Viral targets of acylguanidines

Drug Discovery Today - Tập 17 - Trang 1039-1043 - 2012
Elena V. Gazina1, Steven Petrou1
1Florey Neuroscience Institutes, The University of Melbourne, Victoria 3010, Australia

Tài liệu tham khảo

Cragoe, 1967, Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides, J. Med. Chem., 10, 66, 10.1021/jm00313a014 Kleyman, 1988, Amiloride and its analogs as tools in the study of ion transport, J. Membr. Biol., 105, 1, 10.1007/BF01871102 Masereel, 2003, An overview of inhibitors of Na(+)/H(+) exchanger, Eur. J. Med. Chem., 38, 547, 10.1016/S0223-5234(03)00100-4 Lee, 2005, (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1, J. Med. Chem., 48, 2882, 10.1021/jm0492305 Kilmarx, 2009, Global epidemiology of HIV, Curr. Opin. HIV AIDS, 4, 240, 10.1097/COH.0b013e32832c06db Fanales-Belasio, 2010, HIV virology and pathogenetic mechanisms of infection: a brief overview, Ann. Ist. Super. Sanita, 46, 5 Ruiz, 2010, The Vpu protein: new concepts in virus release and CD4 down-modulation, Curr. HIV Res., 8, 240, 10.2174/157016210791111124 Singh, 2003, The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4+ T cell loss caused by the simian-human immunodeficiency virus SHIVKU-lbMC33 in pig-tailed macaques, Virology, 313, 435, 10.1016/S0042-6822(03)00339-8 Sato, 2012, Vpu augments the initial burst phase of HIV-1 propagation and downregulates BST2 and CD4 in humanized mice, J. Virol., 10.1128/JVI.07062-11 Ewart, 1996, The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels, J. Virol., 70, 7108, 10.1128/JVI.70.10.7108-7115.1996 Schubert, 1996, Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells, FEBS Lett., 398, 12, 10.1016/S0014-5793(96)01146-5 Ewart, 2002, Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu, Eur. Biophys. J., 31, 26, 10.1007/s002490100177 Ewart, 2004, Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages, Antimicrob. Agents Chemother., 48, 2325, 10.1128/AAC.48.6.2325-2330.2004 Khoury, 2010, Antiviral efficacy of the novel compound BIT225 against HIV-1 release from human macrophages, Antimicrob. Agents Chemother., 54, 835, 10.1128/AAC.01308-09 Schubert, 1996, The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains, J. Virol., 70, 809, 10.1128/JVI.70.2.809-819.1996 Bolduan, 2011, Ion channel activity of HIV-1 Vpu is dispensable for counteraction of CD317, Virology, 416, 75, 10.1016/j.virol.2011.04.009 Kuhl, 2011, The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism, PLoS One, 6, E27660, 10.1371/journal.pone.0027660 Shah, 2010, Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu, Cell Host Microbe, 8, 397, 10.1016/j.chom.2010.10.008 Moll, 2010, Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments, Blood, 116, 1876, 10.1182/blood-2009-09-243667 Lavanchy, 2011, Evolving epidemiology of hepatitis C virus, Clin. Microbiol. Infect., 17, 107, 10.1111/j.1469-0691.2010.03432.x Vermehren, 2011, New hepatitis C therapies in clinical development, Eur. J. Med. Res., 16, 303, 10.1186/2047-783X-16-7-303 Ashfaq, 2011, An overview of HCV molecular biology, replication and immune responses, Virol. J., 8, 161, 10.1186/1743-422X-8-161 Carrere-Kremer, 2002, Subcellular localization and topology of the p7 polypeptide of hepatitis C virus, J. Virol., 76, 3720, 10.1128/JVI.76.8.3720-3730.2002 Clarke, 2006, Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro, J. Biol. Chem., 281, 37057, 10.1074/jbc.M602434200 Griffin, 2003, The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, amantadine, FEBS Lett., 535, 34, 10.1016/S0014-5793(02)03851-6 Pavlovic, 2003, The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives, Proc. Natl. Acad. Sci. U.S.A., 100, 6104, 10.1073/pnas.1031527100 Premkumar, 2004, Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride, FEBS Lett., 557, 99, 10.1016/S0014-5793(03)01453-4 Jones, 2007, Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus, J. Virol., 81, 8374, 10.1128/JVI.00690-07 Steinmann, 2007, Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions, PLoS Pathog., 3, E103, 10.1371/journal.ppat.0030103 Sakai, 2003, The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences, Proc. Natl. Acad. Sci. U.S.A., 100, 11646, 10.1073/pnas.1834545100 Gastaminza, 2008, Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion, J. Virol., 82, 2120, 10.1128/JVI.02053-07 Rouille, 2006, Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus, J. Virol., 80, 2832, 10.1128/JVI.80.6.2832-2841.2006 Boson, 2011, A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly, PLoS Pathog., 7, E1002144, 10.1371/journal.ppat.1002144 Tedbury, 2011, The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein, J. Gen. Virol., 92, 819, 10.1099/vir.0.027441-0 Wozniak, 2010, Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production, PLoS Pathog., 6, E1001087, 10.1371/journal.ppat.1001087 Luscombe, 2010, A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues, Antiviral Res., 86, 144, 10.1016/j.antiviral.2010.02.312 Guzman, 2010, Dengue: a continuing global threat, Nat. Rev. Microbiol., 8, S7, 10.1038/nrmicro2460 Urcuqui-Inchima, 2010, Recent developments in understanding dengue virus replication, Adv. Virus Res., 77, 1, 10.1016/B978-0-12-385034-8.00001-6 Yu, 2008, Structure of the immature dengue virus at low pH primes proteolytic maturation, Science, 319, 1834, 10.1126/science.1153264 Premkumar, 2005, Dengue virus M protein C-terminal peptide (DVM-C) forms ion channels, J. Membr. Biol., 204, 33, 10.1007/s00232-005-0744-9 Wong, 2011, Dengue virus PrM/M proteins fail to show pH-dependent ion channel activity in Xenopus oocytes, Virology, 412, 83, 10.1016/j.virol.2010.12.050 Perlman, 2009, Coronaviruses post-SARS: update on replication and pathogenesis, Nat. Rev. Microbiol., 7, 439, 10.1038/nrmicro2147 DeDiego, 2007, A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo, J. Virol., 81, 1701, 10.1128/JVI.01467-06 DeDiego, 2008, Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice, Virology, 376, 379, 10.1016/j.virol.2008.03.005 Nieto-Torres, 2011, Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein, Virology, 415, 69, 10.1016/j.virol.2011.03.029 Torres, 2006, Model of a putative pore: the pentameric alpha-helical bundle of SARS coronavirus E protein in lipid bilayers, Biophys. J., 91, 938, 10.1529/biophysj.105.080119 Wilson, 2004, SARS coronavirus E protein forms cation-selective ion channels, Virology, 330, 322, 10.1016/j.virol.2004.09.033 Torres, 2007, Conductance and amantadine binding of a pore formed by a lysine-flanked transmembrane domain of SARS coronavirus envelope protein, Protein Sci., 16, 2065, 10.1110/ps.062730007 Pervushin, 2009, Structure and inhibition of the SARS coronavirus envelope protein ion channel, PLoS Pathog., 5, E1000511, 10.1371/journal.ppat.1000511 Wilson, 2006, Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication, Virology, 353, 294, 10.1016/j.virol.2006.05.028 Andreoletti, 2009, Viral causes of human myocarditis, Arch Cardiovasc. Dis., 102, 559, 10.1016/j.acvd.2009.04.010 Cameron, 2010, Expanding knowledge of P3 proteins in the poliovirus lifecycle, Future Microbiol., 5, 867, 10.2217/fmb.10.40 Ferrer-Orta, 2009, Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase, Curr. Opin. Struct. Biol., 19, 752, 10.1016/j.sbi.2009.10.016 Steil, 2009, Cis-active RNA elements (CREs) and picornavirus RNA replication, Virus Res., 139, 240, 10.1016/j.virusres.2008.07.027 Harrison, 2008, Amiloride derivatives inhibit coxsackievirus B3 RNA replication, J. Virol., 82, 1465, 10.1128/JVI.01374-07 Gazina, 2011, Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase, J. Virol., 85, 10364, 10.1128/JVI.05022-11 de Jong, 2003, Determinants for membrane association and permeabilization of the coxsackievirus 2B protein and the identification of the Golgi complex as the target organelle, J. Biol. Chem., 278, 1012, 10.1074/jbc.M207745200 van Kuppeveld, 2002, Homomultimerization of the coxsackievirus 2B protein in living cells visualized by fluorescence resonance energy transfer microscopy, J. Virol., 76, 9446, 10.1128/JVI.76.18.9446-9456.2002 Zemach, 1990, The interaction of amiloride with acetylcholinesterase and butyrylcholinesterase, FEBS Lett., 263, 166, 10.1016/0014-5793(90)80730-7 Zeslawska, 2000, Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design, J. Mol. Biol., 301, 465, 10.1006/jmbi.2000.3966