Validation of Anti-pyretic-Derived Natural Products and Their Potentials for Drug Discovery

Revista Brasileira de Farmacognosia - Tập 33 - Trang 696-712 - 2023
Ahmed Zayed1,2, Mohamed A. Salem3, Walaa A. Negm1, Shahira M. Ezzat4,5
1Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt
2Institute of Bioprocess Engineering, Rheinland-Pfälzische Technische Universität Kaiserslautern Landau, Kaiserslautern, Germany
3Department of Pharmacognosy and Natural Products, Faculty of Pharmacy, Menoufia University, Shibin Elkom, Egypt
4Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
5Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt

Tóm tắt

Fever is a complicated process that occurs in response to infection and inflammatory diseases, stimulating the immune system that may cause severe biological changes in the human body. Hence, anti-pyretic agents are prescribed to reduce elevated body temperature in order to maintain thermal homeostasis and protect the brain from damage. Additionally, there is always a growing need for safe and effective anti-pyretic drugs derived from natural products, especially that anti-pyretic pathways have been investigated well in previous literature. Many animal models are established for assessing anti-pyretic candidates resulting in two types of anti-pyretics. They are the endogenous anti-pyretics that act as a defense mechanism for temperature regulation and the exogenous anti-pyretics. The current article discusses the main anti-pyretic pathways, models for assessing anti-pyretics, metabolomics applications in anti-pyretic assays, and screening of anti-pyretic and analgesic natural products. Screening of plant-derived natural products and active principles with anti-pyretic, anti-inflammatory, and analgesic activities, in addition to their mechanism of action and validation methods, is described in the current article. Hence, this review could contribute to the introduction of a site-specific and safe naturally derived anti-pyretic medications with potential therapeutic qualities compared to currently available synthetic anti-pyretics.

Tài liệu tham khảo

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