Validating real-time three-dimensional echocardiography against cardiac magnetic resonance, for the determination of ventricular mass, volume and ejection fraction: a meta-analysis

Clinical Research in Cardiology - 2024
Thilini Dissabandara1, Kelly Lin2, M. R. Forwood1, Jing Sun2
1School of Pharmacy and Medical Science, Griffith University, Gold Coast, Australia
2Schools of Medicine and Dentistry, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia

Tóm tắt

Abstract Introduction Real-time three-dimensional echocardiography (RT3DE) is currently being developed to overcome the challenges of two-dimensional echocardiography, as it is a much cheaper alternative to the gold standard imaging method, cardiac magnetic resonance (CMR). The aim of this meta-analysis is to validate RT3DE by comparing it to CMR, to ascertain whether it is a practical imaging method for routine clinical use. Methods A systematic review and meta-analysis method was used to synthesise the evidence and studies published between 2000 and 2021 were searched using a PRISMA approach. Study outcomes included left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), left ventricular mass (LVM), right ventricular end-systolic volume (RVESV), right ventricular end-diastolic volume (RVEDV) and right ventricular ejection fraction (RVEF). Subgroup analysis included study quality (high, moderate), disease outcomes (disease, healthy and disease), age group (50 years old and under, over 50 years), imaging plane (biplane, multiplane) and publication year (2010 and earlier, after 2010) to determine whether they explained the heterogeneity and significant difference results generated on RT3DE compared to CMR. Results The pooled mean differences for were − 5.064 (95% CI − 10.132, 0.004, p > 0.05), 4.654 (95% CI − 4.947, 14.255, p > 0.05), − 0.783 (95% CI − 5.630, 4.065, p > 0.05, − 0.200 (95% CI − 1.215, 0.815, p > 0.05) for LVEF, LVM, RVESV and RVEF, respectively. We found no significant difference between RT3DE and CMR for these variables. Although, there was a significant difference between RT3DE and CMR for LVESV, LVEDV and RVEDV where RT3DE reports a lower value. Subgroup analysis indicated a significant difference between RT3DE and CMR for studies with participants with an average age of over 50 years but no significant difference for those under 50. In addition, a significant difference between RT3DE and CMR was found in studies using only participants with cardiovascular diseases but not in those using a combination of diseased and healthy participants. Furthermore, for the variables LVESV and LVEDV, the multiplane method shows no significant difference between RT3DE and CMR, as opposed to the biplane showing a significant difference. This potentially indicates that increased age, the presence of cardiovascular disease and the biplane analysis method decrease its concordance with CMR. Conclusion This meta-analysis indicates promising results for the use of RT3DE, with limited difference to CMR. Although in some cases, RT3DE appears to underestimate volume, ejection fraction and mass when compared to CMR. Further research is required in terms of imaging method and technology to validate RT3DE for routine clinical use. Graphical abstract

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Tài liệu tham khảo

Sanz JA, Galar M, Jurio A, Brugos A, Pagola M, Bustince H (2014) Medical diagnosis of cardiovascular diseases using an interval-valued fuzzy rule-based classification system. Appl Soft Comput 20:103–111

Tsao CW, Gona PN, Salton CJ, Chuang ML, Levy D, Manning WJ et al (2015) Left ventricular structure and risk of cardiovascular events: a framingham heart study cardiac magnetic resonance study. J Am Heart Assoc 4(9):e002188

Mangion JR (2010) Right ventricular imaging by two-dimensional and three-dimensional echocardiography. Curr Opin Cardiol 25(5):423–429

Grune J, Blumrich A, Brix S, Jeuthe S, Drescher C, Grune T et al (2018) Evaluation of a commercial multi-dimensional echocardiography technique for ventricular volumetry in small animals. Cardiovasc Ultrasound 16(1):10

Wu VC, Takeuchi M (2017) Three-dimensional echocardiography: current status and real-life applications. Acta Cardiol Sin 33(2):107–118

Cheng K, Monaghan MJ, Kenny A, Rana B, Steeds R, Mackay C, van der Westhuizen D (2018) 3D echocardiography: benefits and steps to wider implementation. J Cardiol 25:63–68. https://doi.org/10.5837/bjc.2018.014

Lang RM, Mor-Avi V, Sugeng L, Nieman PS, Sahn DJ (2006) Three-dimensional echocardiography: the benefits of the additional dimension. J Am Coll Cardiol 48(10):2053–2069

Dorosz JL, Lezotte DC, Weitzenkamp DA, Allen LA, Salcedo EE (2012) Performance of 3-dimensional echocardiography in measuring left ventricular volumes and ejection fraction: a systematic review and meta-analysis. J Am Coll Cardiol 59(20):1799–1808

Kitano T, Nabeshima Y, Otsuji Y, Negishi K, Takeuchi M (2019) Accuracy of left ventricular volumes and ejection fraction measurements by contemporary three-dimensional echocardiography with semi- and fully automated software: systematic review and meta-analysis of 1,881 subjects. J Am Soc Echocardiogr 32(9):1105–15 e5

Pickett CA, Cheezum MK, Kassop D, Villines TC, Hulten EA (2015) Accuracy of cardiac CT, radionucleotide and invasive ventriculography, two- and three-dimensional echocardiography, and SPECT for left and right ventricular ejection fraction compared with cardiac MRI: a meta-analysis. Eur Heart J Cardiovasc Imaging 16(8):848–852

Shimada YJ, Shiota T (2012) Meta-analysis of accuracy of left ventricular mass measurement by three-dimensional echocardiography. Am J Cardiol 110(3):445–452

Shimada YJ, Shiota T (2011) A meta-analysis and investigation for the source of bias of left ventricular volumes and function by three-dimensional echocardiography in comparison with magnetic resonance imaging. Am J Cardiol 107(1):126–138

Yap SC, van Geuns RJ, Nemes A, Meijboom FJ, McGhie JS, Geleijnse ML et al (2008) Rapid and accurate measurement of LV mass by biplane real-time 3D echocardiography in patients with concentric LV hypertrophy: comparison to CMR. Eur J Echocardiogr 9(2):255–260

Le HT, Hangiandreou N, Timmerman R, Rice MJ, Smith WB, Deitte L, Janelle GM (2016) Imaging Artifacts in Echocardiography. Anesth Analg 122(3):633–646. https://doi.org/10.1213/ANE.0000000000001085

Mohamed AA, Arifi AA, Omran A (2010) The basics of echocardiography. J Saudi Heart Assoc 22(2):71–76. https://doi.org/10.1016/j.jsha.2010.02.011

Adab P, Pallan MJ, Lancashire ER, Hemming K, Frew E, Griffin T et al (2015) A cluster-randomised controlled trial to assess the effectiveness and cost-effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6–7 year old children: the WAVES study protocol. BMC Public Health 15:488

Bland JM, Altman DG (1999) Measuring agreement in method comparison studies. Stat Methods Med Res 8(2):135-160. https://doi.org/10.1177/096228029900800204

Avegliano GP, Costabel JP, Asch FM, Sciancalepore A, Kuschnir P, Huguet M et al (2016) Utility of real time 3D echocardiography for the assessment of left ventricular mass in patients with hypertrophic cardiomyopathy: comparison with cardiac magnetic resonance. Echocardiography 33(3):431–436

Bech-Hanssen O, Polte CL, Lagerstrand KM, Johnsson AA, Fadel BM, Gao SA (2016) Left ventricular volumes by echocardiography in chronic aortic and mitral regurgitations. Scand Cardiovasc J 50(3):154–161

Bicudo LS, Tsutsui JM, Shiozaki A, Rochitte CE, Arteaga E, Mady C et al (2008) Value of real time three-dimensional echocardiography in patients with hypertrophic cardiomyopathy: comparison with two-dimensional echocardiography and magnetic resonance imaging. Echocardiography 25(7):717–726

Caiani EG, Corsi C, Sugeng L, MacEneaney P, Weinert L, Mor-Avi V et al (2006) Improved quantification of left ventricular mass based on endocardial and epicardial surface detection with real time three dimensional echocardiography. Heart 92(2):213–219

Gopal AS, Chukwu EO, Iwuchukwu CJ, Katz AS, Toole RS, Schapiro W et al (2007) Normal values of right ventricular size and function by real-time 3-dimensional echocardiography: comparison with cardiac magnetic resonance imaging. J Am Soc Echocardiogr 20(5):445–455

Jaochim Nesser H, Sugeng L, Corsi C, Weinert L, Niel J, Ebner C et al (2007) Volumetric analysis of regional left ventricular function with real-time three-dimensional echocardiography: validation by magnetic resonance and clinical utility testing. Heart 93(5):572–578

Kim J, Cohen SB, Atalay MK, Maslow AD, Poppas A (2015) Quantitative assessment of right ventricular volumes and ejection fraction in patients with left ventricular systolic dysfunction by real time three-dimensional echocardiography versus cardiac magnetic resonance imaging. Echocardiography 32(5):805–812

Mor-Avi V, Sugeng L, Weinert L, MacEneaney P, Caiani EG, Koch R et al (2004) Fast measurement of left ventricular mass with real-time three-dimensional echocardiography: comparison with magnetic resonance imaging. Circulation 110(13):1814–1818

Sugeng L, Mor-Avi V, Weinert L, Niel J, Ebner C, Steringer-Mascherbauer R et al (2010) Multimodality comparison of quantitative volumetric analysis of the right ventricle. JACC Cardiovasc Imaging 3(1):10–18

Sugeng L, Mor-Avi V, Weinert L, Niel J, Ebner C, Steringer-Mascherbauer R et al (2006) Quantitative assessment of left ventricular size and function: side-by-side comparison of real-time three-dimensional echocardiography and computed tomography with magnetic resonance reference. Circulation 114(7):654–661

Chang SA, Kim HK, Lee SC, Kim EY, Hahm SH, Kwon OM et al (2013) Assessment of left ventricular mass in hypertrophic cardiomyopathy by real-time three-dimensional echocardiography using single-beat capture image. J Am Soc Echocardiogr 26(4):436–442

Driessen MM, Kort E, Cramer MJ, Doevendans PA, Angevaare MJ, Leiner T et al (2014) Assessment of LV ejection fraction using real-time 3D echocardiography in daily practice: direct comparison of the volumetric and speckle tracking methodologies to CMR. Neth Heart J 22(9):383–390

Marsan NA, Westenberg JJ, Roes SD, van Bommel RJ, Delgado V, van der Geest RJ et al (2011) Three-dimensional echocardiography for the preoperative assessment of patients with left ventricular aneurysm. Ann Thorac Surg 91(1):113–121

Grapsa J, O’Regan DP, Pavlopoulos H, Durighel G, Dawson D, Nihoyannopoulos P (2010) Right ventricular remodelling in pulmonary arterial hypertension with three-dimensional echocardiography: comparison with cardiac magnetic resonance imaging. Eur J Echocardiogr 11(1):64–73

Miller CA, Pearce K, Jordan P, Argyle R, Clark D, Stout M et al (2012) Comparison of real-time three-dimensional echocardiography with cardiovascular magnetic resonance for left ventricular volumetric assessment in unselected patients. Eur Heart J Cardiovasc Imaging 13(2):187–195

Jenkins C, Moir S, Chan J, Rakhit D, Haluska B, Marwick TH (2009) Left ventricular volume measurement with echocardiography: a comparison of left ventricular opacification, three-dimensional echocardiography, or both with magnetic resonance imaging. Eur Heart J 30(1):98–106

Lu KJ, Chen JX, Profitis K, Kearney LG, DeSilva D, Smith G et al (2015) Right ventricular global longitudinal strain is an independent predictor of right ventricular function: a multimodality study of cardiac magnetic resonance imaging, real time three-dimensional echocardiography and speckle tracking echocardiography. Echocardiography 32(6):966–974

Zhang QB, Sun JP, Gao RF, Lee AP, Feng YL, Liu XR et al (2013) Feasibility of single-beat full-volume capture real-time three-dimensional echocardiography for quantification of right ventricular volume: validation by cardiac magnetic resonance imaging. Int J Cardiol 168(4):3991–3995

Kuhl HP, Schreckenberg M, Rulands D, Katoh M, Schafer W, Schummers G et al (2004) High-resolution transthoracic real-time three-dimensional echocardiography: quantitation of cardiac volumes and function using semi-automatic border detection and comparison with cardiac magnetic resonance imaging. J Am Coll Cardiol 43(11):2083–2090

Leibundgut G, Rohner A, Grize L, Bernheim A, Kessel-Schaefer A, Bremerich J et al (2010) Dynamic assessment of right ventricular volumes and function by real-time three-dimensional echocardiography: a comparison study with magnetic resonance imaging in 100 adult patients. J Am Soc Echocardiogr 23(2):116–126

Li Y, Wang Y, Zhai Z, Guo X, Yang Y, Lu X (2015) Real-time three-dimensional echocardiography to assess right ventricle function in patients with pulmonary hypertension. PLoS ONE 10(6):e0129557

Macron L, Lim P, Bensaid A, Nahum J, Dussault C, Mitchell-Heggs L et al (2010) Single-beat versus multibeat real-time 3D echocardiography for assessing left ventricular volumes and ejection fraction: a comparison study with cardiac magnetic resonance. Circ Cardiovasc Imaging 3(4):450–455

Moceri P, Doyen D, Bertora D, Cerboni P, Ferrari E, Gibelin P (2012) Real time three-dimensional echocardiographic assessment of left ventricular function in heart failure patients: underestimation of left ventricular volume increases with the degree of dilatation. Echocardiography 29(8):970–977

Oe H, Hozumi T, Arai K, Matsumura Y, Negishi K, Sugioka K et al (2005) Comparison of accurate measurement of left ventricular mass in patients with hypertrophied hearts by real-time three-dimensional echocardiography versus magnetic resonance imaging. Am J Cardiol 95(10):1263–1267

Shibayama K, Watanabe H, Iguchi N, Sasaki S, Mahara K, Umemura J et al (2013) Evaluation of automated measurement of left ventricular volume by novel real-time 3-dimensional echocardiographic system: Validation with cardiac magnetic resonance imaging and 2-dimensional echocardiography. J Cardiol 61(4):281–288

Qi X, Cogar B, Hsiung MC, Nanda NC, Miller AP, Yelamanchili P et al (2007) Live/real time three-dimensional transthoracic echocardiographic assessment of left ventricular volumes, ejection fraction, and mass compared with magnetic resonance imaging. Echocardiography 24(2):166–173

Squeri A, Censi S, Reverberi C, Gaibazzi N, Baldelli M, Binno SM et al (2017) Three-dimensional echocardiography in various types of heart disease: a comparison study of magnetic resonance imaging and 64-slice computed tomography in a real-world population. J Echocardiogr 15(1):18–26

Jenkins C, Bricknell K, Hanekom L, Marwick TH (2004) Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography. J Am Coll Cardiol 44(4):878–886

Wood PW, Choy JB, Nanda NC, Becher H (2014) Left ventricular ejection fraction and volumes: it depends on the imaging method. Echocardiography 31(1):87–100

Rigolli M, Anandabaskaran S, Christiansen JP, Whalley GA (2016) Bias associated with left ventricular quantification by multimodality imaging: a systematic review and meta-analysis. Open Heart 3(1):e000388

Shimada YJ, Shiota T (2012) Underestimation of left atrial volume by three-dimensional echocardiography validated by magnetic resonance imaging: a meta-analysis and investigation of the source of bias. Echocardiography 29(4):385-390. https://doi.org/10.1111/j.1540-8175.2011.01593.x

Kitzman DW (2000) Normal age-related changes in the heart: relevance to echocardiography in the elderly. Am J Geriatr Cardiol 9(6):311–320

Kou S, Caballero L, Dulgheru R, Voilliot D, De Sousa C, Kacharava G et al (2014) Echocardiographic reference ranges for normal cardiac chamber size: results from the NORRE study. Eur Heart J Cardiovasc Imaging 15(6):680–690

Siadecki S, Frasure S, Saul T, Lewiss R (2015) 2089557 High body mass index is strongly correlated with decreased image quality in focused bedside echocardiography. Ultrasound Med Biol 41:S34

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