Web-Based Survival Analysis Tool Tailored for Medical Research (KMplot): Development and Implementation

Journal of Medical Internet Research - Tập 23 Số 7 - Trang e27633
András Lánczky1,2, Balázs Györffy1,2
1Department of Bioinformatics, Semmelweis University, Budapest, Hungary
2TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary

Tóm tắt

Background Survival analysis is a cornerstone of medical research, enabling the assessment of clinical outcomes for disease progression and treatment efficiency. Despite its central importance, no commonly used spreadsheet software can handle survival analysis and there is no web server available for its computation. Objective Here, we introduce a web-based tool capable of performing univariate and multivariate Cox proportional hazards survival analysis using data generated by genomic, transcriptomic, proteomic, or metabolomic studies. Methods We implemented different methods to establish cut-off values for the trichotomization or dichotomization of continuous data. The false discovery rate is computed to correct for multiple hypothesis testing. A multivariate analysis option enables comparing omics data with clinical variables. Results We established a registration-free web-based survival analysis tool capable of performing univariate and multivariate survival analysis using any custom-generated data. Conclusions This tool fills a gap and will be an invaluable contribution to basic medical and clinical research.

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Journal of Medical Internet Research

Tập 23 Số 7

e27633

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