Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Vitamin E thể hiện tác động đồng hóa xương trên chuột đực bình thường
Tóm tắt
Gần đây, người ta phát hiện ra rằng vitamin E có khả năng thúc đẩy cấu trúc xương của chuột điều trị bằng nicotine vượt xa các giá trị cơ bản của chúng, từ đó gợi ý rằng vitamin E có thể có một số tác động đồng hóa. Một tác nhân đồng hóa xương hoạt động bằng cách cải thiện cấu trúc xương dẫn đến xương chắc khỏe hơn. Để đánh giá khả năng tác động đồng hóa của vitamin E đối với xương, chúng tôi đã bổ sung α-tocopherol (ATF) hoặc γ-tocotrienol (GTT) với liều lượng 60 mg/kg hoặc giả dược [nhóm kiểm soát bình thường (NC)] trong 4 tháng cho chuột đực bình thường và đo cấu trúc xương cũng như các thuộc tính cơ học của chúng. Phân tích hình thái mô cho thấy chuột được bổ sung vitamin E có thể tích xương tổ ong, độ dày, số lượng và độ tách biệt tốt hơn so với chuột chỉ nhận giả dược. Đây là lần đầu tiên chúng tôi báo cáo rằng GTT cải thiện tất cả các thông số của sức mạnh cơ học xương, trong khi ATF chỉ cải thiện một số thông số so với nhóm NC. Việc bổ sung vitamin E, đặc biệt là với đồng phân gamma, cải thiện cấu trúc xương, từ đó góp phần làm xương chắc khỏe hơn. Do đó, vitamin E có tiềm năng được sử dụng như một tác nhân đồng hóa để điều trị bệnh loãng xương hoặc như một bổ sung cho xương cho người trẻ tuổi để ngăn ngừa loãng xương trong những năm sau.
Từ khóa
#Vitamin E #tác động đồng hóa #cấu trúc xương #chuột đực bình thường #sức mạnh cơ học xương #loãng xươngTài liệu tham khảo
Canalis E, Giustina A, Bilezikian JP (2007) Mechanisms of anabolic therapies for osteoporosis. N Engl J Med 357:905–916
Buehler J, Chappuis P, Saffar JL, Foos E, Vignery A (2001) Strontium ranelate inhibits bone resorption whilst maintaining bone formation in alveolar bone in monkeys. Bone 29:176–179
Delannoy P, Bazot D, Marie PJ (2002) Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice. Metabolism 51:906–911
Ammann P, Shen V, Robin B, Mauras Y, Bonjour JP, Rizzoli R (2004) Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. J Bone Miner Res 19:2012–2020
Riggs BL, Parfitt AM (2005) Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling. J Bone Miner Res 20:177–184
Hermizi H, Faizah O, Ima-Nirwana S, Ahmad Nazrun S, Norazlina M (2009) Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in Sprague–Dawley male rats after nicotine cessation. Calcif Tissue Int 84:65–74
Azzi A, Strocker A (2000) Vitamin E: non-antioxidant roles. Prog Lipid Res 39:231–255
Qureshi AA, Sami SA, Salser WA, Khan FA (2002) Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis 161:199–207
Mahadevappa VG, Sicilia F, Holub BJ (1991) Effect of tocotrienol derivatives on collagen and ADP-induced human platelet aggregation. In: Proceedings 1989 international palm oil conference on nutrition and health aspects of palm oil (PORIM), Kuala Lumpur, Malaysia, pp 36–38
Ngah WZ, Jarien Z, San MM, Marzuki A, Top GM, Shamaan NA, Kadir KA (1991) Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats. Am J Clin Nutr 53:1076–1081
Nesaretnam K, Stephen R, Dils R, Darbre P (1998) Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 33:461–469
Melhus H, Michalsson K, Holmberg L, Wolk A, Ljunghall S (1999) Smoking, antioxidant vitamins, and the risk of hip fracture. J Bone Miner Res 14:129–135
Xu H, Watkins BA, Seifert MF (1995) Vitamin E stimulates trabecular bone formation and alters epiphyseal cartilage morphometry. Calcif Tissue Int 57:293–300
Ima-Nirwana S, Kiftiah A, Sariza T, Gapor MT, Khalid BAK (1999) Palm vitamin E improves bone metabolism and survival rate in thyrotoxic rats. Gen Pharmacol 32:621–626
Ima-Nirwana S, Norazlina M, Khalid BAK (2000) Palm vitamin E prevents osteoporosis in orchidectomized growing male rats. Nat Prod Sci 694:155–160
Norazlina M, Ima-Nirwana S, Gapor MT, Khalid BAK (2000) Palm vitamin E is comparable to alpha-tocopherol in maintaining bone mineral density in ovariectomised female rats. Exp Clin Endocrinol Diabetes 108:305–310
Ima-Nirwana S, Fakhrurazi H (2002) Palm vitamin E protects bone against dexamethasone-induced osteoporosis in male rats. Med J Malaysia 57:136–144
Ahmad NS, Khalid BAK, Luke DA, Ima-Nirwana S (2005) Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone. Clin Exp Pharmacol Physiol 32:761–770
Czerny B, Pawlik A, Juzyszyn Z, Myśliwiec Z (2004) The effect of tamoxifen and fluoride on bone mineral density, biomechanical properties and blood lipids in ovariectomized rats. Basic Clin Pharmacol Toxicol 92:162–165
Turner CH, Hinckley WR, Wilson ME, Zhang W, Dunipace AJ (2001) Combined effects of diets with reduced calcium and phosphate and increased fluoride intake on vertebral bone strength and histology in rats. Calcif Tissue Int 69:51–57
Bohatyrewicz A (1999) Effects of fluoride on mechanical properties of femoral bone in growing rats. Fluoride 32:47–54
Chacha D, Turner CH, Dunipace AJ, Grynpas MD (1999) The effect of fluoride treatment on bone mineral in rabbits. Calcif Tissue Int 64:345–351
Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR (1987) Bone histomorphometry: standardization of nomenclature, symbols and units. Report of the ASMBR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595–610
Difford J (1974) A simplified method for the preparation of methyl methacrylate embedding medium. Med Lab Technol 31:79–81
Von Kossa J (1974) Nachweis von Kalk. Beitrage zur pathologischen Anatomie und zur allgemeinen. Pathologie 29:163
Baldock PA, Morris HA, Need AG, Moore RJ, Durbridge TC (1998) Variation in the short-term changes in bone cell activity in three regions of the distal femur immediately following ovariectomy. J Bone Miner Res 13:1451–1457
Haffa A, Krueger D, Bruner J, Engelke J, Gundberg C, Akhter M, Binkley N (2000) Diet- or warfarin-induced vitamin K insufficiency elevates circulating undercarboxylated osteocalcin without altering skeletal status in growing female rats. J Bone Miner Res 15:872–878
Fort FL (1991) Drug safety evaluation. In: Swarbrick J, Boylan JC (eds) Encyclopedia of pharmaceutical technology, vol 4. Marcel Dekker, New York, pp 416–421
Rico H, Revilla M, Villa LF, Alvarez de Buergo M, Ruiz-Contreras D (1994) Determinants of total and regional bone mineral content and density in postpubertal normal women. Metabolism 43:263–266
Rico H, Amo C, Revilla M, Arribas I, González-Riola J et al (1994) Etidronate versus clodronate in the prevention of postovariectomy bone loss. An experimental study in rats. Clin Exp Rheumatol 12:301–304
Umegaki K, Itoh T, Ichikawa T (1994) Effect of vitamin E on chromosomal damage in bone marrow cells of mice having received low dose of X-ray irradiation. Int J Vitam Nutr Res 64:249–252
Meydani SN, Meydani M, Rall LC, Morrow F, Blumberg JB (1994) Assessment of the safety of high-dose, short-term supplementation with vitamin E in healthy older adults. Am J Clin Nutr 60:704–709
Nakamura H, Furukawa F, Nishikawa A, Miyauchi M, Son H-Y, Imazawa T, Hirose M (2001) Oral toxicity of a tocotrienol preparation in rats. Food Chem Toxicol 39:799–805
Oo SL, Chang P, Chan KE (1992) Toxicological and pharmacological studies on palm vitee. Nutr Res 2:217–222
Vignery A, Baron R (1980) Dynamic histomorphometry of alveolar bone remodeling in the adult rat. Anat Rec 196:191–200
Barengolts EL, Curry DJ, Bapna MS, Kukreja SC (1993) Effects of two non-endurance exercise protocols on established bone loss in ovariectomized adult rats. Calcif Tissue Int 52:239–243
Currey JD (1988) The effect of porosity and ash content on the Young’s modulus of elasticity of compact bone. J Biomech 21:131–139
Schaffler MB, Burr DB (1988) Stiffness of compact bone: effects of porosity and density. J Biomech 21:13–16
Arjmandi BH, Juma S, Beharka A, Bapna S, Akhter M, Meydani SN (2002) Vitamin E improves bone quality in the aged but not in young adult male mice. J Nutr Biochem 13:543–549
Turan B, Balcik C, Akkas N (1997) Effect of dietary selenium and vitamin E on the biomechanical properties of rabbit bones. Clin Rheumatol 16:441–449
Erikson EH (1950) Childhood and society. Norton, New York
Wang L, Banu J, McMahan CA, Kalu DN (2001) Male rodent model of age-related bone loss in men. Bone 29:141–148
Sandra M, Norazlina M, Nazrun AS, Ima Nirwana S (2008) Palm tocotrienol exerted better antioxidant activities in bone than alpha-tocopherol. Basic Clin Pharmacol Toxicol 103:55–60
Ebina Y, Okada S, Hamazaki S, Toda Y, Midorikawa O (1991) Impairment of bone formation with aluminium and ferric nitrilotriacetate complexes. Calcif Tissue Int 48:28–36
Abhaya A, Khatri K, Pradhan S, Prakash R (2003) Effect of alpha tocopherol on the growth plate of albino rats. J Anat Soc India 52:58–63
Meydani SN, Barklund MP, Liu S, Meydani M, Miller RA, Cannon JG, Morrow FD, Rocklin R, Blumberg JB (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr 52:557–563
Khanduja KL, Avti PK, Kumar S, Pathania V, Pathak CM (2005) Inhibitory effect of vitamin E on proinflammatory cytokines-and endotoxin-induced nitric oxide release in alveolar macrophages. Life Sci 76:2669–2680
Pathania V, Syal N, Pathak CM, Khanduja KL (1999) Vitamin E suppresses the induction of reactive oxygen species release by lipopolysaccharide, interleukin-1β and tumor necrosis factor-α in rat alveolar macrophages. J Nutr Sci Vitaminol 45:675–686
Devaraj S, Jialal I (2005) α-Tocopherol decreases tumor necrosis factor-α mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase. Free Radic Biol Med 38:1212–1220
Kamat JP, Devasagayam TPA (1995) Tocotrienols from palm oil as a potent inhibitor of lipid peroxidation and protein oxidation in rat brain mitochondria. Neurosci Lett 195:179–182
Serbinova E, Kagan V, Han D, Packer L (1991) Free radical recycling and intramembrane mobility in the antioxidant properties of tocopherol and tocotrienol. Free Radic Biol Med 10:263–275
