Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Sự biến đổi trong tổn thương nhiễm sắc thể tự phát như một chức năng của nhịp sinh học ở phụ nữ
Tóm tắt
Một quan sát rõ ràng về tỷ lệ tổn thương di truyền tế bào cao hơn, thể hiện qua sự gia tăng tần suất các trao đổi chromatid chị em (SCEs) và các biến dạng nhiễm sắc thể trong giai đoạn "rụng trứng" và "estrogen" so với giai đoạn "progesterone" của chu kỳ kinh nguyệt ở phụ nữ, cùng với những biến động đã báo cáo về SCEs theo thời gian ở nam giới, chỉ ra rằng các yếu tố sinh học theo chu kỳ là rất quan trọng trong thiết kế các nghiên cứu về con người và thực nghiệm động vật. Dường như các đối tượng nữ bị ảnh hưởng nhiều hơn bởi nhịp sinh học do các chu kỳ hormone đặc thù và nhạy cảm với tổn thương di truyền trong các giai đoạn rụng trứng/estrogen của chu kỳ kinh nguyệt.
Từ khóa
#tổn thương di truyền #chu kỳ kinh nguyệt #nhịp sinh học #trao đổi chromatid chị em #biến dạng nhiễm sắc thểTài liệu tham khảo
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