Wound healing: Abnormalities and future therapeutic targets

Singer, 1999, Cutaneous wound healing, N Engl J Med, 341, 738, 10.1056/NEJM199909023411006 Clark, 1996 Loots, 1999, Cultured fibroblasts from chronic diabetic wounds on the lower extremity (non-insulin-dependent diabetes mellitus) show disturbed proliferation, Arch Dermatol Res, 291, 93, 10.1007/s004030050389 Abd-El-Aleem, 2001, Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers, J Pathol, 195, 616, 10.1002/path.992 Uitto, 1991 LeRoy, 1974, Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast, J Clin Invest, 54, 880, 10.1172/JCI107827 Abergel, 1985, Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures, J Invest Dermatol, 84, 384, 10.1111/1523-1747.ep12265471 Mancini, 1997, The diabetic foot: epidemiology, Rays, 22, 511 Fagerberg, 1959, Diabetic neuropathy: a clinical and histological study on the significance of vascular affections, Acta Med Scand, 164, 1 Spanheimer, 1988, Decreased collagen production in diabetic rats, Diabetes, 37, 371, 10.2337/diabetes.37.4.371 Diegelmann, 2004, Wound healing: an overview of acute, fibrotic and delayed healing, Front Biosci, 9, 283, 10.2741/1184 Jude, 2002, Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers, Diabet Med, 19, 440, 10.1046/j.1464-5491.2002.00692.x Blakytny, 2000, Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers, J Pathol, 190, 589, 10.1002/(SICI)1096-9896(200004)190:5<589::AID-PATH553>3.0.CO;2-T Appleton, 1996, Apoptosis, necrosis, and proliferation: possible implications in the etiology of keloids, Am J Pathol, 149, 1441 Murray, 1981, Keloids: a review, J Am Acad Dermatol, 4, 461, 10.1016/S0190-9622(81)70048-3 Alhady, 1969, Keloids in various races. A review of 175 cases, Plast Reconstr Surg, 44, 564, 10.1097/00006534-196912000-00006 Nirodi, 2000, Chemokine and chemokine receptor expression in keloid and normal fibroblasts, Wound Repair Regen, 8, 371, 10.1111/j.1524-475X.2000.00371.x Luo, 2001, Abnormal balance between proliferation and apoptotic cell death in fibroblasts derived from keloid lesions, Plast Reconstr Surg, 107, 87, 10.1097/00006534-200101000-00014 Peltonen, 1991, Activation of collagen gene expression in keloids: co-localization of type I and VI collagen and transforming growth factor-beta 1 mRNA, J Invest Dermatol, 97, 240, 10.1111/1523-1747.ep12480289 Berman, 1995, Keloids, J Am Acad Dermatol, 33, 117, 10.1016/0190-9622(95)90035-7 Seifter, 1978, Arginine: an essential amino acid for injured rats, Surgery, 84, 224 Gartner, 1991, Wound fluid amino acid concentrations regulate the effect of epidermal growth factor on fibroblast replication, Surgery, 110, 448 Nussler, 1993, Inflammation, immunoregulation, and inducible nitric oxide synthase, J Leukoc Biol, 54, 171, 10.1002/jlb.54.2.171 Stuehr, 1987, Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma, J Immunol, 139, 518 Yamasaki, 1998, Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer, J Clin Invest, 101, 967, 10.1172/JCI2067 Frank, 1998, Induction of inducible nitric oxide synthase and its corresponding tetrahydrobiopterin-cofactor-synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair, J Invest Dermatol, 111, 1058, 10.1046/j.1523-1747.1998.00434.x Ignarro, 1990, Biosynthesis and metabolism of endothelium-derived nitric oxide, Annu Rev Pharmacol Toxicol, 30, 535, 10.1146/annurev.pa.30.040190.002535 Zachary, 2001, Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor, Am J Physiol Cell Physiol, 280, C1375, 10.1152/ajpcell.2001.280.6.C1375 Schaffer, 1997, Nitric oxide metabolism in wounds, J Surg Res, 71, 25, 10.1006/jsre.1997.5137 Witte, 2002, Role of nitric oxide in wound repair, Am J Surg, 183, 406, 10.1016/S0002-9610(02)00815-2 Stallmeyer, 1999, The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization, J Invest Dermatol, 113, 1090, 10.1046/j.1523-1747.1999.00784.x Schaffer, 1999, Inhibition of nitric oxide synthesis in wounds: pharmacology and effect on accumulation of collagen in wounds in mice, Eur J Surg, 165, 262, 10.1080/110241599750007153 Ferrini, 2002, Antifibrotic role of inducible nitric oxide synthase, Nitric Oxide, 6, 283, 10.1006/niox.2001.0421 Ferrara, 2003, Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries, Am J Pathol, 162, 1881, 10.1016/S0002-9440(10)64322-2 Most, 2002, Characterization of incisional wound healing in inducible nitric oxide synthase knockout mice, Surgery, 132, 866, 10.1067/msy.2002.127422 Lee, 1999, Impaired wound healing and angiogenesis in eNOS-deficient mice, Am J Physiol, 277, H1600 Wu, 1998, Arginine metabolism: nitric oxide and beyond, Biochem J, 336, 1, 10.1042/bj3360001 Jones, 1985, Conversion of glutamate to ornithine and proline: pyrroline-5-carboxylate, a possible modulator of arginine requirements, J Nutr, 115, 509, 10.1093/jn/115.4.509 Hui, 2001, Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1alpha, Ann Rheum Dis, 60, 254, 10.1136/ard.60.3.254 Tabor, 1984, Polyamines, Annu Rev Biochem, 53, 749, 10.1146/annurev.bi.53.070184.003533 Vockley, 1996, Cloning and characterization of the human type II arginase gene, Genomics, 38, 118, 10.1006/geno.1996.0606 Albina, 1990, Temporal expression of different pathways of 1-arginine metabolism in healing wounds, J Immunol, 144, 3877 Witte, 2002, Upregulation of arginase expression in wound-derived fibroblasts, J Surg Res, 105, 35, 10.1006/jsre.2002.6443 Louis, 1998, Distinct arginase isoforms expressed in primary and transformed macrophages: regulation by oxygen tension, Am J Physiol, 274, R775 Buga, 1996, Arginase activity in endothelial cells: inhibition by NG-hydroxy-l-arginine during high-output NO production, Am J Physiol, 271, H1988 Porporatto, 2003, Chitosan induces different l-arginine metabolic pathways in resting and inflammatory macrophages, Biochem Biophys Res Commun, 304, 266, 10.1016/S0006-291X(03)00579-5 Abd-El-Aleem, 2000, Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers, J Pathol, 191, 434, 10.1002/1096-9896(2000)9999:9999<::AID-PATH654>3.0.CO;2-S Jude, 1999, The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1, Diabetologia, 42, 748, 10.1007/s001250051224 Gunby, 1980, Vitamin C may enhance healing of caustic corneal burns, JAMA, 243, 623, 10.1001/jama.1980.03300330003001 Scholl, 2001, Nutrient recommendations for wound healing, J Intraven Nurs, 24, 124 Hirschmann, 1999, Adult scurvy, J Am Acad Dermatol, 41, 895, 10.1016/S0190-9622(99)70244-6 Kapoor, 2004, Effects of epicatechin gallate on wound healing and scar formation in a full thickness incisional wound healing model in rats, Am J Pathol, 165, 299, 10.1016/S0002-9440(10)63297-X Eldor, 2004, New and experimental approaches to treatment of diabetic foot ulcers: a comprehensive review of emerging treatment strategies, Diabet Med, 21, 1161, 10.1111/j.1464-5491.2004.01358.x