Vitamin D in obesity

Current Opinion in Endocrinology, Diabetes and Obesity - Tập 24 Số 6 - Trang 389-394 - 2017
Jennifer Walsh1,2, Simon Bowles1,2, Amy Evans1,2
1Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK
2e-mail: [email protected]

Tóm tắt

Purpose of review Vitamin D is essential for bone health, and may also have important functions in immunity and other systems. Vitamin D deficiency is common, and testing and supplementation is increasing. Serum vitamin D is lower in obese people; it is important to understand the mechanism of this effect and whether it indicates clinically significant deficiency. Recent findings Vitamin D is fat soluble, and distributed into fat, muscle, liver, and serum. All of these compartments are increased in volume in obesity, so the lower vitamin D likely reflects a volumetric dilution effect and whole body stores of vitamin D may be adequate. Despite lower serum vitamin D, obese adults do not have higher bone turnover or lower bone mineral density. Patients undergoing bariatric surgery do have bone loss, and ensuring vitamin D sufficiency in these patients may help to attenuate bone loss. Summary Lower vitamin D in obese people is a consistent finding across age, ethnicity, and geography. This may not always reflect a clinical problem. Obese people need higher loading doses of vitamin D to achieve the same serum 25-hydroxyvitamin D as normal weight.

Từ khóa


Tài liệu tham khảo

Hypponen, 2007, Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors, Am J Clin Nutr, 85, 860, 10.1093/ajcn/85.3.860

2011, Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Dietary Reference Intakes for Calcium and Vitamin D

Holick, 2011, Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline, J Clin Endocrinol Metab, 96, 1911, 10.1210/jc.2011-0385

Walsh, 2016, Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health, Am J Clin Nutr, 103, 1465, 10.3945/ajcn.115.120139

Macdonald, 2008, Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D, Bone, 42, 996, 10.1016/j.bone.2008.01.011

Ardawi, 2012, High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers, and lifestyle factors, Osteoporos Int, 23, 675, 10.1007/s00198-011-1606-1

Shea, 2011, Correlates and prevalence of insufficient 25-hydroxyvitamin D status in black and white older adults: the health, aging and body composition study, J Am Geriatr Soc, 59, 1165, 10.1111/j.1532-5415.2011.03476.x

Rajakumar, 2011, Vitamin D status, adiposity, and lipids in black American and Caucasian children, J Clin Endocrinol Metab, 96, 1560, 10.1210/jc.2010-2388

Lagunova, 2009, The dependency of vitamin D status on body mass index, gender, age and season, Anticancer Res, 29, 3713

McKinney, 2008, Association of race, body fat and season with vitamin D status among young women: a cross-sectional study, Clin Endocrinol (Oxf), 69, 535, 10.1111/j.1365-2265.2008.03233.x

Palacios, 2012, Determinants of vitamin D status among overweight and obese Puerto Rican adults, Ann Nutr Metab, 60, 35, 10.1159/000335282

Samuel, 2013, The effect of body mass index on optimal vitamin D status in U.S. adults: the National Health and Nutrition Examination Survey 2001-2006, Ann Epidemiol, 23, 409, 10.1016/j.annepidem.2013.05.011

Ardawi, 2011, Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre and postmenopausal women, Osteoporos Int, 22, 463, 10.1007/s00198-010-1249-7

Lagunova, 2011, Serum 25-hydroxyvitamin D is a predictor of serum 1,25-dihydroxyvitamin D in overweight and obese patients, J Nutr, 141, 112, 10.3945/jn.109.119495

Snijder, 2005, Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women, J Clin Endocrinol Metab, 90, 4119, 10.1210/jc.2005-0216

Hultin, 2010, Left-shifted relation between calcium and parathyroid hormone in obesity, J Clin Endocrinol Metab, 95, 3973, 10.1210/jc.2009-2822

Vimaleswaran, 2013, Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts, PLoS Med, 10, e1001383, 10.1371/journal.pmed.1001383

Chandler, 2015, Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials, Nutr Rev, 73, 577, 10.1093/nutrit/nuv012

Kull, 2009, Body mass index determines sunbathing habits: implications on vitamin D levels, Intern Med J, 39, 256, 10.1111/j.1445-5994.2009.01900.x

Macdonald, 2011, Skin color change in Caucasian postmenopausal women predicts summer-winter change in 25-hydroxyvitamin D: findings from the ANSAViD cohort study, J Clin Endocrinol Metab, 96, 1677, 10.1210/jc.2010-2032

Wortsman, 2000, Decreased bioavailability of vitamin D in obesity, Am J Clin Nutr, 72, 690, 10.1093/ajcn/72.3.690

Winters, 2009, Influence of obesity on vitamin D-binding protein and 25-hydroxy vitamin D levels in African American and white women, Metabolism, 58, 438, 10.1016/j.metabol.2008.10.017

Heaney, 2009, Vitamin D3 distribution and status in the body, J Am Coll Nutr, 28, 252, 10.1080/07315724.2009.10719779

Bolland, 2007, The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency, Am J Clin Nutr, 86, 959, 10.1093/ajcn/86.4.959

Blum, 2008, Vitamin D(3) in fat tissue, Endocrine, 33, 90, 10.1007/s12020-008-9051-4

Gallagher, 2013, The effect of vitamin D supplementation on serum 25(OH)D in thin and obese women, J Steroid Biochem Mol Biol, 136, 195, 10.1016/j.jsbmb.2012.12.003

Drincic, 2013, 25-hydroxyvitamin d response to graded vitamin D3 supplementation among obese adults, J Clin Endocrinol Metab, 98, 4845, 10.1210/jc.2012-4103

Didriksen, 2015, Vitamin D3 increases in abdominal subcutaneous fat tissue after supplementation with vitamin D3, Eur J Endocrinol, 172, 235, 10.1530/EJE-14-0870

Heaney, 2011, Vitamin D(3) is more potent than vitamin D(2) in humans, J Clin Endocrinol Metab, 96, E447, 10.1210/jc.2010-2230

Di Nisio, 2017, Impaired release of vitamin D in dysfunctional adipose tissue: new cues on vitamin D supplementation in obesity, J Clin Endocrinol Metab, 10.1210/jc.2016-3591

Wamberg, 2013, Expression of vitamin D-metabolizing enzymes in human adipose tissue: the effect of obesity and diet-induced weight loss, Int J Obes (London), 37, 651, 10.1038/ijo.2012.112

Carrelli, 2017, Vitamin D storage in adipose tissue of obese and normal weight women, J Bone Miner Res, 32, 237, 10.1002/jbmr.2979

Evans, 2015, Bone density, microstructure and strength in obese and normal weight men and women in younger and older adulthood, J Bone Miner Res, 30, 920, 10.1002/jbmr.2407

Dimitri, 2012, Obesity is a risk factor for fracture in children but is protective against fracture in adults: A paradox, Bone, 50, 457, 10.1016/j.bone.2011.05.011

Autier, 2014, Vitamin D status and ill health: a systematic review, Lancet Diabetes Endocrinol, 2, 76, 10.1016/S2213-8587(13)70165-7

Shanmugalingam, 2014, Obesity and cancer: the role of vitamin D, BMC Cancer, 14, 712, 10.1186/1471-2407-14-712

Eaton, 2011, Prospective association of vitamin D concentrations with mortality in postmenopausal women: results from the Women's Health Initiative (WHI), Am J Clin Nutr, 94, 1471, 10.3945/ajcn.111.017715

Manousopoulou, 2015, Vitamin D and cardiovascular risk among adults with obesity: a systematic review and meta-analysis, Eur J Clin Invest, 45, 1113, 10.1111/eci.12510

Vilarrasa, 2010, Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population?, Endocrine, 38, 235, 10.1007/s12020-010-9379-4

Beilfuss, 2012, Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects, Cytokine, 60, 870, 10.1016/j.cyto.2012.07.032

Wamberg, 2013, Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels: results from a randomized trial, Eur J Intern Med, 24, 644, 10.1016/j.ejim.2013.03.005

Jorde, 2010, No effect of supplementation with cholecalciferol on cytokines and markers of inflammation in overweight and obese subjects, Cytokine, 50, 175, 10.1016/j.cyto.2009.12.006

Himbert, 2017, A systematic review of the interrelation between diet and surgery-induced weight loss and vitamin D status, Nutr Res, 38, 13, 10.1016/j.nutres.2016.12.004

Pramyothin, 2011, Vitamin D in adipose tissue and serum 25-hydroxyvitamin D after roux-en-Y gastric bypass, Obesity (Silver Spring), 19, 2228, 10.1038/oby.2011.170

Aasheim, 2009, Vitamin status after bariatric surgery: a randomized study of gastric bypass and duodenal switch, Am J Clin Nutr, 90, 15, 10.3945/ajcn.2009.27583

Switzer, 2017, Long-term hypovitaminosis D and secondary hyperparathyroidism outcomes of the roux-en-Y gastric bypass: a systematic review, Obes Rev, 18, 560, 10.1111/obr.12525

Shanbhogue, 2017, Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study, Eur J Endocrinol, 176, 685, 10.1530/EJE-17-0014

Muschitz, 2016, The impact of vitamin D, calcium, protein supplementation, and physical exercise on bone metabolism after bariatric surgery: the BABS study, J Bone Miner Res, 31, 672, 10.1002/jbmr.2707

Thông tin
Thông tin xuất bản

Current Opinion in Endocrinology, Diabetes and Obesity

Tập 24 Số 6

389-394

Thông tin tác giả