Wnt Signaling in Stem Cells and Non–Small-Cell Lung Cancer
Tóm tắt
Từ khóa
Tài liệu tham khảo
Preston, 2003, The new stem cell biology: something for everyone, Mol Pathol, 56, 86, 10.1136/mp.56.2.86
Morrison, 1994, The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype, Immunity, 1, 661, 10.1016/1074-7613(94)90037-X
Baum, 1992, Isolation of a candidate human hematopoietic stem-cell population, Proc Natl Acad Sci U S A, 89, 2804, 10.1073/pnas.89.7.2804
Spangrude, 1988, Purification and characterization of mouse hematopoietic stem cells, Science, 241, 58, 10.1126/science.2898810
Zimmermann, 2003, Lack of telomerase activity in human mesenchymal stem cells, Leukemia, 17, 1146, 10.1038/sj.leu.2402962
Simonsen, 2002, Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells, Nat Biotechnol, 20, 592, 10.1038/nbt0602-592
Marx, 2003, Cancer research. Mutant stem cells may seed cancer, Science, 301, 1308, 10.1126/science.301.5638.1308
Park, 1971, Mouse myeloma tumor stem cells: a primary cell culture assay, J Natl Cancer Inst, 46, 411
Till, 1961, A direct measurement of the radiation sensitivity of normal mouse bone marrow cells, Radiat Res, 14, 213, 10.2307/3570892
Hope, 2004, Acute myeloid leukemia originates from hierarchy of leukemic stem cell classes that differ in self-renewal capacity, Nat Immunol, 5, 738, 10.1038/ni1080
Bonnet, 1997, Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, Nat Med, 3, 730, 10.1038/nm0797-730
Smith, 2004, The care of the lung cancer patient in the 21st century: a new age, Semin Oncol, 31, 11, 10.1053/j.seminoncol.2004.02.012
Wechsler-Reya, 2001, The developmental biology of brain tumors, Annu Rev Neurosci, 24, 385, 10.1146/annurev.neuro.24.1.385
Taipale, 2001, The Hedgehog and Wnt signalling pathways in cancer, Nature, 411, 349, 10.1038/35077219
Thayer, 2003, Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis, Nature, 425, 851, 10.1038/nature02009
Berman, 2003, Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours, Nature, 425, 846, 10.1038/nature01972
Watkins, 2003, Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer, Nature, 422, 313, 10.1038/nature01493
Beachy, 2004, Tissue repair and stem cell renewal in carcinogenesis, Nature, 432, 324, 10.1038/nature03100
Karhadkar, 2004, Hedgehog signalling in prostate regeneration, neoplasia and metastasis, Nature, 431, 707, 10.1038/nature02962
Lustig, 2003, The Wnt signaling pathway and its role in tumor development, J Cancer Res Clin Oncol, 129, 199, 10.1007/s00432-003-0431-0
van Es, 2003, You Wnt some, you lose some: oncogenes in the Wnt signaling pathway, Curr Opin Genet Dev, 13, 28, 10.1016/S0959-437X(02)00012-6
Polakis, 2000, Wnt signaling and cancer, Genes Dev, 14, 1837
Akiyama, 2000, Wnt/beta-catenin signaling, Cytokine Growth Factor Rev, 11, 273, 10.1016/S1359-6101(00)00011-3
Eastman, 1999, Regulation of LEF-1/TCF transcription factors by Wnt and other signals, Curr Opin Cell Biol, 11, 233, 10.1016/S0955-0674(99)80031-3
Veeman, 2003, A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling, Dev Cell, 5, 367, 10.1016/S1534-5807(03)00266-1
Korinek, 1998, Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4, Nat Genet, 19, 379, 10.1038/1270
Brennan, 2004, Wnt proteins in mammary development and cancer, J Mammary Gland Biol Neoplasia, 9, 119, 10.1023/B:JOMG.0000037157.94207.33
Pandur, 2002, Wnt-11 activation of non-canonical Wnt signalling pathway is required for cardiogenesis, Nature, 418, 636, 10.1038/nature00921
Reya, 2003, A role for Wnt signalling in self-renewal of haematopoietic stem cells, Nature, 423, 409, 10.1038/nature01593
Morrisey, 2003, Wnt signaling and pulmonary fibrosis, Am J Pathol, 162, 1393, 10.1016/S0002-9440(10)64271-X
Yamaguchi, 1999, A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo, Development, 126, 1211, 10.1242/dev.126.6.1211
Weidenfeld, 2002, The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium, J Biol Chem, 277, 21061, 10.1074/jbc.M111702200
Li, 2002, Wnt5a participates in distal lung morphogenesis, Dev Biol, 248, 68, 10.1006/dbio.2002.0729
Shu, 2002, Wnt7b regulates mesenchymal proliferation and vascular development in the lung, Development, 129, 4831, 10.1242/dev.129.20.4831
Bonner, 2003, Gene expression signatures identify novel regulatory pathways during murine lung development: implications for lung tumorigenesis, J Med Genet, 40, 408, 10.1136/jmg.40.6.408
Chilosi, 2003, Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis, Am J Pathol, 162, 1495, 10.1016/S0002-9440(10)64282-4
Zhang, 2001, Hedgehog acts as a somatic stem cell factor in the Drosophila ovary, Nature, 410, 599, 10.1038/35069099
Machold, 2003, Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches, Neuron, 39, 937, 10.1016/S0896-6273(03)00561-0
Lai, 2003, Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo, Nat Neurosci, 6, 21, 10.1038/nn983
Pinto, 2003, Canonical Wnt signals are essential for homeostasis of the intestinal epithelium, Genes Dev, 17, 1709, 10.1101/gad.267103
Polesskaya, 2003, Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration, Cell, 113, 841, 10.1016/S0092-8674(03)00437-9
Owens, 2003, Contribution of stem cells and differentiated cells to epidermal tumours, Nat Rev Cancer, 3, 444, 10.1038/nrc1096
Bhardwaj, 2001, Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation, Nat Immunol, 2, 172, 10.1038/84282
Ramalho-Santos, 2000, Hedgehog signals regulate multiple aspects of gastrointestinal development, Development, 127, 2763, 10.1242/dev.127.12.2763
Gat, 1998, De Novo hair follicle morphogenesis and hair tumors in mice expressing truncated beta-catenin in skin, Cell, 95, 605, 10.1016/S0092-8674(00)81631-1
van de Wetering, 2002, The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells, Cell, 111, 241, 10.1016/S0092-8674(02)01014-0
Shackel, 2001, Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression, Gut, 49, 565, 10.1136/gut.49.4.565
Surendran, 2003, CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury, Am J Physiol Renal Physiol, 284, F653, 10.1152/ajprenal.00343.2002
Monga, 2001, Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration, Hepatology, 33, 1098, 10.1053/jhep.2001.23786
Liu, 2004, The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells, Proc Natl Acad Sci U S A, 101, 4158, 10.1073/pnas.0400699101
Dvorak, 1986, Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing, N Engl J Med, 315, 1650, 10.1056/NEJM198612253152606
Bienz, 2000, Linking colorectal cancer to Wnt signaling, Cell, 103, 311, 10.1016/S0092-8674(00)00122-7
(http://www.cancer.org).
Morin, 1997, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC, Science, 275, 1787, 10.1126/science.275.5307.1787
Korinek, 1997, Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma, Science, 275, 1784, 10.1126/science.275.5307.1784
Rhee, 2002, Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas, Oncogene, 21, 6598, 10.1038/sj.onc.1205920
Weeraratna, 2002, Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma, Cancer Cell, 1, 279, 10.1016/S1535-6108(02)00045-4
Lu, 2004, Activation of the Wnt signaling pathway in chronic lymphocytic leukemia, Proc Natl Acad Sci U S A, 101, 3118, 10.1073/pnas.0308648100
Nusse, 1982, Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of host genome, Cell, 31, 99, 10.1016/0092-8674(82)90409-3
Katoh, 2003, Expression and regulation of WNT1 in human cancer: up-regulation of WNT1 by beta-estradiol in MCF-7 cells, Int J Oncol, 22, 209
Wong, 2002, Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours, J Pathol, 196, 145, 10.1002/path.1035
Chen, 2001, Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription, J Cell Biol, 152, 87, 10.1083/jcb.152.1.87
He, 2004, A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells, Neoplasia, 6, 7, 10.1016/S1476-5586(04)80048-4
Katoh, 2001, Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer, Int J Oncol, 19, 1003
Yoshida, 1988, Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer, Proc Natl Acad Sci U S A, 85, 4861, 10.1073/pnas.85.13.4861
Roelink, 1992, Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors, Oncogene, 7, 487
Nessling, 1998, Mapping of chromosomal imbalances in gastric adenocarcinoma revealed amplified protooncogenes MYCN, MET, WNT2, and ERBB2, Genes Chromosomes Cancer, 23, 307, 10.1002/(SICI)1098-2264(199812)23:4<307::AID-GCC5>3.0.CO;2-#
Katoh, 2001, WNT2B2 mRNA, up-regulated in primary gastric cancer, is a positive regulator of the WNT- beta-catenin-TCF signaling pathway, Biochem Biophys Res Commun, 289, 1093, 10.1006/bbrc.2001.6076
Vider, 1996, Evidence for the involvement of the Wnt 2 gene in human colorectal cancer, Oncogene, 12, 153
Holcombe, 2002, Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma, Mol Pathol, 55, 220, 10.1136/mp.55.4.220
Katoh, 2001, Differential regulation of WNT2 and WNT2B expression in human cancer, Int J Mol Med, 8, 657
Pham, 2003, Wnt expression in malignant melanoma: pilot study indicating correlation with histopathological features, Mol Pathol, 56, 280, 10.1136/mp.56.5.280
You, 2004, Inhibition of Wnt-2-mediated signaling induces programmed cell death in non small cell lung cancer cells, Oncogene, 23, 6170, 10.1038/sj.onc.1207844
Calvo, 2000, Altered HOX and WNT7A expression in human lung cancer, Proc Natl Acad Sci U S A, 97, 12776, 10.1073/pnas.97.23.12776
Winn, 2005, Restoration of Wnt-7a expression reverses nonsmall cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation, J Biol Chem, 280, 19625, 10.1074/jbc.M409392200
Ohira, 2003, WNT7a induces E-cadherin in lung cancer cells, Proc Natl Acad Sci U S A, 100, 10429, 10.1073/pnas.1734137100
Kengaku, 1998, Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud, Science, 280, 1274, 10.1126/science.280.5367.1274
Moon, 1997, WNTs modulate cell fate and behavior during vertebrate development, Trends Genet, 13, 157, 10.1016/S0168-9525(97)01093-7
Saitoh, 2002, Frequent up-regulation of WNT5A mRNA in primary gastric cancer, Int J Mol Med, 9, 515
Liang, 2003, Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue, Cancer Cell, 4, 349, 10.1016/S1535-6108(03)00268-X
Nakano, 2003, Biological properties and gene expression associated with metastatic potential of human osteosarcoma, Clin Exp Metastasis, 20, 665, 10.1023/A:1027355610603
Kawano, 2003, Secreted antagonists of the Wnt signalling pathway, J Cell Sci, 116, 2627, 10.1242/jcs.00623
Ko, 2002, Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer, Exp Cell Res, 280, 280, 10.1006/excr.2002.5649
Ugolini, 2001, WNT pathway and mammary carcinogenesis: loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type, Oncogene, 20, 5810, 10.1038/sj.onc.1204706
To, 2001, Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer, Life Sci, 70, 483, 10.1016/S0024-3205(01)01422-9
Suzuki, 2002, A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer, Nat Genet, 31, 141, 10.1038/ng892
Suzuki, 2004, Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer, Nat Genet, 36, 417, 10.1038/ng1330
Caldwell, 2004, The Wnt antagonist sFRP1 in colorectal tumorigenesis, Cancer Res, 64, 883, 10.1158/0008-5472.CAN-03-1346
Hsieh, 1999, A new secreted protein that binds to Wnt proteins and inhibits their activities, Nature, 398, 431, 10.1038/18899
Wissmann, 2003, WIF1, a component of the Wnt pathway, is downregulated in prostate, breast, lung and bladder cancer, J Pathol, 201, 204, 10.1002/path.1449
Mazieres, 2004, Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer, Cancer Res, 64, 4717, 10.1158/0008-5472.CAN-04-1389
Lee, 2004, Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma, Oncogene, 23, 6672, 10.1038/sj.onc.1207881
Fedi, 1999, Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling, J Biol Chem, 274, 19465, 10.1074/jbc.274.27.19465
Tsuji, 2000, A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines, Biochem Biophys Res Commun, 268, 20, 10.1006/bbrc.1999.2067
Nozaki, 2001, Reduced expression of REIC/Dkk-3 gene in nonsmall cell lung cancer, Int J Oncol, 19, 117
Tsuji, 2001, Antiproliferative activity of REIC/DKK-3 and its significant down-regulation in non-small-cell lung carcinomas, Biochem Biophys Res Commun, 289, 257, 10.1006/bbrc.2001.5972
Kobayashi, 2002, Reduced expression of the REIC/DKK-3 gene by promoter-hypermethylation in human tumor cells, Gene, 282, 151, 10.1016/S0378-1119(01)00838-1
Zeng, 1997, The mouse Fused locus encodes Axin, an inhibitor of the Wnt pathway that regulates embryonic axis formation, Cell, 90, 181, 10.1016/S0092-8674(00)80324-4
Ponting, 1997, PDZ domains: targeting signalling molecules to sub-membranous sites, Bioessays, 19, 469, 10.1002/bies.950190606
Ponting, 1996, Pleckstrin's repeat performance: a novel domain in G-protein signaling?, Trends Biochem Sci, 21, 245, 10.1016/S0968-0004(96)30027-3
Uematsu, 2003, Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression, Oncogene, 22, 7218, 10.1038/sj.onc.1206817
Uematsu, 2003, Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin, Cancer Res, 63, 4547
Wharton, 2003, Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction, Dev Biol, 253, 1, 10.1006/dbio.2002.0869
Cooper, 1996, Loss of heterozygosity at 5q21 in non-small cell lung cancer: a frequent event but without evidence of apc mutation, J Pathol, 180, 33, 10.1002/(SICI)1096-9896(199609)180:1<33::AID-PATH642>3.0.CO;2-Y
Horii, 1992, Frequent somatic mutations of the APC gene in human pancreatic cancer, Cancer Res, 52, 6696
Furuuchi, 2000, Somatic mutations of the APC gene in primary breast cancers, Am J Pathol, 156, 1997, 10.1016/S0002-9440(10)65072-9
Ohgaki, 2004, APC mutations are infrequent but present in human lung cancer, Cancer Lett, 207, 197, 10.1016/j.canlet.2003.10.020
Hommura, 2002, Increased expression of beta-catenin predicts better prognosis in nonsmall cell lung carcinomas, Cancer, 94, 752, 10.1002/cncr.10213
Retera, 1998, The expression of beta-catenin in non-smallcell lung cancer: a clinicopathological study, J Clin Pathol, 51, 891, 10.1136/jcp.51.12.891
Kase, 2000, Expression of E-cadherin and beta-catenin in human non-small cell lung cancer and the clinical significance, Clin Cancer Res, 6, 4789
Barker, 2000, The Yin-Yang of TCF/beta-catenin signaling, Adv Cancer Res, 77, 1, 10.1016/S0065-230X(08)60783-6
Sunaga, 2001, Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma, Genes Chromosomes Cancer, 30, 316, 10.1002/1098-2264(2000)9999:9999<::AID-GCC1097>3.0.CO;2-9
Shigemitsu, 2001, Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion, Oncogene, 20, 4249, 10.1038/sj.onc.1204557
Ueda, 2001, Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas, Br J Cancer, 85, 64, 10.1054/bjoc.2001.1863
Nakatani, 2002, Aberrant nuclear localization and gene mutation of beta-catenin in low-grade adenocarcinoma of fetal lung type: up-regulation of the Wnt signaling pathway may be a common denominator for the development of tumors that form morules, Mod Pathol, 15, 617, 10.1038/modpathol.3880575
Habas, 2001, Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires novel Formin homology protein Daam1, Cell, 107, 843, 10.1016/S0092-8674(01)00614-6
Choi, 2002, Xenopus Cdc42 regulates convergent extension movements during gastrulation through Wnt/Ca2+ signaling pathway, Dev Biol, 244, 342, 10.1006/dbio.2002.0602
Penzo-Mendez, 2003, Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation, Dev Biol, 257, 302, 10.1016/S0012-1606(03)00067-8
Hordijk, 1997, Inhibition of invasion of epithelial cells by Tiam1-Rac signaling, Science, 278, 1464, 10.1126/science.278.5342.1464
Soon, 2003, Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation, J Biol Chem, 278, 11465, 10.1074/jbc.M210945200
Tao, 2001, Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1, Genes Dev, 15, 1796, 10.1101/gad.894301
Habas, 2003, Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation, Genes Dev, 17, 295, 10.1101/gad.1022203
Allal, 2000, RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription, J Biol Chem, 275, 31001, 10.1074/jbc.M005264200
Mazieres, 2004, Loss of RhoB expression in human lung cancer progression, Clin Cancer Res, 10, 2742, 10.1158/1078-0432.CCR-03-0149
Ikoma, 2004, A definitive role of RhoC in metastasis of orthotopic lung cancer in mice, Clin Cancer Res, 10, 1192, 10.1158/1078-0432.CCR-03-0275
del Peso, 1997, Rho proteins induce metastatic properties in vivo, Oncogene, 15, 3047, 10.1038/sj.onc.1201499
Yao, 2002, Differentially expressed genes associated with mouse lung tumor progression, Oncogene, 21, 5814, 10.1038/sj.onc.1205422
Malliri, 2003, Role of Rho-family proteins in cell adhesion and cancer, Curr Opin Cell Biol, 15, 583, 10.1016/S0955-0674(03)00098-X
Boutros, 1998, Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling, Cell, 94, 109, 10.1016/S0092-8674(00)81226-X
Moriguchi, 1999, Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates, J Biol Chem, 274, 30957, 10.1074/jbc.274.43.30957
You, 2004, Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells, Cancer Res, 64, 3474, 10.1158/0008-5472.CAN-04-0115
He, 2005, Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells, Cancer Res, 65, 743, 10.1158/0008-5472.743.65.3