Wound Healing Dressings and Drug Delivery Systems: A Review

Journal of Pharmaceutical Sciences - Tập 97 Số 8 - Trang 2892-2923 - 2008
Joshua Boateng1, Kerr H. Matthews2, Howard N.E. Stevens1, Gillian M. Eccleston1
1Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, UK
2School of Pharmacy, The Robert Gordon University, School Hill, Aberdeen AB10 1FR, UK

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The Annual UK Drug Tariff. 1988 (Nov), 1998 (May), 2007 (Feb) The Stationary Office. London, UK: The UK Drug Tariff.

Morgan, 2002, Wounds—What should a dressing formulary include?, Hosp Pharmacist, 9, 261

Lazarus, 1994, Definitions and guidelines for assessment of wounds and evaluation of healing, Arch Dermatol, 130, 489, 10.1001/archderm.1994.01690040093015

Percival, 2002, Classification of wounds and their management, Surgery, 20, 114

Naradzay FX, Alson R. 2005. Burns, thermal. Web MD.

Harding, 2002, Science, medicine and the future: Healing chronic wounds, Br Med J, 324, 160, 10.1136/bmj.324.7330.160

Moore, 2006, Prediction and monitoring the therapeutic response of chronic dermal wounds, Int Wound J, 3, 89, 10.1111/j.1742-4801.2006.00212.x

Bolton, 1991, Wound dressings: Meeting clinical and biological needs, Dermatol Nurs, 3, 146

Krasner, 1993, The ABCs of wound care dressings, Wound Manag, 66, 68

Ferreira, 2006, Complex wounds, Clinics, 61, 571, 10.1590/S1807-59322006000600014

Strodtbeck, 2001, Physiology of wound healing, New Inf Nurs Rev, 1, 43, 10.1053/nbin.2001.23176

Russell, 1999, Understanding physiology of wound healing and how dressings help, Br J Nurs, 9, 10, 10.12968/bjon.2000.9.1.6406

Mast, 1999, The skin, 344

Schultz, 1999, Molecular regulation of wound healing, 413

Rothe, 1989, Growth factors, their biology and promise in dermatologic disease and tissue repair, Arch Dermatol, 125, 1390, 10.1001/archderm.1989.01670220086015

Shakespeare, 2001, Burn wound healing and skin substitutes, Burns, 27, 517, 10.1016/S0305-4179(01)00017-1

Cooper, 1999, Wound healing: New understandings, Nurs Pract Forum, 10, 74

Debra JB, Cheri O. 1998. Wound healing: Technological innovations and market overview. 2: 1–185.

Martin, 1997, Wound healing—Aiming for perfect skin regeneration, Science, 276, 75, 10.1126/science.276.5309.75

Musset, 1998, Wound management, stoma and incontinence products, 176

Eccleston, 2007, Wound dressings, 264

Thomas, 1997, Assessment and management of wound exudates, J Wound Care, 6, 327, 10.12968/jowc.1997.6.7.327

Gray, 2004, 19

Eaglstein, 1988, Optimal use of an occlusive dressing to enhance healing: Effect of delayed application and early removal on wound healing, Arch Dermatol, 124, 392, 10.1001/archderm.1988.01670030058022

Quick, 1994, Dressing choices, Nurs Times, 90, 71

Armstrong, 1997, Use of a fibrous dressing in exuding leg ulcers, J Wound Care, 7, 322, 10.12968/jowc.1997.6.7.322

Sibbald, 2003, Preparing the wound bed: Focus on infection and inflammation, Ostomy Wound Manag, 49, 24

Cutting, 2002, Maceration of the skin and wound bed 1: Its nature and causes, J Wound Care, 11, 275, 10.12968/jowc.2002.11.7.26414

Chen, 1992, Characterization of biological properties of wound fluid collected during early stages of wound healing, J Invest Dermatol, 99, 559, 10.1111/1523-1747.ep12667378

Hareendran, 2005, Measuring the impact of venous leg ulcers on quality of life, J Wound Care, 14, 53, 10.12968/jowc.2005.14.2.26732

Gilliland, 1988, Bacterial colonisation of leg ulcers and its effect on success rate of skin grafting, Ann R Coll Surg, 70, 105

Krasner, 1995, Minimizing factors that impair wound healing: A nursing approach, Ostomy Wound Manag, 41, 22

Lee, 2006, Surgical site infection in the elderly following orthopaedic surgery. Risk factors and outcomes, J Bone Joint Surg Am, 88, 1705, 10.2106/JBJS.E.01156

Hemila, 1999, Vitamin C and acute respiratory infections, Int J Tuberc Lung Dis, 3, 756

Rojas, 1999, Patients with chronic leg ulcers show diminished levels of vitamins A and E, carotenes and zinc, Dermatol Surg, 25, 601, 10.1046/j.1524-4725.1999.99074.x

Patel, 2005, The role of nutrition in the management of lower extremity wounds, Int J Low Extrem Wounds, 4, 12, 10.1177/1534734605274574

Falanga, 2005, Wound healing and its impairment in the diabetic foot, Lancet, 366, 1736, 10.1016/S0140-6736(05)67700-8

Pierce, 1989, Transforming growth factor β reverses the glucocorticoid-induced wound healing deficit in rats: Possible regulation in macrophages by platelet-derived growth factor, Proc Nat1 Acad Sci USA, 86, 2229, 10.1073/pnas.86.7.2229

Beck, 1993, One systemic administration of transforming growth factor β1 reverses age- or glucocorticoid-impaired wound healing, J Clin Invest, 92, 2841, 10.1172/JCI116904

Chedid, 1996, Glucocorticoids inhibit keratinocyte growth factor production in primary dermal fibroblasts, Endocrinol, 137, 2232, 10.1210/endo.137.6.8641170

Falabella, 2006, Debridement and wound bed preparation, Dermatol Ther, 19, 317, 10.1111/j.1529-8019.2006.00090.x

Leaper, 2002

Schultz, 2003, Wound bed preparation: A systematic approach to wound management, Wound Repair Regen, 11, S1, 10.1046/j.1524-475X.11.s2.1.x

Douglas, 2003, Wound bed preparation: A systematic approach to chronic wounds, Br J Comm Nurs, 8, S26, 10.12968/bjcn.2003.8.Sup2.11554

Schultz, 2004, Wound bed preparation and a brief history of TIME, Int Wound J, 1, 19, 10.1111/j.1742-481x.2004.00008.x

Fletcher, 2005, Wound bed preparation and the TIME principles, Nurs Stand, 20, 57, 10.7748/ns.20.12.57.s59

Carville, 2006, Which dressing should I use? It all depends on the ‘TIMEING’, Aust Fam Phys, 35, 486

Stoddard, 1995, Maggot debridement therapy—An alternative treatment for nonhealing ulcers, J Am Paediatr Med Assoc, 85, 218, 10.7547/87507315-85-4-218

Sherman, 1995, Maggot therapy for treating pressure ulcers in spinal cord injury patients, J Spinal Cord Med, 18, 71, 10.1080/10790268.1995.11719382

Nigam, 2006, Maggot therapy: Science and implication for CAM Part I-history and bacterial resistance, Evid Based Complement Alternat Med, 3, 223, 10.1093/ecam/nel021

Wollina, 2000, Biosurgery in wound healing—The renaissance of maggot therapy, J Eur Acad Dermatol Venereol, 14, 285, 10.1046/j.1468-3083.2000.00105.x

Wollina, 2005, Maggot therapy in the treatment of wounds of exposed knee prostheses, Int J Dermatol, 44, 884, 10.1111/j.1365-4632.2005.02366c.x

Nigam, 2006, Maggot therapy: Science and implication for CAM Part II-maggots combat infection, Evid Based Complement Alternat Med, 3, 303, 10.1093/ecam/nel022

Thomas, 1996, Using larvae in modern wound management, J Wound Care, 5, 60, 10.12968/jowc.1996.5.2.60

Prete, 1997, Growth effects of Phaenicia sericata larval extracts on fibroblasts: Mechanism for wound healing by maggot therapy, Life Sci, 60, 505, 10.1016/S0024-3205(96)00688-1

1990, Wounds and wound healing in: Wound management and dressings, 1

Kudi, 1999, Screening of some Nigerian medicinal plants for antibacterial activity, J Ethnopharmacol, 67, 225, 10.1016/S0378-8741(98)00214-1

Inngjerdingen, 2004, An ethnopharmacological survey of plants used for wound healing in Dogonland, Mali, West Africa, J Ethnopharmacol, 92, 233, 10.1016/j.jep.2004.02.021

Mensah, 2006, In vitro evaluation of effects of two Ghanaian plants relevant to wound healing, Phytother Res, 20, 941, 10.1002/ptr.1978

Purner, 2000, Collagen based dressings—A review, Burns, 26, 54, 10.1016/S0305-4179(99)00103-5

Queen, 2004, A dressing history, Int Wound J, 1, 59, 10.1111/j.1742-4801.2004.0009.x

Falabella, 2006, Debridement and wound bed preparation, Dermatol Ther, 19, 317, 10.1111/j.1529-8019.2006.00090.x

van Rijswijk, 2006, Ingredient-based wound dressing classification: A paradigm shift that is passé and in need of replacement, J Wound Care, 15, 11, 10.12968/jowc.2006.15.1.26859

Misra, 2003, Use of gauze soaked in povidone iodine for dressing acute wounds, Plast Reconstr Surg, 111, 2105, 10.1097/01.PRS.0000057076.71217.B2

Motta, 2004, Impact of antimicrobial gauze on bacterial colonies in wounds that require packing, Ostomy Wound Manag, 50, 48

Fukunaga, 2006, Our method of povidone-iodine and gauze dressings reduced catheter-related infection in serious cases, Dermatology, 212, 47, 10.1159/000089199

Farstvedt, 2004, Update on topical wound medications, Clin Tech Equine Pract, 3, 164, 10.1053/j.ctep.2004.08.003

Dealey, 1993, Role of hydrocolloids in wound management, Br J Nurs, 2, 358, 10.12968/bjon.1993.2.7.358

Hudspith, 2004, ABC of burns; first aid and treatment ofminor burns, Br Med J, 328, 1487, 10.1136/bmj.328.7454.1487

Liao, 2006, Multi-centre clinical study of the effect of silver nitrate ointment on the partial thickness burn wounds, Zhonghua Shao Shang Za Zhi, 22, 359

British Pharmacopoiea Monograph 1988. Cotton Conforming Bandage BP.

British Pharmacopoiea Monograph 1988. Polyamide and Cellulose Contour Bandage, Knitted BP.

Jones, 2006, The use of gauze: Will it ever change, Int Wound J, 3, 79, 10.1111/j.1742-4801.2006.00215.x

Dinah, 2006, Gauze packing of open surgical wounds: Empirical or evidence-based practice?, Ann R Coll Surg Engl, 88, 33, 10.1308/003588406X83014

Harding, 2000, The cost-effectiveness of wound management protocols of care, Br J Nurs, 9, S6, 10.12968/bjon.2000.9.Sup3.12483

Chang, 1998, Pressure ulcers–randomised controlled trial comparing hydrocolloid and saline gauze dressings, Med J Malaysia, 53, 428

Fletcher, 2005, Understanding wound dressings: Hydrocolloids, Nurs Times, 101, 51

Heenan, 1998, Hydrocolloids: Frequently asked questions, World Wide Wounds, 1, 1, 10.1023/A:1019247227505

Koksal, 2003, Combination of hydrocolloid dressing and medical compression stocking versus Unn's boot for the treatment of venous leg ulcers, Swiss Med Wkly, 133, 364

Thomas, 1997, A comparative study of twelve hydrocolloid dressings, World Wide Wounds, 1, 1

Thomas, 1992, Hydrocolloids, J Wound Care, 1, 27, 10.12968/jowc.1992.1.2.27

Cadier, 1996, Dermasorb versus Jelonet in patients with burns skin graft donor sites, J Burn Care Rehabil, 17, 246, 10.1097/00004630-199605000-00012

Heffernan, 1994, A comparison of a modified form of Granuflex (Granuflex Extra Thin) and a conventional dressing in the management of lacerations, abrasions andminor operation wounds in an accident and emergency department, J Accid Emerg Med, 11, 227, 10.1136/emj.11.4.227

Nemeth, 1991, Faster healing and less pain in skin biopsy sites treated with an occlusive dressing, Arch Dermatol, 127, 1679, 10.1001/archderm.1991.01680100079008

Hoekstra, 2002, A histological comparison of acute inflammatory responses with a hydrofibre or tulle gauze dressing, J Wound Care, 11, 113, 10.12968/jowc.2002.11.3.26384

Walker, 2003, Scanning electron microscopic examination of bacterial immobilisation in a carboxymethylcellulose (AquacelR) and alginate dressings, Biomaterials, 24, 883, 10.1016/S0142-9612(02)00414-3

Heenan, 1998, Alginates: Frequently asked questions, World Wide Wounds, 1, 1, 10.1023/A:1019247227505

Thomas, 2000, Alginate dressings in surgery and wound management—Part 1, J Wound Care, 9, 56, 10.12968/jowc.2000.9.2.26338

Kuo, 2001, Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part 1. Structure, gelation rate and mechanical properties, Biomaterials, 22, 511, 10.1016/S0142-9612(00)00201-5

Wang, 2003, Evaluation of sodium alginate for bone marrow cell tissue engineering, Biomaterials, 24, 3475, 10.1016/S0142-9612(03)00167-4

Ichioka, 1998, An experimental comparison of hydrocolloid and alginate dressings, and the effect of calcium ions on the behaviour of alginate gel, Scand J Plast Reconstr Surg Hand Surg, 32, 311, 10.1080/02844319850158660

Schmidt, 1986, Calcium alginate dressings, Pharm J, 236, 578

Doyle, 1996, Effects of calcium alginate on cellular wound healing processes modelled in vitro, J Biomed Mater Res, 32, 561, 10.1002/(SICI)1097-4636(199612)32:4<561::AID-JBM9>3.0.CO;2-P

Thomas, 2000, Alginates from wound dressings activate human macrophages to secrete tumour necrosis factor-α, Biomaterials, 21, 1797, 10.1016/S0142-9612(00)00072-7

Lansdown, 2002, Calcium: A potential central regulator in wound healing in the skin, Wound Repair Regen, 10, 271, 10.1046/j.1524-475X.2002.10502.x

Jarvis PM, Galvin DAJ, Blair SD. 1987. How does calcium alginate achieve haemostasis in surgery? Proceedings of the 11th Congress on Thrombosis and Haemostasis, 58: 50.

Collins, 2002

Blair, 1990, Clinical trial of calcium alginate haemostatic swabs, Br J Surg, 77, 568, 10.1002/bjs.1800770534

Blair, 1988, Comparison of absorbable materials for surgical haemostasis, Br J Surg, 75, 69, 10.1002/bjs.1800751010

Blaine, 1947, Experimental observations on absorbable alginate products in surgery, Ann Surg, 125, 102, 10.1097/00000658-194701000-00011

Oliver, 1950, Haemostasis with absorbable alginates in neurosurgical practice, Br J Surg, 37, 307, 10.1002/bjs.18003714712

Gilchrist, 1983, Wound treatment with Sorbsan—An Alginate fibre dressing, Biomaterials, 4, 317, 10.1016/0142-9612(83)90036-4

Agren, 1996, Four alginate dressings in the treatment of partial thickness wounds: A comparative study, J Plast Surg, 49, 129, 10.1016/S0007-1226(96)90088-0

Lay-Flurrie, 2004, The properties of hydrogel dressings and their impact on wound healing, Prof Nurse, 19, 269

Martin, 2002, The release of model macromolecules may be controlled by the hydrophobicity of palmitoyl glycol chitosan hydrogels, J Control Release, 80, 87, 10.1016/S0168-3659(02)00005-6

Morgan, 1999, Wound management products in the drug tariff, Pharm J, 263, 820

Wichterle, 1960, Hydrophilic gels for biological use, Nature, 185, 117, 10.1038/185117a0

Moody, 2006, Use of a hydrogel dressing for management of a painful ulcer, Br J Comm Nurs, 11, S12, 10.12968/bjcn.2006.11.Sup3.21212

Winter, 1962, Formation of the scab and the rate of epithelisation of superficial wounds in the skin of the young domestic pig, Nature, 193, 293, 10.1038/193293a0

Hinman, 1963, Effect of air exposure and occlusion on experimental human skin wounds, Nature, 200, 377, 10.1038/200377a0

Moshakis, 1984, Tegaderm versus gauze dressing in breast surgery, Br J Clin Pract, 38, 149, 10.1111/j.1742-1241.1984.tb07273.x

Thomas, 1988, Comparative review of the properties of six semipermeable film dressings, Pharm J, 240, 785

Hampton, 1999, Dressing for the occasion, Nurs Times, 95, 58

Wound care guidelines, 2005. Medicines Management Committee Report. 1–33.

Thomson T. 2006. Foam Composite. US Patent 7048966.

Marcia, 2002, New dressings, including tissue engineered living skin, Clin Dermatol, 20, 715, 10.1016/S0738-081X(02)00298-5

Vermeulen, 2005, Systematic review of dressings and topical agents for surgical wounds healing by secondary intention, Br J Surg, 6, 665, 10.1002/bjs.5055

Young, 1997, Matching the dressing to the wound, Community Nurse, 3, 31

Barlett, 1981, Skin substitutes, J Trauma, 21, S731, 10.1097/00005373-198108001-00041

Ramshaw, 1995, Collagen based biomaterials, Biotechnol Rev, 13, 336

Doillon, 1986, Collagen-based wound dressing: Effect of hyaluronic acid and fibronectin on wound healing, Biomaterials, 7, 3, 10.1016/0142-9612(86)90080-3

Ishihara, 2002, Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process, Biomaterials, 23, 833, 10.1016/S0142-9612(01)00189-2

Kollenberg, 1998

Ueno, 1999, Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs, Biomaterials, 20, 1407, 10.1016/S0142-9612(99)00046-0

Liu, 1995, Collagen in tendon, ligament and bone healing, Clin Orthop Res, 318, 265

Rao, 1995, Recent developments of collagen-based materials for medical applications and drug delivery, J Biomater Sci Polym Ed, 7, 623

Mian, 1992, Collagen as a pharmacological approach in wound healing, Int J Tissue React, 14, 1

Schwarzer, 1999, Manufacturing principles of freeze-dried collagen sponges: Characteristics and applications, 359

Ruszczak, 2003, Collagen as a carrier for on-site antibacterial drugs, Adv Drug Deliv Rev, 55, 1679, 10.1016/j.addr.2003.08.007

Vercruysse, 1998, Hyalurunate derivatives in drug delivery, Crit Rev Ther Carrier Syst, 15, 513

Luo, 2000, Cross-linked hyaluronic acid hydrogel films: New biomaterials for drug delivery, J Control Release, 69, 169, 10.1016/S0168-3659(00)00300-X

Yerushalmi, 1994, Molecular and cellular studies of hyaluronic acid-modified liposomes as bioadhesive carriers for topical drug delivery in wound healing, Arch Biochem Biophys, 313, 267, 10.1006/abbi.1994.1387

Voinchet, 2006, Efficacy and safety of hyaluronic acid in the management of acute wounds, Am J Dermatol, 7, 353, 10.2165/00128071-200607060-00003

Ueno, 2001, Topical formulations and wound healing applications of chitosan, Adv Drug Deliv Rev, 52, 105, 10.1016/S0169-409X(01)00189-2

Pruitt, 1984, Characteristics of and uses of biological dressings and skin substitutes, Arch Surg, 19, 312, 10.1001/archsurg.1984.01390150050013

Andreadis, 2006, Biomimetic approaches to protein and gene delivery for tissue regeneration, Trends Biotechnol, 24, 331, 10.1016/j.tibtech.2006.05.001

Horch, 2005, Tissue engineering of cultured skin substitutes, J Cell Mol Med, 9, 592, 10.1111/j.1582-4934.2005.tb00491.x

Whitaker, 2001, Growth factor release from tissue engineering scaffolds, J Pharm Pharmacol, 53, 1427, 10.1211/0022357011777963

Supp, 2005, Engineered skin substitutes: Practices and potentials, Clin Dermatol, 23, 403, 10.1016/j.clindermatol.2004.07.023

Burke, 1981, Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury, Ann Surg, 194, 413, 10.1097/00000658-198110000-00005

Sefton, 1998, Tissue engineering, J Cutan Med Surg, 3, 18

Storie, 2006, Sustained delivery of plasmid DNA from polymeric scaffolds for tissue engineering, Adv Drug Deliv Rev, 58, 500, 10.1016/j.addr.2006.03.004

Hoffman, 2002, Hydrogels for biomedical applications, Adv Drug Deliv Rev, 43, 3, 10.1016/S0169-409X(01)00239-3

Ruszczak, 2003, Effect of collagen matrices on dermal wound healing, Adv Drug Deliv Rev, 55, 1595, 10.1016/j.addr.2003.08.003

Stewart, 2002

Heenan, 1998

O'Meara, 2000, Systematic reviews of wound care management (3) antimicrobial agents for chronic wounds (4) diabetic foot ulceration, Health Technol Assess, 4, 1

Nelson, 2006, A series of systematic reviews to inform a decision analysis for sampling treating infected diabetic foot ulcers, Health Technol Assess, 10, 1, 10.3310/hta10120

Harihara, 2006, Effects of applying povidone-iodine just before skin closure, Dermatology, 212, 53, 10.1159/000089200

Lee-Min Mai, 2003, Synergistic effect of bismuth subgallate and borneol, the major components of Sulbogin® on the healing of skin wound, Biomaterials, 24, 3005, 10.1016/S0142-9612(03)00126-1

Rutten, 1997, Prevention of wound infection in elective colorectal surgery by local application of gentamicin-containing collagen sponge, Eur J Surg, 163, 31

Sawada, 1990, Treatment of dermal depth burn wounds with an antimicrobial agent-releasing silicone gel sheet, Burns, 16, 347, 10.1016/0305-4179(90)90007-J

Sawada, 1994, An evaluation of a new lactic acid polymer drug delivery system: A preliminary report, Br J Plast Surg, 47, 158, 10.1016/0007-1226(94)90046-9

Ganlanduik, 1997, Absorbable, delayed-release antibiotic beads reduce surgical wound infection, Am J Surg, 63, 831

Kumar, 2004, A freeze-dried fibrin disc as a biodegradable drug release matrix, Biologicals, 32, 49, 10.1016/j.biologicals.2003.11.002

Aoyagi, 2007, Novel chitosan wound dressing loaded withminocycline for the treatment of severe burn wounds, Int J Pharm, 330, 138, 10.1016/j.ijpharm.2006.09.016

Chu, 2006, Aminoglycoside ototoxicity in three murine strains and effects on NKCC1 of stria vascularis, Chin Med J, 119, 980, 10.1097/00029330-200606020-00003

Patrick, 2006, Acute renal failure associated with vancomycin- and tobramycin-laden cement in total hip arthroplasty, Ann Pharmacother, 40, 2037, 10.1345/aph.1H173

Komarcevic, 2000, The modern approach to wound treatment, Med Pregl, 53, 363

Dijke, 1989, Growth factors for wound healing, Biotechnology, 7, 793, 10.1038/nbt0889-793

Steenfos, 1994, Growth factors and wound healing Scand, J Plast Reconstr Surg, 28, 95, 10.3109/02844319409071186

Greenhalgh, 1996, The role of growth factors in wound healing, J Trauma Inj Infect Crit Care, 41, 159, 10.1097/00005373-199607000-00029

Mann, 2006, Granulocyte-macrophage colony-stimulating factor is essential for normal wound healing, J Investig Dermatol Symp Proc, 11, 87, 10.1038/sj.jidsymp.5650013

Lee, 2005, Reversal of silver sulfadiadine-impaired wound healing by epidermal growth factor, Biomaterials, 26, 4670, 10.1016/j.biomaterials.2004.11.041

Puolakkainen, 1995, The enhancement in wound healing by transforming growth factor-β1 (TGF-β1) depends on the topical delivery system, J Surg Res, 58, 321, 10.1006/jsre.1995.1050

Defail, 2006, Controlled release of bioactive doxorubicin from microspheres embedded within gelatin scaffolds, J Biomed Mater Res, 79, 954, 10.1002/jbm.a.30865

Koempel, 1998, The effect of platelet-derived growth factor on tracheal wound healing, Int J Pediatr Otorhinolaryngo, l46, 1, 10.1016/S0165-5876(98)00084-6

Maeda, 2001, Sustained release of human growth hormone (hGH) from collagen film and evaluation of effect on wound healing in mice, J Control Release, 77, 261, 10.1016/S0168-3659(01)00512-0

Gu, 2004, Sustained delivery of vascular endothelial growth factor with alginate beads, J Control Release, 96, 463, 10.1016/j.jconrel.2004.02.021

Grzybowski, 1999, New cytokine dressings. I. Kinetics of the in vitro rhG-CSF, rhGM-CSF, and rhEGF release from the dressings, Int J Pharm, 184, 173, 10.1016/S0378-5173(99)00065-4

Park, 2004, Evaluation of antibiotic loaded collagen-hyaluronic acid matrix as a skin substitute, Biomaterials, 25, 3689, 10.1016/j.biomaterials.2003.10.072

Brown, 1988, Acceleration of tensile strength of incisions treated with EGF and TGF-beta, Ann Surg, 208, 788, 10.1097/00000658-198812000-00019

Khan, 2006, Advances in the management of leg ulcers—The potential role of growth factors, Int Wound J, 3, 113, 10.1111/j.1742-4801.2006.00211.x

Wallace, 1994, Feeding the wound: Nutrition and wound healing, Br J Nurs, 3, 662, 10.12968/bjon.1994.3.13.662

Linda, 1991

Flanigan, 1997, Nutritional aspects of wound healing, Adv Wound Care, 10, 48

Ehrlich, 1973, Effects of vitamin A and glucocorticoids upon inflammation and collagen synthesis, Ann Surg, 177, 222, 10.1097/00000658-197302000-00017

Cohen, 1979, Reversal of postoperative immunosuppression in man by vitamin A, Surg Gynecol Obstet, 149, 658

Pugliese, 1998, The skin's antioxidant systems, Dermatol Nurs, 10, 401

Delafuente, 1986, Immunologic modulation by vitamin C in the elderly, Int J Immunopharmacol, 8, 205, 10.1016/0192-0561(86)90060-3

Porto da Rocha, 2002, Effects of a vitamin pool (vitamins A, E, and C) on the tissue necrosis process: Experimental study on rats, Aesthetic Plast Surg, 26, 197, 10.1007/s00266-002-1359-5

Bauman, 1999, The effects of topical vitamin E on the cosmetic appearance of scars, Dermatol Surg, 25, 311, 10.1046/j.1524-4725.1999.08223.x

Osieki, 1995

Kirschmann, 1996

Palmieri, 1995, Vitamin E added silicone gel sheets for treatment of hypertrohic scars and keloids, Int J Dermatol, 34, 506, 10.1111/j.1365-4362.1995.tb00628.x

Lazovic, 2005, The application of collagen sheet in open wound healing, Ann Burns Fire Disasters, 18, 151

Agren, 1990, Studies on zinc in wound healing, Acta Derm Venereol Suppl, 154, 1

Kietzmann, 2006, Effects of the zinc oxide and cod liver oil containing ointment Zincojecol in an animal model of wound healing, Dtsch Tierarztl Wochenschr, 113, 331

Lansdown, 2002, Metallothioneins: Potential therapeutic aids for wound healing in the skin, Wound Repair Regen, 10, 130, 10.1046/j.1524-475X.2002.20101.x

Yang, 2001, Effect of improved topical agents on healing time of deep second-degree burn wound, Zhonngguo Xiu Fu Chong Jian Wai Ke Za Zhi, 15, 3162

Agren, 2006, A randomized, double-blind, placebo-controlled multicenter trial evaluating topical zinc oxide for acute open wounds following pilonidal disease excision, Wound Repair Regen, 14, 526, 10.1111/j.1743-6109.2006.00159.x

Cangul, 2006, Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits, Vet Dermatol, 17, 417, 10.1111/j.1365-3164.2006.00551.x

1987, Controlled drug delivery: Fundamentals and applications

Lisa, 1997

Lee, 2000, Bioadhesive-based dosage forms: The next generation, J Pharm Sci, 89, 850, 10.1002/1520-6017(200007)89:7<850::AID-JPS2>3.0.CO;2-G

Langer, 1980, Polymeric delivery systems for controlled drug release, Chem Eng Commun, 6, 1, 10.1080/00986448008912519

Rao, 1988, Swelling controlled-release systems: Recent developments and applications, Int J Pharm, 48, 1, 10.1016/0378-5173(88)90245-1

Katti, 2004, Bioresobable nanofiber-based systems for wound healing and drug delivery: Optimisation of fabrication parameters, J Biomed Mater Res B Appl Biomater, 70, 286, 10.1002/jbm.b.30041

Thorn, 2006, An in vitro study of antimicrobial activity and efficacy of iodine-generating hydrogel dressings, J Wound Care, 15, 305, 10.12968/jowc.2006.15.7.26929

Tsou, 2002, Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies, J Mater Sci Mater Med, 16, 95, 10.1007/s10856-005-5954-2

Blanco, 2000, In-vivo drug delivery of 5-fluorouracil using poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels, J Pharm Pharmacol, 52, 1319, 10.1211/0022357001777469

Blanco, 1997, Controlled release of cytarabine from poly(2-hydroxyethyl methacrylate-co-N-vinyl-2-pyrrolidone, J Biomater Sci Polym Ed, 8, 709, 10.1163/156856297X00515

Gottrup, 2007, Less pain with Biatain-Ibu: Initial findings from a randomised, controlled, double-blind clinical investigation on painful leg ulcers, Int Wound J, 4, 24, 10.1111/j.1742-481X.2007.00312.x

Jorgensen, 2006, Pain and quality of life for patients with venous leg ulcers: Proof of concept of the efficacy of Biatain-Ibu, a new pain reducing wound dressing, Wound Repair Regen, 14, 233, 10.1111/j.1743-6109.2006.00116.x

Jorgensen, 2005, The silver-releasing form dressing, Contreet Foam, promotes faster healing of critically colonised venous leg ulcers: A randomised, controlled trial, Int Wound J, 2, 64, 10.1111/j.1742-4801.2005.00084.x

Rayman, 2005, Sustained silver-releasing dressing in the treatment of diabetic foot ulcers, Br J Nurs, 9, 109, 10.12968/bjon.2005.14.2.17441

Cho, 2002, Hyaluronic acid and silver sulfadiazine-impregnated polyurethane foams for wound dressing application, J Mater Sci Mater Med, 13, 861, 10.1023/A:1016500429225

Schaller, 2004, Toxicity and antimicrobial activity of a hydrocolloid dressing containing silver particles in an ex vivo model of cutaneous infection, Skin Pharmacol Physiol, 17, 31, 10.1159/000074060

Lin, 2000, In vitro elution of antibiotic from antibiotic-impregnated biodegradable calcium alginate wound dressing, J Trauma, 47, 136, 10.1097/00005373-199907000-00027

Meaume, 2005, Evaluation of a silver-releasing hydroalginate dressing in chronic wounds with signs of local infection, J Wound Care, 14, 411, 10.12968/jowc.2005.14.9.26835

Mi, 2002, Control of wound infections using a bilayer chitosan wound dressing with sustainable antibiotic delivery, J Biomed Mater Res, 59, 438, 10.1002/jbm.1260

Denkbas, 2004, Norfloxacin-loader chitosan sponges as wound dressing material, J Biomater Appl, 18, 291, 10.1177/0885328204041510

Ishihara, 2006, Controlled releases of FGF-2 and paclitaxel from chitosan hydrogels and their subsequent effects on wound repair, angiogenesis, and tumour growth, Curr Drug Deliv, 3, 351, 10.2174/156720106778559047

Burrell RE, Morris LR. 1998. Anti-microbial coating for medical devices. US Patent 5770255.

Keuch P, Murdock K, Czap CA, Lennon L1992. Non-Stingy adhesive hydrophilic gels. US Patent 5143071.

Smith DJ, Pulfer S, ShabaniM 1996. Polymeric Wound healing accelerators. US Patent 5519020.

Suwelack W, Tewes-Schwarzer P, Ecmayer Z 1994. Freeze-dried polysaccharide bio-matrix useful as pharmaceutical or cosmetic carrier. German Patent DE4328329.

Holgaard A. 1991. Pharmaceutical preparation. World Patent WO9119480.

Qin Y, Keith D, Nephente W1997. Dehydrated hydrogels. World patent WO 9739781.

Sakchai, 2006, Development and in vitro evaluation of chitosan-eudragit RS 30D composite wound dressings, AAPS Pharm SciTech, 7, E1

Mangala, 2003, Dev of chitosan/polyvinylalcohol blend membranes as burn dressings, Trends Biomater Artif Organs, 17, 34

Matthews, 2005, Wafers for wound healing, Int J Pharm, 289, 51, 10.1016/j.ijpharm.2004.10.022

Hubbell, 1996, Hydrogel systems for barriers and local drug delivery in the control of wound healing, J Control Release, 39, 305, 10.1016/0168-3659(95)00162-X

Shang-Yang, 2000, Organic esters of plasticizers affecting the water absorption, adhesive property, glass transition temperature and plasticizer performance of Eudragit acrylic films, J Control Release, 68, 343, 10.1016/S0168-3659(00)00259-5

Burnett S, Edwardson PAD, Mandley DJ, Velada J. 2002. World Patent WO 0234304A1.

Knapp B, Disalvo R. 2004. Gel-based cosmetic and wound healing formulation and method. US Patent 2004101515.

Walacavage AJ, Holland JF. 2004. Biodegradable wound dressing. US Patent 2004131663.

Matthews, 2006, Gamma irradiation of lyophilised wound healing wafers, Int J Pharm, 313, 78, 10.1016/j.ijpharm.2006.01.023

Papadimitriou, 1993, Probing the mechanisms of swelling of hydroxypropylmethylcellulose matrices, Int J Pharm, 98, 57, 10.1016/0378-5173(93)90041-D

Korsmeyer, 1983, Mechanisms of solute release from porous hydrophilic polymers, Int J Pharm, 15, 25, 10.1016/0378-5173(83)90064-9

Higuchi, 1961, Rate of release of medicaments from ointment bases containing drugs in suspension, J Pharm Sci, 50, 875, 10.1002/jps.2600501018

Sujja-areevath, 1998, Relationship between swelling, erosion and drug release in hydrophilic natural gummini-matrix formulations, Eur J Pharm Sci, 6, 207, 10.1016/S0928-0987(97)00072-9

Martin, 1993, Chapter 13, 324

Bourke, 2003, A photo-crosslinked poly(vinyl alcohol) hydrogel growth factor release vehicle for wound healing applications, AAPS Pharm Sci, 5, E33, 10.1208/ps050433

Hanes, 1998, Degradation of porous polyanhydride-co-imide) microspheres and implications for controlled macromolecule delivery, Biomaterials, 19, 163, 10.1016/S0142-9612(97)00221-4

Gimeno, 2003, A novel controlled drug-delivery system for growth hormone applied to healing skin wounds in diabetic rats, J Biomater Sci Polym Ed, 14, 821, 10.1163/156856203768366549

Aoyagi, 2007, Novel chitosan wound dressing loaded withminocycline for the treatment of severe burn wounds, Int J Pharm, 330, 138, 10.1016/j.ijpharm.2006.09.016

Gombotz, 1998, Protein release from alginate matrices, Adv Drug Deliv Rev, 31, 267, 10.1016/S0169-409X(97)00124-5

Dubose, 2005, Controlled release of tethered molecules via engineered hydrogel degradation: Model development and validation, J Biomed Mater Res A, 74A, 104, 10.1002/jbm.a.30307

Suzuki, 1998, A new drug delivery system with controlled release of antibiotic only in the presence of infection, J Biomed Mater Res, 42, 112, 10.1002/(SICI)1097-4636(199810)42:1<112::AID-JBM14>3.0.CO;2-N

Peppas, 1983, The swelling interface number as a criterion for prediction of diffusional solute release mechanisms in swellable polymers, J Polym Sci Polym Phys Ed, 21, 983, 10.1002/pol.1983.180210614

Ritger, 1987, A simple equation for the description of solute release II. Fickian and anomalous release from swellable devices, J Control Release, 5, 37, 10.1016/0168-3659(87)90035-6

Siepmann, 1999, HPMC-matrices for controlled drug delivery: A new model combining diffusion, swelling and dissolution mechanisms and predicting the release kinetics, Pharm Res, 16, 1748, 10.1023/A:1018914301328

Siepmann, 2000, Hydrophilic matrices for controlled drug delivery: An improved mathematical model to predict the resulting drug release kinetics (the “Sequential Layer” model), Pharm Res, 17, 1290, 10.1023/A:1026455822595

Narasimhan, 1996, Disentanglement and reptation during dissolution of rubbery polymers, J Polym Sci Polym Phys, 34, 947, 10.1002/(SICI)1099-0488(19960415)34:5<947::AID-POLB13>3.0.CO;2-B

Narasimhan, 1996, On the importance of chain reptation in models of dissolution of glassy polymers, Macromol, 29, 3283, 10.1021/ma951450s

Gatti, 2004, Physical characterization of a new biomaterial for wound management, J Mater Sci Mater Med, 5, 190, 10.1007/BF00121087

White, 2006, Modern exudate management: A review of wound treatments, World Wide Wounds 1.0

Test method for water vapour permeability of thin films. 2002. Surgical Materials Testing Laboratory Report, Wales, UK.

British Standards BS EN 13726-1. 2002. Test methods for primary wound dressings. Part 1: Aspects of Absorbency, section 3.3 Fluid Handling Capacity.

British Pharmacopoiea. 1996. Semi permeable hydrocolloid dressing Addendum, 1943–1944.

British Pharmacopoeia 1995. Alginates Addendum.

Thomas, 1996, The effect of dressings on the production of exudate from venous leg ulcers, Wounds, 8, 145

Ferrari, 1994, Comparative evaluation of hydrocolloid dressings by means of water uptake and swelling force measurements I, Int J Pharm, 112, 29, 10.1016/0378-5173(94)90258-5

Waring, 2001, Physico-chemical characterisation of carboxymethylated spun cellulose fibres, Biomaterials, 22, 903, 10.1016/S0142-9612(00)00254-4

Thomas, 1992, Observations on the fluid handling properties of alginate dressings, Pharm J, 248, 850

British Standards, BS EN 13726-2. 2002. Test methods for primary wound dressings. Part 2: Moisture vapour transmission rate of permeable film dressings.

Erasmus, 1989, Water vapour permeance: A meaningful measure for water vapour permeability of wound coverings, Burns, 15, 371, 10.1016/0305-4179(89)90101-0

Palamand, 1992, Testing intelligent wound dressings, J Biomater Appl, 6, 198, 10.1177/088532829200600302

Vowden, 2004, Wound management: The considerations involved in dressing selection, Nurs Prescr, 2, 152, 10.12968/npre.2004.2.4.15367

Sakchai, 2006, Development and in vitro evaluation of Chitosan-Eudragit RS 300 Composite Wound Dressings, AAPS PharSci Tech, 7, E1

Khan, 2003, A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats, J Pharm Sci, 6, 20

British Standards BS EN 13726-1 2002. Test methods for primary wound dressings. Part 1 Aspects of absorbency, Section 3.4, Fluid affinity of amorphous hydrogel wound dressings.

Thomas, 2005, An in vitro comparison of the physical characteristics of hydrocolloids, hydrogels, foams and alginate/cmc fibrous dressings, SMTL Rep, 1

Thomas, 1995, Fluid handling properties of hydrogel dressings, Ostomy Wound Manag, 41, 54

Thomas, 1994, Assessing the hydro-affinity of hydrogel dressings, J Wound Care, 3, 89, 10.12968/jowc.1994.3.2.89

Lanel, 1997, Swelling of hydrocolloid dressings, Biorheology, 34, 139, 10.1016/S0006-355X(97)00010-3

Daniels, 2002, Evaluation of a new composite dressing for the management of chronic leg ulcer wounds, J Wound Care, 11, 290, 10.12968/jowc.2002.11.8.26430

Thomas, 2001, The development of a novel technique for predicting the exudate handling properties of modern wound dressings, J Tissue Viability, 11, 145, 10.1016/S0965-206X(01)80003-6

Lee, 2001, Characterization of UV-irradiated dense/porous collagen membranes: Morphology, enzymatic degradation and mechanical properties, Yonsei Med J, 42, 172, 10.3349/ymj.2001.42.2.172

Khan, 2000, Mechanical, bioadhesive and biological evaluations of chitosan films for wound dressing, J Pharm Pharm Sci, 3, 303

2002, 156

British Standards, BS 7505 1995. Specification for the elastic properties of flat, non-adhesive, extendible fabric bandages.

Beumer, 1993, A new biodegradable matrix as part of a cell seeded skin substitute for the treatment of deep skin defects: A physico-chemical characterisation, Clin Mater, 14, 21, 10.1016/0267-6605(93)90043-7

Jurgens, 1995, Development and characterisation of an absorbable temporary wound dressing, Unfallchirurg, 98, 233

Boateng J. 2005. PhD Thesis, University of Strathclyde.

Turhan, 2004, Water vapor permeability, tensile properties and solubility of methylcellulose-based edible films, J Food Eng, 61, 459, 10.1016/S0260-8774(03)00155-9

Debeaufort, 1997, Methylcellulose-based edible films and coatings: 2. Mechanical and thermal properties as a function of plasticizer content, J Agric Food Chem, 45, 685, 10.1021/jf9606621

Siew, 2000, The properties of amylose–ethylcellulose films cast from organic-based solvents as potential coatings for colonic drug delivery, Eur J Pharm, 11, 133, 10.1016/S0928-0987(00)00098-1

Dallan, 2007, Effects of chitosan solution concentration and incorporation of chitin and glycerol on dense chitosan membrane properties, J Biomed Mater Res B Appl Biomater, 80, 394, 10.1002/jbm.b.30610

Grosvenor, 1996, The effect of molecular weight on the rheological and tensile properties of poly(-caprolactone), Int Pharm, 135, 103, 10.1016/0378-5173(95)04404-3

Lazaridou, 2003, Molecular weight effects on solution rheology of pullulan and mechanical properties of its films, Carbohydr Polym, 52, 151, 10.1016/S0144-8617(02)00302-8

Remunan-Lopez, 1997, Mechanical, water uptake and permeability properties of chitosan glutamate and alginate films, J Control Release, 44, 215, 10.1016/S0168-3659(96)01525-8

Yang, 2000, Mechanical and water vapour barrier properties of edible gellan films, Food Res Int, 33, 563, 10.1016/S0963-9969(00)00092-2

Hypolla, 1996, Evaluation of physical properties of plasticised ethylcellulose films cast from ethanol solution, Part I, Int J Pharm, 133, 161, 10.1016/0378-5173(96)04436-5

Lin, 1991, The effect of plasticizers on compatibility, mechanical properties and adhesion strength of drug free Eudragit E films, Pharm Res, 8, 1137, 10.1023/A:1015850301214

Bashaiwoldu, 2004, Application of dynamic mechanical analysis (DMA) to the determination of the mechanical properties of coated pellets, Int J Pharm, 274, 53, 10.1016/j.ijpharm.2003.12.030

Ferreira, 2006, Thermal characterization of chitosan grafted membranes to be used as wound dressings, J Carbohydr Chem, 25, 233, 10.1080/07328300600734085

Lai, 2003, The preparation and characterisation of drug-loaded alginate and chitosan sponges, Int J Pharm, 251, 175, 10.1016/S0378-5173(02)00590-2

Johnson, 1997, The effects of alginate molecular structure and formulation variables on the physical characteristics of alginate raft systems, Int J Pharm, 159, 35, 10.1016/S0378-5173(97)00266-4

Razzak, 1999, The characterization of dressing component materials and radiation formation of PVA-PVP hydrogel, Rad Phys Chem, 55, 153, 10.1016/S0969-806X(98)00320-X

Tamburic, 1997, A comparison of different in vitro methods for measuring mucoadhesive performance, Eur J Pharm Biopharm, 44, 159, 10.1016/S0939-6411(97)00073-8

Peh, 1999, Polymeric film as vehicle for buccal delivery: Swelling, mechanical, and bioadhesive properties, J Pharm Pharm Sci, 2, 253

Woolfson, 1995, A bioadhesive patch cervical drug delivery system for the administration of 5-fluorouracil to cervical tissue, J Control Release, 35, 49, 10.1016/0168-3659(95)00018-4

Woolfson, 1998, Development and characterisation of a moisture-activated bioadhesive drug delivery system for percutaneous local anaesthesia, Int J Pharm, 169, 83, 10.1016/S0378-5173(98)00109-4

Jacques, 1997, In vivo evaluation of hydrophilic and hydrophobic mucoadhesive semi-solid formulations containing sucralfate and lidocaine for intraoral use, Eur J Pharm Biopharm, 43, 59, 10.1016/S0939-6411(96)00011-2

Peppas, 1985, Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues, J Control Release, 2, 257, 10.1016/0168-3659(85)90050-1

Lehr, 1992, In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers, Int J Pharm, 78, 43, 10.1016/0378-5173(92)90353-4

Lin, 2001, Design and evaluation of drug-loaded wound dressing having thermoresponsive, adhesive, absorptive and easy peeling properties, Biomaterials, 22, 2999, 10.1016/S0142-9612(01)00046-1