Sự biến đổi trong tổn thương nhiễm sắc thể tự phát như một chức năng của nhịp sinh học ở phụ nữ

Springer Science and Business Media LLC - Tập 79 - Trang 83-85 - 1988
Doris D'Souza1, I. M. Thomas1, B. C. Das2
1Human Genetics Laboratory, Department of Anatomy, St. John's Medical College, Bangalore, India
2Cytogenetics Division, Cytology Research Centre (ICMR), Maulana Azad Medical College Campus, New Delhi, India

Tóm tắt

Một quan sát rõ ràng về tỷ lệ tổn thương di truyền tế bào cao hơn, thể hiện qua sự gia tăng tần suất các trao đổi chromatid chị em (SCEs) và các biến dạng nhiễm sắc thể trong giai đoạn "rụng trứng" và "estrogen" so với giai đoạn "progesterone" của chu kỳ kinh nguyệt ở phụ nữ, cùng với những biến động đã báo cáo về SCEs theo thời gian ở nam giới, chỉ ra rằng các yếu tố sinh học theo chu kỳ là rất quan trọng trong thiết kế các nghiên cứu về con người và thực nghiệm động vật. Dường như các đối tượng nữ bị ảnh hưởng nhiều hơn bởi nhịp sinh học do các chu kỳ hormone đặc thù và nhạy cảm với tổn thương di truyền trong các giai đoạn rụng trứng/estrogen của chu kỳ kinh nguyệt.

Từ khóa

#tổn thương di truyền #chu kỳ kinh nguyệt #nhịp sinh học #trao đổi chromatid chị em #biến dạng nhiễm sắc thể

Tài liệu tham khảo

Beaconsfield P, Ginsberg J (1968) Oral contraceptives and cell replication. Lancet I:592 Block AW, Evans SS, Ozer H, Sandberg AA (1985) Sister chromatid exchange analysis of T-cell subsets isolated by antibody-mediated plate binding. Am J Hum Genet 37:A87 (abstr) Carrano AV, Minkler JL, Stetka DG, Moore DH II (1980) Variation in baseline sister chromatid exchange frequency in human lymphocytes. Environ Mutagen 2:325–337 Das BC (1988) Factors that influence formation of sister chromatid exchanges in lymphocyte cultures. CRC Crit Rev Oncol Hematol (in press) Dewdney RS, Lovell DP, Jenkinson PC, Anderson D (1986) Variation in sister chromatid exchange among 106 members of the general UK population. Mutat Res 171:43–51 Haus E, Lakatua JD, Swoyer J, Lundeen LS (1983) Chronobiology in hematology and immunology. Am J Anat 168:467–528 Hill A, Wolff S (1982) Increased induction of sister chromatid exchange by diethylstilbestrol in lymphocytes from pregnant and premenopausal women. Cancer Res 42:893–896 Hrushesky WJM (1983) The clinical application of chronobiology to oncology. Am J Anat 168:519–534 Husgafavel-Pursiainen K, Sersa M, Jarventaus H, Norppa H (1984) Sister chromatid exchanges in lymphocytes of smokers in an experimental study. Mutat Res 138:197–203 Kochhar TS (1985) Inducibility of chromosome aberrations by steroid hormones in cultured Chinese hamster ovary cells. Toxicol Lett 29:201–206 Littlefield LG, Lever WE, Miller FL, Goh KO (1975) Chromosome breakage studies in lymphocytes from normal women, pregnant women, and women taking oral contraceptives. Am J Obstet Gynecol 121:976–980 Liu LF, Liu CC, Alberts BM (1980) Type II DNA topoisomerases: enzymes that can unknot a topologically knoted DNA molecule via a reversible doublestrand break. Cell 19:697–707 Lukić B, Barjaktarović N (1987) Sister chromatid exchanges in newborns after normal and progesterone treated pregnancies. Mutat Res 191:121–124 Margolin BH, Shelby MD (1985) Sister chromatid exchanges: a reexamination of the evidence for sex and race differences in humans. Environ Mutagen[Suppl 4] 7:63–72 McQuarrie HG, Scott C, Ellworth HS, Harris JW, Stone RA (1970) Cytogenetic studies on women using oral contraceptives and their pregnancy. Am J Obstet Gynecol 108:659–662 Moore DH II, Carrano AV (1984) Statistical analysis of high SCE frequency cells in human lymphocytes. In: Tice RR, Hollaender A (eds) Basic life sciences, vol 29. Plenum Press, New York, pp 149–152 Murthy PBK, Prema K (1979) Sister chromatid exchange in oral contraceptive users. Mutat Res 68:149–152 Murthy PBK, Prema K (1983) Further study on sister chromatid exchange frequency in users of hormonal contraceptives. Mutat Res 119:351–354 Parkes DT, Scott D, Stewart A (1985) Changes in spontaneous SCE frequencies as a function of sampling time in lymphocytes from normal donors and cancer patients. Mutat Res 147:113–122 Pinto MR (1986) Possible effects of hormonal contraceptives on human miotic chromosomes. Mutat Res 169: 149–158 Santesson B (1986) Different baseline sister chromatid exchange levels in density fractionated human lymphocytes. Hum Genet 73:114–118 Schulster D, Burstein S, Cooke BA (1976) Molecular endocrinology of steroid hormones. Wiley, New York Sharma T, Das BC (1986) Higher incidence of spontaneous sister chromatid exchanges (SCEs) and X-ray-induced chromosome aberrations in peripheral blood lymphocytes during pregnancy. Mutat Res 174:27–33 Slozina NM, Golovachev GD (1986) Frequency of sister chromatid exchanges in human lymphocytes at different times of the day. Tsitologiia 28:127–132 Snope AJ, Rary JM (1979) Cell cycle duration and sister chromatid exchange frequency in cultured human lymphocytes. Mutat Res 63:345–349 Soper KA, Stolley PD, Galloway SM, Smith JG, Nichols WW, Wolman SR (1984) Sister chromatid exchange (SCE) report on control subjects in a study of occupationally exposed workers. Mutat Res 129:77–88 Speit G, Duering R, Mehnert K (1986) Variation in the frequency of sister chromatid exchanges in repeated human lymphocyte cultures. Hum Genet 72:179–181 Stetka DG, Minkler J, Carrano AV (1978) Induction of long-lived chromosome damage as manifested by sister chromatid exchange in lymphocytes of animals exposed to mitomycin C. Mutat Res 51:383–396 Tucker JD, Christensen ML, Strout CL, McGee KA, Carrano AV (1987) Variation in the human lymphocyte sister chromatid exchange frequency as a function of time: results of daily and twice-weekly sampling. Environ Mol Mutagen 10:69–78 Wang J, Liu LF (1979) DNA topoisomerases: enzymes that catalyze the concerted breaking and rejoining of DNA backbone bonds. In: Taylor JH (ed) Molecular genetics, vol 3. Academic Press, New York London, pp 65–88 Williams DL, Runyan JW Jr, Hagen AA (1968) Meiotic chromosome alterations produced by progesterone. Nature 220:1145–1146