Voluntary wheel exercise ameliorates cognitive impairment, hippocampal neurodegeneration and microglial abnormalities preceded by demyelination in a male mouse model of noise-induced hearing loss
Tài liệu tham khảo
Abitbol, 2016, Differential effects of pannexins on noise-induced hearing loss, Biochem. J, 473, 4665, 10.1042/BCJ20160668
Anacker, 2017, Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood, Nat. Rev. Neurosci., 18, 335, 10.1038/nrn.2017.45
Andoh, 2020, Exercise, microglia, and beyond – workout to communicate with microglia, Neural Regen. Res., 15, 2029, 10.4103/1673-5374.282241
Augusto-Oliveira, 2021, Lifestyle-dependent microglial plasticity: training the brain guardians, Biol. Direct, 16, 12, 10.1186/s13062-021-00297-4
Baik, 2019, A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease, Cell Metab., 30, e496
Barnes-Velez, 2023, Myelin lipid metabolism and its role in myelination and myelin maintenance, Innovation (Camb), 4
Ben Abdallah, 2010, Early age-related changes in adult hippocampal neurogenesis in C57 mice, Neurobiol. Aging, 31, 151, 10.1016/j.neurobiolaging.2008.03.002
Berghoff, 2021, Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis, Nat. Neurosci., 24, 47, 10.1038/s41593-020-00757-6
Bernier, 2020, Microglial metabolic flexibility supports immune surveillance of the brain parenchyma, Nat. Commun., 11, 1559, 10.1038/s41467-020-15267-z
Bernier, 2020, Immunometabolism in the Brain: How Metabolism Shapes Microglial Function, Trends Neurosci., 43, 854, 10.1016/j.tins.2020.08.008
Bonetto, 2021, Myelin: A gatekeeper of activity-dependent circuit plasticity?, Science, 374, eaba6905, 10.1126/science.aba6905
Burgess, 2002, The Human Hippocampus and Spatial and Episodic Memory, Neuron, 35, 625, 10.1016/S0896-6273(02)00830-9
Burke, 2006, Neural plasticity in the ageing brain, Nat. Rev. Neurosci., 7, 30, 10.1038/nrn1809
Butovsky, 2018, Microglial signatures and their role in health and disease, Nat. Rev. Neurosci., 19, 622, 10.1038/s41583-018-0057-5
Cane, 2014, The Relationship between PSD-95 Clustering and Spine Stability In Vivo, J. Neurosci., 34, 2075, 10.1523/JNEUROSCI.3353-13.2014
Chatani, 2016, Neuromagnetic evidence for hippocampal modulation of auditory processing, Neuroimage, 124, 256, 10.1016/j.neuroimage.2015.09.006
Chausse, 2021, Microglia and lipids: how metabolism controls brain innate immunity, Semin. Cell Dev. Biol., 112, 137, 10.1016/j.semcdb.2020.08.001
Choi, 2019, Modulation of Neural Activity for Myelination in the Central Nervous System, Front. Neurosci., 13, 952, 10.3389/fnins.2019.00952
Cignarella, 2020, TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis, Acta Neuropathol., 140, 513, 10.1007/s00401-020-02193-z
Colonna, 2017, Microglia Function in the Central Nervous System During Health and Neurodegeneration, Annu. Rev. Immunol., 35, 441, 10.1146/annurev-immunol-051116-052358
Corcoran, 2016, HIF1alpha and metabolic reprogramming in inflammation, J. Clin. Invest., 126, 3699, 10.1172/JCI84431
Damani, 2011, Age-related alterations in the dynamic behavior of microglia, Aging Cell, 10, 14, 10.1111/j.1474-9726.2010.00660.x
De la Rosa, 2020, Physical exercise in the prevention and treatment of Alzheimer's disease, J. Sport Health Sci., 9, 394, 10.1016/j.jshs.2020.01.004
Dillard, 2022, Prevalence and global estimates of unsafe listening practices in adolescents and young adults: a systematic review and meta-analysis, BMJ Glob Health, 7, 10.1136/bmjgh-2022-010501
Etxeberria, 2016, Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity, J. Neurosci., 36, 6937, 10.1523/JNEUROSCI.0908-16.2016
Eyo, 2019, Microglia: Lifelong patrolling immune cells of the brain, Prog. Neurobiol., 179, 10.1016/j.pneurobio.2019.04.003
Fairley, 2021, Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer's Disease, Front. Immunol., 12, 10.3389/fimmu.2021.624538
Faraco, 2018, Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response, Nat. Neurosci., 21, 240, 10.1038/s41593-017-0059-z
Fernandez-Arjona, 2017, Microglia Morphological Categorization in a Rat Model of Neuroinflammation by Hierarchical Cluster and Principal Components Analysis, Front. Cell. Neurosci., 11, 235, 10.3389/fncel.2017.00235
Fields, 2015, A new mechanism of nervous system plasticity: activity-dependent myelination, Nat. Rev. Neurosci., 16, 756, 10.1038/nrn4023
Frank, 2019, Microglia: Neuroimmune-sensors of stress, Semin. Cell Dev. Biol., 94, 176, 10.1016/j.semcdb.2019.01.001
Franklin, 2001
Fuger, 2017, Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging, Nat. Neurosci., 20, 1371, 10.1038/nn.4631
Gabande-Rodriguez, 2019, Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders, EMBO J., 38, 10.15252/embj.201899553
Gibson, 2014, Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain, Science, 344, 1252304, 10.1126/science.1252304
Hahad, 2019, Environmental Noise-Induced Effects on Stress Hormones, Oxidative Stress, and Vascular Dysfunction: Key Factors in the Relationship between Cerebrocardiovascular and Psychological Disorders, Oxid. Med. Cell. Longev., 2019, 4623109, 10.1155/2019/4623109
Hayes, 2019, Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats, Hear. Res., 379, 43, 10.1016/j.heares.2019.04.013
Hendrickx, 2022, Age-related cognitive decline in spatial learning and memory of C57BL/6J mice, Behav. Brain Res., 418, 10.1016/j.bbr.2021.113649
Holden, 2012, Spatial pattern separation in cognitively normal young and older adults, Hippocampus, 22, 1826, 10.1002/hipo.22017
Horchar, 2019, Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress, Brain Behav. Immun., 81, 329, 10.1016/j.bbi.2019.06.030
Huang, 2018, Effects of Voluntary Wheel-Running Types on Hippocampal Neurogenesis and Spatial Cognition in Middle-Aged Mice, Front. Cell. Neurosci., 12, 177, 10.3389/fncel.2018.00177
Jin, 2022, Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease, Cell Stem Cell, 29, e1138
Johnson, 2021, Hearing and dementia: from ears to brain, Brain J. Neurol., 144, 391, 10.1093/brain/awaa429
Kee, 2002, The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis, J. Neurosci. Methods, 115, 10.1016/S0165-0270(02)00007-9
Kettenmann, 2011, Physiology of microglia, Physiol. Rev., 91, 461, 10.1152/physrev.00011.2010
Kim, 2021, Reorganized Brain White Matter in Early- and Late-Onset Deafness with Diffusion Tensor Imaging, Ear Hear., 42, 223, 10.1097/AUD.0000000000000917
Koellhoffer, 2017, Old Maids: Aging and Its Impact on Microglia Function, Int. J. Mol. Sci., 18, 769, 10.3390/ijms18040769
Koyama, 2012, A modified and highly sensitive Golgi-Cox method to enable complete and stable impregnation of embryonic neurons, J. Neurosci. Methods, 209, 58, 10.1016/j.jneumeth.2012.06.007
Kraus, 2012, Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus, Hear. Res., 288, 34, 10.1016/j.heares.2012.02.009
Kreisel, 2014, Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis, Mol. Psychiatry, 19, 699, 10.1038/mp.2013.155
Kujawa, 2006, Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth, J. Neurosci., 26, 2115, 10.1523/JNEUROSCI.4985-05.2006
Kurioka, 2021, Activity-Dependent Neurodegeneration and Neuroplasticity of Auditory Neurons Following Conductive Hearing Loss in Adult Mice, Cell. Mol. Neurobiol., 41, 31, 10.1007/s10571-020-00829-y
Kurioka, 2021, Decreasing auditory input induces neurogenesis impairment in the hippocampus, Sci. Rep., 11, 423, 10.1038/s41598-020-80218-z
Lazarov, 2010, When neurogenesis encounters aging and disease, Trends Neurosci., 33, 569, 10.1016/j.tins.2010.09.003
Le, 2017, Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options, J. Otolaryngol. Head Neck Surg., 46, 41, 10.1186/s40463-017-0219-x
Leyh, 2021, Classification of Microglial Morphological Phenotypes Using Machine Learning, Front. Cell. Neurosci., 15, 10.3389/fncel.2021.701673
Li, Q., Li, H., Yao, X., Wang, C., Liu, H., Xu, D., Yang, C., Zhuang, H., Xiao, Y., Liu, R., Shen, S., Zhou, S., Fu, C., Wang, Y., Teng, G., Liu, L., 2021. Stress Response and Hearing Loss Differentially Contribute to Dynamic Alterations in Hippocampal Neurogenesis and Microglial Reactivity in Mice Exposed to Acute Noise Exposure. Frontiers in neuroscience 15.
Lie, 2015, The prevalence of notched audiograms in a cross-sectional study of 12,055 railway workers, Ear Hear., 36, e86, 10.1097/AUD.0000000000000129
Lieberwirth, 2016, Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory, Brain Res., 1644, 127, 10.1016/j.brainres.2016.05.015
Liu, 2016, Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice, Sci. Rep., 6, 20374, 10.1038/srep20374
Liu, 2016, Effects of Noise Exposure on Systemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistance in Male Mice, Environ. Health Perspect., 124, 1390, 10.1289/EHP162
Liu, 2018, Hippocampal Mechanisms Underlying Impairment in Spatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBA Mice, Front. Syst. Neurosci., 12, 35, 10.3389/fnsys.2018.00035
Livingston, 2020, Dementia prevention, intervention, and care: 2020 report of the Lancet Commission, Lancet, 396, 413, 10.1016/S0140-6736(20)30367-6
Lloyd, 2019, The pro-remyelination properties of microglia in the central nervous system, Nat. Rev. Neurol., 15, 447, 10.1038/s41582-019-0184-2
Loving, 2020, Lipid and Lipoprotein Metabolism in Microglia, Front. Physiol., 11, 393, 10.3389/fphys.2020.00393
Lu, 2022, A breakdown in microglial metabolic reprogramming causes internalization dysfunction of alpha-synuclein in a mouse model of Parkinson's disease, J. Neuroinflammation, 19, 113, 10.1186/s12974-022-02484-0
Luan, 2021, High-frequency Noise-induced Hearing Loss Disrupts Functional Connectivity in Non-auditory Areas with Cognitive Disturbances, Neurosci. Bull., 37, 720, 10.1007/s12264-021-00663-2
Luo, 2010, Microglia in the aging brain: relevance to neurodegeneration, Mol. Neurodegener., 5, 12, 10.1186/1750-1326-5-12
Manohar, 2022, Unexpected Consequences of Noise-Induced Hearing Loss: Impaired Hippocampal Neurogenesis, Memory, and Stress, Front. Integr. Neurosci., 16, 10.3389/fnint.2022.871223
Manzanares, 2018, Voluntary wheel running: patterns and physiological effects in mice, Braz. J. Med. Biol. Res., 52, e7830, 10.1590/1414-431x20187830
Mao, 2012, Blast-induced tinnitus and hearing loss in rats: behavioral and imaging assays, J. Neurotrauma, 29, 430, 10.1089/neu.2011.1934
Marschallinger, 2020, Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain, Nat. Neurosci., 23, 194, 10.1038/s41593-019-0566-1
Marzan, 2021, Activated microglia drive demyelination via CSF1R signaling, Glia, 6, 1583, 10.1002/glia.23980
Masterson, 2016, Hearing Impairment Among Noise-Exposed Workers - United States, 2003–2012, MMWR-Morbidity and Mortality Weekly Report, 65, 389, 10.15585/mmwr.mm6515a2
Matt, 2018, Visualizing BDNF Transcript Usage During Sound-Induced Memory Linked Plasticity, Front. Mol. Neurosci., 11, 260, 10.3389/fnmol.2018.00260
McCarrey, 2016, Sex differences in cognitive trajectories in clinically normal older adults, Psychol. Aging, 31, 166, 10.1037/pag0000070
McNamara, 2023, Microglia regulate central nervous system myelin growth and integrity, Nature, 613, 120, 10.1038/s41586-022-05534-y
Mela, 2020, Exercise-induced re-programming of age-related metabolic changes in microglia is accompanied by a reduction in senescent cells, Brain Behav. Immun., 87, 413, 10.1016/j.bbi.2020.01.012
Menassa, 2018, Microglial Dynamics during Human Brain Development, Front. Immunol., 9, 1014, 10.3389/fimmu.2018.01014
Moreno-Jimenez, 2019, Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease, Nat. Med., 25, 554, 10.1038/s41591-019-0375-9
Mu, 2011, Adult hippocampal neurogenesis and its role in Alzheimer's disease, Mol. Neurodegener., 6, 85, 10.1186/1750-1326-6-85
Murphy, 2018, CDC Grand Rounds: Promoting Hearing Health Across the Lifespan, MMWR Morb. Mortal. Wkly Rep., 67, 243, 10.15585/mmwr.mm6708a2
Neely, 2019, Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice, J. Visualiz. Exp.: JoVE., 10.3791/60139-v
Neves, 2008, Synaptic plasticity, memory and the hippocampus: a neural network approach to causality, Nat. Rev. Neurosci., 9, 65, 10.1038/nrn2303
Nickel, 2018, Regulation of Central Nervous System Myelination in Higher Brain Functions, Neural Plast., 2018, 6436453, 10.1155/2018/6436453
Niraula, 2017, Microglia Priming with Aging and Stress, Neuropsychopharmacology, 42, 318, 10.1038/npp.2016.185
Panganiban, 2018, Noise-Induced Dysregulation of Quaking RNA Binding Proteins Contributes to Auditory Nerve Demyelination and Hearing Loss, J. Neurosci., 38, 2551, 10.1523/JNEUROSCI.2487-17.2018
Pankiewicz, 2017, APOE Genotype Differentially Modulates Effects of Anti-Abeta, Passive Immunization in APP Transgenic Mice, Mol. Neurodegener., 12, 12, 10.1186/s13024-017-0156-1
Perry, 2010, Microglia in neurodegenerative disease, Nat. Rev. Neurol., 6, 193, 10.1038/nrneurol.2010.17
Pini, 2016, Brain atrophy in Alzheimer's Disease and aging, Ageing Res. Rev., 30, 25, 10.1016/j.arr.2016.01.002
Robledinos-Anton, 2017, Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus, Redox Biol., 13, 393, 10.1016/j.redox.2017.06.010
Rodriguez-Callejas, 2016, Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset, Front. Aging Neurosci., 8, 315, 10.3389/fnagi.2016.00315
Ryan, 2016, Temporary and Permanent Noise-induced Threshold Shifts: A Review of Basic and Clinical Observations, Otol. Neurotol., 37, e271, 10.1097/MAO.0000000000001071
Safaiyan, 2016, Age-related myelin degradation burdens the clearance function of microglia during aging, Nat. Neurosci., 19, 995, 10.1038/nn.4325
Salter, 2017, Microglia emerge as central players in brain disease, Nat. Med., 23, 1018, 10.1038/nm.4397
Santiago, 2017, Microglia in Health and Disease: A Double-Edged Sword, Mediators Inflamm., 2017, 7034143, 10.1155/2017/7034143
Savage, 2020, Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington's disease pathology, J. Neuroinflammation, 17, 98, 10.1186/s12974-020-01782-9
Shahidehpour, 2021, Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain, Neurobiol. Aging, 99, 19, 10.1016/j.neurobiolaging.2020.12.003
Shansky, 2019, Are hormones a “female problem” for animal research?, Science, 364, 825, 10.1126/science.aaw7570
Schafer, D.P., Lehrman Ek Fau - Kautzman, A.G., Kautzman Ag Fau - Koyama, R., Koyama R Fau - Mardinly, A.R., Mardinly Ar Fau - Yamasaki, R., Yamasaki R Fau - Ransohoff, R.M., Ransohoff Rm Fau - Greenberg, M.E., Greenberg Me Fau - Barres, B.A., Barres Ba Fau - Stevens, B., Stevens, B., 2012. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.Neuron. 74, 691-705.
Simpson, D.S.A., Oliver, P.L., 2020. ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease. Antioxidants (Basel) 9.
Sinclair, 2017, Sound-Evoked Activity Influences Myelination of Brainstem Axons in the Trapezoid Body, J. Neurosci., 37, 8239, 10.1523/JNEUROSCI.3728-16.2017
Singer, 2018, The glucocorticoid antagonist mifepristone attenuates sound-induced long-term deficits in auditory nerve response and central auditory processing in female rats, FASEB J., 32, 3005, 10.1096/fj.201701041RRR
Singhal, 2017, Microglia: An Interface between the Loss of Neuroplasticity and Depression, Front. Cell. Neurosci., 11, 270, 10.3389/fncel.2017.00270
Streit, 2019, Dystrophic microglia in late‐onset Alzheimer’s disease, Glia, 68, 10
Streit, 2004, Dystrophic microglia in the aging human brain, Glia, 45, 208, 10.1002/glia.10319
Streit, 2020, Dystrophic microglia in late-onset Alzheimer's disease, Glia, 68, 845, 10.1002/glia.23782
Tagoe, 2014, Auditory nerve perinodal dysmyelination in noise-induced hearing loss, J. Neurosci., 34, 2684, 10.1523/JNEUROSCI.3977-13.2014
Tahera, 2006, NF-kappaB mediated glucocorticoid response in the inner ear after acoustic trauma, J. Neurosci. Res., 83, 1066, 10.1002/jnr.20795
Tao, 2015, Spatial learning and memory deficits in young adult mice exposed to a brief intense noise at postnatal age, J Otol, 10, 21, 10.1016/j.joto.2015.07.001
Teng, 2022, Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death, Cell Host Microbe, 30, e948
Tomassy, 2016, Diversity Matters: A Revised Guide to Myelination, Trends Cell Biol., 26, 135, 10.1016/j.tcb.2015.09.002
Valero, 2016, Lifestyle Shapes the Dialogue between Environment, Microglia, and Adult Neurogenesis, ACS Chem. Nerosci., 7, 442, 10.1021/acschemneuro.6b00009
Voet, 2019, Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology, Trends Mol. Med., 25, 112, 10.1016/j.molmed.2018.11.005
von Bohlen und Halbach, 2011, Immunohistological markers for proliferative events, gliogenesis, and neurogenesis within the adult hippocampus, Cell Tissue Res., 345, 1, 10.1007/s00441-011-1196-4
Vorhees, 2006, Morris water maze: procedures for assessing spatial and related forms of learning and memory, Nat. Protoc., 1, 848, 10.1038/nprot.2006.116
Wan, 2022, Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice, Nat. Commun., 13, 1134, 10.1038/s41467-022-28777-9
Wang, Q.X., Wang, X.L., Yang, L., Han, K., Huang, Z.W., Wu, H., 2021. Sex differences in noise-induced hearing loss: a cross-sectional study in China. Biology of Sex Differences 12.
Wilson, 2021, Addressing the global burden of hearing loss, Lancet, 397, 945, 10.1016/S0140-6736(21)00522-5
World Health, A., 2022. Deafness and hearing loss. World Health Organization, Geneva.
Wright-Jin, 2019, Microglia as Dynamic Cellular Mediators of Brain Function, Trends Mol. Med., 25, 967, 10.1016/j.molmed.2019.08.013
Xiong, 2018, Age- and Gender-Based Differences in Nest-Building Behavior and Learning and Memory Performance Measured Using a Radial Six-Armed Water Maze in C57BL/6 Mice, Behav. Neurol., 2018, 8728415, 10.1155/2018/8728415
Xu, 2022, Auditory-limbic-cerebellum interactions and cognitive impairments in noise-induced hearing loss, CNS Neurosci. Therapeutics
Xu, 2022, Alterations to cognitive abilities and functional networks in rats post broad-band intense noise exposure, Brain Imaging Behav., 16, 8, 10.1007/s11682-022-00643-8
Xue, 2019, Altered Directed Functional Connectivity of the Hippocampus in Mild Cognitive Impairment and Alzheimer's Disease: A Resting-State fMRI Study, Front. Aging Neurosci., 11, 326, 10.3389/fnagi.2019.00326
Yanai, 2021, Functional Aging in Male C57BL/6J Mice Across the Life-Span: A Systematic Behavioral Analysis of Motor, Emotional, and Memory Function to Define an Aging Phenotype, Front. Aging Neurosci., 13, 10.3389/fnagi.2021.697621
Yang, 2021, Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system, Neurobiol. Dis., 152, 10.1016/j.nbd.2021.105290
York, 2020, Neuroinflammatory inhibition of synaptic long-term potentiation requires immunometabolic reprogramming of microglia, Glia, 69, 567, 10.1002/glia.23913
Zhang, 2022, Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice, J. Neuroinflammation, 19, 34, 10.1186/s12974-022-02401-5
Zhou, 2022, Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C-terminal AAs 2–5 to mitogen-activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3-MKK3-p38 module assembly, Aging Cell, 21, e13543, 10.1111/acel.13543
Zhuang, 2020, Accelerated age-related decline in hippocampal neurogenesis in mice with noise-induced hearing loss is associated with hippocampal microglial degeneration, Aging, 12, 19493, 10.18632/aging.103898
Zhuang, 2021, Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by augmented microglial lipid accumulation, Brain Behav. Immun., 100, 155, 10.1016/j.bbi.2021.11.018