Virtual Multidisciplinary Tumor Boards: A Narrative Review Focused on Lung Cancer

Vittorio Gebbia1, Aurelia Guarini2, Dario Piazza3, Alessandro Bertani4, Massimiliano Spada2, Francesco Verderame5, Concetta Sergi6, Enrico Potenza6, Ivan Fazio7, Livio Blasi8, Alba La Sala9, Gianluca Mortillaro10, Elena Roz11, Roberto Marchese12, Maurizio Chiarenza13, Héctor Soto Parra14, Maria Rosaria Valerio15, Giuseppe Agneta16, C Amato17, Helga Lipari18, Sergio Baldari19, Francesco Ferraù20, Alfio Di Grazia21, Gianfranco Mancuso1, Sérgio Rizzo1, Alberto Firenze22
1Medical Oncology Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, La Maddalena Clinic for Cancer, University of Palermo, Via San Lorenzo Colli n. 312D, 90100, Palermo, Italy
2Medical Oncology Unit, Fondazione Ospedale Giglio, Cefalù, Palermo, Italy
3GSTU Foundation, Palermo, Italy
4Division of Thoracic Surgery and Lung Transplantation, Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS Ismett, UPMC, Palermo, Italy
5Medical Oncology Unit, Ospedale Cervello Villa Sofia, Palermo, Italy
6Thoracic Surgery Unit, ARNAS, Ospedale Garibaldi, Nesima, Catania, Italy
7Radiation Therapy Unit, Clinica Macchiarella, Palermo, Italy
8Medical Oncology Unit, Arnas Civico, Palermo, Italy
9Bronchial Endoscopy Unit, Arnas Civico, Palermo, Italy
10Radiation Therapy Unit, Arnas Civico, Palermo, Italy
11Pathology Unit, La Maddalena Clinic for Cancer, Palermo, Italy
12Thoracic Surgery Unit, La Maddalena Clinic for Cancer, Palermo, Italy
13Medical Oncology Unit, Istituto Clinico Humanitas, Catania, Italy
14Medical Oncology Unit, Policlinico, Catania, Italy
15Medical Oncology Unit, Policlinico, Palermo, Italy
16Thoracic Surgery Unit, Ospedale Cervello Villa Sofia, Palermo, Italy
17Patients Advocacy “Serena a Palermo”, Palermo, Italy
18Medical Oncology Unit, Ospedale Cannizzaro, Catania, Italy
19Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University Hospital G. Martino, Messina, Italy
20Medical Oncology Unit, Ospedale San Vincenzo, Taormina, Messina, Italy
21Radiation Oncology Unit, Istituto Clinico Humanitas, Catania, Italy
22Risk Management Unit, Policlinico, University of Palermo, Palermo, Italy

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Barta JA, Powell CA, Wisnivesky JP. Global epidemiology of lung cancer. Ann Glob Health. 2019; 22;85(1):8.

Spira A, Ettinger DS. Multidisciplinary management of lung cancer. N Engl J Med. 2004;350(4):379–92.

Karas PL, Rankin NM, Stone E. Medicolegal Considerations in Multidisciplinary Cancer Care. JTO Clin Res Rep. 2020;1(4):100073.

Calman–Hine Report. A Report by the Expert Advisory Group on Cancer to the Chief Medical Officers of England and Wales. A Policy Framework for Commissioning Cancer Services – The Calman–Hine Report. London: Department of Health; 1995.

Morris E, Haward RA, Gilthorpe MS, Craigs C, Forman D. The impact of the Calman–Hine report on the processes and outcomes of care for Yorkshire’s colorectal cancer patients. Br J Cancer. 2006;95(8):979–85.

Lesslie M, Parikh JR. Implementing a multidisciplinary tumor board in the community practice setting. Diagnostics (Basel). 2017;7(4):55–8.

Heuser C, Diekmann A, Schellenberger B, Bohmeier B, Kuhn W, Karbach U, et al. Patient Participation in Multidisciplinary Tumor Conferences from the Providers’ Perspective: Is It Feasible in Routine Cancer Care? J Multidiscip Healthc. 2020;13:1729–39.

Kowalczyk A, Jassem J. Multidisciplinary team care in advanced lung cancer. Transl Lung Cancer Res. 2020;9(4):1690–8.

Denton E, Conron M. Improving outcomes in lung cancer: the value of the multidisciplinary health care team. J Multidiscip Healthc. 2016;9:137–44.

Sirintrapun SJ, Lopez AM. Telemedicine in Cancer Care. Am Soc Clin Oncol Educ Book. 2018;38:540–5.

Shea CM, Teal R, Haynes-Maslow L, McIntyre M, Weiner BJ, Wheeler SB, et al. Assessing the feasibility of a virtual tumor board program: a case study. J Healthc Manag. 2014;59(3):177–93.

Dharmarajan H, Anderson JL, Kim S, Sridharan S, Duvvuri U, Ferris RL, et al. Transition to a virtual multidisciplinary tumor board during the COVID-19 pandemic: University of Pittsburgh experience. Head Neck. 2020;42(6):1310–6.

Stevenson MM, Irwin T, Lowry T, Ahmed MZ, Walden TL, Watson M, Sutton L. Development of a virtual multidisciplinary lung cancer tumor board in a community setting. J Oncol Pract. 2013;9(3):e77-80.

Popat S, Navani N, Kerr KM, Smit EF, Batchelor TJP, Van Schil P, Senan S, McDonald F. Navigating diagnostic and treatment decisions in non-small cell lung cancer: expert commentary on the multidisciplinary team approach. Oncologist. 2021;26(2):e306–15.

Rao S, Pitel B, Wagner AH, Boca SM, McCoy M, King I, et al. Collaborative, Multidisciplinary Evaluation of Cancer Variants Through Virtual Molecular Tumor Boards Informs Local Clinical Practices. JCO Clin Cancer Inform. 2020;4:602–13.

Specchia ML, Frisicale EM, Carini E, Di Pilla A, Cappa D, Barbara A, et al. The impact of tumor board on cancer care: evidence from an umbrella review. BMC Health Serv Res. 2020;20(1):73–82.

Coory M, Gkolia P, Yang IA, Bowman RV, Fong KM. Systematic review of multidisciplinary teams in the management of lung cancer. Lung Cancer. 2008;60(1):14–21.

Stone E, Rankin N, Currow D, Fong KM, Phillips JL, Shaw T. Optimizing lung cancer MDT data for maximum clinical impact-a scoping literature review. Transl Lung Cancer Res. 2020;9(4):1629–38.

Chang JH, Vines E, Bertsch H, Fraker DL, Czerniecki BJ, Rosato EF, et al. The impact of a multidisciplinary breast cancer center on recommendations for patient management: the University of Pennsylvania experience. Cancer. 2001;91(7):1231–7.

Leo F, Venissac N, Poudenx M, Otto J, Mouroux J, Groupe d’Oncologie Thoracique Azuréen. Multidisciplinary management of lung cancer: how to test its efficacy? J Thorac Oncol. 2007;2(1):69–72.

Boxer MM, Vinod SK, Shafiq J, Duggan KJ. Do multidisciplinary team meetings make a difference in the management of lung cancer? Cancer. 2011;117(22):5112–20.

Kesson EM, Allardice GM, George WD, Burns HJ, Morrison DS. Effects of multidisciplinary team working on breast cancer survival: retrospective, comparative, interventional cohort study of 13722 women. Brit Med J. 2012;344:e27118.

Kehl KL, Landrum MB, Kahn KL, Gray SW, Chen AB, Keating NL. Tumor board participation among physicians caring for patients with lung or colorectal cancer. J Oncol Pract. 2015;11(3):e267-278.

Pan CC, Kung PT, Wang YH, Chang YC, Wang ST, Tsai WC. Effects of multidisciplinary team care on the survival of patients with different stages of non-small cell lung cancer: a national cohort study. PLoS ONE. 2015;10(5):e0126547.

Stone E, Rankin N, Kerr S, Fong K, Currow DC, Phillips J, et al. Does presentation at multidisciplinary team meetings improve lung cancer survival? Findings from a consecutive cohort study. Lung Cancer. 2018;124:199–204.

Tamburini N, Maniscalco P, Mazzara S, Maietti E, Santini A, Calia N, et al. Multidisciplinary management improves survival at 1 year after surgical treatment for non-small-cell lung cancer: a propensity score-matched study. Eur J Cardiothorac Surg. 2018;53(6):1199–204.

Freytag M, Herrlinger U, Hauser S, Bauernfeind FG, Gonzalez-Carmona MA, Landsberg J, et al. Higher number of multidisciplinary tumor board meetings per case leads to improved clinical outcome. BMC Cancer. 2020;20(1):355.

Hung HY, Tseng YH, Chao HS, Chiu CH, Hsu WH, Hsu HS, et al. Multidisciplinary team discussion results in survival benefit for patients with stage III non-small-cell lung cancer. PLoS ONE. 2020;15(10):e0236503.

Bruni A, Giaj-Levra N, Ciammella P, Maragna V, Ferrari K, Bonti V, et al. Management of locally advanced non-small cell lung cancer in the modern era: a national Italian survey on diagnosis, treatment and multidisciplinary approach. PLoS ONE. 2019;14(11):e0224027.

Hoeijmakers F, Heineman DJ, Daniels JM, Beck N, Tollenaar RAEM, Wouters MWJM, MDT Study Group, et al. Variation between multidisciplinary tumor boards in clinical staging and treatment recommendations for patients with locally advanced non-small cell lung cancer. Chest. 2020;158(6):2675–87.

Rankin NM, Fradgley EA, Barnes DJ. Implementation of lung cancer multidisciplinary teams: a review of evidence-practice gaps. Transl Lung Cancer Res. 2020;9(4):1667–79.

Rosell L, Alexandersson N, Hagberg O, Nilbert M. Benefits, barriers and opinions on multidisciplinary team meetings: a survey in Swedish cancer care. BMC Health Serv Res. 2018;18(1):249.

Klarenbeek SE, Schuurbiers-Siebers OCJ, van den Heuvel MM, Prokop M, Tummers M. Barriers and facilitators for implementation of a computerized clinical decision support system in lung cancer multidisciplinary team meetings—a qualitative assessment. Biology (Basel). 2020;10(1):9.

Rosell L, Wihl J, Nilbert M, Malmström M. Health professionals’ views on key enabling factors and barriers of national multidisciplinary team meetings in cancer care: a qualitative study. J Multidiscip Healthc. 2020;13:179–86.

Stone E, Rankin NM, Vinod SK, Nagarajah M, Donnelly C, Currow DC, Fong KM, Phillips JL, Shaw T. Clinical impact of data feedback at lung cancer multidisciplinary team meetings: a mixed methods study. Asia Pac J Clin Oncol. 2020;16(1):45–55.

Wakeham E, Odell D, Samson P. Measuring the quality of multidisciplinary thoracic oncology care. J Thorac Dis. 2019;11(Suppl 4):S562–5.

Hahlweg P, Didi S, Kriston L, Härter M, Nestoriuc Y, Scholl I. Process quality of decision-making in multidisciplinary cancer team meetings: a structured observational study. BMC Cancer. 2017;17(1):772.

Kim MS, Park HY, Kho BG, Park CK, Oh IJ, Kim YC, et al. Artificial intelligence and lung cancer treatment decision: agreement with recommendation of multidisciplinary tumor board. Transl Lung Cancer Res. 2020;9(3):507–14.

Sutton RT, Pincock D, Baumgart DC, Sadowski DC, Fedorak RN, Kroeker KI. An overview of clinical decision support systems: benefits, risks, and strategies for success. NPJ Digit Med. 2020;3:17.

Khairat S, Marc D, Crosby W, Al SA. Reasons for physicians not adopting clinical decision support systems: critical analysis. JMIR Med Inf. 2018;6(2):e24.

Pluyter JR, Jacobs I, Langereis S, Cobben D, Williams S, Curfs J, van den Borne B. Looking through the eyes of the multidisciplinary team: the design and clinical evaluation of a decision support system for lung cancer care. Transl Lung Cancer Res. 2020;9(4):1422–32.

Smotherman C, Norez D, Austin-Datta R, Yaghjyan L. COVID-19 in patients with cancer. Lancet Oncol. 2020;21(12):e539.

Blasi L, Bordonaro R, Serretta V, Piazza D, Firenze A, Gebbia V. Virtual Clinical and Precision Medicine Tumor Boards: a Cloud-based Platform-mediated Implementation of Multi-disciplinary Reviews among Oncology Centers in the Covid-19 Era. JMIR Res Protoc. 2021. (in press)

Rankin NM, Collett GK, Brown CM, Shaw TJ, White KM, Beale PJ, et al. Implementation of a lung cancer multidisciplinary team standardised template for reporting to general practitioners: a mixed-method study. Brit Med J Open. 2017;7(12):e018629.

Jalil R, Soukup T, Akhter W, Sevdalis N, Green JSA. Quality of leadership in multidisciplinary cancer tumor boards: development and evaluation of a leadership assessment instrument (ATLAS). World J Urol. 2018;36(7):1031–8.

Wihl J, Rosell L, Bendahl PO, De Mattos CBR, Kinhult S, Lindell G, et al. Leadership perspectives in multidisciplinary team meetings; observational assessment based on the ATLAS instrument in cancer care. Cancer Treat Res Commun. 2020;25:100231.

Kane B, Luz S, O’Briain DS, McDermott R. Multidisciplinary team meetings and their impact on workflow in radiology and pathology departments. BMC Med. 2007;5:15.

Rangabashyam M, Wee HE, Wang W, Mueller S, Karim KABA, Skanthakumar T, et al. Electronic tumor board presentations as the basis for the development of a head and neck cancer database. Laryngosc Investig Otolaryngol. 2020;5(1):46–54.