Which parameters influence the quantitative determination of halogenated substances? A summary of systematic investigations
Tóm tắt
In recent years, we have intensively studied the ion chemistry of halogenated substances in ion mobility spectrometry (IMS). During atmospheric pressure chemical ionization (APCI) processes, dissociative electron transfer reactions between reactant ions and halogenated molecules occur and (H2O)nX− product ions are formed, which appear as distinct product ion peak in negative ion mobility spectra. These product ion peaks (obtained for different compounds) were used for comparing differences in detectability, sensitivity, peak position and resolution. We identified that structural features clearly affect detection capability in IMS, which can be attributed to the different bonding states of halogens within the molecule. Then we subsequently established that the resulting different bond strengths also determine the degree of mutual influence when various halogenated substances are simultaneously investigated. Regarding the experimental conditions, we observed that increasing humidity generally leads to a decrease in the relative abundance of product ions. However, the effect of humidity strongly depends on the way in which the water vapor is transported into the ion mobility spectrometer (carrier or drift gas). In contrast to the results achieved which were affected by increased humidity, elevating IMS cell temperatures resulted in more accurate detection of all substances investigated.
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