Wound healing activity of the hydroethanolic extract of the leaves of Maytenus ilicifolia Mart. Ex Reis

Cañedo-Dorantes, 2019, Skin acute wound healing: a comprehensive review, Int J Inflamm, 1, 10.1155/2019/3706315 Aplleton, 2003, Wound healing: future directions, 6, 1067 Nussbaum, 2018, An economic evaluation of the impact, cost, and medicare policy implications of chronic nonhealing wounds, Value Health, 21, 27, 10.1016/j.jval.2017.07.007 Heyer, 2016, Epidemiology of chronic wounds in Germany: analysis of statutory health insurance data, Wound Repair Regen, 24, 434, 10.1111/wrr.12387 Guest, 2015, Health economic burden that wounds impose on the National Health Service in the UK, BMJ Open, 5, 1, 10.1136/bmjopen-2015-009283 Mantle, 2021, Adverse and beneficial effects of plant extracts on skin and skin disorders, Adverse Drug React Toxicol Rev, 20, 89 Newman, 2016, Natural products as sources of new drugs from 1981 to 2014, J Nat Prod, 79, 629, 10.1021/acs.jnatprod.5b01055 Gharaboghaz, 2020, Topical co-administration of Teucrium polium hydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model, Biomed Pharmacother, 127, 110189, 10.1016/j.biopha.2020.110189 Farahpour, 2021, Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis, Pharm Biol, 59, 1, 10.1080/13880209.2020.1861029 De Moura, 2019, Pro-fibrogenic and anti-inflammatory potential of a polyphenol-enriched fraction from Annona crassiflora in skin repair, Planta Med, 85, 570, 10.1055/a-0733-7151 Almeida, 2015, Espinheira-santa (Maytenus ilicifolia Mart. ex Reiss.): saber de erveiros e feirantes em Pelotas (RS), Rev Bras Plantas Med, 17, 722, 10.1590/1983-084X/14_003 Jorge, 2004, Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia, J Ethnopharmacol, 94, 93, 10.1016/j.jep.2004.04.019 Wang, 2018, Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol, PloS One, 13, 1, 10.1371/journal.pone.0197563 Seifried, 2007, A review of the interaction among dietary antioxidants and reactive oxygen species, J Nutr Biochem, 18, 567, 10.1016/j.jnutbio.2006.10.007 Zhao, 2020, Masking the perceived astringency of proanthocyanidins in beverages using oxidized starch hydrogel microencapsulation, Foods, 9, 756, 10.3390/foods9060756 Júnior, 2013, Maytenus ilicifolia dry extract protects normal cells, induces apoptosis and regulates Bcl-2 in human cancer cells, Exp Biol Med, 238, 1251, 10.1177/1535370213494563 Wonfor, 2017, Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line, J Ethnopharmacol, 209, 283, 10.1016/j.jep.2017.08.006 Tabach, 2017, Pharmacological and toxicological study of Maytenus ilicifolia leaf extract Part II—clinical study (phase I), Phyther Res, 31, 921, 10.1002/ptr.5816 Cunha-Laura, 2014, Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats, Genet Mol Res, 13, 3711, 10.4238/2014.May.9.16 Ecker, 2017, Safety evaluation of supratherapeutic dose of Maytenus ilicifolia Mart. ex Reissek extracts on fertility and neurobehavioral status of male and pregnant rats, Regul Toxicol Pharmacol, 90, 160, 10.1016/j.yrtph.2017.09.007 Heijmen, 1997, Cross-linking of dermal sheep collagen with tannic acid, Biomaterials, 18, 749, 10.1016/S0142-9612(96)00202-5 Habibi Zadeh, 2020, The effect of topical administration of an ointment prepared from Trifolium repens hydroethanolic extract on the acceleration of excisional cutaneous, Wound Heal, 32, 253 Daemi, 2019, Topical administration of hydroethanolic extract of Lawsonia inermis (Henna) accelerates excisional wound healing process by reducing tissue inflammation and amplifying glucose uptake, Kaohsiung J Med Sci, 35, 24, 10.1002/kjm2.12005 Barbosa, 2021, Recombinant protein rP21 from Trypanosoma cruzi has effect on inflammation , angiogenesis and fibrogenesis in skin wound model C57BL/6 mouse, 22, 28 Salehi, 2021, Accelerating healing of excisional wound with alginate hydrogel containing naringenin in rat model, Drug Deliv Transl Res, 11, 142, 10.1007/s13346-020-00731-6 Pinto, 2016, Pereskia aculeata Miller leaves accelerate excisional wound healing in mice, J Ethnopharmacol, 194, 131, 10.1016/j.jep.2016.09.005 Barcelos, 2005, Impaired inflammatory angiogenesis , but not leukocyte influx , in mice lacking TNFR1, J Leukoc Biol, 78, 352, 10.1189/jlb.1104682 Cassini-Vieira, 2015, Estimation of wound tissue neutrophil and macrophage accumulation by measuring myeloperoxidase (MPO) and N-Acetyl-β-D-glucosaminidase (NAG) activities, Bio-Protocol, 5, 10.21769/BioProtoc.1662 Ferreira, 2020, Sesquiterpene polygodial from Drimys brasiliensis (winteraceae) down-regulates implant-induced inflammation and fibrogenesis in mice, J Nat Prod, 83, 3698, 10.1021/acs.jnatprod.0c00958 Silva, 2015, Prostate hyperplasia caused by long-term obesity is characterized by high deposition of extracellular matrix and increased content of MMP-9 and VEGF, Int J Exp Pathol, 96, 21, 10.1111/iep.12107 Esquisatto, 2014, Changes in the connective tissue sheath of Wistar rat nerve with aging, Ann Anat, 196, 441, 10.1016/j.aanat.2014.08.005 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal Biochem, 72, 248, 10.1016/0003-2697(76)90527-3 Hu, 1995, Correlation of 133Xe clearance, blood flow and histology in the rat sponge model for angiogenesis. Further studies with angiogenic modifiers, Lab Invest, 72, 601 Plunkett, 1990, An in vivo quantitative angiogenesis model using tumor cells entrapped in alginate, Lab Invest, 62, 510 Seifert, 2014, New insights into vertebrate skin regeneration, Int Rev Cell Mol Biol, 310, 129, 10.1016/B978-0-12-800180-6.00004-9 Junqueira, 1979, Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections, Histochem J, 11, 447, 10.1007/BF01002772 Phillips, 2004, Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis, J Clin Invest, 114, 438, 10.1172/JCI200420997 Campos, 2008, Mechanisms of wound healing responses in lupus-prone New Zealand White mouse strain, Wound Repair Regen, 16, 416, 10.1111/j.1524-475X.2008.00381.x Reinke, 2012, Wound repair and regeneration, Eur Surg Res, 49, 35, 10.1159/000339613 Klass, 2010, The effect of epigallocatechin-3-gallate, a constituent of green tea, on transforming growth factor-β1-stimulated wound contraction, Wound Repair Regen, 18, 80, 10.1111/j.1524-475X.2009.00552.x Yin, 2018, Topical application of quercetin improves wound healing in pressure ulcer lesions, Exp Dermatol, 27, 779, 10.1111/exd.13679 Özay, 2019, Wound healing effect of kaempferol in diabetic and nondiabetic rats, J Surg Res, 233, 284, 10.1016/j.jss.2018.08.009 Wilgus, 2013, Neutrophils and wound repair: positive actions and negative reactions, Adv Wound Care, 2, 379, 10.1089/wound.2012.0383 Shiba, 2008, Flavonoids as substrates and inhibitors of myeloperoxidase: Molecular actions of aglycone and metabolites, Chem Res Toxicol, 21, 1600, 10.1021/tx8000835 Miri, 1999, (—)-Epiafzelechin: cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus, Planta Med, 65, 460, 10.1055/s-2006-960813 De Melo, 2009, Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum, J Ethnopharmacol, 124, 228, 10.1016/j.jep.2009.04.024 Loria, 2008, Myeloperoxidase: a new biomarker of inflammation in ischemic heart disease and acute coronary syndromes, Mediat Inflamm, 1, 10.1155/2008/135625 Abel, 2008, Mast cell-fibroblast interactions induce matrix metalloproteinase-9 release from fibroblasts: role for IgE-mediated mast cell activation, J Immunol, 180, 3543, 10.4049/jimmunol.180.5.3543 Tchougounova, 2005, A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2, J Biol Chem, 280, 9291, 10.1074/jbc.M410396200 Häkkinen, 2000, Cell biology of gingival wound healing, Periodontol, 24, 127, 10.1034/j.1600-0757.2000.2240107.x Hattori, 2009, MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing, Am J Pathol, 175, 533, 10.2353/ajpath.2009.081080 Caley, 2015, Metalloproteinases and wound healing, Adv Wound Care, 4, 225, 10.1089/wound.2014.0581 Goldberg, 2017, Basic science of wound healing, Crit Limb Ischemia, 117, 131, 10.1007/978-3-319-31991-9_14 Kapoor, 2004, Effects of epicatechin gallate on wound healing and scar formation in a full thickness incisional wound healing model in rats, Am J Pathol, 165, 299, 10.1016/S0002-9440(10)63297-X Komi, 2019, A review of the contribution of mast cells in wound healing: involved molecular and cellular mechanisms, Clin Rev Allergy Immunol, 1 Blair, 1997, Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor, J Clin Invest, 99, 2691, 10.1172/JCI119458 Farahpour, 2015, Hydroethanolic Pistacia atlantica hulls extract improved wound healing process; evidence for mast cells infiltration, angiogenesis and RNA stability, Int J Surg, 17, 88, 10.1016/j.ijsu.2015.03.019 Barker, 2011, The role of ECM proteins and protein fragments in guiding cell behavior in regenerative medicine, Biomaterials, 32, 4211, 10.1016/j.biomaterials.2011.02.027 Stipcevic, 2006, Effect of different flavonoids on collagen synthesis in human fibroblasts, Plant Foods Hum Nutr, 61, 29, 10.1007/s11130-006-0006-8 Koganov, 1999, Activities of plant-derived phenols in a fibroblast cell culture model, J Nat Prod, 62, 481, 10.1021/np9801559 Li, 2015, A topical aqueous oxygen emulsion stimulates granulation tissue formation in a porcine second-degree burn wound, Burns, 41, 1049, 10.1016/j.burns.2014.11.016 Kim, 2005, A novel binding site in collagen type III for integrins α1β1 and α2β1, J Biol Chem, 280, 32512, 10.1074/jbc.M502431200