Vitamin D and the Host-Gut Microbiome: A Brief Overview

1 Ahluwalia, B., Magnusson, M. K. and Ohman, L. (2017) Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad. Scand. J. Gastroenterol. 52; 1185–1193.

2 Akimbekov, N. S., Ortoski, R. A. and Razzaque, M. S. (2020) Effects of sunlight exposure and vitamin D supplementation on HIV patients. J. Steroid Biochem. Mol. Biol. 200; 105664.

3 Ananthakrishnan, A. N., Cheng, S.-C., Cai, T., Cagan, A., Gainer, V. S., Szolovits, P., et al. (2014) Association between reduced plasma 25-hydroxy vitamin D and increased risk of cancer in patients with inflammatory bowel diseases. Clin. Gastroenterol. Hepatol. 12; 821–827.

4 Ardesia, M., Ferlazzo, G. and Fries, W. (2015) Vitamin D and inflammatory bowel disease. Biomed. Res. Int. 2015; 470805.

5 Bashir, M., Prietl, B., Tauschmann, M., Mautner, S. I., Kump, P. K., Treiber, G., et al. (2016) Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract. Eur. J. Nutr. 55; 1479–1489.

6 Bengmark, S. (1998) Ecological control of the gastrointestinal tract. The role of probiotic flora. Gut 42; 2–7.

7 Bilen, M., Dufour, J.-C., Lagier, J.-C., Cadoret, F., Daoud, Z., Dubourg, G., et al. (2018) The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species. Microbiome 6; 94.

8 Boirivant, M., Amendola, A. and Butera, A. (2008) Intestinal microflora and immunoregulation. Mucosal Immunol. 1 Suppl 1; S47–49.

9 Brown, R. B. and Razzaque, M. S. (2018) Phosphate toxicity and tumorigenesis. Biochim. Biophys. Acta Rev. Cancer 1869; 303–309.

10 Cantarel, B. L., Waubant, E., Chehoud, C., Kuczynski, J., DeSantis, T. Z., Warrington, J., et al. (2015) Gut microbiota in multiple sclerosis: possible influence of immunomodulators. J. Investig. Med. 63; 729–734.

11 Carding, S., Verbeke, K., Vipond, D. T., Corfe, B. M. and Owen, L. J. (2015) Dysbiosis of the gut microbiota in disease. Microb. Ecol. Health. Dis. 26; 26191.

12 Chambers, E. S., Preston, T., Frost, G. and Morrison, D. J. (2018) Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health. Curr. Nutr. Rep. 7; 198–206.

13 Claus, S. P., Guillou, H. and Ellero-Simatos, S. (2016) The gut microbiota: a major player in the toxicity of environmental pollutants? NPJ. Biofilms. Microbiomes 2; 16003.

14 Cohen-Poradosu, R. and Kasper, D. L. (2015) 244—Anaerobic Infections: General Concepts. In “Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases”, ed. by J. E. Bennett, R. Dolin, M. J. Blaser, Content Repository Only!, Philadelphia, pp. 2736–2743.e1.

15 Edfeldt, K., Liu, P. T., Chun, R., Fabri, M., Schenk, M., Wheelwright, M., et al. (2010) T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc. Natl. Acad. Sci. U S A 107; 22593–22598.

16 Egbert, M. D., Barandiaran, X. E. and Di Paolo, E. A. (2010) A minimal model of metabolism-based chemotaxis. PLoS Comput. Biol. 6; e1001004.

17 Erem, S. and Razzaque, M. S. (2018) Dietary phosphate toxicity: an emerging global health concern. Histochem. Cell Biol. 150; 711–719.

18 Erem, S., Atfi, A. and Razzaque, M. S. (2019) Anabolic effects of vitamin D and magnesium in aging bone. J. Steroid Biochem. Mol. Biol. 193; 105400.

19 Galland, L. (2014) The gut microbiome and the brain. J. Med. Food 17; 1261–1272.

20 Guo, C., Sinnott, B., Niu, B., Lowry, M. B., Fantacone, M. L. and Gombart, A. F. (2014) Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Mol. Nutr. Food. Res. 58; 528–536.

21 Haque, S. Z. and Haque, M. (2017) The ecological community of commensal, symbiotic, and pathogenic gastrointestinal micro­organisms—an appraisal. Clin. Exp. Gastroenterol. 10; 91–103.

22 Harmsen, H. J. M. and de Goffau, M. C. (2016) The Human Gut Microbiota. In “Microbiota of the Human Body: Implications in Health and Disease”, ed. by A. Schwiertz, Springer International Publishing, Cham, pp. 95–108.

23 Haussler, M. R., Haussler, C. A., Bartik, L., Whitfield, G. K., Hsieh, J.-C., Slater, S., et al. (2008) Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutr. Rev. 66; S98–112.

24 He, Q., Ananaba, G. A., Patrickson, J., Pitts, S., Yi, Y., Yan, F., et al. (2013) Chlamydial infection in vitamin D receptor knockout mice is more intense and prolonged than in wild-type mice. J. Steroid Biochem. Mol. Biol. 135; 7–14.

25 Hewison, M. (2011) Antibacterial effects of vitamin D. Nat. Rev. Endocrinol. 7; 337–345.

26 Hill, M. J. (1997) Intestinal flora and endogenous vitamin synthesis. Eur. J. Cancer Prev. 6 Suppl 1; S43–45.

27 Hillman, E. T., Lu, H., Yao, T. and Nakatsu, C. H. (2017) Microbial Ecology along the Gastrointestinal Tract. Microbes. Environ. 32; 300–313.

28 Holick, M. F. (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am. J. Clin. Nutr. 80; 1678S–1688S.

29 Jandhyala, S. M., Talukdar, R., Subramanyam, C., Vuyyuru, H., Sasikala, M. and Nageshwar Reddy, D. (2015) Role of the normal gut microbiota. World J. Gastroenterol. 21; 8787–8803.

30 Jepson, M. A. (2012) Chapter 12—Gastrointestinal Tract. In “Adverse Effects of Engineered Nanomaterials”, ed. by B. Fadeel, A. Pietroiusti and A. A. Shvedova, Academic Press, Boston, pp. 209–224.

31 Jones, M. L., Martoni, C. J. and Prakash, S. (2013) Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial. J. Clin. Endocrinol. Metab. 98; 2944–2951.

32 Jones, R. M., Desai, C., Darby, Trevor M., Luo, L., Wolfarth, Alexandra A., Scharer, C. D., et al. (2015) Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Cell Rep. 12; 1217–1225.

33 Kanhere, M., He, J., Chassaing, B., Ziegler, T. R., Alvarez, J. A., Ivie, E. A., et al. (2018) Bolus Weekly Vitamin D3 Supplemen­tation Impacts Gut and Airway Microbiota in Adults With Cystic Fibrosis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. J. Clin. Endocrinol. Metab. 103; 564–574.

34 Kataoka, K. (2016) The intestinal microbiota and its role in human health and disease. J. Med. Invest. 63; 27–37.

35 Kempker, J. A., Han, J. E., Tangpricha, V., Ziegler, T. R. and Martin, G. S. (2012) Vitamin D and sepsis: An emerging relationship. Dermatoendocrinol. 4; 101–108.

36 Kong, J., Zhang, Z., Musch, M. W., Ning, G., Sun, J., Hart, J., et al. (2008) Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am. J. Physiol. Gastrointest. Liver Physiol. 294; G208–216.

37 Korecka, A. and Arulampalam, V. (2012) The gut microbiome: scourge, sentinel or spectator? J. Oral Microbiol. 4; doi: 10.3402/jom.v4i0.9367.

38 Krutzik, S. R., Hewison, M., Liu, P. T., Robles, J. A., Stenger, S., Adams, J. S., et al. (2008) IL-15 links TLR2/1-induced macro­phage differentiation to the vitamin D-dependent antimicrobial pathway. J. Immunol. 181; 7115–7120.

39 Lach, G., Schellekens, H., Dinan, T. G. and Cryan, J. F. (2018) Anxiety, Depression, and the Microbiome: A Role for Gut Peptides. Neurotherapeutics 15; 36–59.

40 Lagier, J.-C., Million, M., Hugon, P., Armougom, F. and Raoult, D. (2012) Human gut microbiota: repertoire and variations. Front. Cell. Infect. Microbiol. 2; 136.

41 Lazar, V., Ditu, L.-M., Pircalabioru, G. G., Gheorghe, I., Curutiu, C., Holban, A. M., et al. (2018) Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer. Front. Immunol. 9; 1830.

42 LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van Sinderen, D. and Ventura, M. (2013) Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Curr. Opin. Biotechnol. 24; 160–168.

43 Lehrer, R. I. and Ganz, T. (2002) Cathelicidins: a family of endogenous antimicrobial peptides. Curr. Opin. Hematol. 9; 18–22.

44 Ley, R. E., Peterson, D. A. and Gordon, J. I. (2006) Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine. Cell 124; 837–848.

45 Liang, D., Leung, R. K.-K., Guan, W. and Au, W. W. (2018) Involvement of gut microbiome in human health and disease: brief overview, knowledge gaps and research opportunities. Gut Pathog. 10; 3.

46 Maji, D. (2012) Vitamin D toxicity. Indian J. Endocrinol. Metab. 16; 295–296.

47 Manes, N. P., Shulzhenko, N., Nuccio, A. G., Azeem, S., Morgun, A. and Nita-Lazar, A. (2017) Multi-omics Comparative Analysis Reveals Multiple Layers of Host Signaling Pathway Regulation by the Gut Microbiota. mSystems 2; e00107–00117.

48 Meeker, S., Seamons, A., Maggio-Price, L. and Paik, J. (2016) Protective links between vitamin D, inflammatory bowel disease and colon cancer. World J. Gastroenterol. 22; 933–948.

49 Merriman, K. E., Kweh, M. F., Powell, J. L., Lippolis, J. D. and Nelson, C. D. (2015) Multiple β-defensin genes are upregulated by the vitamin D pathway in cattle. J. Steroid Biochem. Mol. Biol. 154; 120–129.

50 Million, M., Tomas, J., Wagner, C., Lelouard, H., Raoult, D. and Gorvel, J.-P. (2018) New insights in gut microbiota and mucosal immunity of the small intestine. Human Microbiome J. 7–8; 23–32.

51 Mischke, M. and Plösch, T. (2016) The Gut Microbiota and their Metabolites: Potential Implications for the Host Epigenome. In “Microbiota of the Human Body: Implications in Health and Disease”, ed. by A. Schwiertz, Springer International Publishing, Cham, pp. 33–44.

52 Mohajeri, M. H., Brummer, R. J. M., Rastall, R. A., Weersma, R. K., Harmsen, H. J. M., Faas, M., et al. (2018) The role of the microbiome for human health: from basic science to clinical applications. Eur. J. Nutr. 57; 1–14.

53 Morrison, D. J. and Preston, T. (2016) Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes 7; 189–200.

54 Nair, R. and Maseeh, A. (2012) Vitamin D: The “sunshine” vitamin. J. Pharmacol. Pharmacother. 3; 118–126.

55 Nardone, G. and Compare, D. (2015) The human gastric microbiota: Is it time to rethink the pathogenesis of stomach diseases? United European Gastroenterol. J. 3; 255–260.

56 Nava, G. M. and Stappenbeck, T. S. (2011) Diversity of the autochthonous colonic microbiota. Gut Microbes 2; 99–104.

57 Nicholson, I., Dalzell, A. M. and El-Matary, W. (2012) Vitamin D as a therapy for colitis: a systematic review. J. Crohns. Colitis. 6; 405–411.

58 Niess, J. H. and Reinecker, H.-C. (2006) Dendritic cells in the recognition of intestinal microbiota. Cell. Microbiol. 8; 558–564.

59 O’Hara, A. M. and Shanahan, F. (2006) The gut flora as a forgotten organ. EMBO Rep. 7; 688–693.

60 Pascal, M., Perez-Gordo, M., Caballero, T., Escribese, M. M., Lopez Longo, M. N., Luengo, O., et al. (2018) Microbiome and Allergic Diseases. Front. Immunol. 9; 1584.

61 Posserud, I., Stotzer, P.-O., Björnsson, E. S., Abrahamsson, H. and Simrén, M. (2007) Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut 56; 802–808.

62 Preidis, G. A. and Versalovic, J. (2009) Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastro­enterology enters the metagenomics era. Gastroenterology 136; 2015–2031.

63 Razzaque, M. S. (2018) Magnesium: are we consuming enough? Nutrients 10; 1863. doi: 10.3390/nu10121863.

64 Razzaque, M. S. (2018) Sunlight exposure: Do health benefits outweigh harm? J. Steroid Biochem. Mol. Biol. 175; 44–48.

65 Razzaque, M. S. (2020) Overconsumption of sugar-sweetened beverages: why is it difficult to control? J. Popul. Ther. Clin. Pharmacol. 27; e62–e68. doi: 10.15586/jptcp.v27i2.678.

66 Razzaque, M. S. (2020) Can excessive dietary phosphate intake influence oral diseases? Adv. Hum. Biol. 10; 35–37. doi: 10.4103/AIHB.AIHB_3_20.

67 Reich, K. M., Fedorak, R. N., Madsen, K. and Kroeker, K. I. (2014) Vitamin D improves inflammatory bowel disease outcomes: basic science and clinical review. World J. Gastroenterol. 20; 4934–4947.

68 Reid, G. and Burton, J. (2002) Use of Lactobacillus to prevent infection by pathogenic bacteria. Microbes Infect. 4; 319–324.

69 Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., et al. (2018) Gut microbiota functions: metabolism of nutrients and other food components. Eur. J. Nutr. 57; 1–24.

70 Rubio-Tapia, A., Barton, S. H., Rosenblatt, J. E. and Murray, J. A. (2009) Prevalence of small intestine bacterial overgrowth diagnosed by quantitative culture of intestinal aspirate in celiac disease. J. Clin. Gastroenterol. 43; 157–161.

71 Sadykov, R., Digel, I., Artmann, A., uuml, l, T., Porst, D., et al. (2009) Oral Lead Exposure Induces Dysbacteriosis in Rats. J. Occup. Health. 51; 64–73.

72 Scarpellini, E., Ianiro, G., Attili, F., Bassanelli, C., De Santis, A. and Gasbarrini, A. (2015) The human gut microbiota and virome: Potential therapeutic implications. Dig. Liver Dis. 47; 1007–1012.

73 Schaffler, H., Herlemann, D. P., Klinitzke, P., Berlin, P., Kreikemeyer, B., Jaster, R., et al. (2018) Vitamin D adminis­tration leads to a shift of the intestinal bacterial composition in Crohn’s disease patients, but not in healthy controls. J. Dig. Dis. 19; 225–234.

74 Schirmer, M., Smeekens, S. P., Vlamakis, H., Jaeger, M., Oosting, M., Franzosa, E. A., et al. (2016) Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity. Cell 167; 1125–1136.e8.

75 Shi, N., Li, N., Duan, X. and Niu, H. (2017) Interaction between the gut microbiome and mucosal immune system. Mil. Med. Res. 4; 14.

76 Shoaie, S. and Nielsen, J. (2014) Elucidating the interactions between the human gut microbiota and its host through metabolic modeling. Front. Genet. 5; 86.

77 Stinson, L. F., Boyce, M. C., Payne, M. S. and Keelan, J. A. (2019) The Not-so-Sterile Womb: Evidence That the Human Fetus Is Exposed to Bacteria Prior to Birth. Front. Microbiol. 10; 1124.

78 Sun, J. (2018) Dietary vitamin D, vitamin D receptor, and microbiome. Curr. Opin. Clin. Nutr. Metab. Care. 21; 471–474.

79 Sun, M., He, C., Cong, Y. and Liu, Z. (2015) Regulatory immune cells in regulation of intestinal inflammatory response to microbiota. Mucosal Immunol. 8; 969–978.

80 Thursby, E. and Juge, N. (2017) Introduction to the human gut microbiota. Biochem. J. 474; 1823–1836.

81 Uwitonze, A. M. and Razzaque, M. S. (2018) Role of magnesium in vitamin D activation and function. J. Am. Osteopath. Assoc. 118; 181–189.

82 Uwitonze, A. M., Ojeh, N., Murererehe, J., Atfi, A. and Razzaque, M. S. (2020) Zinc adequacy is essential for the maintenance of optimal oral health. Nutrients 12; doi: 10.3390/nu12040949.

83 Uwitonze, A. M., Rahman, S., Ojeh, N., Grant, W. B., Kaur, H., Haq, A., et al. (2020) Oral manifestations of magnesium and vitamin D inadequacy. J. Steroid Biochem. Mol. Biol. 200; 105636.

84 Valdes, A. M., Walter, J., Segal, E. and Spector, T. D. (2018) Role of the gut microbiota in nutrition and health. BMJ 361; k2179.

85 Veldurthy, V., Wei, R., Oz, L., Dhawan, P., Jeon, Y. H. and Christakos, S. (2016) Vitamin D, calcium homeostasis and aging. Bone Res. 4; 16041.

86 Wang, B., Yao, M., Lv, L., Ling, Z. and Li, L. (2017) The Human Microbiota in Health and Disease. Engineering 3; 71–82.

87 Wang, G., Huang, S., Wang, Y., Cai, S., Yu, H., Liu, H., et al. (2019) Bridging intestinal immunity and gut microbiota by metabolites. Cell. Mol. Life Sci. 76; 3917–3937.

88 Wang, H., Chen, W., Li, D., Yin, X., Zhang, X., Olsen, N., et al. (2017) Vitamin D and Chronic Diseases. Aging Dis. 8; 346–353.

90 Waterhouse, M., Hope, B., Krause, L., Morrison, M., Protani, M. M., Zakrzewski, M., et al. (2019) Vitamin D and the gut microbiome: a systematic review of in vivo studies. Eur. J. Nutr. 58; 2895–2910.

91 Wen, L. and Duffy, A. (2017) Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes. J. Nutr. 147; 1468S–1475S.

92 Wimalawansa, S. J., Razzaque, M. S. and Al-Daghri, N. M. (2018) Calcium and vitamin D in human health: Hype or real? J. Steroid Biochem. Mol. Biol. 180; 4–14.

93 Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., et al. (2011) Linking long-term dietary patterns with gut microbial enterotypes. Science 334; 105–108.

94 Wu, S., Liao, A. P., Xia, Y., Li, Y. C., Li, J.-D., Sartor, R. B., et al. (2010) Vitamin D receptor negatively regulates bacterial-stimulated NF-kappaB activity in intestine. Am. J. Pathol. 177; 686–697.

95 Wu, S., Zhang, Y.-G., Lu, R., Xia, Y., Zhou, D., Petrof, E. O., et al. (2015) Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis. Gut 64; 1082–1094.

96 Yoon, S., Wu, S., Zhang, Y.-g., Lu, R., Petrof, E. O., Yuan, L., et al. (2011) Probiotic Regulation of Vitamin D Receptor in Intestinal Inflammation. Gastroenterology 140; S-19.

97 Yoon, S. S. and Sun, J. (2011) Probiotics, nuclear receptor signaling, and anti-inflammatory pathways. Gastroenterol. Res. Pract. 2011; 971938.

98 Zhang, C., Derrien, M., Levenez, F., Brazeilles, R., Ballal, S. A., Kim, J., et al. (2016) Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes. ISME J. 10; 2235–2245.

99 Zhang, Y.-G., Wu, S. and Sun, J. (2013) Vitamin D, Vitamin D Receptor, and Tissue Barriers. Tissue Barriers 1; e23118.

100 Zhao, J., Wang, Y., Gu, Q., Du, Z. and Chen, W. (2019) The association between serum vitamin D and inflammatory bowel disease. Medicine 98; e15233.