Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

Nature - Tập 405 Số 6785 - Trang 458-462 - 2000
Lyudmila V. Borovikova1, Svetlana Ivanova1, Minghuang Zhang1, Huan Yang1, Galina I. Botchkina1, Linda R. Watkins2, Haichao Wang, Naji N. Abumrad3, John W. Eaton4, Kevin J. Tracey5
1The Picower Institute for Medical Research, Manhasset, 11030, New York, USA
2Department of Psychology, University of Colorado, Boulder, 80309, Colorado, USA
3Department of Emergency Medicine
4Department of Pediatrics, Baylor College of Medicine, Houston, 77030, Texas, USA
5Department of Surgery, North Shore University Hospital, Manhasset, 11030, New York, USA

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Tracey, K. J. et al. Shock and tissue injury induced by recombinant human cachectin. Science 234, 470–474 (1986).

Dinarello, C. A. The interleukin-1 family: 10 years of discovery. FASEB J. 8, 1314–1325 (1994).

Wang, H. et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285, 248–251 ( 1999).

Nathan, C. F. Secretory products of macrophages. J. Clin. Invest. 79, 319–326 (1987).

Besedovsky, H., Rey, D. A., Sorkin, E. & Dinarello, C. A. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233, 652–654 ( 1986).

Woiciechowsky, C. et al. Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury. Nature Med. 4, 808–813 (1998).

Hu, X. X., Goldmuntz, E. A. & Brosnan, C. F. The effect of norepinephrine on endotoxin-mediated macrophage activation. J. Neuroimmunol. 31, 35–42 (1991).

Lipton, J. M. & Catania, A. Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH. Immunol. Today 18, 140–145 (1997).

Watkins, L. R. & Maier, S. F. Implications of immune-to-brain communication for sickness and pain. Proc. Natl Acad. Sci. USA 96, 7710–7713 ( 1999).

Sternberg, E. M. Neural-immune interactions in health and disease. J. Clin. Invest. 100, 2641–2647 ( 1997).

Scheinman, R. I., Cogswell, P. C., Lofquist, A. K. & Baldwin, A. S. Jr Role of transcriptional activation of IkappaB alpha in mediation of immunosuppression by glucocorticoids. Science 270, 283– 286 (1995).

Gaykema, R. P., Dijkstra, I. & Tilders, F. J. Subdiaphragmatic vagotomy suppresses endotoxin-induced activation of hypothalamic corticotropin-releasing hormone neurons and ACTH secretion. Endocrinology 136, 4717– 4720 (1995).

Fleshner, M. et al. Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy. J. Neuroimmunol. 86, 134–141 (1998).

Watkins, L. R. et al. Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci. Lett. 183, 27–31 (1995).

Romanovsky, A. A., Simons, C. T., Szekely, M. & Kulchitsky, V. A. The vagus nerve in the thermoregulatory response to systemic inflammation. Am. J. Physiol. 273, R407– R413 (1997).

Antonica, A., Magni, F., Mearini, L. & Paolocci, N. Vagal control of lymphocyte release from rat thymus. J. Auton. Nerv. Syst. 48, 187–197 (1994).

Guslandi, M. Nicotine treatment for ulcerative colitis. Br. J. Clin. Pharmacol. 48, 481–484 ( 1999).

Sandborn, W. J. et al. Transdermal nicotine for mildly to moderately active ulcerative colitis. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 126, 364–371 (1997).

Sher, M. E. et al. The influence of cigarette smoking on cytokine levels in patients with inflammatory bowel disease. Inflamm. Bowel Dis. 5, 73–78 (1999).

Sato, E., Koyama S., Okubo, Y., Kubo, K. & Sekigushi, M. Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. Am. J. Physiol. 274, L970–L979 (1998).

Whaley, K., Lappin, D. & Barkas, T. C2 synthesis by human monocytes is modulated by a nicotinic cholinergic receptor. Nature 293, 580– 583 (1981).

Sato, K. Z. et al. Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. Neurosci. Lett. 266, 17–20 ( 1999).

Wathey, J. C., Nass, M. M. & Lester, H. A. Numerical reconstruction of the quantal event at nicotinic synapses. Biophys. J. 27, 145– 164 (1979).

Kumins, N. H., Hunt, J., Gamelli, R. L. & Filkins, J. P. Partial hepatoectomy reduces the endotoxin-induced peak circulating level of tumor necrosis factor in rats. Shock 5, 385–388 (1996).

Gregory, S. H. & Wing, E. J. Neutrophil-Kupffer-cell interaction in host defenses to systemic infections. Immunol. Today 19, 507–510 ( 1998).

Tracey, K. J. et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330, 662 –664 (1987).

Madretsma, G. S. et al. Nicotine inhibits the in vitro production of interleukin 2 and tumour necrosis factor-alpha by human mononuclear cells. Immunopharmacology 35, 47–51 ( 1996).

van Dijk, A. P. et al. Transdermal nicotine inhibits interleukin 2 synthesis by mononuclear cells derived from healthy volunteers. Eur. J. Clin. Invest. 28, 664–671 (1998).