Visceral Fat Accumulation as a Risk Factor for Prostate Cancer

Wiley - Tập 12 Số 12 - Trang 1930-1935 - 2004
Pedro von Hafe1, F. Pina2, Ana María Puebla Pérez3, Margarida Tavares4, Henrique Barros4
1Department of Medicine, Faculdade de Medicina do Porto, Porto, Portugal
2Urology Department, Hospital S. João, Porto, Portugal
3Radiology Department, Hospital S. João, Porto, Portugal
4Epidemiology Department, Faculdade de Medicina do Porto, Porto, Portugal

Tóm tắt

AbstractObjective: No clear association between obesity or body fat distribution and prostate cancer has been shown. We investigated the relation between visceral fat accumulation as measured by computed tomography (CT) and the occurrence of prostate cancer.Research Methods and Procedures: We compared body fat distribution assessed by a direct method (CT) in 63 prostate cancer cases with 63 age‐matched healthy community controls. A CT scan at the level of the fourth lumbar vertebra was performed in all participants.Results: Patients presented a significantly higher mean total abdominal fat area (509.2 ± 226.1 vs. 334.3 ± 132.9 cm2, p < 0.001), mostly because of a higher mean visceral fat area (VF; 324.7 ± 145.6 vs. 177.4 ± 88.4 cm2, p < 0.001) and a significantly higher mean ratio between visceral and subcutaneous fat areas (V/S ratio; 1.8 ± 0.4 vs. 1.2 ± 0.4, p < 0.001). A significantly higher risk of prostate cancer was found for participants with higher VF (odds ratio = 4.6; 95% confidence interval = 2.6 to 8.2 per SD increase) and V/S ratio (odds ratio = 6.0; 95% confidence interval = 2.3 to 11.0 per SD increase).Discussion: These results suggest a role for visceral obesity, quantified by CT, as a risk factor for prostate cancer. The action of the adipocytokines secreted by visceral fat cells, steroid hormone disturbances, and increased levels of insulin or other hormones noted in visceral obesity may explain this association.

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Wiley

Tập 12 Số 12

1930-1935

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