Wnt Signaling and Cardiac Differentiation

Michael P. Flaherty1, Timothy J. Kamerzell2, Buddhadeb Dawn2
1Division of Cardiovascular Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
2Division of Cardiovascular Diseases, University of Kansas Medical Center, Kansas City, Kansas, USA

Tài liệu tham khảo

Czyz, 2001, Embryonic stem cell differentiation: the role of extracellular factors, Differentiation, 68, 167, 10.1046/j.1432-0436.2001.680404.x Wobus, 1997, Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes, J Mol Cell Cardiol, 29, 1525, 10.1006/jmcc.1997.0433 Behfar, 2002, Stem cell differentiation requires a paracrine pathway in the heart, FASEB J, 16, 1558, 10.1096/fj.02-0072com Fukuda, 2006, Stem cells as a source of regenerative cardiomyocytes, Circ Res, 98, 1002, 10.1161/01.RES.0000218272.18669.6e Makino, 1999, Cardiomyocytes can be generated from marrow stromal cells in vitro, J Clin Invest, 103, 697, 10.1172/JCI5298 Hattan, 2005, Purified cardiomyocytes from bone marrow mesenchymal stem cells produce stable intracardiac grafts in mice, Cardiovasc Res, 65, 334, 10.1016/j.cardiores.2004.10.004 Abdel-Latif, 2008, TGF-beta1 enhances cardiomyogenic differentiation of skeletal muscle-derived adult primitive cells, Basic Res Cardiol, 103, 514, 10.1007/s00395-008-0729-9 Flaherty, 2008, Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells, Circulation, 117, 2241, 10.1161/CIRCULATIONAHA.107.741066 Rose, 2008, Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro, Stem Cells, 26, 2884, 10.1634/stemcells.2008-0329 Nusse, 1991, A new nomenclature for int-1 and related genes: the Wnt gene family, Cell, 64, 231, 10.1016/0092-8674(91)90633-A Eisenberg, 2006, Wnt signal transduction and the formation of the myocardium, Dev Biol, 293, 305, 10.1016/j.ydbio.2006.02.014 Gessert, 2010, The multiple phases and faces of wnt signaling during cardiac differentiation and development, Circ Res, 107, 186, 10.1161/CIRCRESAHA.110.221531 Augustine, 1993, Antisense attenuation of Wnt-1 and Wnt-3a expression in whole embryo culture reveals roles for these genes in craniofacial, spinal cord, and cardiac morphogenesis, Dev Genet, 14, 500, 10.1002/dvg.1020140611 Park, 1996, The wingless signaling pathway is directly involved in Drosophila heart development, Dev Biol, 177, 104, 10.1006/dbio.1996.0149 Eisenberg, 1997, Wnt-11 is expressed in early avian mesoderm and required for the differentiation of the quail mesoderm cell line QCE-6, Development, 124, 525, 10.1242/dev.124.2.525 Schneider, 2001, Wnt antagonism initiates cardiogenesis in Xenopus laevis, Genes Dev, 15, 304, 10.1101/gad.855601 Marvin, 2001, Inhibition of Wnt activity induces heart formation from posterior mesoderm, Genes Dev, 15, 316, 10.1101/gad.855501 Eisenberg, 1999, WNT11 promotes cardiac tissue formation of early mesoderm, Dev Dyn, 216, 45, 10.1002/(SICI)1097-0177(199909)216:1<45::AID-DVDY7>3.0.CO;2-L Pandur, 2002, Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis, Nature, 418, 636, 10.1038/nature00921 Nakamura, 2003, A Wnt- and beta-catenin-dependent pathway for mammalian cardiac myogenesis, Proc Natl Acad Sci USA, 100, 5834, 10.1073/pnas.0935626100 Cadigan, 1997, Wnt signaling: a common theme in animal development, Genes Dev, 11, 3286, 10.1101/gad.11.24.3286 Rao, 2010, An updated overview on Wnt signaling pathways: a prelude for more, Circ Res, 106, 1798, 10.1161/CIRCRESAHA.110.219840 Flaherty, 2008, Noncanonical Wnt11 signaling and cardiomyogenic differentiation, Trends Cardiovasc Med, 18, 260, 10.1016/j.tcm.2008.12.001 Nusse, 1982, Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome, Cell, 31, 99, 10.1016/0092-8674(82)90409-3 Moon, 2004, WNT and beta-catenin signalling: diseases and therapies, Nat Rev Genet, 5, 691, 10.1038/nrg1427 Logan, 2004, The Wnt signaling pathway in development and disease, Annu Rev Cell Dev Biol, 20, 781, 10.1146/annurev.cellbio.20.010403.113126 Eisenberg, 2007, Evaluating the role of Wnt signal transduction in promoting the development of the heart, ScientificWorldJournal, 7, 161, 10.1100/tsw.2007.71 Klaus, 2008, Wnt signalling and its impact on development and cancer, Nat Rev Cancer, 8, 387, 10.1038/nrc2389 Barker, 2008, The canonical Wnt/beta-catenin signalling pathway, Methods Mol Biol, 468, 5, 10.1007/978-1-59745-249-6_1 MacDonald, 2009, Wnt/beta-catenin signaling: components, mechanisms, and diseases, Dev Cell, 17, 9, 10.1016/j.devcel.2009.06.016 Slusarski, 1997, Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling, Nature, 390, 410, 10.1038/37138 Kuhl, 2000, The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape, Trends Genet, 16, 279, 10.1016/S0168-9525(00)02028-X Kuhl, 2004, The WNT/calcium pathway: biochemical mediators, tools and future requirements, Front Biosci, 9, 967, 10.2741/1307 Kohn, 2005, Wnt and calcium signaling: beta-catenin-independent pathways, Cell Calcium, 38, 439, 10.1016/j.ceca.2005.06.022 Boutros, 1998, Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling, Cell, 94, 109, 10.1016/S0092-8674(00)81226-X Tada, 2000, Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway, Development, 127, 2227, 10.1242/dev.127.10.2227 Veeman, 2003, A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling, Dev Cell, 5, 367, 10.1016/S1534-5807(03)00266-1 Fanto, 2004, Planar polarity from flies to vertebrates, J Cell Sci, 117, 527, 10.1242/jcs.00973 Hume, 1993, Cwnt-8C: a novel Wnt gene with a potential role in primitive streak formation and hindbrain organization, Development, 119, 1147, 10.1242/dev.119.4.1147 Bouillet, 1996, A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid, Mech Dev, 58, 141, 10.1016/S0925-4773(96)00569-2 Malaterre, 2007, Wnt-Frizzled signalling and the many paths to neural development and adult brain homeostasis, Front Biosci, 12, 492, 10.2741/2077 Nelson, 2011, Wnt-signaling pathways in progressive renal fibrosis, Expert Opin Ther Targets, 15, 1073, 10.1517/14728222.2011.588210 Macsai, 2008, Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair, J Cell Physiol, 215, 578, 10.1002/jcp.21342 Gregory, 2005, How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow, Ann N Y Acad Sci, 1049, 97, 10.1196/annals.1334.010 Doucas, 2005, Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance, Eur J Cancer, 41, 365, 10.1016/j.ejca.2004.11.005 Bergmann, 2011, Inhibition of glycogen synthase kinase 3beta induces dermal fibrosis by activation of the canonical Wnt pathway, Ann Rheum Dis, 70, 2191, 10.1136/ard.2010.147140 Lad, 2009, Wnt-signaling in retinal development and disease, Stem Cells Dev, 18, 7, 10.1089/scd.2008.0169 Vinson, 1989, A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains, Nature, 338, 263, 10.1038/338263a0 Pinson, 2000, An LDL-receptor-related protein mediates Wnt signalling in mice, Nature, 407, 535, 10.1038/35035124 Aberle, 1997, beta-catenin is a target for the ubiquitin-proteasome pathway, EMBO J, 16, 3797, 10.1093/emboj/16.13.3797 Ikeda, 1998, Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin, EMBO J, 17, 1371, 10.1093/emboj/17.5.1371 Lee, 1999, Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway, J Biol Chem, 274, 21464, 10.1074/jbc.274.30.21464 Kishida, 2001, Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon, J Biol Chem, 276, 33147, 10.1074/jbc.M103555200 Behrens, 1996, Functional interaction of beta-catenin with the transcription factor LEF-1, Nature, 382, 638, 10.1038/382638a0 Ishitani, 2003, Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling, Mol Cell Biol, 23, 1379, 10.1128/MCB.23.4.1379-1389.2003 Slusarski, 1997, Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A, Dev Biol, 182, 114, 10.1006/dbio.1996.8463 Sheldahl, 1999, Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner, Curr Biol, 9, 695, 10.1016/S0960-9822(99)80310-8 Sheldahl, 2003, Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos, J Cell Biol, 161, 769, 10.1083/jcb.200211094 Miller, 1999, Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways, Oncogene, 18, 7860, 10.1038/sj.onc.1203245 Kinoshita, 2003, PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements, Genes Dev, 17, 1663, 10.1101/gad.1101303 Zaffran, 2002, Early signals in cardiac development, Circ Res, 91, 457, 10.1161/01.RES.0000034152.74523.A8 Brand, 2003, Heart development: molecular insights into cardiac specification and early morphogenesis, Dev Biol, 258, 1, 10.1016/S0012-1606(03)00112-X Olson, 2003, Sizing up the heart: development redux in disease, Genes Dev, 17, 1937, 10.1101/gad.1110103 Koyanagi, 2005, Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells, J Biol Chem, 280, 16838, 10.1074/jbc.M500323200 Belema Bedada, 2005, Activation of myogenic differentiation pathways in adult bone marrow-derived stem cells, Mol Cell Biol, 25, 9509, 10.1128/MCB.25.21.9509-9519.2005 Naito, 2006, Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis, Proc Natl Acad Sci USA, 103, 19812, 10.1073/pnas.0605768103 Ueno, 2007, Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells, Proc Natl Acad Sci USA, 104, 9685, 10.1073/pnas.0702859104 Wu, 1995, Heart development in Drosophila requires the segment polarity gene wingless, Dev Biol, 169, 619, 10.1006/dbio.1995.1174 Yamashita, 2005, Prospective identification of cardiac progenitors by a novel single cell-based cardiomyocyte induction, FASEB J, 19, 1534, 10.1096/fj.04-3540fje Manisastry, 2006, Early temporal-specific responses and differential sensitivity to lithium and Wnt-3A exposure during heart development, Dev Dyn, 235, 2160, 10.1002/dvdy.20878 Zhu, 2008, IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis, Nature, 454, 345, 10.1038/nature07027 Naito, 2005, Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling, Circ Res, 97, 144, 10.1161/01.RES.0000175241.92285.f8 Lin, 2007, Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis, Proc Natl Acad Sci USA, 104, 9313, 10.1073/pnas.0700923104 Kwon, 2007, Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors, Proc Natl Acad Sci USA, 104, 10894, 10.1073/pnas.0704044104 Singh, 2007, Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells, Circulation, 115, 617, 10.1161/CIRCULATIONAHA.106.642298 Ren, 2011, Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells, J Mol Cell Cardiol, 51, 280, 10.1016/j.yjmcc.2011.04.012 Willems, 2011, Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm, Circ Res, 109, 360, 10.1161/CIRCRESAHA.111.249540 Ai, 2007, Canonical Wnt signaling functions in second heart field to promote right ventricular growth, Proc Natl Acad Sci USA, 104, 9319, 10.1073/pnas.0701212104 Klaus, 2007, Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis, Proc Natl Acad Sci USA, 104, 18531, 10.1073/pnas.0703113104 Kispert, 1996, Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips, Development, 122, 3627, 10.1242/dev.122.11.3627 Baranski, 2000, The dynamic expression pattern of frzb-1 suggests multiple roles in chick development, Dev Biol, 217, 25, 10.1006/dbio.1999.9516 Chapman, 2004, Expression analysis of chick Wnt and frizzled genes and selected inhibitors in early chick patterning, Dev Dyn, 229, 668, 10.1002/dvdy.10491 Kuhl, 2000, Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus, J Biol Chem, 275, 12701, 10.1074/jbc.275.17.12701 Heisenberg, 2000, Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation, Nature, 405, 76, 10.1038/35011068 Garriock, 2005, Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus, Dev Biol, 279, 179, 10.1016/j.ydbio.2004.12.013 Abdul-Ghani, 2011, Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals, Mol Cell Biol, 31, 163, 10.1128/MCB.01539-09 Terami, 2004, Wnt11 facilitates embryonic stem cell differentiation to Nkx2.5-positive cardiomyocytes, Biochem Biophys Res Commun, 325, 968, 10.1016/j.bbrc.2004.10.103 Strauer, 2002, Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans, Circulation, 106, 1913, 10.1161/01.CIR.0000034046.87607.1C Assmus, 2006, Transcoronary transplantation of progenitor cells after myocardial infarction, N Engl J Med, 355, 1222, 10.1056/NEJMoa051779 Schachinger, 2006, Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction, N Engl J Med, 355, 1210, 10.1056/NEJMoa060186 Abdel-Latif, 2007, Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis, Arch Intern Med, 167, 989, 10.1001/archinte.167.10.989 Chugh, 2009, Bone marrow-derived mesenchymal stems cells and cardiac repair, Minerva Cardioangiol, 57, 185 Dawn, 2009, Cardiac repair with adult bone marrow-derived cells: the clinical evidence, Antioxid Redox Signal, 11, 1865, 10.1089/ars.2009.2462 Auda-Boucher, 2000, Staging of the commitment of murine cardiac cell progenitors, Dev Biol, 225, 214, 10.1006/dbio.2000.9817 Xu, 2006, Cardiac bodies: a novel culture method for enrichment of cardiomyocytes derived from human embryonic stem cells, Stem Cells Dev, 15, 631, 10.1089/scd.2006.15.631 Kuhl, 2001, Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling, Mech Dev, 106, 61, 10.1016/S0925-4773(01)00416-6 Maye, 2004, Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway, J Biol Chem, 279, 24659, 10.1074/jbc.M311724200 Lev, 2005, Differentiation pathways in human embryonic stem cell-derived cardiomyocytes, Ann N Y Acad Sci, 1047, 50, 10.1196/annals.1341.005 Foley, 2005, Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex, Genes Dev, 19, 387, 10.1101/gad.1279405 Li, 1999, Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells, J Biol Chem, 274, 129, 10.1074/jbc.274.1.129 Zhou, 2007, Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2, Nat Genet, 39, 1225, 10.1038/ng2112 Ventura, 2003, Protein kinase C signaling transduces endorphin-primed cardiogenesis in GTR1 embryonic stem cells, Circ Res, 92, 617, 10.1161/01.RES.0000065168.31147.5B Afouda, 2008, GATA transcription factors integrate Wnt signalling during heart development, Development, 135, 3185, 10.1242/dev.026443 Singla, 2006, wnt3a but not wnt11 supports self-renewal of embryonic stem cells, Biochem Biophys Res Commun, 345, 789, 10.1016/j.bbrc.2006.04.125 Brandon, 2000, WNT signaling modulates the diversification of hematopoietic cells, Blood, 96, 4132, 10.1182/blood.V96.13.4132 Nikolova, 2007, WNT-conditioned media differentially affect the proliferation and differentiation of cord blood-derived CD133+ cells in vitro, Differentiation, 75, 100, 10.1111/j.1432-0436.2006.00119.x Strauer, 2005, Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study, J Am Coll Cardiol, 46, 1651, 10.1016/j.jacc.2005.01.069