Vieillissement et évolution démentielle du trouble bipolaire
Tóm tắt
Le trouble bipolaire est un trouble de l’humeur fréquent qui concerne 1 à 2 % de la population. Il est sous-tendu par des mécanismes physiopathologiques multiples et revêt une présentation clinique polymorphe. Son vieillissement, encore peu étudié, est variable d’un sujet à l’autre avec une grande hétérogénéité interindividuelle. La symptomatologie des décompensations thymiques pourrait se modifier avec le temps. L’évolution démentielle observée chez certains individus semble relever de plusieurs étiologies. Il pourrait s’agir dans certaines situations d’un déclin cognitif spécifique directement en lien avec le vieillissement du trouble bipolaire, et dans d’autre cas d’une association fortuite avec une maladie neurodégénérative. Plus récemment, des liens avec la démence frontotemporale ont également été suggérés.
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