What Is Recent in Pancreatic Cancer Immunotherapy?

BioMed Research International - Tập 2013 - Trang 1-14 - 2013
Elena Niccolai1, Domenico Prisco2, Mario Milco D’Elios3,1, Amedeo Amedei3,1,4
1Department of Internal Medicine, University of Florence and Patologia Medica Unit Department of Biomedicine, Azienda Ospedaliero-Universitaria Careggi, 50134 Florence, Italy
2Department of Medical and Surgical Critical Care, University of Florence and Patologia Medica Unit Department of Biomedicine, Azienda Ospedaliero Universitaria Careggi, 50134 Florence, Italy
3Center of Oncologic Minimally Invasive Surgery, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
4Division of Immunology, Department of Internal Medicine, University of Florence, Viale Pieraccini, 6, 50134 Florence, Italy

Tóm tắt

Pancreatic cancer (PC) represents an unresolved therapeutic challenge, due to the poor prognosis and the reduced response to currently available treatments. Pancreatic cancer is the most lethal type of digestive cancers, with a median survival of 4–6 months. Only a small proportion of PC patients is curative by surgical resection, whilst standard chemotherapy for patients in advanced disease generates only modest effects with considerable toxic damages. Thus, new therapeutic approaches, specially specific treatments such as immunotherapy, are needed. In this paper we analyze recent preclinical and clinical efforts towards immunotherapy of pancreatic cancer, including passive and active immunotherapy approaches, designed to target pancreatic-cancer-associated antigens and to elicit an antitumor responsein vivo.

Từ khóa


Tài liệu tham khảo

2011, Journal of the Pancreas, 12, 316

2007, Journal of the Pancreas, 8, 545

1997, Journal of Clinical Oncology, 15, 2403, 10.1200/JCO.1997.15.6.2403

10.1200/JCO.2006.07.9525

10.1158/1078-0432.CCR-05-0596

2001, Cancer Research, 61, 869

10.1158/1078-0432.CCR-09-0565

1994, Cancer Research, 54, 2856

10.1158/1078-0432.CCR-05-1672

10.1158/1078-0432.CCR-07-4590

10.1111/j.1349-7006.2007.00429.x

10.1111/j.1349-7006.2004.tb02490.x

2005, Hepato-Gastroenterology, 52, 398

2001, Clinical Cancer Research, 7, 1976

1995, The Lancet, 346, 1399, 10.1016/S0140-6736(95)92408-6

10.1007/s00262-005-0102-x

1991, Journal of Surgical Oncology, 47, 148, 10.1002/jso.2930470303

10.1111/j.1349-7006.2009.01176.x

1997, British Journal of Cancer, 75, 1501, 10.1038/bjc.1997.256

10.1002/ijc.24355

10.1002/ijc.10801

10.1038/onc.2009.416

10.1038/nrd3365

10.1158/1055-9965.EPI-08-0039

10.1158/1078-0432.CCR-04-2304

10.1158/1078-0432.CCR-03-0801

2001, Clinical Cancer Research, 7, 3862

10.1309/F1B6-4CL7-H8VJ-KEAF

10.1158/1078-0432.CCR-07-0869

10.1016/j.addr.2007.02.001

10.1158/1078-0432.CCR-09-0062

2007, Journal of Clinical Oncology, 25

10.1158/1535-7163.MCT-08-0945

10.1002/ijc.25557

2004, International Journal of Oncology, 24, 107

10.1038/sj.bjc.6602232

10.1136/jcp.2003.013292

10.1158/1078-0432.CCR-05-1197

10.1002/ijc.20004

10.1007/s00262-006-0135-9

10.1016/j.prp.2010.03.006

10.1097/CJI.0b013e31817c37ff

2007, Oncology Reports, 18, 433

10.1158/1078-0432.CCR-06-2302

2010, Annals of Oncology, 21, 98, 10.1093/annonc/mdp496

10.1007/s00262-004-0597-6

1992, Journal of Pathology, 166, 7, 10.1002/path.1711660103

1993, Anticancer Research, 13, 565

2000, Cancer Research, 60, 2926

2002, Molecular Cancer Therapeutics, 1, 777

10.1200/JCO.2005.11.890

10.1200/JCO.2009.25.7550

2007, Journal of Clinical Oncology, 25

10.1002/ijc.20696

10.1038/sj.bjc.6603083

10.1186/1476-4598-2-8

10.1016/S0304-3835(03)00047-8

10.1200/JCO.2005.01.9661

10.1200/JCO.2010.28.1386

2005, Anticancer Research, 25, 3637

10.1002/cncr.21655

10.1200/JCO.2003.06.018

1997, Cancer Research, 57, 326

2000, Gastrointestinal Endoscopy, 51, 708, 10.1067/mge.2000.104654

10.1002/1097-0142(20010201)91:3<496::AID-CNCR1028>3.0.CO;2-0

10.1016/S0002-9270(02)03979-5

2000, British Journal of Cancer, 82, 1819, 10.1054/bjoc.2000.1117

2000, Journal of Immunology, 165, 3451, 10.4049/jimmunol.165.6.3451

2008, Oncology Reports, 20, 155

2008, Anticancer Research, 28, 379

1997, Infection and Immunity, 65, 2283, 10.1128/IAI.65.6.2283-2291.1997

10.1245/ASO.2003.02.007

2000, Surgery, 127, 309, 10.1067/msy.2000.104118

10.1016/j.clim.2010.02.003

10.1002/ijc.1205

10.1158/1078-0432.CCR-05-1330

10.1186/bcr1621

2001, Journal of Clinical Oncology, 19, 145, 10.1200/JCO.2001.19.1.145

2007, Journal of Clinical Oncology, 25

10.1084/jem.20031435

10.1016/j.ejca.2007.08.028

10.1158/1078-0432.CCR-07-0371

10.1080/08830180600992498

10.2217/imt.10.17

10.1111/j.1863-2378.2008.01191.x

10.1016/j.bbagen.2007.11.003

10.1158/0008-5472.CAN-09-4313

10.1038/nrd2224

10.1586/14760584.6.4.591

10.1586/14760584.7.10.1533

10.2174/156652409788970724

10.2174/092986709789909648

10.1016/j.clim.2004.09.007

10.1038/nm0303-269

10.1056/NEJMra072739

10.1111/j.1349-7006.2009.01416.x

10.1007/s00262-004-0581-1

2005, Anticancer Research, 25, 3575

10.1038/sj.bjc.6603437

2009, Journal of Clinical Oncology, 27

10.1097/COC.0b013e3181e84b1f

10.1007/s00262-008-0477-6

10.1038/nrc2373

10.1002/eji.200737995

10.1002/ijc.25449

10.1158/1078-0432.CCR-07-4804

10.1158/0008-5472.CAN-05-4310

10.1172/JCI200422685

10.1158/1940-6207.CAPR-10-0040

10.1172/JCI200421695

10.1158/1078-0432.CCR-1011-03

10.3892/or-00000923

1997, BioDrugs, 8, 273, 10.2165/00063030-199708040-00004

10.1155/2010/169484

10.1186/1471-2407-9-191

10.1016/j.vaccine.2007.08.050

2006, American Association For Cancer Research, 47, article 329a

10.1158/0008-5472.CAN-05-2813

2005, Journal of Immunology, 174, 7869, 10.4049/jimmunol.174.12.7869

1991, Annual Review of Immunology, 9, 271, 10.1146/annurev.iy.09.040191.001415

10.1038/nri1592

10.1038/nm0398-328

2000, International Journal of Cancer, 89, 385

10.1097/01.cji.0000211309.90621.8b

10.1111/j.0105-2896.2004.00139.x

10.1038/nbt0498-364

1997, Nature Medicine, 3, 558, 10.1038/nm0597-558

2003, Cancer Research, 63, 8962

2002, Cancer Research, 62, 2347

2008, Cancer Therapy, 6, 955

10.1007/s00262-002-0317-z

2002, International Journal of Gastrointestinal Cancer, 32, 1, 10.1385/IJGC:32:1:1

10.1200/JCO.2005.03.158

10.1200/JCO.2005.00.463

10.1007/s00005-007-0034-6

10.1586/14760584.7.7.1055

10.2217/1750743X.1.1.49

10.3892/or_00000442

1973, Cancer, 31, 324, 10.1002/1097-0142(197302)31:2<324::AID-CNCR2820310208>3.0.CO;2-Y

1995, International Journal of Pancreatology, 17, 15, 10.1007/BF02788354

10.1016/j.ctrv.2009.05.003

10.1021/pr901109w

10.1586/14760584.1.1.49

10.1586/14760584.7.7.963

1993, The American Journal of Pathology, 142, 1534

10.1016/j.bcp.2010.04.031

1988, Cell, 53, 549, 10.1016/0092-8674(88)90571-5

1997, Clinical Cancer Research, 3, 1309

10.1158/1535-7163.MCT-07-0483

10.1107/S0907444908008561

Thông tin
Thông tin xuất bản

BioMed Research International

Tập 2013

1-14

Thông tin tác giả