Which exposure stage (gestation or lactation) is more vulnerable to atrazine toxicity? Studies on mouse dams and their pups

US-EPA (U.S. Environmental Protection Agency), 1994, Atrazine, simazine and cyanosine: notice of initiation of special review, Federal Registr., 59, 60412 Duke, 2010 Ross, 2009, Disposition of the herbicide 2-chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine (atrazine) and its major metabolites in mice: a liquid chromatography/mass spectrometry analysis of urine, plasma, and tissue levels, Drug Metabol. Dispos., 37, 776, 10.1124/dmd.108.024927 Sass, 2006, European Union bans atrazine, while the United States negotiates continued use, Int. J. Occup. Environ. Health, 12, 260, 10.1179/oeh.2006.12.3.260 Islam, 2002, Induction of P-glycoprotein, glutathione-S-transferase and cytochrome P450 in rat liver by atrazine, Environ. Toxicol. Pharmacol., 12, 1, 10.1016/S1382-6689(01)00121-1 Singh, 2011, Effects on antioxidant status of liver following atrazine exposure and its attenuation by vitamin E, Exp. Toxicol. Pathol., 63, 269, 10.1016/j.etp.2010.01.005 Eisler, 1989, Atrazine hazards in fish, wildlife and in prior to estrus and during early pregnancy in pigs. Endo-vertebrates: a synoptic review, U.S. Fish Wildl. Crinol., 91, 675 Perry, 2001, Urinalysis of atrazine exposure in farm pesticide applicators, Toxicol. Ind. Health, 16, 285 Van den Berg, 2003, Role of metabolism in the endocrine-disrupting effects of chemicals in aquatic and terrestrial systems, Pure Appl. Chem., 75, 1917, 10.1351/pac200375111917 Cragin, 2011, Menstrual cycle characteristics and reproductive hormone levels in women exposed to atrazine in drinking water, Environ. Res., 111, 1293, 10.1016/j.envres.2011.09.009 Crain, 1997, Alterations in steroidogenesis in alligators (Alligator mississippiensis) exposed naturally and experimentally to environmental contaminants, Environ. Health Perspect., 105, 528, 10.1289/ehp.97105528 Wilhelms, 2005, Atrazine and the hypothalamo-pituitary–gonadal axis in sexually maturing precocial birds: studies in male Japanese quail, Toxicol. Sci., 86, 152, 10.1093/toxsci/kfi170 Sharma, 2001, Atrazine induced morphological alterations in spermatocytes of goat in vitro, J. Med. Sci., 11, 177, 10.3923/jms.2011.177.184 Hayes, 2003, Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence, Environ. Health Perspect., 111, 568, 10.1289/ehp.5932 Hayes, 2010, Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis), Proc. Natl. Acad. Sci. U.S.A., 107, 4612, 10.1073/pnas.0909519107 Spano, 2004, Effects of atrazine on sex steroid dynamics, plasma vitellogenin concentration and gonad development in adult goldfish (Carassius auratus), Aquat. Toxicol., 66, 369, 10.1016/j.aquatox.2003.10.009 Pathak, 2011, Atrazine and human health, Int. J. Ecosyst., 1, 14, 10.5923/j.ije.20110101.03 Pogrmic-Majkic, 2012, Atrazine effects on antioxidant status and xenobiotic metabolizing enzymes after oral administration in peripubertal male rat, Environ. Toxicol. Pharmacol., 34, 495, 10.1016/j.etap.2012.06.004 ATSDR, 2003 Stoker, 1999, Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring, Toxicol. Sci., 52, 68, 10.1093/toxsci/52.1.68 Fraites, 2011, Gestational atrazine exposure: effects on male reproductive development and metabolite distribution in the dam, fetus, and neonate, Reprod. Toxicol., 32, 52, 10.1016/j.reprotox.2011.04.003 Eldridge, 1999, Estrous cycle patterns of Sprague-Dawley rats during acute and chronic atrazine administration, Reprod. Toxicol., 13, 491, 10.1016/S0890-6238(99)00056-8 Stoker, 2000, The effect of atrazine on puberty in male Wistar rats: an evaluation in the protocol for the assessment of pubertal development and thyroid function, Toxicol. Sci., 58, 50, 10.1093/toxsci/58.1.50 Cooper, 2007, Atrazine and reproductive function: mode and mechanism of action studies, Birth Defects Res. B: Dev. Reprod. Toxicol., 80, 98, 10.1002/bdrb.20110 Victor-Costa, 2010, Changes in testicular morphology and steroidogenesis in adult rats exposed to Atrazine, Reprod. Toxicol., 29, 323, 10.1016/j.reprotox.2009.12.006 Abarikwu, 2010, Changes in sperm characteristics and induction of oxidative stress in the testis and epididymis of experimental rats by a herbicide, atrazine, Arch. Environ. Contam. Toxicol., 58, 874, 10.1007/s00244-009-9371-2 Jin, 2010, Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio), Chemosphere, 78, 846, 10.1016/j.chemosphere.2009.11.044 Adesiyan, 2011, Selenium provides protection to the liver but not the reproductive organs in an atrazine-model of experimental toxicity, Exp. Toxicol. Pathol., 63, 201, 10.1016/j.etp.2009.11.008 Andric, 2003, Parallelism and dissociation in the action of an Aroclor 1260-based transformer fluid on testicular steroidogenesis and antioxidant enzymes, Toxicology, 194, 65, 10.1016/j.tox.2003.08.002 USDA, 2011 Traber, 2006, Vitamin E, 396 Institute of Medicine, 2000 Horwitt, 1976, Vitamin E: a reexamination, Am. J. Clin. Nutr., 29, 569, 10.1093/ajcn/29.5.569 Cooper, 2010 Davis, 2011, The effects of prenatal exposure to atrazine on pubertal and postnatal reproductive indices in the female rat, Reprod. Toxicol., 32, 43, 10.1016/j.reprotox.2011.04.004 Rayner, 2004, Exposure parameters necessary for delayed puberty and mammary gland development in Long-Evans rats exposed in utero to atrazine, Toxicol. Appl. Pharmacol., 195, 23, 10.1016/j.taap.2003.11.005 Rosenberg, 2008, Gestational exposure to atrazine: effects on the postnatal development of male offspring, J. Androl., 29, 304, 10.2164/jandrol.107.003020 FAO/WHO, 2010 Kalender, 2004, Endosulfan-induced cardiotoxicity and free radical metabolism in rats: the protective effect of vitamin E, Toxicology, 202, 227, 10.1016/j.tox.2004.05.010 Fishbeck, 1987, Effect of repeated cycles on maternal nutritional status, lactational performance and litter growth in ad libitum fed and chronically food, J. Nutr., 117, 1967, 10.1093/jn/117.11.1967 Knedel, 1967, A kinetic method for determination of the activity of pseudocholinesterase (acylcholine acyl-hydrolase 3.1.1.8.), Klin. Wochenschr., 45, 325, 10.1007/BF01747115 Belfield, 1971, Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine, Enzyme, 12, 561, 10.1159/000459586 Fawcett, 1960, A rapid and precise method for the determination of urea, J. Clin. Pathol., 13, 156, 10.1136/jcp.13.2.156 Satoh, 1978, Plasma lipid peroxide in cerebrovascular disorder determined by a new colorimetric method, Clin. Chim. Acta, 90, 37, 10.1016/0009-8981(78)90081-5 Nishikimi, 1972, The occurrence of superoxide anion in the reaction of reduced phenazine methosulphate and molecular oxygen, Biochem. Biophysiol. Res. Commun., 46, 849, 10.1016/S0006-291X(72)80218-3 Önder, 2012, The protective effects of curcumin on intestine and remote organs against mesenteric ischemia/reperfusion injury, Turk. J. Gastroenterol., 23, 141, 10.4318/tjg.2012.0446 Crissman, 2004, Best practices guideline: toxicologic histopathology, Toxicol. Pathol., 32, 126, 10.1080/01926230490268756 Lu, 1996 Santa Maria, 1987, Hepatotoxicity induced by the herbicide atrazine in the rat, J. Appl. Toxicol., 7, 373, 10.1002/jat.2550070605 Aso, 2000, Twenty-eight-day repeated-dose toxicity studies for detection of weak endocrine disrupting effects of nonylphenol and atrazine in female rats, J. Toxicol. Pathol., 13, 13, 10.1293/tox.13.13 Jamjute, 2009, Liver function test and pregnancy, J. Maternal–Fetal Neonat. Med., 22, 274, 10.1080/14767050802211929 Brown, 1981, The plasma cholinesterases: a new perspective, Adv. Clin. Chem., 22, 82 Moss, 1999, Enzymes, 735 2010 Boonthai, 2000, Acetylcholinesterase as a biomarker to assess the effect of chlorpyrifos and atrazine on some New Zealand aquatic invertebrates, Aust. J. Ecotoxicol., 6, 59 Anderson, 2002, Increased toxicity to invertebrates associated with a mixture of atrazine and organophosphate insecticides, Environ. Toxicol. Chem., 21, 1507, 10.1002/etc.5620210724 Wacksman, 2006, Impact of atrazine on chlorpyrifos toxicity to four aquatic vertebrates, Arch. Environ. Contam. Toxicol., 51, 681, 10.1007/s00244-005-0264-8 Xing, 2010, Effects of atrazine and chlorpyrifos on acetylcholinesterase and carboxylesterase in brain and muscle of common carp, Environ. Toxicol. Pharmacol., 30, 26, 10.1016/j.etap.2010.03.009 Singh, 2008, Atrazine-induced alterations in rat erythrocyte membranes: ameliorating effect of vitamin E, J. Biochem. Mol. Toxicol., 22, 363, 10.1002/jbt.20249 Abdollahi, 2004, Pesticides and oxidative stress: a review, Med. Sci. Monit., 10, RA141 Halliwell, 1996, Antioxidants in human health and disease, Ann. Rev. Nutr., 16, 33, 10.1146/annurev.nu.16.070196.000341 Verhagen, 2006, The state of antioxidant affairs, Nutr. Today, 41, 244, 10.1097/00017285-200611000-00003 Banerjee, 1999, Biochemical effects of pesticides on lipid peroxidation and free radicals scavengers, Toxicol. Lett., 107, 33, 10.1016/S0378-4274(99)00029-6 Mansour, 2009, Lipid peroxidation and oxidative stress in rat erythrocytes induced by chlorpyrifos and the protective effect of zinc, Pestic. Biochem. Physiol., 93, 34, 10.1016/j.pestbp.2008.09.004 Mansour, 2010, Adverse effects of lactational exposure to chlorpyrifos in suckling rats, Hum. Exp. Toxicol., 29, 77, 10.1177/0960327109357276 Mansour, 2010, Oxidative damage, biochemical and histopathological alterations in rats exposed to chlorpyrifos and the antioxidant role of zinc, Pestic. Biochem. Physiol., 96, 14, 10.1016/j.pestbp.2009.08.008 Mansour, 2011, Adverse effects of exposure to low doses of chlorpyrifos in lactating rats, Toxicol. Ind. Health, 27, 213, 10.1177/0748233710384054 McCord, 1969, Superoxide dismutase: an enzymatic function for erythrocuprein (hemocuprein), J. Biol. Chem., 244, 6049, 10.1016/S0021-9258(18)63504-5 Mansour, 2009, Effects of methomyl on lipid peroxidation and antioxidant enzymes in rat erythrocytes: in vitro studies, Toxicol. Ind. Health, 25, 557, 10.1177/0748233709349829 Mansour, 2011, Antihepatotoxic activity of fennel (Foeniculum vulgare Mill.) essential oil against chlorpyrifos-induced liver injury in rats, Glob. J. Environ. Sci. Technol., 1, 10 Mansour, 2012, Ameliorative effect of selenium on the hepatotoxicity of methomyl, some common drugs and their combinations, ScienceJet, 1, 18 Campos-Pereira, 2012, Early cytotoxic and genotoxic effects of atrazine on Wistar rat liver: a morphological, immunohistochemical, biochemical, and molecular study, Ecotoxicol. Environ. Saf., 78, 170, 10.1016/j.ecoenv.2011.11.020 Pascoe, 1987, Vitamin E protection against chemical induced cell injury. I. Maintenance of cellular protein thiols as a cytoprotective mechanism, Arch. Biochem. Biophysiol., 256, 150, 10.1016/0003-9861(87)90433-4 Infante-Rivard, 1999, Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms, Epidemiology, 10, 481, 10.1097/00001648-199909000-00004 Gallenberg, 1989, Transfer of persistent chemicals in milk, Drug Metabol. Rev., 21, 277, 10.3109/03602538909029943 Perera, 2002, The challenge of preventing environmentally related disease in young children: community-based research in New York City, Environ. Health Perspect., 110, 197, 10.1289/ehp.02110197 Deacon, 1980, Embryotoxicity and fetotoxicity of orally administered chlorpyrifos in mice, Toxicol. Appl. Pharmacol., 54, 31, 10.1016/0041-008X(80)90005-8 Breslin, 1996, Evaluation of the developmental and reproductive toxicity of chlorpyrifos in the rat, Fundam. Appl. Toxicol., 29, 119, 10.1006/faat.1996.0013 Stoker, 2007, Distribution of 14C-atrazine following an acute lactational exposure in the Wistar rat, Reprod. Toxicol., 23, 607, 10.1016/j.reprotox.2007.02.004 Thalacker, 1996 Breitzka, 1997, Principles of drug transfer into breast milk and drug disposition in the nursing infant, J. Hum. Lactat., 13, 155, 10.1177/089033449701300219 US-EPA, 2003 Minh, 2006, Human blood monitoring program in Japan: contamination and bioaccumulation of persistent organochlorines in Japanese residents, Arch. Environ. Contam. Toxicol., 296, 10.1007/s00244-004-0251-5 Munoz-de-Toro, 2006, Organochlorine levels in adipose tissue of women from a littoral region of Argentina, Environ. Res., 107, 10.1016/j.envres.2005.12.017 Kalantzi, 2004, Different levels of polybrominated diphenyl ethers (PBDEs) and chlorinated compounds in breast milk from two U.K. regions, Environ. Health Perspect., 1085, 10.1289/ehp.6991 Gojmerac, 1995, Serum biochemical and histopathological changes related to the hepatic function in pigs following atrazine treatment, J. Appl. Toxicol., 30, 233, 10.1002/jat.2550150315 Gojmerac, 1996, Serum biochemical changes associated with cystic ovarian degeneration in pigs after atrazine treatment, Toxicol. Lett., 85, 9, 10.1016/0378-4274(96)03631-4 Santa Maria, 1986, Subacute atrazine effects on rat renal function, Bull. Environ. Contam. Toxicol., 36, 325, 10.1007/BF01623515