Vitamin D and serum leptin: a systematic review and meta-analysis of observational studies and randomized controlled trials

European Journal of Clinical Nutrition - Tập 71 Số 10 - Trang 1144-1153 - 2017
M Hajimohammadi1, Sakineh Shab‐Bidar1, Tirang R. Neyestani2
1Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
2Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute (NNFTRI), Faculty of Nutrition and Food Technology Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Tóm tắt

Từ khóa


Tài liệu tham khảo

Kelishadi R, Alikhani S, Delavari A, Alaedini F, Safaie A, Hojatzadeh E . Obesity and associated lifestyle behaviours in Iran: findings from the first national non-communicable disease risk factor surveillance survey. Public Health Nutr 2008; 11: 246–251.

Organization WH Obesity: preventing and managing the global epidemic. World Health Organization, 2000.

Berg AH, Scherer PE . Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005; 96: 939–949.

Holick MF, Chen TC . Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008; 87: 1080S–1086S.

Troesch B, Hoeft B, McBurney M, Eggersdorfer M, Weber P . Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries. Br J Nutr 2012; 108: 692–698.

Moschonis G, Tanagra S, Koutsikas K, Nikolaidou A, Androutsos O, Manios Y . Association between serum 25-hydroxyvitamin D levels and body composition in postmenopausal women: the postmenopausal Health Study. Menopause 2009; 16: 701–707.

Arunabh S, Pollack S, Yeh J, Aloia JF . Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab 2003; 88: 157–161.

Kamycheva E, Joakimsen RM, Jorde R . Intakes of calcium and vitamin D predict body mass index in the population of Northern Norway. J Nutr 2003; 133: 102–106.

Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF . Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72: 690–693.

Young KA, Engelman CD, Langefeld CD, Hairston KG, Haffner SM, Bryer-Ash M et al. Association of plasma vitamin D levels with adiposity in Hispanic and African Americans. J Clin Endocrinol Metab 2009; 94: 3306–3313.

Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J et al. The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 2004; 89: 1196–1199.

Zemel MB, Miller SL . Dietary calcium and dairy modulation of adiposity and obesity risk. Nutr Rev 2004; 62: 125–131.

Jorde R, Sneve M, Emaus N, Figenschau Y, Grimnes G . Cross-sectional and longitudinal relation between serum 25-hydroxyvitamin D and body mass index: the Tromsø study. Eur J of Nutr 2010; 49: 401–407.

Zhou J, Zhao L-J, Watson P, Zhang Q, Lappe JM . The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial. Nutr Metab 2010; 7: 62.

Kirsty Forsythe L, Livingstone MBE, Barnes MS, Horigan G, McSorley EM, Bonham MP et al. Effect of adiposity on vitamin D status and the 25-hydroxycholecalciferol response to supplementation in healthy young and older Irish adults. Br J Nutr 2012; 107: 126–134.

Menendez C, Lage M, Peino R, Baldelli R, Concheiro P, Dieguez C et al. Retinoic acid and vitamin D (3) powerfully inhibit in vitro leptin secretion by human adipose tissue. J Endocrinol 2001; 170: 425–431.

Moher D, Liberati A, Tetzlaff J, Altman DG . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Int Med 2009; 151: 264–269.

Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17: 1–12.

Lipsey MW, Wilson DB . Practical Meta-analysis. Sage publications: Thousand Oaks, CA, USA, 2001.

Hozo SP, Djulbegovic B, Hozo I . Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005; 5: 13.

Egger M, Smith GD, Altman D . Systematic Reviews in Health Care: Meta-analysis in Context. John Wiley & Sons, 2008.

Orsini N, Bottai M, Higgins J, Buchan I . Heterogi: Stata Module to Quantify Heterogeneity in a Meta-analysis (software program). (Statistical Software Components S449201). Department of Economics, Boston College: Boston, MA, USA 2006.

Higgins JP, Green S . Cochrane Handbook For Systematic Reviews of Interventions. Wiley Online Library, 2008.

DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177–188.

Egger M, Smith GD, Schneider M . Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629–634.

Begg CB, Mazumdar M . Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; pp 1088–1101.

Bellia A, Garcovich C, D'Adamo M, Lombardo M, Tesauro M, Donadel G et al. Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects. Intern Emerg Med 2013; 8: 33–40.

de Luis DA, Soto GD, Conde R, Izaola O, de la Fuente B . Relation of leptin and adiponectin with cardiovascular risk factors, intact parathormone, and vitamin D levels in patients with primary hyperparathyroidism. J Clin Lab Anal 2012; 26: 398–402.

Figuiredo-Dias V, Cuppari L, Garcia-Lopes MG, de Carvalho AB, Draibe SA, Kamimura MA . Risk factors for hypovitaminosis D in nondialyzed chronic kidney disease patients. J Renal Nutr 2012; 22: 4–11.

Fisher A, Srikusalanukul W, Davis M, Smith P . Interactions between serum adipokines and osteocalcin in older patients with hip fracture. Int J Endocrinol 2012; 2012.

Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2006; 114: 577–583.

Kovesdy CP, Molnar MZ, Czira ME, Rudas A, Ujszaszi A, Rosivall L et al. Associations between serum leptin level and bone turnover in kidney transplant recipients. Clin J Am Soc Nephrol 2010; 5: 2297–2304.

Maetani M, Maskarinec G, Franke AA, Cooney RV . Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women. Nutr Cancer 2009; 61: 225–231.

Olmos JM, Vazquez LA, Amado JA, Hernandez JL, Gonzalez Macias J . Mineral metabolism in obese patients following vertical banded gastroplasty. Obes Surg 2008; 18: 197–203.

Pedone C, Napoli N, Pozzilli P, Lauretani F, Bandinelli S, Ferrucci L et al. Bone health as a function of adipokines and vitamin D pattern in elderly patients. Rejuvenation Res 2013; 16: 467–474.

Polymeris A, Doumouchtsis K, Grapsa E . Bone mineral density and bone metabolism in hemodialysis patients. Correlation with PTH 25OHD3 and leptin. Nefrologia 2012; 32: 73–78.

Shabat S, Nyska M, Eintacht S, Lis M, Bogomolni A, Berner Y et al. Serum leptin level in geriatric patients with hip fractures: possible correlation to biochemical parameters of bone remodeling. Arch Gerontol Geriatr 2009; 48: 250–253.

Teles FR, Teles RP, Martin L, Socransky SS, Haffajee AD . Relationships among interleukin-6, tumor necrosis factor-alpha, adipokines, vitamin D, and chronic periodontitis. J Periodontol 2012; 83: 1183–1191.

Vilarrasa N, Vendrell J, Maravall J, Elio I, Solano E, San Jose P et al. Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population? Endocrine 2010; 38: 235–242.

Gomez JM, Maravall FJ, Gomez N, Navarro MA, Casamitjana R, Soler J . Relationship between 25-(OH) D3, the IGF-I system, leptin, anthropometric and body composition variables in a healthy, randomly selected population. Horm Metab Res 2004; 36: 48–53.

Taes YE, Goemaere S, Huang G, Van Pottelbergh I, De Bacquer D, Verhasselt B et al. Vitamin D binding protein, bone status and body composition in community-dwelling elderly men. Bone 2006; 38: 701–707.

Figuiredo-Dias V, Cuppari L, Garcia-Lopes MG, de Carvalho AB, Draibe SA, Kamimura MA . Risk factors for hypovitaminosis D in nondialyzed chronic kidney disease patients. J Renal Nutr 2012; 22: 4–11.

Vilarrasa N, Vendrell J, Maravall J, Elío I, Solano E, San José P et al. Is plasma 25 (OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population? Endocrine 2010; 38: 235–242.

Waterhouse M, Tran B, Ebeling PR, English DR, Lucas RM, Venn AJ et al. Effect of vitamin D supplementation on selected inflammatory biomarkers in older adults: a secondary analysis of data from a randomised, placebo-controlled trial. Br J Nutr 2015; 114: 693–699.

Tabesh M, Azadbakht L, Faghihimani E, Tabesh M, Esmaillzadeh A . Calcium-vitamin D cosupplementation influences circulating inflammatory biomarkers and adipocytokines in vitamin D-insufficient diabetics: a randomized controlled clinical trial. J Clin Endocrinol Metab 2014; 99: E2485–E2493.

Maggi S, Siviero P, Brocco E, Albertin M, Romanato G, Crepaldi G . Vitamin D deficiency, serum leptin and osteoprotegerin levels in older diabetic patients: an input to new research avenues. Acta Diabetol 2014; 51: 461–469.

Breslavsky A, Frand J, Matas Z, Boaz M, Barnea Z, Shargorodsky M . Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients. Clin Nutr 2013; 32: 970–975.

Ghavamzadeh S, Mobasseri M, Mahdavi R . The effect of vitamin D supplementation on adiposity, blood glycated hemoglobin, serum leptin and TNF-[alpha] in type 2 diabetic patients. Int J Prev Med 2014; 5: 1091–1098.

Chai W, Bostick RM, Ahearn TU, Franke AA, Custer LJ, Cooney RV . Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites. Nutr Cancer 2012; 64: 57–64.

Maggi S, Siviero P, Brocco E, Albertin M, Romanato G, Crepaldi G . Vitamin D deficiency, serum leptin and osteoprotegerin levels in older diabetic patients: an input to new research avenues. Acta Diabetol 2014; 51: 1–9.

van den Bout-van den Beukel CJ, van den Bos M, Oyen WJ, Hermus AR, Sweep FC, Tack CJ et al. The effect of cholecalciferol supplementation on vitamin D levels and insulin sensitivity is dose related in vitamin D-deficient HIV-1-infected patients. HIV Med 2008; 9: 771–779.

Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 2009; 94: 4023–4030.

Ulutas O, Taskapan H, Taskapan MC, Temel I . Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients. Int Urol Nephrol 2013; 45: 879–884.

De Oliveira RB, Graciolli FG, Dos Reis LM, Cancela ALE, Cuppari L, Canziani ME et al. Disturbances of Wnt/β-catenin pathway and energy metabolism in early CKD: effect of phosphate binders. Nephrol Dial Transplant 2013; 28: 2510–2517.

Vaidya A, Underwood PC, Annes JP, Sun B, Williams GH, Forman JP et al. The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes. Metabolism 2013; 62: 539–547.

Conroy R, Girotra M, Shane E, McMahon DJ, Pavlovich KH, Leibel RL et al. Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss. Metabolism 2011; 60: 1222–1226.

Aronis KN, Diakopoulos KN, Fiorenza CG, Chamberland JP, Mantzoros CS . Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans. Diabetologia 2011; 54: 2358–2367.

Kraśniak A, Drozdz M, Pasowicz M, Chmiel G, Michałek M, Szumilak D et al. Factors involved in vascular calcification and atherosclerosis in maintenance haemodialysis patients. Nephrol Dial Transplant 2007; 22: 515–521.

Coen G, Pierantozzi A, Spizzichino D, Sardella D, Mantella D, Manni M et al. Risk factors of one year increment of coronary calcifications and survival in hemodialysis patients. BMC Nephrol 2010; 11: 10.

Bacchetta J, Boutroy S, Guebre-Egziabher F, Juillard L, Drai J, Pelletier S et al. The relationship between adipokines, osteocalcin and bone quality in chronic kidney disease. Nephrol Dial Transplant 2009; 24: 3120–3125.

Chai W, Conroy SM, Maskarinec G, Franke AA, Pagano IS, Cooney RV . Associations between obesity and serum lipid-soluble micronutrients among premenopausal women. Nutr Res (New York, NY) 2010; 30: 227–232.

Oros S, Tanas O, Vladoiu S, Giurcaneanu M, Tonescu L, Ncacsu E et al. Does obesity protect postmenopausal women against osteoporosis? Acta Endocrinol 2012; 8: 67–76.

Fontana L, Shew JL, Holloszy JO, Villareal DT . Low bone mass in subjects on a long-term raw vegetarian diet. Arch Intern Med 2005; 165: 684–689.

Lucey AJ, Paschos GK, Thorsdottir I, Martinez JA, Cashman KD, Kiely M . Young overweight and obese women with lower circulating osteocalcin concentrations exhibit higher insulin resistance and concentrations of C-reactive protein. Nutr Res 2013; 33: 67–75.

Maser RE, James Lenhard M, Balagopal P, Kolm P, Peters MB . Effects of surgically induced weight loss by Roux-en-Y gastric bypass on osteocalcin. Surg Obes Relat Dis 2013; 9: 950–955.

Bozic B, Loncar G, Prodanovic N, Radojicic Z, Cvorovic V, Dimkovic S et al. Relationship between high circulating adiponectin with bone mineral density and bone metabolism in elderly males with chronic heart failure. J Card Fail 2010; 16: 301–307.

Doknic M, Maric NP, Britvic D, Pekic S, Damjanovic A, Miljic D et al. Bone remodeling, bone mass and weight gain in patients with stabilized schizophrenia in real-life conditions treated with long-acting injectable risperidone. Neuroendocrinology 2011; 94: 246–254.

Loncar G, Bozic B, Von Haehling S, Düngen HD, Prodanovic N, Lainscak M et al. Association of adiponectin with peripheral muscle status in elderly patients with heart failure. Eur J Int Med 2013; 24: 818–823.

Savastano S, Valentino R, Di Somma C, Orio F, Pivonello C, Passaretti F et al. Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS. Nutr Metab 2011; 8: 84.

Bove RM, Brick DJ, Healy BC, Mancuso SM, Gerweck AV, Bredella MA et al. Metabolic and endocrine correlates of cognitive function in healthy young women. Obesity (Silver Spring, Md) 2013; 21: 1343–1349.

Bruno C, Fulford AD, Potts JR, McClintock R, Jones R, Cacucci BM et al. Serum markers of bone turnover are increased at six and 18 months after Roux-en-Y bariatric surgery: correlation with the reduction in leptin. J Clin Endocrinol Metab 2010; 95: 159–166.

Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000; 100: 197–207.

Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 2009; 94: 4023–4030.

Ghavamzadeh S, Mobasseri M, Mahdavi R . The effect of vitamin D supplementation on adiposity, blood glycated hemoglobin, serum leptin and tumor necrosis factor-α in type 2 diabetic patients. Int J Prev Med 2014; 5: 1091.

Song JW, Chung KC . Observational studies: cohort and case-control studies. Plast Reconstr Surg 2010; 126: 2234.

Shrier I, Boivin J-F, Steele RJ, Platt RW, Furlan A, Kakuma R et al. Should meta-analyses of interventions include observational studies in addition to randomized controlled trials? A critical examination of underlying principles. Am J Epidemiol 2007; 166: 1203–1209.

Souberbielle J-C, Body J-J, Lappe JM, Plebani M, Shoenfeld Y, Wang TJ et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: recommendations for clinical practice. Autoimmun Rev 2010; 9: 709–715.

Wang L, Song Y, Manson JE, Pilz S, März W, Michaëlsson K et al. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease a meta-analysis of prospective studies. Circ Cardiovasc QualOutcomes 2012; 5: 819–829.

Yao Y, Zhu L, He L, Duan Y, Liang W, Nie Z et al. A meta-analysis of the relationship between vitamin D deficiency and obesity. Int J Clin Exp Med 2015; 8: 14977.

Katsiki N, Mikhailidis DP, Gotzamani-Psarrakou A, Yovos JG, Karamitsos D . Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus. Expert Opin Ther Targets 2011; 15: 401–420.

Sugden J, Davies J, Witham M, Morris A, Struthers A . Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabetic Med 2008; 25: 320–325.

Shab‐Bidar S, Neyestani TR, Djazayery A, Eshraghian MR, Houshiarrad A, Kalayi A et al. Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes. Diabetes Metab Res Rev 2012; 28: 424–430.

Ostlund R Jr, Yang J, Klein S, Gingerich R . Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 1996; 81: 3909–3913.

Holick MF . Vitamin D deficiency. New Engl J Med 2007; 357: 266–281.

Berlin JA . Invited commentary: benefits of heterogeneity in meta-analysis of data from epidemiologic studies. Am J Epidemiol 1995; 142: 383–387.

Kontopantelis E, Springate DA, Reeves D . A re-analysis of the Cochrane Library data: the dangers of unobserved heterogeneity in meta-analyses. PLoS One 2013; 8: e69930.

Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM . Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425–432.

Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Engl J Med 1996; 334: 292–295.