Wingless Repression of Drosophila frizzled 2 Expression Shapes the Wingless Morphogen Gradient in the Wing

Baker, 1988, Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila, and the phenotype of a pupal-lethal wg mutation, Development, 102, 489, 10.1242/dev.102.3.489 Bejsovec, 1991, Roles of wingless in patterning the larval epidermis of Drosophila, Development, 113, 471, 10.1242/dev.113.2.471 Bhanot, 1996, A new member of the frizzled family from Drosophila functions as a Wingless receptor, Nature, 382, 225, 10.1038/382225a0 Blair, 1994, A role for the segment polarity gene shaggy-zeste white 3 in the specification of regional identity in the developing wing of Drosophila, Dev. Biol., 162, 229, 10.1006/dbio.1994.1081 Brand, 1993, Targeted gene expression as a means of altering cell fates and generating dominant phenotypes, Development, 118, 401, 10.1242/dev.118.2.401 Cadigan, 1996, wingless signaling in the Drosophila eye and embryonic epidermis, Development, 122, 2801, 10.1242/dev.122.9.2801 Cadigan, 1997, Wnt signaling, Genes Dev., 11, 3286, 10.1101/gad.11.24.3286 Campuzano, 1992, Patterning of the Drosophila nervous system, Trends Genet., 8, 202, 10.1016/0168-9525(92)90099-P Capdevila, 1994, The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development, EMBO J., 13, 71, 10.1002/j.1460-2075.1994.tb06236.x Casanova, 1993, The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila, Nature, 362, 152, 10.1038/362152a0 Casanova, 1995, Similarities between trunk and spätzle, putative extracellular ligands specifying body pattern in Drosophila, Genes Dev., 9, 2539, 10.1101/gad.9.20.2539 Chen, 1996, Dual roles for patched in sequestering and transducing hedgehog, Cell, 87, 553, 10.1016/S0092-8674(00)81374-4 Couso, 1994, The wingless signaling pathway and the patterning of the wing margin in Drosophila, Development, 120, 621, 10.1242/dev.120.3.621 Freeman, 1997, Cell determination strategies in the Drosophila eye, Development, 124, 261, 10.1242/dev.124.2.261 Golembo, 1996, argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop, Development, 122, 223, 10.1242/dev.122.1.223 Hacohen, 1998, sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways, Cell, 92, 253, 10.1016/S0092-8674(00)80919-8 Hajnal, 1997, Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase, Genes Dev., 11, 2715, 10.1101/gad.11.20.2715 Hill, 1992, The gene lin-3 encodes an inductive signal for vulval development in C. elegans, Nature, 358, 470, 10.1038/358470a0 Hoppler, 1995, Two different thresholds of wingless signaling with distinct developmental consequences in the Drosophila midgut, EMBO J., 14, 5016, 10.1002/j.1460-2075.1995.tb00184.x Hulme, E.C., and Birdsall, N.J.M. (1992). Strategy and tactics in receptor binding studies. In Receptor-Ligand Interactions: A Practical Approach, E. Hulme, ed., (Oxford: Oxford University Press), pp. 63–176. Johnson, 1995, patched overexpression alters wing disc size and pattern, Development, 121, 4161, 10.1242/dev.121.12.4161 Klingensmith, 1994, Signaling by wingless in Drosophila, Dev. Biol., 166, 396, 10.1006/dbio.1994.1325 Klingensmith, 1994, The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal, Genes Dev., 8, 118, 10.1101/gad.8.1.118 Kozopas, 1998, D Wnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate, Genes Dev., 12, 1155, 10.1101/gad.12.8.1155 Lawrence, 1996, Morphogens, compartments, and pattern, Cell, 85, 951, 10.1016/S0092-8674(00)81297-0 Lawrence, 1996, Compartments, wingless and engrailed, Development, 122, 4095, 10.1242/dev.122.12.4095 Marigo, 1996, Biochemical evidence that Patched is the Hedgehog receptor, Nature, 384, 176, 10.1038/384176a0 Micchelli, 1997, The function and regulation of cut expression on the wing margin of Drosophila, Development, 124, 1485, 10.1242/dev.124.8.1485 Morisato, 1994, The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo, Cell, 76, 677, 10.1016/0092-8674(94)90507-X Neumann, 1996, Distinct mitogenic and cell fate specification functions of wingless in different regions of the wing, Development, 122, 1781, 10.1242/dev.122.6.1781 Neumann, 1997, Morphogens and pattern formation, Bioessays, 19, 721, 10.1002/bies.950190813 Neumann, 1997, Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing, Development, 124, 871, 10.1242/dev.124.4.871 Oda, 1993, Identification of a Drosophila homologue of α-Catenin and its association with the armadillo protein, J. Cell Biol., 121, 1133, 10.1083/jcb.121.5.1133 Pai, 1997, Negative regulation of Armadillo, a Wingless effector in Drosophila, Development, 124, 2255, 10.1242/dev.124.11.2255 Pan, 1995, cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs, Cell, 80, 543, 10.1016/0092-8674(95)90508-1 Phillips, 1993, wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development, Development, 118, 427, 10.1242/dev.118.2.427 Pignoni, 1997, Induction of Drosophila eye development by Decapentaplegic, Development, 124, 271, 10.1242/dev.124.2.271 Porter, 1996, Hedgehog patterning activity, Cell, 86, 21, 10.1016/S0092-8674(00)80074-4 Porter, 1996, Cholesterol modification of hedgehog signaling proteins in animal development, Science, 274, 255, 10.1126/science.274.5285.255 Reichsman, 1996, Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction, J. Cell Biol., 135, 819, 10.1083/jcb.135.3.819 Rubin, 1982, Genetic transformation of Drosophila with transposable element vectors, Science, 218, 348, 10.1126/science.6289436 Rulifson, 1996, wingless refines its own expression domain on the Drosophila wing margin, Nature, 384, 72, 10.1038/384072a0 Siegfried, 1992, wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate, Cell, 71, 1167, 10.1016/S0092-8674(05)80065-0 Slack, 1987 Slack, 1987, Morphogenetic gradients, Trends Biochem., 12, 200, 10.1016/0968-0004(87)90094-6 Stein, 1991, The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal, Cell, 65, 725, 10.1016/0092-8674(91)90381-8 Stone, 1996, The tumour suppressor gene patched encodes a candidate receptor for Sonic hedgehog, Nature, 384, 129, 10.1038/384129a0 Struhl, 1993, Organizing activity of wingless protein in Drosophila, Cell, 72, 527, 10.1016/0092-8674(93)90072-X Tabata, 1994, Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs, Cell, 76, 89, 10.1016/0092-8674(94)90175-9 Tsuneizumi, 1997, daughters against dpp modulates dpp organizing activity in Drosophila wing development, Nature, 389, 627, 10.1038/39362 van de Wetering, 1997, Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF, Cell, 88, 789, 10.1016/S0092-8674(00)81925-X van den Heuvel, 1993, Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein, EMBO J., 12, 5293, 10.1002/j.1460-2075.1993.tb06225.x van Leeuwen, 1994, Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells, Nature, 368, 342, 10.1038/368342a0 Vincent, 1994, Drosophila wingless sustains engrailed expression only in adjoining cells, Cell, 77, 909, 10.1016/0092-8674(94)90139-2 Willert, 1997, Casein kinase 2 associates with and phosphorylates dishevelled, EMBO J., 16, 3089, 10.1093/emboj/16.11.3089 Williams, 1993, Pattern formation in a secondary field, Development, 117, 571, 10.1242/dev.117.2.571 Xu, 1993, Analysis of genetic mosaics in developing and adult Drosophila tissues, Development, 117, 1223, 10.1242/dev.117.4.1223 Zecca, 1996, Direct and long-range action of a wingless morphogen gradient, Cell, 87, 833, 10.1016/S0092-8674(00)81991-1