WITHDRAWN: MiR-363-3p attenuates simvastatin-induced osteogenic differentiation of periodontal ligament stem cells by targeting KLF2

Aly, 2015, Stem cells: Sources, and regenerative therapies in dental research and practice, World J Stem Cells, 7, 1047 Bing, 2016, Simvastatin improves the homing of BMSCs via the PI3K/AKT/miR-9 pathway, J Cell Mol Med, 20, 949, 10.1111/jcmm.12795 Bruderer, 2014, Role and regulation of RUNX2 in osteogenesis, Eur Cell Mater, 28, 269, 10.22203/eCM.v028a19 Chen, 2012, Stem cell-delivery therapeutics for periodontal tissue regeneration, Biomaterials, 33, 6320, 10.1016/j.biomaterials.2012.05.048 Chen, 2017, Runx2 alleviates high glucose-suppressed osteogenic differentiation via PI3K/AKT/GSK3β/β-catenin pathway, Cell Biol Int, 41, 822, 10.1002/cbin.10779 Couto de Carvalho, 2020, Mesenchymal stem cell markers in periodontal tissues and periapical lesions, Acta Histochem, 122, 10.1016/j.acthis.2020.151636 de Lara Janz, 2014, Simvastatin induces osteogenic differentiation in human amniotic fluid mesenchymal stem cells (AFMSC), Fundam Clin Pharmacol, 28, 211, 10.1111/fcp.12006 Feng, 2010, Utility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases, Oral Dis, 16, 20, 10.1111/j.1601-0825.2009.01593.x Hao, 2017, Identification of MicroRNAs by Microarray Analysis and Prediction of Target Genes Involved in Osteogenic Differentiation of Human Periodontal Ligament Stem Cells, J Periodontol, 88, 1105, 10.1902/jop.2017.170079 Hou, 2019, KLF2 regulates osteoblast differentiation by targeting of Runx2, Lab Invest, 99, 271, 10.1038/s41374-018-0149-x Jadhav, 2006, Statins and osteoporosis: new role for old drugs, J Pharm Pharmacol, 58, 3, 10.1211/jpp.58.1.0002 Jeong, 2013, Risedronate increases osteoblastic differentiation and function through connexin43, Biochem Biophys Res Commun, 432, 152, 10.1016/j.bbrc.2013.01.068 Kim, 2019, The IRF2BP2-KLF2 axis regulates osteoclast and osteoblast differentiation, BMB Rep, 52, 469, 10.5483/BMBRep.2019.52.7.104 Lee, 2012, Effects of VEGF and FGF-2 on proliferation and differentiation of human periodontal ligament stem cells, Cell Tissue Res, 348, 475, 10.1007/s00441-012-1392-x Li, 2019, Hypermethylation of microRNA-149 activates SDF-1/CXCR4 to promote osteogenic differentiation of mesenchymal stem cells, J Cell Physiol, 234, 23485, 10.1002/jcp.28917 Li, 2016, Expression of RUNX2 and MDM21 in rats with periodontitis under chronic intermittent hypoxia, Asian Pac J Trop Med, 9, 781, 10.1016/j.apjtm.2016.06.002 Li, 2019, miR-363-3p is activated by MYB and regulates osteoporosis pathogenesis via PTEN/PI3K/AKT signaling pathway, In Vitro Cell Dev Biol Anim, 55, 376, 10.1007/s11626-019-00344-5 Li, 2020, MicroRNA-15b shuttled by bone marrow mesenchymal stem cell-derived extracellular vesicles binds to WWP1 and promotes osteogenic differentiation, Arthritis Res Ther, 22, 269, 10.1186/s13075-020-02316-7 Li, 2020, Epigenetic silencing of KLF2 by long non-coding RNA SNHG1 inhibits periodontal ligament stem cell osteogenesis differentiation, Stem Cell Res Ther, 11, 435, 10.1186/s13287-020-01953-8 Li, 2017, Effects of altered CXCL12/CXCR4 axis on BMP2/Smad/Runx2/Osterix axis and osteogenic gene expressions during osteogenic differentiation of MSCs, Am J Transl Res, 9, 1680 Liu, 2008, Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine, Stem Cells, 26, 1065, 10.1634/stemcells.2007-0734 Ma, 2017, Primary cilium is required for the stimulating effect of icaritin on osteogenic differentiation and mineralization of osteoblasts in vitro, J Endocrinol Invest, 40, 357, 10.1007/s40618-016-0568-8 Meier, 2000, HMG-CoA reductase inhibitors and the risk of fractures, JAMA, 283, 3205, 10.1001/jama.283.24.3205 Michaud, 2017, Periodontal Disease, Tooth Loss, and Cancer Risk, Epidemiol Rev, 39, 49, 10.1093/epirev/mxx006 Mundy, 1999, Stimulation of bone formation in vitro and in rodents by statins, Science, 286, 1946, 10.1126/science.286.5446.1946 Okamoto, 2009, Simvastatin induces the odontogenic differentiation of human dental pulp stem cells in vitro and in vivo, J Endod, 35, 367, 10.1016/j.joen.2008.11.024 Ozer, 2013, Domain of dentine sialoprotein mediates proliferation and differentiation of human periodontal ligament stem cells, PLoS One, 8, 10.1371/journal.pone.0081655 Pizzicannella, 2018, MicroRNA 210 Mediates VEGF Upregulation in Human Periodontal Ligament Stem Cells Cultured on 3DHydroxyapatite Ceramic Scaffold, Int J Mol Sci, 19 Pizzicannella, 2019, 3D Printing PLA/Gingival Stem Cells/ EVs Upregulate miR-2861 and -210 during Osteoangiogenesis Commitment, Int J Mol Sci, 20 Qiao, 2011, Simvastatin promotes osteogenic differentiation of mouse embryonic stem cells via canonical Wnt/β-catenin signaling, Mol Cells, 32, 437, 10.1007/s10059-011-0107-6 Saito, 2009, Influence of residual bone on recombinant human bone morphogenetic protein-2-induced periodontal regeneration in experimental periodontitis in dogs, J Periodontol, 80, 961, 10.1902/jop.2009.080568 Schointuch, 2014, Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer, Gynecol Oncol, 134, 346, 10.1016/j.ygyno.2014.05.015 Seo, 2004, Investigation of multipotent postnatal stem cells from human periodontal ligament, Lancet, 364, 149, 10.1016/S0140-6736(04)16627-0 Taipaleenmäki, 2018, Regulation of Bone Metabolism by microRNAs, Curr Osteoporos Rep, 16, 1, 10.1007/s11914-018-0417-0 Tang, 2014, The role of microRNAs in osteoclasts and osteoporosis, RNA Biol, 11, 1355, 10.1080/15476286.2014.996462 Wadagaki, 2011, Osteogenic induction of bone marrow-derived stromal cells on simvastatin-releasing, biodegradable, nano- to microscale fiber scaffolds, Ann Biomed Eng, 39, 1872, 10.1007/s10439-011-0327-0 Walter, 2014, Simvastatin-activated implant surface promotes osteoblast differentiation in vitro, J Biomater Appl, 28, 897, 10.1177/0885328213486364 Wang, 2016, Klf2 contributes to the stemness and self-renewal of human bone marrow stromal cells, Cytotechnology, 68, 839, 10.1007/s10616-014-9837-6 Wang, 2020, MiR-375 promotes human periodontal ligament stem cells proliferation and osteogenic differentiation by targeting transducer of ERBB2, 2, Arch Oral Biol, 117, 10.1016/j.archoralbio.2020.104818 Wang, 2017, Taxifolin enhances osteogenic differentiation of human bone marrow mesenchymal stem cells partially via NF-κB pathway, Biochem Biophys Res Commun, 490, 36, 10.1016/j.bbrc.2017.06.002 Wu, 2020, Downregulating microRNA-152-3p promotes the viability and osteogenic differentiation of periodontal ligament stem cells via targeting integrin alpha 5, Arch Oral Biol, 120, 10.1016/j.archoralbio.2020.104930 Xu, 2019, microRNA-132 inhibits osteogenic differentiation of periodontal ligament stem cells via GDF5 and the NF-κB signaling pathway, Pathol Res Pract, 215, 10.1016/j.prp.2019.152722 Yao, 2017, MicroRNA-214 Suppresses Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting ATF4, Stem Cells Int, 2017, 10.1155/2017/3028647 Zajdel, 2017, Osteogenic differentiation of human mesenchymal stem cells from adipose tissue and Wharton’s jelly of the umbilical cord, Acta Biochim Pol, 64, 365, 10.18388/abp.2016_1488 Zhang, 2018, Simvastatin induces osteogenic differentiation of MSCs via Wnt/β-catenin pathway to promote fracture healing, Eur Rev Med Pharmacol Sci, 22, 2896 Zhao, 2014, Simvastatin induces the osteogenic differentiation of human periodontal ligament stem cells, Fundam Clin Pharmacol, 28, 583, 10.1111/fcp.12050 Zhu, 2019, The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42, Theranostics, 9, 8294, 10.7150/thno.36256