What is transforming growth factor-beta (TGF-β)?

Derynck, 1996, Nomenclature: vertebrate mediators of TGF-beta family signals, Cell, 87, 173, 10.1016/S0092-8674(00)81335-5 Roberts, 1990, Mesoderm induction in Xenopus laevis distinguishes between the various TGF-beta isoforms, Growth Factors, 3, 277, 10.3109/08977199009003670 Massague, 1992, Transforming growth factor-beta, Cancer Surv, 12, 81 Saarma, 2000, GDNF—a stranger in the TGF-beta superfamily?, Eur J Biochem, 267, 6968, 10.1046/j.1432-1327.2000.01826.x Jamin, 2002, Requirement of Bmpr1a for Mullerian duct regression during male sexual development, Nat Genet, 32, 408, 10.1038/ng1003 Burt, 1994, Evolution of the transforming growth factor-beta superfamily, Prog Growth Factor Res, 5, 99, 10.1016/0955-2235(94)90020-5 Akhurst, 1990, Transforming growth factor betas in mammalian embryogenesis, Prog Growth Factor Res, 2, 153, 10.1016/0955-2235(90)90002-2 Frenkel, 2000, Transforming growth factor beta superfamily members: role in cartilage modeling, Plast Reconstr Surg, 105, 980, 10.1097/00006534-200003000-00022 Reddi, 1990, Bone induction by osteogenin and bone morphogenetic proteins, Biomaterials, 11, 33 Glick, 1996, Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb, Cancer Res, 56, 3645 Massague, 1999, Wounding Smad, Nat Cell Biol, 1, E117, 10.1038/12944 Moustakas, 2002, Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation, Immunol Lett, 82, 85, 10.1016/S0165-2478(02)00023-8 Roberts, 1998, Molecular and cell biology of TGF-beta, Miner Electrolyte Metab, 24, 111, 10.1159/000057358 Anzano, 1983, Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors, Proc Natl Acad Sci USA, 80, 6264, 10.1073/pnas.80.20.6264 Roberts, 1983, Transforming growth factors from neoplastic and nonneoplastic tissues, Fed Proc, 42, 2621 Coffey, 1987, Production and auto-induction of transforming growth factor-alpha in human keratinocytes, Nature, 328, 817, 10.1038/328817a0 Kehrl, 1986, Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth, J Exp Med, 163, 1037, 10.1084/jem.163.5.1037 Sporn, 1986, Transforming growth factor-beta: biological function and chemical structure, Science, 233, 532, 10.1126/science.3487831 Centrella, 1985, Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae, Proc Natl Acad Sci USA, 82, 7335, 10.1073/pnas.82.21.7335 Frolik, 1983, Purification and initial characterization of a type beta transforming growth factor from human placenta, Proc Natl Acad Sci USA, 80, 3676, 10.1073/pnas.80.12.3676 Kothapalli, 1997, Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily association of gene expression with endometrial bleeding, J Clin Invest, 99, 2342, 10.1172/JCI119415 Moses, 1987, Transforming growth factor beta regulation of cell proliferation, J Cell Physiol Suppl, 1, 10.1002/jcp.1041330403 Taipale, 1998, Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion, Adv Cancer Res, 75, 87, 10.1016/S0065-230X(08)60740-X Kretzschmar, 1997, Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1, Nature, 389, 618, 10.1038/39348 Bikfalvi, 1995, Significance of angiogenesis in tumour progression and metastasis, Eur J Cancer, 31A, 1101, 10.1016/0959-8049(95)00169-J Sporn, 1992, Transforming growth factor-beta: recent progress and new challenges, J Cell Biol, 119, 1017, 10.1083/jcb.119.5.1017 Streuli, 1993, Extracellular matrix regulates expression of the TGF-beta 1 gene, J Cell Biol, 120, 253, 10.1083/jcb.120.1.253 Ignotz, 1987, Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta, J Biol Chem, 262, 6443, 10.1016/S0021-9258(18)48258-0 Laiho, 1987, Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase, J Biol Chem, 262, 17467, 10.1016/S0021-9258(18)45403-8 Roberts, 1988, Transforming growth factor-beta: possible roles in carcinogenesis, Br J Cancer, 57, 594, 10.1038/bjc.1988.135 Blottner, 1996, TGF-beta rescues target-deprived preganglionic sympathetic neurons in the spinal cord, Eur J Neurosci, 8, 202, 10.1111/j.1460-9568.1996.tb01181.x Lindholm, 1992, Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation, J Cell Biol, 117, 395, 10.1083/jcb.117.2.395 Prehn, 1993, Isoform-specific effects of transforming growth factors-beta on degeneration of primary neuronal cultures induced by cytotoxic hypoxia or glutamate, J Neurochem, 60, 1665, 10.1111/j.1471-4159.1993.tb13389.x Massague, 1992, TGF-beta receptors, Mol Reprod Dev, 32, 99 Fanger, 1986, Structure and properties of the cellular receptor for transforming growth factor type beta, Biochemistry, 25, 3083, 10.1021/bi00359a003 Wu, 2000, Structural basis of Smad2 recognition by the Smad anchor for receptor activation, Science, 287, 92, 10.1126/science.287.5450.92 Wells, 1997, Biosynthesis of the type I and type II TGF-beta receptors. Implications for complex formation, J Biol Chem, 272, 11444, 10.1074/jbc.272.17.11444 Kolodziejczyk, 1996, Signal transduction and TGF-beta superfamily receptors, Biochem Cell Biol, 74, 299, 10.1139/o96-033 Lopez-Casillas, 1993, Betaglycan presents ligand to the TGF-beta signaling receptor, Cell, 73, 1435, 10.1016/0092-8674(93)90368-Z Liu, 1996, A human Mad protein acting as a BMP-regulated transcriptional activator, Nature, 381, 620, 10.1038/381620a0 Massague, 2000, How cells read TGF-beta signals, Nat Rev Mol Cell Biol, 1, 169, 10.1038/35043051 Massague, 2000, Controlling TGF-beta signaling, Genes Dev, 14, 627, 10.1101/gad.14.6.627 Miyazono, 2000, TGF-beta signaling by Smad proteins, Adv Immunol, 75, 115, 10.1016/S0065-2776(00)75003-6 Miyazono, 2000, Positive and negative regulation of TGF-beta signaling, J Cell Sci, 113, 1101, 10.1242/jcs.113.7.1101 Massague, 2000, Transcriptional control by the TGF-beta/Smad signaling system, EMBO J, 19, 1745, 10.1093/emboj/19.8.1745 O'Kane, 1997, Transforming growth factor betas and wound healing, Int J Biochem Cell Biol, 29, 63, 10.1016/S1357-2725(96)00120-3 Beck, 1991, TGF-beta 1 accelerates wound healing: reversal of steroid-impaired healing in rats and rabbits, Growth Factors, 5, 295, 10.3109/08977199109000293 Steinbrech, 2000, Gene expression of TGF-beta, TGF-beta receptor, and extracellular matrix proteins during membranous bone healing in rats, Plast Reconstr Surg, 105, 2028, 10.1097/00006534-200005000-00018 Beck, 1991, Rapid publication. TGF-beta 1 induces bone closure of skull defects, J Bone Miner Res, 6, 1257, 10.1002/jbmr.5650061117 Hirshberg, 2001, TGF-beta3 in the treatment of pressure ulcers: a preliminary report, Adv Skin Wound Care, 14, 91, 10.1097/00129334-200103000-00013 Niessen, 2001, Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars, J Pathol, 194, 207, 10.1002/path.853 Lee, 1999, Expression of transforming growth factor beta 1, 2, and 3 proteins in keloids, Ann Plast Surg, 43, 179, 10.1097/00000637-199943020-00013 Polo, 1999, Effect of TGF-beta2 on proliferative scar fibroblast cell kinetics, Ann Plast Surg, 43, 185, 10.1097/00000637-199943020-00014 Bettinger, 1996, The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesis, Plast Reconstr Surg, 98, 827, 10.1097/00006534-199610000-00012 Shang, 2001, An experimental study of antisense TGF-beta 1 inhibiting keloid fibroblast proliferation in vitro, Zhonghua Zheng Xing Wai Ke Za Zhi, 17, 325 Chin, 2001, Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts, Plast Reconstr Surg, 108, 423, 10.1097/00006534-200108000-00022 Carroll, 2002, Triamcinolone stimulates bFGF production and inhibits TGF-beta1 production by human dermal fibroblasts, Dermatol Surg, 28, 704, 10.1046/j.1524-4725.2002.02012.x Chau, 1998, Tamoxifen downregulates TGF-beta production in keloid fibroblasts, Ann Plast Surg, 40, 490, 10.1097/00000637-199805000-00008 Solheim, 1998, Growth factors in bone, Int Orthop, 22, 410, 10.1007/s002640050290 Suzawa, 1999, Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro, Endocrinology, 140, 2125, 10.1210/endo.140.5.6704 Abe, 2000, Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin, J Bone Miner Res, 15, 663, 10.1359/jbmr.2000.15.4.663 Sherris, 1998, Mandibular reconstruction with transforming growth factor-beta1, Laryngoscope, 108, 368, 10.1097/00005537-199803000-00011 Miura, 2002, Brief exposure to high-dose transforming growth factor-beta1 enhances periosteal chondrogenesis in vitro: a preliminary report, J Bone Joint Surg Am, 84, 793, 10.2106/00004623-200205000-00015 Noda, 1989, Type beta transforming growth factor regulates expression of genes encoding bone matrix proteins, Connect Tissue Res, 21, 71, 10.3109/03008208909049997 Yeung, 2002, Sustained expression of transforming growth factor-beta1 by distraction during distraction osteogenesis, Life Sci, 71, 67, 10.1016/S0024-3205(02)01575-8 Lieberman, 2002, The role of growth factors in the repair of bone. Biology and clinical applications, J Bone Joint Surg Am, 84-A, 1032, 10.2106/00004623-200206000-00022 Lee, 2002, Repair of bone allograft fracture using bone morphogenetic protein-2, Clin Orthop, 119, 10.1097/00003086-200204000-00017 Valentin-Opran, 2002, Clinical evaluation of recombinant human bone morphogenetic protein-2, Clin Orthop, 110, 10.1097/00003086-200202000-00011 Massague, 1991, Mechanisms in TGF-beta action, Ciba Found Symp, 157, 51 Moustakas, 2001, Smad regulation in TGF-beta signal transduction, J Cell Sci, 114, 4359, 10.1242/jcs.114.24.4359 Park, 1994, Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta, Proc Natl Acad Sci USA, 91, 8772, 10.1073/pnas.91.19.8772 Markowitz, 1995, Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability, Science, 268, 1336, 10.1126/science.7761852 Kimchi, 1988, Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells, Science, 240, 196, 10.1126/science.2895499 Kadin, 1994, Loss of receptors for transforming growth factor beta in human T-cell malignancies, Proc Natl Acad Sci USA, 91, 6002, 10.1073/pnas.91.13.6002 Muro-Cacho, 1999, Expression of transforming growth factor beta type II receptors in head and neck squamous cell carcinoma, Clin Cancer Res, 5, 1243 Duff, 1998, Smad4 (DPC4)—a potent tumour suppressor?, Br J Cancer, 78, 1615, 10.1038/bjc.1998.731 Hata, 1997, Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4, Nature, 388, 82, 10.1038/40424 Ramachandra, 2002, Restoration of transforming growth factor Beta signaling by functional expression of smad4 induces anoikis, Cancer Res, 62, 6045 Xie, 2002, Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study, Cancer Res, 62, 497 Massague, 2000, TGFbeta signaling in growth control, cancer, and heritable disorders, Cell, 103, 295, 10.1016/S0092-8674(00)00121-5 Berking, 2001, Transforming growth factor-beta1 increases survival of human melanoma through stroma remodeling, Cancer Res, 61, 8306