Vitamin D supplementation differentially affects seasonal multiple sclerosis disease activity

Brain and Behavior - Tập 7 Số 8 - 2017
Andrei Miclea1,2, Marius Miclea2, Maximilian Pistor1, Andreas G. F. Hoepner3, Andrew Chan4, Robert Hoepner4
1Medical Faculty, Ruhr-University Bochum, Bochum, Germany
2Neurological outpatient department, Neurocenter Peine, Peine, Germany
3Banking & Finance group Michael Smurfit Graduate Business School & UCD Lochlann Quinn School of Business University College Dublin Belfield Dublin Ireland
4Department of Neurology, University Hospital Bern and University of Bern, Bern, Switzerland

Tóm tắt

AbstractObjectivesLow ultraviolet‐B (UVB) radiation causes hypovitaminosis D, which is a known risk factor for multiple sclerosis (MS) and associated with MS disease activity. Our objective is to test whether vitamin D supplementation is most effective in lowering disease activity during the period of the year with low UVB radiation and consequently low serum 25‐hydroxyvitamin D3 (25(OH)D3) concentration.MethodsRetrospective analysis of medical records from our outpatient department identified 40 MS patients with available data of at least 6 months before and during oral vitamin D supplementation. Serum 25(OH)D3 concentration was analyzed using immunoassay. UVB radiation data were provided by the local government. Annualized and quarterly relapse rates before and during vitamin D supplementation served as outcome parameters.ResultsDuring vitamin D supplementation (18,950 international units/week (mean, SD 3,397)), serum 25(OH)D3 concentration increased by 51 nmol/L and the UVB‐related seasonal variability in 25(OH)D3 levels ceased (rho = −0.13, p > .05). Furthermore, the annualized relapse rate decreased by approximately 50%. This was almost solely driven by the prominent reduction in the quarterly relapse rate in late winter/early spring, when 25(OH)D3 levels of nonsupplemented patients were the lowest.ConclusionsOur study demonstrated the modulation of seasonal MS disease activity through vitamin D supplementation. Given the prominent reduction in the quarterly relapse rate in late winter/early spring, our data indicate a beneficial effect of supplementing MS patients with vitamin D, especially during this period of the year.

Từ khóa


Tài liệu tham khảo

10.1002/ana.21141

10.1001/jamaneurol.2013.5993

10.1212/WNL.57.5.892

10.1002/ana.24165

10.1038/ejcn.2016.51

10.1212/WNL.0b013e3181e1cec2

10.1016/j.cell.2015.08.025

10.1111/cns.12071

Federal Office for Radiation Protection (Germany).UV‐abhängige Vitamin D Synthese ‐ Bilanzierung der Expositionszeit durch UV zur Produktion des optimalen Vitamin D3‐Bedarfs im menschlichen Körper (UV‐dependent vitamin D3 synthesis – balancing of UV exposure time and the production of an optimal vitamin D3 status in the human body). BfS‐RESFOR‐70/12 2012. Retrieved fromhttp://nbn-resolving.de/urn:nbn:de:0221-201210029658.

Gold R.(2012).Diagnose und Therapie der Multiplen Sklerose. Retrieved fromwww.dgn.orgAccessed December 15 2016.

10.1016/j.imbio.2014.07.009

10.1016/j.bbadis.2010.07.017

10.1038/sj.ejcn.1602825

Institute of Medicine, Food and Nutrition Board, 2010, Dietary Reference Intakes for Calcium and Vitamin D

10.1093/ajcn/88.2.582S

10.1016/j.mam.2008.08.005

Lemire J. M., 1995, Immunosuppressive actions of 1,25‐dihydroxyvitamin D3: preferential inhibition of Th1 functions, Journal of Nutrition, 125, 1704

10.1056/NEJM200009283431307

10.1007/s10072-003-0200-5

10.1212/WNL.0b013e31820a0a9f

10.1177/1756285612447090

10.1371/journal.pgen.1000369

10.1212/NXI.0000000000000167

10.1002/ana.22043

10.1136/jnnp-2011-301876

10.1002/ana.24287

10.1111/sji.12403

10.1159/000166602

10.1210/jcem-67-2-373

Thông tin
Thông tin xuất bản

Brain and Behavior

Tập 7 Số 8

Thông tin tác giả