Watermelon (Citrullus lanatus(Thunb.) Matsum. and Nakai) Juice Modulates Oxidative Damage Induced by Low Dose X-Ray in Mice

BioMed Research International - Tập 2014 - Trang 1-6 - 2014
Mohd Khairul Amran Mohammad1, Muhamad Idham Mohamed1, Ainul Mardhiyah Zakaria1, Hairil Rashmizal Abdul Razak2, Wan Mazlina Md Saad1
1Department of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA, UiTM Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia.
2Department of Medical Imaging, Faculty of Health Sciences, Universiti Teknologi MARA, UiTM Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Selangor, Malaysia.

Tóm tắt

Watermelon is a natural product that contains high level of antioxidants and may prevent oxidative damage in tissues due to free radical generation following an exposure to ionizing radiation. The present study aimed to investigate the radioprotective effects of watermelon (Citrullus lanatus(Thunb.) Matsum. and Nakai) juice against oxidative damage induced by low dose X-ray exposure in mice. Twelve adult male ICR mice were randomly divided into two groups consisting of radiation (Rx) and supplementation (Tx) groups. Rx received filtered tap water, while Tx was supplemented with 50% (v/v) watermelon juice for 28 daysad libitumprior to total body irradiation by 100 μGy X-ray on day 29. Brain, lung, and liver tissues were assessed for the levels of malondialdehyde (MDA), apurinic/apyrimidinic (AP) sites, glutathione (GSH), and superoxide dismutase (SOD) inhibition activities. Results showed significant reduction of MDA levels and AP sites formation of Tx compared to Rx(P<0.05). Mice supplemented with 50% watermelon juice restore the intracellular antioxidant activities by significantly increased SOD inhibition activities and GSH levels compared to Rx. These findings may postulate that supplementation of 50% watermelon (Citrullus lanatus(Thunb.) Matsum. and Nakai) juice could modulate oxidative damage induced by low dose X-ray exposure.

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BioMed Research International

Tập 2014

1-6

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