Vitamin D Deficiency in Obese Children and Its Relationship to Insulin Resistance and Adipokines

Journal of Obesity - Tập 2011 - Trang 1-7 - 2011
Christian Roth1,2, Clinton Elfers2, Mario Kratz3,4,5, Andrew N. Hoofnagle6
1Department of Pediatrics Bonn, University of Bonn, Germany
2Division of Endocrinology, Seattle Children's Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
3Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA
4Department of Medicine, University of Washington, Seattle, WA 98195, USA
5Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
6Department of Laboratory Medicine, University of Washington, Seattle, WA 98195 USA

Tóm tắt

Low-serum concentrations of 25-hydroxyvitamin D [25(OH)D] are associated with insulin resistance in adults. Less data are available in pediatric populations. Serum 25(OH)D serum concentrations were assessed in 125 obese and 31 nonobese children (age11.9±2.7 y, range 6–16 y, 49% male) living in Bonn, Germany. The relationship between 25(OH)D, measured by liquid chromatography-tandem mass spectrometry, and measures of insulin sensitivity and adipokines adiponectin and resistin were analyzed. Seventy-six % of subjects were 25(OH)D deficient (<20 ng/mL). Higher insulin, homeostasis model assessment-insulin resistance (HOMA-IRr=−0.269,P=0.023), and hemoglobin A1c (HbA1c) as well as lower quantitative insulin-sensitivity check index (QUICKIr=0.264,P=0.030) values were found in obese children with lower 25(OH)D concentrations even after adjustment for gender, age, and body mass index. Furthermore, 25(OH)D correlated significantly with adiponectin, but not with resistin. Our results suggest that hypovitaminosis D is a risk factor for developing insulin resistance independent of adiposity.

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Journal of Obesity

Tập 2011

1-7

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