Wiskott-Aldrich syndrome protein senses irradiation-induced DNA damage to coordinate the cell-protective Golgi dispersal response in human T and B lymphocytes

Journal of Allergy and Clinical Immunology - Tập 145 - Trang 324-334 - 2020
Kuo-Kuang Wen1, Seong-Su Han1, Yatin M. Vyas1
1Division of Pediatric Hematology-Oncology, University of Iowa Carver College of Medicine, and the Stead Family University of Iowa Children’s Hospital, Iowa City, Iowa

Tài liệu tham khảo

Derry, 1994, Isolation of a novel gene mutated in Wiskott-Aldrich syndrome, Cell, 78, 635, 10.1016/0092-8674(94)90528-2 Villa, 1995, X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene, Nat Genet, 9, 414, 10.1038/ng0495-414 Zhou, 2017, Abnormal distribution of distinct lymphocyte subsets in children with Wiskott-Aldrich syndrome, Hum Immunol, 78, 565, 10.1016/j.humimm.2017.05.004 Imai, 2004, Clinical course of patients with WASP gene mutations, Blood, 103, 456, 10.1182/blood-2003-05-1480 Albert, 2010, X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options, Blood, 115, 3231, 10.1182/blood-2009-09-239087 Jin, 2004, Mutations of the Wiskott-Aldrich syndrome protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation, Blood, 104, 4010, 10.1182/blood-2003-05-1592 Symons, 1996, Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization, Cell, 84, 723, 10.1016/S0092-8674(00)81050-8 Taylor, 2010, Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome, Sci Transl Med, 2, 37ra44, 10.1126/scitranslmed.3000813 Sadhukhan, 2014, Nuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization, J Immunol, 193, 150, 10.4049/jimmunol.1302923 Sarkar, 2014, Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome, Blood, 124, 3409, 10.1182/blood-2014-07-587642 Sarkar, 2015, SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-kappaB response genes in T cells, Blood, 126, 1670, 10.1182/blood-2015-05-646182 Teitell, 2010, Alternative control: what's WASp doing in the nucleus?, Sci Transl Med, 2, 37ps31, 10.1126/scitranslmed.3001336 Sarkar, 2018, R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome, J Allergy Clin Immunol, 142, 219, 10.1016/j.jaci.2017.11.023 Castellano-Pozo, 2013, R loops are linked to histone H3 S10 phosphorylation and chromatin condensation, Mol Cell, 52, 583, 10.1016/j.molcel.2013.10.006 García-Pichardo, 2017, Histone mutants separate R loop formation from genome instability induction, Mol Cell, 66, 597, 10.1016/j.molcel.2017.05.014 Schrank, 2018, Nuclear ARP2/3 drives DNA break clustering for homology-directed repair, Nature, 559, 61, 10.1038/s41586-018-0237-5 Rengan, 2000, Actin cytoskeletal function is spared, but apoptosis is increased, in WAS patient hematopoietic cells, Blood, 95, 1283, 10.1182/blood.V95.4.1283.004k44_1283_1292 Rawlings, 1999, Spontaneous apoptosis in lymphocytes from patients with Wiskott-Aldrich syndrome: correlation of accelerated cell death and attenuated bcl-2 expression, Blood, 94, 3872, 10.1182/blood.V94.11.3872 Westerberg, 2010, Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes, J Exp Med, 207, 1145, 10.1084/jem.20091245 Moulding, 2007, Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia, J Exp Med, 204, 2213, 10.1084/jem.20062324 Farber-Katz, 2014, DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3, Cell, 156, 413, 10.1016/j.cell.2013.12.023 Alekhina, 2017, Cellular functions of WASP family proteins at a glance, J Cell Sci, 130, 2235, 10.1242/jcs.199570 Matas, 2004, Association of Cdc42/N-WASP/Arp2/3 signaling pathway with Golgi membranes, Traffic, 5, 838, 10.1111/j.1600-0854.2004.00225.x Bhattacharya, 2016, Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology, Sci Rep, 6, 25411, 10.1038/srep25411 Egorov, 2019, Identification of CDC42 effectors operating in FGD1-dependent trafficking at the Golgi, Front Cell Dev Biol, 7, 7, 10.3389/fcell.2019.00007 Campellone, 2008, WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport, Cell, 134, 148, 10.1016/j.cell.2008.05.032 Kondylis, 2007, The Golgi comprises a paired stack that is separated at G2 by modulation of the actin cytoskeleton through Abi and Scar/WAVE, Dev Cell, 12, 901, 10.1016/j.devcel.2007.03.008 Colón-Franco, 2011, Dynamic remodeling of the actin cytoskeleton by FMNL1γ is required for structural maintenance of the Golgi complex, J Cell Sci, 124, 3118, 10.1242/jcs.083725 Wei, 2010, Unraveling the Golgi ribbon, Traffic, 11, 1391, 10.1111/j.1600-0854.2010.01114.x Ouasti, 2007, Death receptor ligation triggers membrane scrambling between Golgi and mitochondria, Cell Death Differ, 14, 453, 10.1038/sj.cdd.4402043 Chia, 2012, RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells, Mol Syst Biol, 8, 629, 10.1038/msb.2012.59 Makhoul, 2018, The Golgi architecture and cell sensing, Biochem Soc Trans, 46, 1063, 10.1042/BST20180323 Liu, 2017, Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice, Proc Natl Acad Sci U S A, 114, 346, 10.1073/pnas.1608576114 Dippold, 2009, GOLPH3 bridges phosphatidylinositol-4-phosphate and actomyosin to stretch and shape the Golgi to promote budding, Cell, 139, 337, 10.1016/j.cell.2009.07.052 How, 2011, Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway, J Biol Chem, 286, 8565, 10.1074/jbc.M110.175174 Wei, 2017, Golgi ribbon disassembly during mitosis, differentiation and disease progression, Curr Opin Cell Biol, 47, 43, 10.1016/j.ceb.2017.03.008 Scott, 2009, GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer, Nature, 459, 1085, 10.1038/nature08109 Tang, 2016, Mena-GRASP65 interaction couples actin polymerization to Golgi ribbon linking, Mol Biol Cell, 27, 137, 10.1091/mbc.E15-09-0650 Egea, 2006, Actin dynamics at the Golgi complex in mammalian cells, Curr Opin Cell Biol, 18, 168, 10.1016/j.ceb.2006.02.007 Heylmann, 2014, Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells, Biochim Biophys Acta, 1846, 121 Bexiga, 2013, Human diseases associated with form and function of the Golgi complex, Int J Mol Sci, 14, 18670, 10.3390/ijms140918670 Buschman, 2015, GOLPH3 links the Golgi, DNA damage, and cancer, Cancer Res, 75, 624, 10.1158/0008-5472.CAN-14-3081 Menotti, 2019, Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma, Nat Med, 25, 130, 10.1038/s41591-018-0262-9 Yoshimi, 2013, Wiskott-Aldrich syndrome presenting with a clinical picture mimicking juvenile myelomonocytic leukaemia, Pediatr Blood Cancer, 60, 836, 10.1002/pbc.24359 Stieglitz, 2015, The genomic landscape of juvenile myelomonocytic leukemia, Nat Genet, 47, 1326, 10.1038/ng.3400 Keszei, 2018, Wiskott-Aldrich syndrome gene mutations modulate cancer susceptibility in the p53± murine model, Oncoimmunology, 7, e1468954, 10.1080/2162402X.2018.1468954 Yu, 2019, NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation, Cell Res, 29, 666, 10.1038/s41422-019-0189-9 Vece, 2016, Copa Syndrome: a novel autosomal dominant immune dysregulatory disease, J Clin Immunol, 36, 377, 10.1007/s10875-016-0271-8