WITHDRAWN: Recent progress in functionalized and targeted polymersomes and chimeric polymeric nanotheranostic platforms for cancer therapy

Dennahy, 2022, Nanotheranostics for image-guided cancer treatment, Pharmaceutics, 14, 917, 10.3390/pharmaceutics14050917 Siegel, 2022, Cancer statistics, 2022, CA Cancer J Clin, 72, 7, 10.3322/caac.21708 Zhou, 2021, Supramolecular cancer nanotheranostics, Chem Soc Rev, 50, 2839, 10.1039/D0CS00011F Wong, 2021, Differences in incidence and mortality trends of colorectal cancer worldwide based on sex, age, and anatomic location, Clin Gastroenterol Hepatol, 19, 955, 10.1016/j.cgh.2020.02.026 Schirrmacher, 2019, From chemotherapy to biological therapy: a review of novel concepts to reduce the side effects of systemic cancer treatment, Int J Oncol, 54, 407, 10.3892/ijo.2018.4661 Khosravi, 2022, Stem cell membrane, stem cell-derived exosomes and hybrid stem cell camouflaged nanoparticles: a promising biomimetic nanoplatforms for cancer theranostics, J Control Release, 348, 706, 10.1016/j.jconrel.2022.06.026 Oroojalian, 2020, Recent advances in nanotechnology-based drug delivery systems for the kidney, J Control Release, 321, 442, 10.1016/j.jconrel.2020.02.027 Gorain, 2018, Paclitaxel loaded vitamin E-TPGS nanoparticles for cancer therapy, Mater Sci Eng C, 91, 868, 10.1016/j.msec.2018.05.054 Moulahoum, 2021, Surface biomodification of liposomes and polymersomes for efficient targeted drug delivery, Bioconjug Chem, 32, 1491, 10.1021/acs.bioconjchem.1c00285 Cao, 2019, Iodine-rich polymersomes enable versatile SPECT/CT imaging and potent radioisotope therapy for tumor in vivo, ACS Appl Mater Interfaces, 11, 18953, 10.1021/acsami.9b04294 Hashemi Goradel, 2018, Nanoparticles as new tools for inhibition of cancer angiogenesis, J Cell Physiol, 233, 2902, 10.1002/jcp.26029 Wiesing, 2019, Theranostics: Is it really a revolution? Evaluating a new term in medicine, Med Health Care Phil, 22, 593, 10.1007/s11019-019-09898-3 Herrmann, 2017, Theranostic concepts: more than just a fashion trend—introduction and overview, J Nucl Med, 58, 1S, 10.2967/jnumed.117.199570 Gorain, 2020, Theranostic application of nanoemulsions in chemotherapy, Drug Discov Today, 25, 1174, 10.1016/j.drudis.2020.04.013 Bhanushali, 2021, 333 Thorat, 2020, Functional smart hybrid nanostructures based nanotheranostic approach for advanced cancer treatment, Appl Surf Sci, 527, 10.1016/j.apsusc.2020.146809 Sohrabi, 2021, Nanoscale metal-organic frameworks: recent developments in synthesis, modifications and bioimaging applications, Chemosphere, 281, 10.1016/j.chemosphere.2021.130717 Oroojalian, 2022, Current trends in stimuli-responsive nanotheranostics based on metal–organic frameworks for cancer therapy, Mater Today, 10.1016/j.mattod.2022.05.024 Olver, 2018, The timeliness of patients reporting the side effects of chemotherapy, Support Care Cancer, 26, 3579, 10.1007/s00520-018-4225-y Lane, 2018, Challenges in chemotherapy delivery: comparison of standard chemotherapy delivery to locoregional vascular mass fluid transfer, Future Oncol, 14, 647, 10.2217/fon-2017-0546 Wang, 2019, Engineering nanoparticles to locally activate T cells in the tumor microenvironment, Sci Immunol, 4, 10.1126/sciimmunol.aau6584 Oroojalian, 2021, Immune cell Membrane-Coated biomimetic nanoparticles for targeted cancer therapy, Small, 17, 10.1002/smll.202006484 Kaur J, Gill GS, Jeet K. Applications of carbon nanotubes in drug delivery: a comprehensive review. Characterization and biology of nanomaterials for drug delivery. 2019:113–35. Sciortino, 2017, Multiwalled carbon nanotubes for drug delivery: efficiency related to length and incubation time, Int J Pharm, 521, 69, 10.1016/j.ijpharm.2017.02.023 Dan, 2018, Antibody-drug conjugates for cancer therapy: chemistry to clinical implications, Pharmaceuticals, 11, 32, 10.3390/ph11020032 Moosavian, 2019, Aptamer-functionalized liposomes for targeted cancer therapy, Cancer Lett., 28, 144, 10.1016/j.canlet.2019.01.045 Aghebati-Maleki, 2020, Nanoparticles and cancer therapy: perspectives for application of nanoparticles in the treatment of cancers, J Cell Physiol, 235, 1962, 10.1002/jcp.29126 Murar, 2022, Advanced optical imaging-guided nanotheranostics towards personalized cancer drug delivery, Nanomaterials, 12, 399, 10.3390/nano12030399 Gong, 2019, Emerging approaches of cell-based nanosystems to target cancer metastasis, Adv Funct Mater, 29, 10.1002/adfm.201903441 Zangabad, 2017, Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger, Nanoscale, 9, 1356, 10.1039/C6NR07315H Moura, 2019, Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders, Mater Horiz, 6, 1956, 10.1039/C9MH00628A de Araujo, 2021, Nanosystem functionalization strategies for prostate cancer treatment: a review, J Drug Target, 29, 808, 10.1080/1061186X.2021.1892121 Pullan, 2019, Exosomes as drug carriers for cancer therapy, Mol Pharm, 16, 1789, 10.1021/acs.molpharmaceut.9b00104 Zhao, 2020, Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake, Biomed Pharmacother, 128, 10.1016/j.biopha.2020.110237 Zendedel, 2019, Use of stem cells as carriers of oncolytic viruses for cancer treatment, J Cell Physiol, 234, 14906, 10.1002/jcp.28320 Xu, 2020, Cell membrane-camouflaged nanoparticles as drug carriers for cancer therapy, Acta Biomater, 105, 1, 10.1016/j.actbio.2020.01.036 Bang, 2019, The delivery strategy of paclitaxel nanostructured lipid carrier coated with platelet membrane, Cancers, 11, 807, 10.3390/cancers11060807 Xia, 2020, Engineering macrophages for cancer immunotherapy and drug delivery, Adv Mater, 32, 10.1002/adma.202002054 Zhang, 2019, Design of outer membrane vesicles as cancer vaccines: a new toolkit for cancer therapy, Cancers, 11, 1314, 10.3390/cancers11091314 Farjadian, 2018, Bacterial components as naturally inspired nano-carriers for drug/gene delivery and immunization: Set the bugs to work?, Biotechnol Adv, 36, 968, 10.1016/j.biotechadv.2018.02.016 Huang, 2022, Outer membrane vesicles (OMVs) enabled bio-applications: a critical review, Biotechnol Bioeng, 119, 34, 10.1002/bit.27965 Youssof, 2019, Bacterial ghosts carrying 5-fluorouracil: a novel biological carrier for targeting colorectal cancer, AAPS PharmSciTech, 20, 1, 10.1208/s12249-018-1249-z Parodi, 2017, Bio-inspired engineering of cell-and virus-like nanoparticles for drug delivery, Biomaterials, 147, 155, 10.1016/j.biomaterials.2017.09.020 Li, 2021, P22 virus-like particles as an effective antigen delivery nanoplatform for cancer immunotherapy, Biomaterials, 271, 10.1016/j.biomaterials.2021.120726 Ong, 2017, Virus like particles as a platform for cancer vaccine development, PeerJ, 5, 10.7717/peerj.4053 Mendes, 2019, Surface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers, Drug Deliv, 26, 443, 10.1080/10717544.2019.1574935 Gad, 2022, Novel approaches of solid lipid nanoparticles as drug carrier, Nanoeng Biomater, 107, 10.1002/9783527832095.ch5 Nasirizadeh, 2020, Solid lipid nanoparticles and nanostructured lipid carriers in oral cancer drug delivery, J Drug Delivery Sci Technol, 55, 10.1016/j.jddst.2019.101458 Haider, 2020, Nanostructured lipid carriers for delivery of chemotherapeutics: a review, Pharmaceutics, 12, 288, 10.3390/pharmaceutics12030288 Li, 2018, Multifunctional smart hydrogels: potential in tissue engineering and cancer therapy, J Mater Chem B, 6, 4714, 10.1039/C8TB01078A Palmerston Mendes, 2017, Dendrimers as nanocarriers for nucleic acid and drug delivery in cancer therapy, Molecules, 22, 1401, 10.3390/molecules22091401 Tiwari, 2018, Carbon coated core–shell multifunctional fluorescent SPIONs, Nanoscale, 10, 10389, 10.1039/C8NR01941J Li, 2019, AuNPs as an important inorganic nanoparticle applied in drug carrier systems, Artif Cells Nanomed Biotechnol, 47, 4222, 10.1080/21691401.2019.1687501 Zare, 2021, Carbon nanotubes: Smart drug/gene delivery carriers, Int J Nanomed, 16, 1681, 10.2147/IJN.S299448 Choudhury, 2019, Strategizing biodegradable polymeric nanoparticles to cross the biological barriers for cancer targeting, Int J Pharm, 565, 509, 10.1016/j.ijpharm.2019.05.042 Butt, 2016, Doxorubicin and siRNA codelivery via chitosan-coated pH-responsive mixed micellar polyplexes for enhanced cancer therapy in multidrug-resistant tumors, Mol Pharm, 13, 4179, 10.1021/acs.molpharmaceut.6b00776 Kesharwani, 2023, A combinatorial delivery of survivin targeted siRNA using cancer selective nanoparticles for triple negative breast cancer therapy, J Drug Delivery Sci Technol, 10.1016/j.jddst.2023.104164 Shukla, 2019, Conclusion and future prospective of polymeric nanoparticles for cancer therapy, 389 Singh, 2022, Taxanes loaded polymersomes as an emerging polymeric nanocarrier for cancer therapy, Eur Polym J, 162, 10.1016/j.eurpolymj.2021.110883 Kesharwani, 2019, Dendrimer-entrapped gold nanoparticles as promising nanocarriers for anticancer therapeutics and imaging, Prog Mater Sci, 103, 484, 10.1016/j.pmatsci.2019.03.003 Khan, 2017, Polymeric nanocarriers: a new horizon for the effective management of breast cancer, Curr Pharm Des, 23, 5315 Rehman, 2022, Polymeric nanoparticles-siRNA as an emerging nano-polyplexes against ovarian cancer, Colloids Surf. B: Biointerfaces, 10.1016/j.colsurfb.2022.112766 Fatima, 2022, Advancements in polymeric nanocarriers to mediate targeted therapy against triple-negative breast cancer, Pharmaceutics, 14, 2432, 10.3390/pharmaceutics14112432 Wickens, 2017, Recent advances in hyaluronic acid-decorated nanocarriers for targeted cancer therapy, Drug Discov Today, 22, 665, 10.1016/j.drudis.2016.12.009 Sheikh, 2021, RGD engineered dendrimer nanotherapeutic as an emerging targeted approach in cancer therapy, J Control Release, 340, 221, 10.1016/j.jconrel.2021.10.028 Bhagwat, 2020, Formulation and development of transferrin targeted solid lipid nanoparticles for breast cancer therapy, Front Pharmacol, 11, 10.3389/fphar.2020.614290 Gorain, 2019, Dendrimer-based nanocarriers in lung Cancer therapy, 161 Singh, 2021, Dendrimer as a promising nanocarrier for the delivery of doxorubicin as an anticancer therapeutics, J Biomater Sci Polym Ed, 32, 1882, 10.1080/09205063.2021.1938859 Zeeshan, 2021, Human serum albumin as multifunctional nanocarrier for cancer therapy, J Pharm Sci, 110, 3111, 10.1016/j.xphs.2021.05.001 Amjad, 2017, Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy, Prog Polym Sci, 64, 154, 10.1016/j.progpolymsci.2016.09.008 Singh, 2020, Immune checkpoint inhibitors: a promising anticancer therapy, Drug Discov Today, 25, 223, 10.1016/j.drudis.2019.11.003 Dhandapani, 2022, Self-assembled multifunctional nanotheranostics against circulating tumor clusters in metastatic breast cancer, Acta Pharm Sin B Shah, 2016, microRNA therapeutics in cancer—an emerging concept, EBioMedicine, 12, 34, 10.1016/j.ebiom.2016.09.017 Ganju, 2017, miRNA nanotherapeutics for cancer, Drug Discov Today, 22, 424, 10.1016/j.drudis.2016.10.014 Chakraborty, 2018, The novel strategies for next-generation cancer treatment: miRNA combined with chemotherapeutic agents for the treatment of cancer, Oncotarget, 9, 10164, 10.18632/oncotarget.24309 Kintzing, 2016, Emerging strategies for developing next-generation protein therapeutics for cancer treatment, Trends Pharmacol Sci, 37, 993, 10.1016/j.tips.2016.10.005 Yun, 2019, Heat shock proteins: agents of cancer development and therapeutic targets in anti-cancer therapy, Cells, 9, 60, 10.3390/cells9010060 Özdemir, 2019, Sex hormones and anticancer immunity sex hormones and anticancer immunity, Clin Cancer Res, 25, 4603, 10.1158/1078-0432.CCR-19-0137 Masiero, 2019, Development of therapeutic anti-JAGGED1 antibodies for cancer therapy anti-JAGGED1 antibodies for cancer therapy, Mol Cancer Ther, 18, 2030, 10.1158/1535-7163.MCT-18-1176 Baldo, 2021, Biologics: monoclonal antibodies for non-cancer therapy, cytokines, fusion proteins, enzymes, and hormones, 533 Watanabe, 2018, Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses, JCI Insight, 3, 10.1172/jci.insight.99573 Ratti, 2020, MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside, Target Oncol, 15, 261, 10.1007/s11523-020-00717-x Shahidi M, Abazari O, Dayati P, Haghiralsadat BF, Oroojalian F, Tofighi D. Targeted delivery of 5-Fluorouracil, miR-532-3p and si-KRAS to colorectal tumor using Layer-by-Layer liposomes. 2022. Hafez, 2020, Nanomedicine-based approaches for improved delivery of phyto-therapeutics for cancer therapy, Expert Opin Drug Deliv, 17, 279, 10.1080/17425247.2020.1723542 Zeya, 2022, Diosmin in combination with naringenin enhances apoptosis in colon cancer cells, Oncol Rep, 47, 1 Jiang, 2017, Resveratrol and cancer treatment: updates, Ann N Y Acad Sci, 1403, 59, 10.1111/nyas.13466 Cheng, 2020, Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway, Exp Ther Med, 19, 3798 Mansouri, 2020, Clinical effects of curcumin in enhancing cancer therapy: a systematic review, BMC Cancer, 20, 1, 10.1186/s12885-020-07256-8 Sodrul, 2018, Role of ginsenosides in reactive oxygen species-mediated anticancer therapy, Oncotarget, 9, 2931, 10.18632/oncotarget.23407 Baek, 2018, Sustained cytotoxicity of wogonin on breast cancer cells by encapsulation in solid lipid nanoparticles, Nanomaterials, 8, 159, 10.3390/nano8030159 Samadi, 2020, Berberine: a novel therapeutic strategy for cancer, IUBMB Life, 72, 2065, 10.1002/iub.2350 Ezzati, 2020, A review on anti-cancer properties of Quercetin in breast cancer, Life Sci, 248, 10.1016/j.lfs.2020.117463 Tan, 2018, Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy, Biomaterials, 154, 169, 10.1016/j.biomaterials.2017.07.036 Ahire, 2017, Ellagic acid enhances apoptotic sensitivity of breast cancer cells to γ-radiation, Nutr Cancer, 69, 904, 10.1080/01635581.2017.1339811 Blackman, 2018, Confinement of therapeutic enzymes in selectively permeable polymer vesicles by polymerization-induced self-assembly (PISA) reduces antibody binding and proteolytic susceptibility, ACS Cent Sci, 4, 718, 10.1021/acscentsci.8b00168 O'Connor, 2017, Imaging biomarker roadmap for cancer studies, Nat Rev Clin Oncol, 14, 169, 10.1038/nrclinonc.2016.162 Tsai, 2022, A high-performance deep neural network model for BI-RADS classification of screening mammography, Sensors, 22, 10.3390/s22031160 Okamoto T, Miyawaki M, Toyokawa G, Karashima T, Abe M, Takumi Y, et al. Clinical significance of part-solid lung cancer in the eighth edition TNM staging system. Interact Cardiovasc Thoracic Surg 2022;34(2):219–26. Huang, 2022, Evaluation of left atrial remodeling using cardiovascular magnetic resonance imaging in breast cancer patients treated with adjuvant trastuzumab, Eur Radiol, 1 Tanaka, 2022, Potential of PALBI-T score as a prognostic model for hepatocellular carcinoma in alcoholic liver disease, JGH Open, 6, 36, 10.1002/jgh3.12705 Lee, 2022, Recent trends in screening breast MRI, J Breast Imaging, 4, 39, 10.1093/jbi/wbab088 Manceau, 2022, What is the optimal elective colectomy for splenic flexure cancer: end of the debate? A multicenter study from the GRECCAR group with a propensity score analysis, Dis Colon Rectum, 65, 55, 10.1097/DCR.0000000000001937 Mustafa, 2021, Chemotherapeutic applications of folate prodrugs: a review, NeuroQuantology, 19, 99, 10.14704/nq.2021.19.8.NQ21120 Wei, 2019, Camrelizumab combined with microwave ablation improves the objective response rate in advanced non-small cell lung cancer, J Cancer Res Ther, 15, 1629, 10.4103/jcrt.JCRT_990_19 Hope, 2019, 111In-pentetreotide scintigraphy versus 68Ga-DOTATATE PET: impact on Krenning scores and effect of tumor burden, J Nucl Med, 60, 1266, 10.2967/jnumed.118.223016 Uryvaev, 2018, The role of tumor-infiltrating lymphocytes (TILs) as a predictive biomarker of response to anti-PD1 therapy in patients with metastatic non-small cell lung cancer or metastatic melanoma, Med Oncol, 35, 1, 10.1007/s12032-018-1080-0 Yang, 2020, The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy, Acta Pharm Sin B, 10, 2156, 10.1016/j.apsb.2020.04.004 Dersh D, Phelan JD, Gumina ME, Wang B, Arbuckle JH, Holly J, et al. Genome-wide screens identify lineage-and tumor-specific genes modulating MHC-I-and MHC-II-restricted immunosurveillance of human lymphomas. Immunity 2021;54(1):116–31.e10. Drost, 2019, Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer, Cochrane Database Syst Rev, 4 Lennon, 2020, Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention, Science, 369, 10.1126/science.abb9601 Tabotta, 2019, Quantitative bone SPECT/CT: high specificity for identification of prostate cancer bone metastases, BMC Musculoskelet Disord, 20, 1, 10.1186/s12891-019-3001-6 Jia, 2018, NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo, Biomaterials, 178, 302, 10.1016/j.biomaterials.2018.06.029 Ranjbar-Navazi, 2018, Doxorubicin-conjugated D-glucosamine-and folate-bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy, J Drug Target, 26, 267, 10.1080/1061186X.2017.1365876 Alamdari, 2022, Recent advances in nanoparticle-based photothermal therapy for breast cancer, J Control Release, 349, 269, 10.1016/j.jconrel.2022.06.050 Jnawali K, Chinni B, Dogra V, Rao N, editors. Transfer learning for automatic cancer tissue detection using multispectral photoacoustic imaging. Medical imaging 2019: computer-aided diagnosis. SPIE; 2019. Cherukula, 2019, “Navigate-dock-activate” anti-tumor strategy: tumor micromilieu charge-switchable, hierarchically activated nanoplatform with ultrarapid tumor-tropic accumulation for trackable photothermal/chemotherapy, Theranostics, 9, 2505, 10.7150/thno.33280 Zhang, 2020, Multifunctional oxygen-enriching nano-theranostics for cancer-specific magnetic resonance imaging and enhanced photodynamic/photothermal therapy, Nano Res, 13, 1389, 10.1007/s12274-020-2646-7 Górecki, 2021, Effect of detergents on morphology, size distribution, and concentration of copolymer-based polymersomes, Langmuir, 37, 2079, 10.1021/acs.langmuir.0c03044 Guo, 2017, Supramolecular polymersomes constructed from water-soluble pillar [5] arene and cationic poly (glutamamide) s and their applications in targeted anticancer drug delivery, Polym Chem, 8, 5718, 10.1039/C7PY01259D Lu, 2018, Micelles with ultralow critical micelle concentration as carriers for drug delivery, Nat Biomed Eng, 2, 318, 10.1038/s41551-018-0234-x Wang, 2020, Universal model for the maximum spreading factor of impacting nanodroplets: from hydrophilic to hydrophobic surfaces, Langmuir, 36, 9306, 10.1021/acs.langmuir.0c01879 Zhang, 2017, Converting metal–organic framework particles from hydrophilic to hydrophobic by an interfacial assembling route, Langmuir, 33, 12427, 10.1021/acs.langmuir.7b02365 Mohammadi, 2017, Biocompatible polymersomes-based cancer theranostics: towards multifunctional nanomedicine, Int J Pharm, 519, 287, 10.1016/j.ijpharm.2017.01.037 Ali, 2020, Progress in polymeric nano-medicines for theranostic cancer treatment, Polymers, 12, 598, 10.3390/polym12030598 Hasannia, 2022, Synthesis of block copolymers used in polymersome fabrication: application in drug delivery, J Control Release, 341, 95, 10.1016/j.jconrel.2021.11.010 Greene, 2016, The role of membrane fluidization in the gel-assisted formation of giant polymersomes, PLoS One, 11, 10.1371/journal.pone.0158729 Liang, 2019, pH-responsive nanoparticles loaded with graphene quantum dots and doxorubicin for intracellular imaging, drug delivery and efficient cancer therapy, ChemistrySelect, 4, 6004, 10.1002/slct.201803807 Dana, 2020, Active targeting liposome-PLGA composite for cisplatin delivery against cervical cancer, Colloids Surf B: Biointerfaces, 196, 10.1016/j.colsurfb.2020.111270 Damiati, 2018, Microfluidic devices for drug delivery systems and drug screening, Genes, 9, 103, 10.3390/genes9020103 Liu, 2019, Lipid nanovesicles by microfluidics: manipulation, synthesis, and drug delivery, Adv Mater, 31, 10.1002/adma.201804788 Ma, 2020, Microfluidic-mediated nano-drug delivery systems: from fundamentals to fabrication for advanced therapeutic applications, Nanoscale, 12, 15512, 10.1039/D0NR02397C Kumar, 2015, ROP and ATRP fabricated dual targeted redox sensitive polymersomes based on pPEGMA-PCL-ss-PCL-pPEGMA triblock copolymers for breast cancer therapeutics, ACS Appl Mater Interfaces, 7, 9211, 10.1021/acsami.5b01731 Zavvar, 2020, Synthesis of multimodal polymersomes for targeted drug delivery and MR/fluorescence imaging in metastatic breast cancer model, Int J Pharm, 578, 10.1016/j.ijpharm.2020.119091 Oz, 2021, A robust optimization approach for the breast cancer targeted design of PEtOx-b-PLA polymersomes, Mater Sci Eng C, 123, 10.1016/j.msec.2021.111929 Lale, 2015, Folic acid and trastuzumab functionalized redox responsive polymersomes for intracellular doxorubicin delivery in breast cancer, Biomacromolecules, 16, 1736, 10.1021/acs.biomac.5b00244 Taghizadeh, 2015, Classification of stimuli–responsive polymers as anticancer drug delivery systems, Drug Deliv, 22, 145, 10.3109/10717544.2014.887157 Li, 2015, Efficacious delivery of protein drugs to prostate cancer cells by PSMA-targeted pH-responsive chimaeric polymersomes, J Control Release, 220, 704, 10.1016/j.jconrel.2015.08.058 Gao, 2018, Effective intracellular delivery and Th1 immune response induced by ovalbumin loaded in pH-responsive polyphosphazene polymersomes, Nanomed Nanotechnol Biol Med, 14, 1609, 10.1016/j.nano.2018.04.001 Ullah, 2017, Bioreducible, hydrolytically degradable and targeting polymers for gene delivery, J Mater Chem B, 5, 3253, 10.1039/C7TB00275K Zou, 2017, Virus-mimicking chimaeric polymersomes boost targeted cancer siRNA therapy in vivo, Adv Mater, 29, 10.1002/adma.201703285 Iqbal, 2020, Polymersomes for therapeutic delivery of protein and nucleic acid macromolecules: from design to therapeutic applications, Biomacromolecules, 21, 1327, 10.1021/acs.biomac.9b01754 Kim, 2016, Stimuli-triggered Formation of Polymersomes from W/O/W Multiple Double Emulsion Droplets Containing Poly (styrene)-block-poly (N-isopropylacrylamide-co-spironaphthoxazine methacryloyl), Langmuir, 32, 9223, 10.1021/acs.langmuir.6b02178 Wang, 2017, pH-responsive polymersome based on PMCP-b-PDPA as a drug delivery system to enhance cellular internalization and intracellular drug release, Chin J Polym Sci, 35, 1352, 10.1007/s10118-017-1982-x Oroojalian, 2018, Encapsulation of thermo-responsive gel in pH-sensitive polymersomes as dual-responsive smart carriers for controlled release of doxorubicin, J Control Release, 288, 45, 10.1016/j.jconrel.2018.08.039 Ramezani, 2020, Targeted MMP-2 responsive chimeric polymersomes for therapy against colorectal cancer, Colloids Surf B: Biointerfaces, 193, 10.1016/j.colsurfb.2020.111135 Taghavi, 2020, Synthesis of chimeric polymersomes based on PLA-b-PHPMA and PCL-b-PHPMA for nucleoline guided delivery of SN38, Nanomed Nanotechnol Biol Med, 28, 10.1016/j.nano.2020.102227 Blackman, 2020, Antimicrobial honey-inspired glucose-responsive nanoreactors by polymerization-induced self-assembly, ACS Appl Mater Interfaces, 12, 11353, 10.1021/acsami.9b22386 Gaballa, 2019, Glucose-responsive polymeric micelles via boronic acid–diol complexation for insulin delivery at neutral pH, Biomacromolecules, 20, 871, 10.1021/acs.biomac.8b01508 Wang, 2020, Liver-target and glucose-responsive polymersomes toward mimicking endogenous insulin secretion with improved hepatic glucose utilization, Adv Funct Mater, 30, 10.1002/adfm.201910168 Kubo, 2019, Synthesis of functional and boronic acid-containing aliphatic polyesters via Suzuki coupling, Chem Commun, 55, 5655, 10.1039/C9CC01975H Brooks, 2016, Synthesis and applications of boronic acid-containing polymers: from materials to medicine, Chem Rev, 116, 1375, 10.1021/acs.chemrev.5b00300 Kim, 2021, Molecular design of a high-performance polymeric carrier for delivery of a variety of boronic acid-containing drugs, Acta Biomater, 121, 554, 10.1016/j.actbio.2020.12.015 Sun, 2018, Photo-and reduction-responsive polymersomes for programmed release of small and macromolecular payloads, Biomacromolecules, 19, 2071, 10.1021/acs.biomac.8b00253 Zhou, 2020, Light-responsive polymersomes with a charge-switch for targeted drug delivery, J Mater Chem B, 8, 727, 10.1039/C9TB02411E Hou, 2020, Photo-responsive polymersomes as drug delivery system for potential medical applications, Molecules, 25, 5147, 10.3390/molecules25215147 Meghani, 2017, Mechanistic applications of click chemistry for pharmaceutical drug discovery and drug delivery, Drug Discov Today, 22, 1604, 10.1016/j.drudis.2017.07.007 Kiene, 2017, PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity, Eur J Pharm Biopharm, 119, 322, 10.1016/j.ejpb.2017.07.002 Moreno, 2021, Multivalent protein-loaded pH-stable polymersomes: first step toward protein targeted therapeutics, Macromol Biosci, 21, 10.1002/mabi.202100102 Wang, 2022, Transferrin/folate dual-targeting Pluronic F127/poly (lactic acid) polymersomes for effective anticancer drug delivery, J Biomater Sci Polym Ed, 1 Pangburn, 2012, Polymersomes functionalized via “click” chemistry with the fibronectin mimetic peptides PR_b and GRGDSP for targeted delivery to cells with different levels of α 5 β 1 expression, Soft Matter, 8, 4449, 10.1039/c2sm06922a Mertz, 2021, Increased protein encapsulation in polymersomes with hydrophobic membrane anchoring peptides in a scalable process, Int J Mol Sci, 22, 7134, 10.3390/ijms22137134 Figueiredo, 2016, Angiopep2-functionalized polymersomes for targeted doxorubicin delivery to glioblastoma cells, Int J Pharm, 511, 794, 10.1016/j.ijpharm.2016.07.066 Klermund, 2016, Simple surface functionalization of polymersomes using non-antibacterial peptide anchors, J Nanobiotechnol, 14, 1, 10.1186/s12951-016-0205-x Leong, 2018, Engineering polymersomes for diagnostics and therapy, Adv Healthc Mater, 7, 10.1002/adhm.201701276 Oz, 2020, Prostate cancer cell-specific BikDDA delivery by targeted polymersomes, Appl Nanosci, 10, 3389, 10.1007/s13204-020-01287-0 Wei, 2020, Transferrin-binding peptide functionalized polymersomes mediate targeted doxorubicin delivery to colorectal cancer in vivo, J Control Release, 319, 407, 10.1016/j.jconrel.2020.01.012 Zhang, 2021, An intelligent cell-selective polymersome-DM1 nanotoxin toward triple negative breast cancer, J Control Release, 340, 331, 10.1016/j.jconrel.2021.11.014 Xia, 2021, Systemic administration of polymersomal oncolytic peptide LTX-315 combining with CpG adjuvant and anti-PD-1 antibody boosts immunotherapy of melanoma, J Control Release, 336, 262, 10.1016/j.jconrel.2021.06.032 Yang, 2018, Selective cell penetrating peptide-functionalized polymersomes mediate efficient and targeted delivery of methotrexate disodium to human lung cancer in vivo, Adv Healthc Mater, 7, 10.1002/adhm.201701135 Wang, 2021, α3 integrin-binding peptide-functionalized polymersomes loaded with volasertib for dually-targeted molecular therapy for ovarian cancer, Acta Biomater, 124, 348, 10.1016/j.actbio.2021.02.007 Yao, 2018, Smart polymersomes dually functionalized with cRGD and fusogenic GALA peptides enable specific and high-efficiency cytosolic delivery of apoptotic proteins, Biomacromolecules, 20, 184, 10.1021/acs.biomac.8b01243 Zhang, 2017, ATN-161 peptide functionalized reversibly cross-linked polymersomes mediate targeted doxorubicin delivery into melanoma-bearing C57BL/6 mice, Mol Pharm, 14, 2538, 10.1021/acs.molpharmaceut.6b00800 Duell, 2019, Bispecific antibodies in the treatment of hematologic malignancies, Clin Pharmacol Ther, 106, 781, 10.1002/cpt.1396 Parhi, 2015, Trastuzumab guided nanotheranostics: A lipid based multifunctional nanoformulation for targeted drug delivery and imaging in breast cancer therapy, J Colloid Interface Sci, 451, 198, 10.1016/j.jcis.2015.03.049 Zhu, 2018, Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way, Artif Cells Nanomed Biotechnol, 46, 1659 Bartusik-Aebisher, 2021, An analytical study of Trastuzumab-dendrimer-fluorine drug delivery system in breast cancer therapy in vitro, Biomed Pharmacother, 133, 10.1016/j.biopha.2020.111053 Godwin, 2017, Gemtuzumab ozogamicin in acute myeloid leukemia, Leukemia, 31, 1855, 10.1038/leu.2017.187 Pandit, 2017, Chitosan-coated PLGA nanoparticles of bevacizumab as novel drug delivery to target retina: optimization, characterization, and in vitro toxicity evaluation, Artif Cells Nanomed Biotechnol, 45, 1397, 10.1080/21691401.2016.1243545 Gerstner, 2020, Bevacizumab reduces permeability and concurrent temozolomide delivery in a subset of patients with recurrent glioblastoma, Clin Cancer Res, 26, 206, 10.1158/1078-0432.CCR-19-1739 Dieu, 2014, Polymersomes conjugated to 83–14 monoclonal antibodies: in vitro targeting of brain capillary endothelial cells, Eur J Pharm Biopharm, 88, 316, 10.1016/j.ejpb.2014.05.021 Debets, 2013, Nanobody-F unctionalized polymersomes for tumor-V essel targeting, Macromol Biosci, 13, 938, 10.1002/mabi.201300039 Yue, 2021, Cetuximab–polymersome–mertansine nanodrug for potent and targeted therapy of EGFR-positive cancers, Biomacromolecules, 23, 100, 10.1021/acs.biomac.1c01065 Ansari, 2020, Lipid-based nano delivery of Tat-peptide conjugated drug or vaccine–promising therapeutic strategy for SARS-CoV-2 treatment, Expert Opin Drug Deliv, 17, 1671, 10.1080/17425247.2020.1813712 Moku, 2019, Improving payload capacity and anti-tumor efficacy of mesenchymal stem cells using TAT peptide functionalized polymeric nanoparticles, Cancers, 11, 491, 10.3390/cancers11040491 Bhatt, 2017, Development of surface-engineered PLGA nanoparticulate-delivery system of Tet1-conjugated nattokinase enzyme for inhibition of Aβ40 plaques in Alzheimer’s disease, Int J Nanomed, 12, 8749, 10.2147/IJN.S144545 Chen, 2017, Peptide-22 and cyclic RGD functionalized liposomes for glioma targeting drug delivery overcoming BBB and BBTB, ACS Appl Mater Interfaces, 9, 5864, 10.1021/acsami.6b15831 Mekuria, 2016, IL-6 antibody and RGD peptide conjugated poly (amidoamine) dendrimer for targeted drug delivery of HeLa cells, J Phys Chem B, 120, 123, 10.1021/acs.jpcb.5b11125 Goyal, 2018, Lactoferrin-conjugated pH and redox-sensitive polymersomes based on PEG-SS-PLA-PCL-OH boost delivery of bacosides to the brain, Nanoscale, 10, 17781, 10.1039/C8NR03828G Goyal, 2020, Bacosides encapsulated in lactoferrin conjugated PEG-PLA-PCL-OH based polymersomes act as epigenetic modulator in chemically induced amnesia, Neurochem Res, 45, 796, 10.1007/s11064-020-02953-z Elzoghby, 2020, Lactoferrin, a multi-functional glycoprotein: active therapeutic, drug nanocarrier & targeting ligand, Biomaterials, 263, 10.1016/j.biomaterials.2020.120355 Wei, 2019, Low-toxicity transferrin-guided polymersomal doxorubicin for potent chemotherapy of orthotopic hepatocellular carcinoma in vivo, Acta Biomater, 92, 196, 10.1016/j.actbio.2019.05.034 Simón-Gracia, 2016, iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes, Biomaterials, 104, 247, 10.1016/j.biomaterials.2016.07.023 Kulkarni, 2018, Tissue-penetrating, hypoxia-responsive echogenic polymersomes for drug delivery to solid tumors, Chem–Eur J, 24, 12490, 10.1002/chem.201802229 Diaz Bessone, 2019, iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacity, J Nanobiotechnol, 17, 1, 10.1186/s12951-019-0553-4 Zhou, 2020, GE11 peptide-installed chimaeric polymersomes tailor-made for high-efficiency EGFR-targeted protein therapy of orthotopic hepatocellular carcinoma, Acta Biomater, 113, 512, 10.1016/j.actbio.2020.06.020 Zou, 2018, GE11-directed functional polymersomal doxorubicin as an advanced alternative to clinical liposomal formulation for ovarian cancer treatment, Mol Pharm, 15, 3664, 10.1021/acs.molpharmaceut.8b00024 Fang, 2017, EGFR-targeted multifunctional polymersomal doxorubicin induces selective and potent suppression of orthotopic human liver cancer in vivo, Acta Biomater, 64, 323, 10.1016/j.actbio.2017.10.013 Simón-Gracia L, Scodeller P, Fuentes SS, Vallejo VG, Ríos X, San Sebastián E, et al. Application of polymersomes engineered to target p32 protein for detection of small breast tumors in mice. bioRxiv. 2018:187716. Gu, 2019, CD44-specific A6 short peptide boosts targetability and anticancer efficacy of polymersomal epirubicin to orthotopic human multiple myeloma, Adv Mater, 31, 10.1002/adma.201904742 Zhang, 2021, SP94 peptide mediating highly specific and efficacious delivery of polymersomal doxorubicin hydrochloride to hepatocellular carcinoma in vivo, Colloids Surf B: Biointerfaces, 197, 10.1016/j.colsurfb.2020.111399 Yang, 2018, Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo, J Control Release, 290, 141, 10.1016/j.jconrel.2018.10.013 Zou, 2018, Targeted chemotherapy for subcutaneous and orthotopic non-small cell lung tumors with cyclic RGD-functionalized and disulfide-crosslinked polymersomal doxorubicin, Signal Transduct Target Ther, 3, 1, 10.1038/s41392-018-0032-7 Zou, 2020, α3β1 integrin-targeting polymersomal docetaxel as an advanced nanotherapeutic for nonsmall cell lung cancer treatment, ACS Appl Mater Interfaces, 12, 14905, 10.1021/acsami.0c01069 Jiang, 2018, Apolipoprotein E peptide-directed chimeric polymersomes mediate an ultrahigh-efficiency targeted protein therapy for glioblastoma, ACS Nano, 12, 11070, 10.1021/acsnano.8b05265 Gu, 2021, A6 peptide-tagged, ultra-small and reduction-sensitive polymersomal vincristine sulfate as a smart and specific treatment for CD44+ acute myeloid leukemia, J Control Release, 329, 706, 10.1016/j.jconrel.2020.10.005 Fatima, 2022, Galactose engineered nanocarriers: hopes and hypes in cancer therapy, Eur Polym J Zhu, 2019, Co-delivery of antigen and dual agonists by programmed mannose-targeted cationic lipid-hybrid polymersomes for enhanced vaccination, Biomaterials, 206, 25, 10.1016/j.biomaterials.2019.03.012 Qin, 2018, Folate-targeted redox-responsive polymersomes loaded with chemotherapeutic drugs and tariquidar to overcome drug resistance, J Biomed Nanotechnol, 14, 1705, 10.1166/jbn.2018.2623 Wang, 2013, Galactose-decorated reduction-sensitive degradable chimaeric polymersomes as a multifunctional nanocarrier to efficiently chaperone apoptotic proteins into hepatoma cells, Biomacromolecules, 14, 2873, 10.1021/bm4007248 Das, 2015, Bioactive polymersomes self-assembled from amphiphilic PPO-glyco polypeptides: synthesis, characterization, and dual-dye encapsulation, Langmuir, 31, 3402, 10.1021/la503993e Zhu, 2017, Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma, Acta Biomater, 58, 399, 10.1016/j.actbio.2017.06.017 Pan, 2019, Folate-conjugated pluronic/polylactic acid polymersomes for oral delivery of paclitaxel, Int J Biol Macromol, 139, 377, 10.1016/j.ijbiomac.2019.07.224 Alibolandi, 2016, Dextran-poly lactide-co-glycolide polymersomes decorated with folate-antennae for targeted delivery of docetaxel to breast adenocarcinima in vitro and in vivo, J Control Release, 241, 45, 10.1016/j.jconrel.2016.09.012 Lu, 2015, Anisamide-decorated pH-sensitive degradable chimaeric polymersomes mediate potent and targeted protein delivery to lung cancer cells, Biomacromolecules, 16, 1726, 10.1021/acs.biomac.5b00193 Chiang, 2013, Functionalized polymersomes with outlayered polyelectrolyte gels for potential tumor-targeted delivery of multimodal therapies and MR imaging, J Control Release, 168, 280, 10.1016/j.jconrel.2013.03.029 Li, 2012, Biodegradable polymersomes with an ionizable membrane: facile preparation, superior protein loading, and endosomal pH-responsive protein release, Eur J Pharm Biopharm, 82, 103, 10.1016/j.ejpb.2012.05.009 Ghorbanizamani, 2020, pH-bioresponsive poly (ε-caprolactone)-based polymersome for effective drug delivery in cancer and protein glycoxidation prevention, Arch Biochem Biophys, 695, 10.1016/j.abb.2020.108643 Li, 2021, Enzymatically transformable polymersome-based nanotherapeutics to eliminate minimal relapsable cancer, Adv Mater, 33, 10.1002/adma.202105254 Mukerabigwi, 2019, Polymersome nanoreactors with tumor pH-triggered selective membrane permeability for prodrug delivery, activation, and combined oxidation-chemotherapy, J Control Release, 303, 209, 10.1016/j.jconrel.2019.04.032 Kauscher, 2019, Physical stimuli-responsive vesicles in drug delivery: Beyond liposomes and polymersomes, Adv Drug Deliv Rev, 138, 259, 10.1016/j.addr.2018.10.012 De Oliveira, 2012, Smart polymersomes for therapy and diagnosis: fast progress toward multifunctional biomimetic nanomedicines, Wiley Interdiscip Rev Nanomed Nanobiotechnol, 4, 525, 10.1002/wnan.1183 Lu, 2019, Immobilized Candida antarctica lipase B catalyzed synthesis of biodegradable polymers for biomedical applications, Biomater Sci, 7, 4963, 10.1039/C9BM00716D Nakamura, 2020, Encapsulation of mRNA into Artificial Viral Capsids via Hybridization of a β-Annulus-dT20 Conjugate and the Poly (A) Tail of mRNA, Appl Sci, 10, 10.3390/app10228004 Wang, 2018, Dually gated polymersomes for gene delivery, Nano Lett, 18, 5562, 10.1021/acs.nanolett.8b01985 Noor, 2012, Polymersome surface decoration by an EGFP fusion protein employing Cecropin A as peptide “anchor”, J Biotechnol, 157, 31, 10.1016/j.jbiotec.2011.10.005 Kim, 2012, Glucose-responsive disassembly of polymersomes of sequence-specific boroxole-containing block copolymers under physiologically relevant conditions, ACS Macro Lett, 1, 1194, 10.1021/mz3004192 Pourtau, 2013, Antibody-functionalized magnetic polymersomes: in vivo targeting and imaging of bone metastases using high resolution MRI, Adv Healthc Mater, 2, 1420, 10.1002/adhm.201300061 Baumann, 2017, Investigation of horseradish peroxidase kinetics in an “Organelle-Like” environment, Small, 13, 10.1002/smll.201603943 Nahire, 2014, Multifunctional polymersomes for cytosolic delivery of gemcitabine and doxorubicin to cancer cells, Biomaterials, 35, 6482, 10.1016/j.biomaterials.2014.04.026 Zhu, 2018, Bubble-generating polymersomes loaded with both indocyanine green and doxorubicin for effective chemotherapy combined with photothermal therapy, Acta Biomater, 75, 386, 10.1016/j.actbio.2018.05.033 Wu, 2022, Folate-targeted co-delivery polymersomes for efficient photo-chemo-antiangiogenic therapy against breast cancer and in vivo evaluation via OCTA/NIRF dual-modal imaging, Chin Chem Lett, 10.1016/j.cclet.2022.04.021 Ouyang, 2021, Doxorubicin Delivered via ApoE-directed reduction-sensitive polymersomes potently inhibit orthotopic human glioblastoma xenografts in nude mice, Int J Nanomed, 16, 4105, 10.2147/IJN.S314895 Iyisan, 2016, Multifunctional and dual-responsive polymersomes as robust nanocontainers: design, formation by sequential post-conjugations, and pH-controlled drug release, Chem Mater, 28, 1513, 10.1021/acs.chemmater.5b05016 Petit, 2018, A modular approach for multifunctional polymersomes with controlled adhesive properties, Soft Matter, 14, 894, 10.1039/C7SM01885A Schwarzer, 2018, Membrane functionalization of polymersomes: Alleviating mass transport limitations by integrating multiple selective membrane transporters for the diffusion of chemically diverse molecules, Nanotechnology, 29, 10.1088/1361-6528/aadb7e Schreiber, 2019, Molecular conjugation using non-covalent click chemistry, Nat Rev Chem, 3, 393, 10.1038/s41570-019-0095-1 Takayama, 2019, Click chemistry as a tool for cell engineering and drug delivery, Molecules, 24, 172, 10.3390/molecules24010172 Xiao, 2022, Co-assembly of liposomes, dendrimersomes, and Polymersomes with amphiphilic Janus dendrimers conjugated to Mono-and Tris-Nitrilotriacetic Acid (NTA, TrisNTA) enhances protein recruitment, Giant, 9, 10.1016/j.giant.2021.100089 Rein, 2016, Click-chemistry of polymersomes on nanoporous polymeric surfaces, J Polym Sci A: Polym Chem, 54, 2032, 10.1002/pola.28069 Mai, 2019, Crosslinked pH-responsive polymersome via Diels-Alder click chemistry: a reversible pH-dependent vesicular nanosystem, Polymer, 165, 19, 10.1016/j.polymer.2019.01.022 Spycher, 2017, Dual, site-specific modification of antibodies by using solid-phase immobilized microbial transglutaminase, Chembiochem, 18, 1923, 10.1002/cbic.201700188 Kunjachan, 2015, Noninvasive imaging of nanomedicines and nanotheranostics: principles, progress, and prospects, Chem Rev, 115, 10907, 10.1021/cr500314d Xiao, 2020, Superparamagnetic nanoparticles for biomedical applications, J Mater Chem B, 8, 354, 10.1039/C9TB01955C Chen, 2018, Synthesis, functionalization, and nanomedical applications of functional magnetic nanoparticles, Chin Chem Lett, 29, 1601, 10.1016/j.cclet.2018.08.007 Bain, 2019, A biomimetic magnetosome: formation of iron oxide within carboxylic acid terminated polymersomes, Nanoscale, 11, 11617, 10.1039/C9NR00498J Askes, 2016, Imaging upconverting polymersomes in cancer cells: biocompatible antioxidants brighten triplet–triplet annihilation upconversion, Small, 12, 5579, 10.1002/smll.201601708 Yan, 2017, Contrast agents in dynamic contrast-enhanced magnetic resonance imaging, Oncotarget, 8, 10.18632/oncotarget.16482 Craciun, 2017, Expanding the potential of MRI contrast agents through multifunctional polymeric nanocarriers, Nanomed Nanotechnol Biol Med, 12, 811 Caspani, 2020, Magnetic nanomaterials as contrast agents for MRI, Materials, 13, 2586, 10.3390/ma13112586 Wu, 2017, Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment, Mol Clin Oncol, 7, 738 Şologan, 2019, Functionalized gold nanoparticles as contrast agents for proton and dual proton/fluorine MRI, Nanomaterials, 9, 10.3390/nano9060879 Tang, 2018, In vivo MRI of functionalized iron oxide nanoparticles for brain inflammation, Contrast Media Mol Imaging, 2018, 10.1155/2018/3476476 Hu, 2020, Recent advances of bioresponsive nano-sized contrast agents for ultra-high-field magnetic resonance imaging, Front Chem, 8, 203, 10.3389/fchem.2020.00203 Sheth, 2020, Artificial intelligence in the interpretation of breast cancer on MRI, J Magn Reson Imaging, 51, 1310, 10.1002/jmri.26878 Jiang, 2021, Artificial intelligence applied to breast MRI for improved diagnosis, Radiology, 298, 38, 10.1148/radiol.2020200292 Dalmis, 2019, Artificial intelligence–based classification of breast lesions imaged with a multiparametric breast mri protocol with ultrafast DCE-MRI, T2, and DWI, Invest Radiol, 54, 325, 10.1097/RLI.0000000000000544 Mehralivand, 2020, Multicenter multireader evaluation of an artificial intelligence-based attention mapping system for the detection of prostate cancer with multiparametric MRI, Am J Roentgenol, 215, 903, 10.2214/AJR.19.22573 Liu, 2020, Yolk-shell nanovesicles endow glutathione-responsive concurrent drug release and T1 MRI activation for cancer theranostics, Biomaterials, 244, 10.1016/j.biomaterials.2020.119979 Roy, 2017, Anisotropic gold nanoparticle decorated magnetopolymersome: an advanced nanocarrier for targeted photothermal therapy and dual-mode responsive T1 MRI imaging, ACS Biomater Sci Eng, 3, 2120, 10.1021/acsbiomaterials.7b00089 Gao, 2018, Tumor-penetrating peptide conjugated and doxorubicin loaded T1–T2 dual mode MRI contrast agents nanoparticles for tumor theranostics, Theranostics, 8, 92, 10.7150/thno.21074 Liu, 2019, Fast fluorescence lifetime imaging techniques: a review on challenge and development, J Innovat Opt Health Sci, 12 Wöll, 2017, Super-resolution fluorescence imaging for materials science, Small Methods, 1, 10.1002/smtd.201700191 Deshpande, 2021, An AIE-driven fluorescent polysaccharide polymersome as an enzyme-responsive FRET nanoprobe to study the real-time delivery aspects in live cells, Polym Chem, 12, 1549, 10.1039/D0PY01085E Cao, 2021, Biodegradable polymersomes with structure inherent fluorescence and targeting capacity for enhanced photo-dynamic therapy, Angew Chem Int Ed, 60, 17629, 10.1002/anie.202105103 Semkova, 2018, Loading efficiency of polymersomes with contrast agents and their intracellular delivery: quantum dots versus organic dyes, Anticancer Res, 38, 825 Moret, 2017, Strategies for optimizing the delivery to tumors of macrocyclic photosensitizers used in photodynamic therapy (PDT), J Porphyrins Phthalocyanines, 21, 239, 10.1142/S1088424617300014 Domagala, 2018, Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy, BMC Cancer, 18, 1, 10.1186/s12885-018-4126-y Boppana, 2016, Enhanced apoptotic cancer cell killing after Foscan photodynamic therapy combined with fenretinide via de novo sphingolipid biosynthesis pathway, J Photochem Photobiol B Biol, 159, 191, 10.1016/j.jphotobiol.2016.02.040 Meier, 2017, Foscan and foslip based photodynamic therapy in osteosarcoma in vitro and in intratibial mouse models, Int J Cancer, 140, 1680, 10.1002/ijc.30572 Feng, 2016, Verteporfin, a suppressor of YAP–TEAD complex, presents promising antitumor properties on ovarian cancer, OncoTargets Ther, 9, 5371, 10.2147/OTT.S109979 Michy, 2019, Verteporfin-loaded lipid nanoparticles improve ovarian cancer photodynamic therapy in vitro and in vivo, Cancers, 11, 1760, 10.3390/cancers11111760 Flegar, 2021, Decision regret and quality of life after focal therapy with vascular-targeted photodynamic therapy (TOOKAD®) for localized prostate cancer, Urol Int, 1 Yano, 2021, Clinical practice of photodynamic therapy using talaporfin sodium for esophageal cancer, J Clin Med, 10, 2785, 10.3390/jcm10132785 Kanda, 2019, Low-density lipoprotein receptor expression is involved in the beneficial effect of photodynamic therapy using talaporfin sodium on gastric cancer cells, Oncol Lett, 17, 3261 Li, 2021, Oxygen-and bubble-generating polymersomes for tumor-targeted and enhanced photothermal–photodynamic combination therapy, Biomater Sci, 9, 5841, 10.1039/D1BM00659B Tang, 2020, Near-infrared laser-triggered, self-immolative smart polymersomes for in vivo cancer therapy, Int J Nanomed, 15, 137, 10.2147/IJN.S224502 Wang, 2017, Killing malignant melanoma cells with protoporphyrin IX-loaded polymersome-mediated photodynamic therapy and cold atmospheric plasma, Int J Nanomed, 12, 4117, 10.2147/IJN.S129266 Changalvaie, 2019, Indocyanine green J aggregates in polymersomes for near-infrared photoacoustic imaging, ACS Appl Mater Interfaces, 11, 46437, 10.1021/acsami.9b14519 Sztandera, 2022, pH-stable polymersome as nanocarrier for post-loaded rose bengal in photodynamic therapy, Colloids Surf B: Biointerfaces, 217, 10.1016/j.colsurfb.2022.112662 You, 2019, Reactive oxygen species mediated theranostics using a Fenton reaction activable lipo-polymersome, J Mater Chem B, 7, 314, 10.1039/C8TB02947D Suridjan, 2019, The application of positron emission tomography (PET) imaging in CNS drug development, Brain Imaging Behav, 13, 354, 10.1007/s11682-018-9967-0 Giovacchini, 2017, PET and PET/CT with radiolabeled choline in prostate cancer: a critical reappraisal of 20 years of clinical studies, Eur J Nucl Med Mol Imaging, 44, 1751, 10.1007/s00259-017-3700-x Treglia, 2019, Radiolabelled choline versus PSMA PET/CT in prostate cancer restaging: a meta-analysis, Am J Nucl Med Mol Imaging, 9, 127 Shukla, 2015, Virus-based nanomaterials as positron emission tomography and magnetic resonance contrast agents: from technology development to translational medicine, Wiley Interdiscip Rev Nanomed Nanobiotechnol, 7, 708, 10.1002/wnan.1335 Kiani, 2016, Main applications of hybrid PET-MRI contrast agents: a review, Contrast Media Mol Imaging, 11, 92, 10.1002/cmmi.1674 Lahooti, 2016, Dual nano-sized contrast agents in PET/MRI: a systematic review, Contrast Media Mol Imaging, 11, 428, 10.1002/cmmi.1719 Generalova, 2017, Multicomponent nanocrystals with anti-Stokes luminescence as contrast agents for modern imaging techniques, Adv Colloid Interface Sci, 245, 1, 10.1016/j.cis.2017.05.006 Fung K. The loading of gallium-68 into polymersomes; 2020. Simón-Gracia, 2018, Application of polymersomes engineered to target p32 protein for detection of small breast tumors in mice, Oncotarget, 9, 10.18632/oncotarget.24588 Simón-Gracia L, Scodeller P, Fuentes SS, Vallejo VG, Ríos X, San Sebastián E, et al. Application of polymersomes engineered to target p32 protein for detection of small breast tumors in mice. Oncotarget 2018;9(27):18682–97. Sneider, 2017, Remotely triggered nano-theranostics for cancer applications, Nanotheranostics, 1, 1, 10.7150/ntno.17109 Simaneka M, Korandab P. SPECT/CT imaging in breast cancer–current status and challenges. Jambor, 2016, Prospective evaluation of planar bone scintigraphy, SPECT, SPECT/CT, 18F-NaF PET/CT and whole body 1.5 T MRI, including DWI, for the detection of bone metastases in high risk breast and prostate cancer patients: SKELETA clinical trial, Acta Oncol, 55, 59, 10.3109/0284186X.2015.1027411 Zou, 2019, Cyclic RGD-functionalized and disulfide-crosslinked iodine-rich polymersomes as a robust and smart theranostic agent for targeted CT imaging and chemotherapy of tumor, Theranostics, 9, 8061, 10.7150/thno.37184 Zou, 2017, Nanopolymersomes with an ultrahigh iodine content for high-performance X-ray computed tomography imaging in vivo, Adv Mater, 29, 10.1002/adma.201603997 De Kruijff, 2018, The therapeutic potential of polymersomes loaded with 225Ac evaluated in 2D and 3D in vitro glioma models, Eur J Pharm Biopharm, 127, 85, 10.1016/j.ejpb.2018.02.008 Huang, 2020, 99mTc radiolabeled HA/TPGS-based curcumin-loaded nanoparticle for breast cancer synergistic theranostics: design, in vitro and in vivo evaluation, Int J Nanomed, 15, 2987, 10.2147/IJN.S242490 Zhu, 2021, Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer, Drug Deliv, 28, 2301, 10.1080/10717544.2021.1995080 Choi, 2018, Clinical photoacoustic imaging platforms, Biomed Eng Lett, 8, 139, 10.1007/s13534-018-0062-7 Li, 2016, Ultrasound-induced reactive oxygen species mediated therapy and imaging using a fenton reaction activable polymersome, ACS Nano, 10, 2017, 10.1021/acsnano.5b06175 Jia, 2020, Recent advances and prospects of carbon dots in cancer nanotheranostics, Mater Chem Front, 4, 449, 10.1039/C9QM00667B Sonali, 2018, Nanotheranostics: emerging strategies for early diagnosis and therapy of brain cancer, Nanotheranostics., 2, 70, 10.7150/ntno.21638 Polyak, 2018, Nanoparticles for SPECT and PET imaging: towards personalized medicine and theranostics, Curr Med Chem, 25, 4328, 10.2174/0929867324666170830095553 Zheng, 2020, 1059 Fu, 2017, In situ generated gold nanoparticle hybrid polymersomes for water-soluble chemotherapeutics: inhibited leakage and pH-responsive intracellular release, Adv Funct Mater, 27, 10.1002/adfm.201604981 Liu, 2017, A superparamagnetic polymersome with extremely high T2 relaxivity for MRI and cancer-targeted drug delivery, Biomaterials, 114, 23, 10.1016/j.biomaterials.2016.10.027 Yang, 2021, Polymers and inorganic nanoparticles: a winning combination towards assembled nanostructures for cancer imaging and therapy, Nano Today, 36, 10.1016/j.nantod.2020.101046 Kaewsaneha, 2021, Poly (styrene-b-acrylic acid) nanoparticles with high magnetic loading for magnetic hyperthermia cancer therapy, ACS Appl Nano Mater, 4, 1841, 10.1021/acsanm.0c03237 Moulahoum, 2022, A polyplex human saliva peptide histatin 5-grafted methoxy PEG-b-polycaprolactone polymersome for intelligent stimuli-oriented doxorubicin delivery, J Drug Delivery Sci Technol, 67, 10.1016/j.jddst.2021.102958 Karandish, 2018, Peptide-targeted, stimuli-responsive polymersomes for delivering a cancer stemness inhibitor to cancer stem cell microtumors, Colloids Surf B: Biointerfaces, 163, 225, 10.1016/j.colsurfb.2017.12.036 Frantellizzi V, Conte M, Pontico M, Pani A, Pani R, De Vincentis G. New Frontiers in molecular imaging with superparamagnetic iron oxide nanoparticles (SPIONs): efficacy, toxicity, and future applications; 2020. Talluri, 2019, Superparamagnetic iron oxide nanoparticles (SPIONs) for diagnosis and treatment of breast, ovarian and cervical cancers, Curr Drug Metab, 20, 942, 10.2174/1389200220666191016124958 Zhi, 2020, Targeting strategies for superparamagnetic iron oxide nanoparticles in cancer therapy, Acta Biomater, 102, 13, 10.1016/j.actbio.2019.11.027 Licciardi, 2019, Smart copolymer coated SPIONs for colon cancer chemotherapy, Int J Pharm, 556, 57, 10.1016/j.ijpharm.2018.11.069 Zhuang, 2020, SPION decorated exosome delivery of TNF-α to cancer cell membranes through magnetism, Nanoscale, 12, 173, 10.1039/C9NR05865F Almaki, 2016, Synthesis, characterization and in vitro evaluation of exquisite targeting SPIONs–PEG–HER in HER2+ human breast cancer cells, Nanotechnology, 27, 10.1088/0957-4484/27/10/105601 Weerathunge, 2019, Transferrin-conjugated quasi-cubic SPIONs for cellular receptor profiling and detection of brain cancer, Sens Actuators B, 297, 10.1016/j.snb.2019.126737 Kania, 2015, Stable polymersomes based on ionic–zwitterionic block copolymers modified with superparamagnetic iron oxide nanoparticles for biomedical applications, J Mater Chem B, 3, 5523, 10.1039/C5TB00182J Geilich, 2016 Roobol, 2020, Uptake and subcellular distribution of radiolabeled polymersomes for radiotherapy, Nanotheranostics, 4, 14, 10.7150/ntno.37080 Wang, 2016, Pharmacokinetics of polymersomes composed of poly (butadiene-ethylene oxide); Healthy versus tumor-bearing mice, J Biomed Nanotechnol, 12, 320, 10.1166/jbn.2016.2178 de Kruijff, 2019, Elucidating the influence of tumor presence on the polymersome circulation time in mice, Pharmaceutics, 11, 241, 10.3390/pharmaceutics11050241 Askes, 2018, Dynamics of dual-fluorescent polymersomes with durable integrity in living cancer cells and zebrafish embryos, Biomaterials, 168, 54, 10.1016/j.biomaterials.2018.03.037 Krzyszczyk, 2018, The growing role of precision and personalized medicine for cancer treatment, Technology, 6, 79, 10.1142/S2339547818300020 Bosserman, 2021, Integrating academic and community cancer care and research through multidisciplinary oncology pathways for value-based care: a review and the City of Hope experience, J Clin Med, 10, 188, 10.3390/jcm10020188 Soufi, 2022, Nanoscale contrast agents for magnetic resonance imaging: a review, ACS Appl Nano Mater, 5, 10151, 10.1021/acsanm.2c03297