Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response
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Eccles, 2013, Critical research gaps and translational priorities for thes uccessful prevention and treatment of breast cancer, Breast Cancer Research, 15, R92, 10.1186/bcr3493
Narod, 2007, Triple-negative breast cancer: clinical features and patterns of recurrence, Clin Cancer Res, 13, 4429
Bissell, 2006, Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer, Cancer research, 66, 7095, 10.1158/0008-5472.CAN-06-0515
Fournier, 2008, Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets, PLoS ONE, 3, e2994, 10.1371/journal.pone.0002994
Bissell, 2007, The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression, Mol Oncol, 1, 84, 10.1016/j.molonc.2007.02.004
Bertucci, 2008, Sixteen-kinase gene expression identifies luminal breast cancers with poor prognosis, Cancer Res, 68, 767, 10.1158/0008-5472.CAN-07-5516
Kim, 2007, Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells, Mol Cell Biol, 27, 8533, 10.1128/MCB.00018-07
Kim, 2012, Macro Histone H2A1.2 (MacroH2A1) Protein Suppresses Mitotic Kinase VRK1 during Interphase, J Biol Chem, 287, 5278, 10.1074/jbc.M111.281709
Lazo, 2004, c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK), Oncogene, 23, 8950, 10.1038/sj.onc.1208015
Lazo, 2004, Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK, J Biol Chem, 279, 27458, 10.1074/jbc.M401009200
Kim, 2008, VRK1 phosphorylates CREB and mediates CCND1 expression, J Cell Sci, 121, 3035
Lazo, 2000, The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein, Oncogene, 19, 3656, 10.1038/sj.onc.1203709
Lazo, 2004, p53 Stabilization and accumulation induced by human vaccinia-related kinase 1, Mol Cell Biol, 24, 10366, 10.1128/MCB.24.23.10366-10380.2004
Lazo, 2011, Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway, PLoS ONE, 6, e17320, 10.1371/journal.pone.0017320
Levine, 2010, The origins and evolution of the p53 family of genes, Cold Spring Harb Perspect Biol, 2, a001198
Lazo, 2011, Roles of VRK1 as a new player in the control of biological processes required for cell division, Cell Signal, 23, 1267, 10.1016/j.cellsig.2011.04.002
Lazo, 2008, Human VRK1 is an early response gene and its loss causes a block in cell cycle progression, PLoS ONE, 3, e1642, 10.1371/journal.pone.0001642
Kim, 2013, Mitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1, Mol Biol Cell, 24, 373, 10.1091/mbc.e12-06-0456
Traktman, 2006, The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus, Mol Biol Cell, 17, 2451, 10.1091/mbc.e05-12-1179
Lazo, 2009, Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation, Mol Cell Biol, 29, 1189, 10.1128/MCB.01341-08
Lazo, 2012, Vaccinia-related Kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage, J Biol Chem, 287, 23757, 10.1074/jbc.M112.353102
Halazonetis, 2004, 53BP1, an activator of ATM in response to DNA damage, DNA repair, 3, 945, 10.1016/j.dnarep.2004.03.017
Lazo, 2006, VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma, Mol Cancer Res, 4, 177, 10.1158/1541-7786.MCR-05-0212
Lazo, 2007, Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas, Lung Cancer, 58, 303, 10.1016/j.lungcan.2007.06.023
Lazo, 2013, VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosis, BMC clinical pathology, 13, 23, 10.1186/1472-6890-13-23
Lazo, 2007, Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations, Arch Biochem Biophys, 465, 219, 10.1016/j.abb.2007.06.005
Dontu, 2009, Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature, Cancer Res, 69, 1302, 10.1158/0008-5472.CAN-08-2741
Lazo, 2010, VRK2 Inhibits Mitogen-Activated Protein Kinase Signaling and Inversely Correlates with ErbB2 in Human Breast Cancer, Mol Cell Biol, 30, 4687, 10.1128/MCB.01581-09
Lazo, 2012, VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling, Cell Mol Life Sci, 69, 3881, 10.1007/s00018-012-1056-8
Kuo, 2006, A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes, Cancer cell, 10, 515, 10.1016/j.ccr.2006.10.008
Aceves, 2013, Iodine and doxorubicin, a good combination for mammary cancer treatment: antineoplastic adjuvancy, chemoresistance inhibition, and cardioprotection, Mol Cancer, 12, 45, 10.1186/1476-4598-12-45
Elledge, 2002, 53BP1, a mediator of the DNA damage checkpoint, Science, 298, 1435, 10.1126/science.1076182
Lazo, 2006, p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop, Mol Cell Biol, 26, 4782, 10.1128/MCB.00069-06
Lazo, 2008, The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53, PLoS ONE, 3, e2649, 10.1371/journal.pone.0002649
Mattaj, 2008, Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly, Embo J, 26, 132
Traktman, 2013, Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo, Oncogenesis, 2, e48, 10.1038/oncsis.2013.11
Balmain, 2013, Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas, Nat Commun, 4, 1701, 10.1038/ncomms2660
Manning, 2009, Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site, Structure, 17, 128, 10.1016/j.str.2008.10.018
Yoon, 2011, NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activity, J Biol Chem, 286, 22131, 10.1074/jbc.M110.200162
Knapp, 2007, A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases, Proc Natl Acad Sci U S A, 104, 20523, 10.1073/pnas.0708800104
Knapp, 2007, Insights for the development of specific kinase inhibitors by targeted structural genomics, Drug Discov Today, 12, 365, 10.1016/j.drudis.2007.03.006
Lazo, 2011, Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2, PLoS ONE, 6, e23235, 10.1371/journal.pone.0023235
Lazo, 2013, Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals, J Biol Inorg Chem, 18, 473, 10.1007/s00775-013-0992-6
Lopez, 2010, AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers, Oncotarget, 1, 691, 10.18632/oncotarget.203
Rosell, 2013, The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy, Oncotarget, 4, 1572, 10.18632/oncotarget.1157
Joensuu, 2011, Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study, Breast Cancer Res, 13, R87, 10.1186/bcr2944
Lazo, 2012, Human VRK2 (Vaccinia-related Kinase 2) Modulates Tumor Cell Invasion by Hyperactivation of NFAT1 and Expression of Cyclooxygenase-2, J Biol Chem, 287, 42739, 10.1074/jbc.M112.404285
Lazo, 2013, Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression, Cell Death Dis, 4, e513, 10.1038/cddis.2013.40
Lazo, 2006, The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines, Febs J, 273, 2487, 10.1111/j.1742-4658.2006.05256.x
Forbes, 2006, Mutation analysis of 24 known cancer genes in the NCI-60 cell line set, Mol Cancer Ther, 5, 2606, 10.1158/1535-7163.MCT-06-0433
Lazo, 2007, Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1, Mol Cell Biol, 27, 7273, 10.1128/MCB.00025-07