Vaginal progesterone treatment for the prevention of preterm birth and intrahepatic cholestasis of pregnancy: A case-control study

Blencowe, 2012, National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications, Lancet, 379, 2162, 10.1016/S0140-6736(12)60820-4 Alfirevic, 2017, Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy, Cochrane Database Syst Rev, 6 Saccone, 2017, Italian preterm birth prevention (IPP) working group. Effect of cervical pessary on spontaneous preterm birth in women with singleton pregnancies and short cervical length: a randomized clinical trial, JAMA, 318, 2317, 10.1001/jama.2017.18956 Dugoff, 2018, Prevention of preterm birth with pessary in singletons (PoPPS): randomized controlled trial, Ultrasound Obstet Gynecol, 51, 573, 10.1002/uog.18908 Geenes, 2009, Intrahepatic cholestasis of pregnancy, World J Gastroenterol, 15, 2049, 10.3748/wjg.15.2049 Romero, 2018, Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data, Am J Obstet Gynecol, 218, 161, 10.1016/j.ajog.2017.11.576 Bicocca, 2018, Intrahepatic cholestasis of pregnancy: review of six national and regional guidelines, Eur J Obstet Gynecol Reprod Biol, 231, 180, 10.1016/j.ejogrb.2018.10.041 Bacq, 2009, ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahepatic cholestasis of pregnancy, J Med Genet, 46, 711, 10.1136/jmg.2009.067397 Floreani, 2016, New insights on intrahepatic cholestasis of pregnancy, Clin Liver Dis, 20, 177, 10.1016/j.cld.2015.08.010 Gonzalez, 1989, ICP in twin pregnancies, J Hepatol, 9, 84, 10.1016/0168-8278(89)90079-2 Bacq, 1997, Dubois F.Intrahepatic cholestasis of pregnancy: a French prospective study, Hepatology, 26, 358, 10.1002/hep.510260216 Vallejo, 2006, Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy, J Hepatol, 44, 1150, 10.1016/j.jhep.2005.09.017 Abu-Hayyeh, 2016, Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum, Hepatology, 63, 1287, 10.1002/hep.28265 Meng, 1997, Profiles of bile acids and progesterone metabolites in the urine and serum of women with intrahepatic cholestasis of pregnancy, J Hepatol, 27, 346, 10.1016/S0168-8278(97)80181-X Laatikainen, 1974, Effect of maternal intrahepatic cholestasis on fetal steroid metabolism, J Clin Invest, 53, 1709, 10.1172/JCI107722 Maiskar, 2019, Early onset intrahepatic cholestasis of pregnancy: is progesterone supplementation to be blamed for?, J Obstet Gynaecol India, 69, 192, 10.1007/s13224-018-1174-9 2011 2011, Royal College of obstetricians and gynaecologists, Obstetric Cholestasis 2019, ACOG committee opinion No. 764 summary: medically indicated late-preterm and early-term deliveries, Obstet Gynecol, 133, 400 Csapo, 1971, Peripheral plasma progesterone levels during human pregnancy and labor, Am J Obstet Gynecol, 110, 630, 10.1016/0002-9378(71)90242-0 Pieber, 2001, Interactions between progesterone receptor isoforms in myometrial cells in human labour, Mol Hum Reprod, 7, 875, 10.1093/molehr/7.9.875 Mesiano, 2004, Myometrial progesterone responsiveness and the control of human parturition, J Soc Gynecol Investig, 11, 193, 10.1016/j.jsgi.2003.12.004 Mazouni, 2006, Termination of pregnancy in patients with previous cesarean section, Contraception, 73, 244, 10.1016/j.contraception.2005.09.007 Smith, 2007, Parturition, N Engl J Med, 356, 271, 10.1056/NEJMra061360 Nadeem, 2016, Molecular evidence of functional progesterone withdrawal in human myometrium, Nat Commun, 7, 11565, 10.1038/ncomms11565 Furcron, 2015, Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface, Am J Obstet Gynecol, 213, 846 Boelig, 2019, Pharmacokinetics of vaginal progesterone in pregnancy, Am J Obstet Gynecol, 221, 263 Benifla, 1997, Effects of micronized natural progesterone on the liver during the third trimester of pregnancy, Contracept Fertil Sex, 25, 165 Ropponen, 2006, Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study, Hepatology, 43, 723, 10.1002/hep.21111 Marschall, 2013, Intrahepatic cholestasis of pregnancy and associated hepatobiliary disease: a population-based cohort study, Hepatology, 58, 1385, 10.1002/hep.26444 Wasmuth, 2007, Intrahepatic cholestasis of pregnancy: the severe form is associated with common variants of the hepatobiliary phospholipid transporter ABCB4 gene, Gut, 56, 265, 10.1136/gut.2006.092742 Hinoshita, 2001, Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection, J Hepatol, 35, 765, 10.1016/S0168-8278(01)00216-1 Wikström Shemer, 2013, Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study, BJOG, 120, 717, 10.1111/1471-0528.12174 Raz, 2015, Severe intrahepatic cholestasis of pregnancy is a risk factor for preeclampsia in singleton and twin pregnancies, Am J Obstet Gynecol, 213, 395 Kongwattanakul, 2018, Incidence, characteristics, maternal complications, and perinatal outcomes associated with preeclampsia with severe features and HELLP syndrome, Int J Womens Health, 10, 371, 10.2147/IJWH.S168569 Houten, 2006, Endocrine functions of bile acids, EMBO J, 25, 1419, 10.1038/sj.emboj.7601049 Thomas, 2008, Targeting bile-acid signalling for metabolic diseases, Nat Rev Drug Discov, 7, 678, 10.1038/nrd2619 Steiner, 2011, Bile acid metabolites in serum: intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitus, PLoS One, 6, e25006, 10.1371/journal.pone.0025006 Kars, 2010, Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women, Diabetes, 59, 1899, 10.2337/db10-0308 Norman, 2016, Thornton S et al; OPPTIMUM study group. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial, Lancet, 387, 2106, 10.1016/S0140-6736(16)00350-0