, Pharmacol. Ther., 52, 407, 10.1016/0163-7258(91)90034-J Brown, 1989, New Engl. J. Med., 321, 76, 10.1056/NEJM198907133210203 Grayson, 1993, Quantitation of cytokine levels in skin graft donor site wound fluid, Burns, 19, 401, 10.1016/0305-4179(93)90061-C Appleton, 1993, Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes, Lab. Investig., 69, 405 Talwar, 1996, The effect of a synthetic analogue of prostaglandin E2 on wound healing in rats, Ann. Clin. Lab. Sci., 26, 451 Abbate, 1990, Cyclooxygenase and lipoxygenase metabolite synthesis by polymorphonuclear neutrophils: in vitro effect of dipyrone, Prostaglandins Leukot. Essent. Fatty Acids, 41, 89, 10.1016/0952-3278(90)90059-T Hsu, 2007, Exogenous nitric oxide stimulated collagen type I expression and TGF-β1 production in keloid fibroblasts by a cGMP-dependent manner, Nitric Oxide, 16, 258, 10.1016/j.niox.2006.09.002 Reno, 2011, Effects of mechanical compression on hypertrophic scars: prostaglandin E2 release, Burns, 27, 215, 10.1016/S0305-4179(00)00101-7 Kolodsick, 2003, Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation, Am. J. Respir. Cell Mol. Biol., 29, 537, 10.1165/rcmb.2002-0243OC Han, 2005, Limb regeneration in higher vertebrates: developing a roadmap, Anat. Rec. B: New Anat., 287, 14, 10.1002/ar.b.20082 Price, 2005, Deer antlers as a model of mammalian regeneration, Curr. Top. Dev. Biol., 67, 1, 10.1016/S0070-2153(05)67001-9 Metcalfe, 2006, Characterizing regeneration in the vertebrate ear, J. Anat., 209, 439, 10.1111/j.1469-7580.2006.00632.x Jia, 2011, Advances in the regulation of liver regeneration, Expert Rev. Gastroenterol. Hepatol., 5, 105, 10.1586/egh.10.87 Goessling, 2009, Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration, Cell, 136, 1136, 10.1016/j.cell.2009.01.015 Kvirkvelia, 2013, Prostaglandin E2 promotes cellular recovery from established nephrotoxic serum nephritis in mice, prosurvival, and regenerative effects on glomerular cells, Am. J. Physiol. Ren. Physiol., 304, F463, 10.1152/ajprenal.00575.2012 Samuelsson, 1964, Prostaglandin and related factors, J. Biol. Chem., 239, 4097, 10.1016/S0021-9258(18)91138-5 Elworthy, 2004, Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents, J. Med. Chem., 47, 6124, 10.1021/jm049290a Xiao, 2007, Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists, Bioorg. Med. Chem. Lett., 17, 4323, 10.1016/j.bmcl.2007.05.025 Xiao, 2008, Synthesis and evaluation of a gamma-lactam as a highly selective EP2 and EP4 receptor agonist, Bioorg. Med. Chem. Lett., 18, 821, 10.1016/j.bmcl.2007.11.020 Cameron, 2006, Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats, Bioorg. Med. Chem. Lett., 16, 1799, 10.1016/j.bmcl.2006.01.018 Kambe, 2012, Synthesis and evaluation of γ-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists, Bioorg. Med. Chem., 20, 3502, 10.1016/j.bmc.2012.04.008 Wu, 2011, Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors, J. Med. Chem., 54, 5260, 10.1021/jm200390u Ensor, 1990, Cloning and sequence analysis of the cDNA for human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, J. Biol. Chem., 265, 14888, 10.1016/S0021-9258(18)77199-8 Sohda, 1982, Studies on anti-diabetic agents. II. Synthesis of 5-[4-(1-methylcyclohexylmethoxy)benzyl]-2,4-thiazolidinedione (ADD-3878) and its derivatives, Chem. Pharm. Bull., 30, 3580, 10.1248/cpb.30.3580 Cho, 2002, Thiazolidinediones as a novel class of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors, Arch. Biochem. Biophys., 405, 247, 10.1016/S0003-9861(02)00352-1 Wu, 2010, Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors, Bioorg. Med. Chem., 18, 1428, 10.1016/j.bmc.2010.01.016 Choi, 2013, Control of the intracellular levels of prostaglandin E2 through inhibition of the 15-hydroxyprostaglandin dehydrogenase for wound healing, Bioorg. Med. Chem., 21, 4477, 10.1016/j.bmc.2013.05.049 Goessling, 2011, Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models, Cell Stem Cell, 8, 445, 10.1016/j.stem.2011.02.003 Porter, 2013, Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury, Stem Cells, 31, 372, 10.1002/stem.1286 Nissim, 2014, Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth, Dev. Cell, 28, 423, 10.1016/j.devcel.2014.01.006