VIR: A computational tool for analysis of immunoglobulin sequences

Almagro, 1995, Variability analysis of the T-cell receptors using three variability indexes, Int. J. Peptide Protein Res., 10.1111/j.1399-3011.1995.tb01038.x Bell, 1990, The human genome: An introduction, Vol. 7, 3 Chothia, 1987, Canonical structures for the hypervariable regions of immunoglobulin, J. Mol. Biol., 196, 901, 10.1016/0022-2836(87)90412-8 Chothia, 1988, The outline structure of the T cell α:β; receptor, EMBO J., 7, 3745, 10.1002/j.1460-2075.1988.tb03258.x Chothia, 1989, Conformations of immunoglobulin hypervariable regions, Nature (Lond.), 342, 877, 10.1038/342877a0 Chothia, 1992, Structural repertoire of the human VH segments, J. Mol. Biol., 227, 799, 10.1016/0022-2836(92)90224-8 Dayhoff, 1966, Vol. 2 Kodeira, 1986, Organization and evolution of the variable region genes of the human immunoglobulin heavy chain, J. Mol. Biol., 190, 529, 10.1016/0022-2836(86)90239-1 Jores, 1990, Resolution of hypervariable regions in T-cell receptor β chains by a modified Wu-Kabat index of amino acids diversity, 87, 9138 Kabat, 1991, Sequences of Proteins of Immunological Interest Lara-Ochoa, 1994, Patterns in the complementarity determining regions of immunoglobulin, BioSystem, 32, 1, 10.1016/0303-2647(94)90014-0 Mian, 1991, Structure, function and properties of antibody binding sites, J. Mol. Biol., 217, 133, 10.1016/0022-2836(91)90617-F Padlan, 1991, Modeling of antibody combining sites, Methods Enzymol., 202-B, 3, 10.1016/0076-6879(91)03003-Y Padlan, 1994, The antibody molecules, Mol. Immunol., 10.1016/0161-5890(94)90001-9 Pascual, 1991, Human immunoglobulin heavy-chain variable region genes: Organization, polymorphism, and expression, Adv. Immunol., 49, 1, 10.1016/S0065-2776(08)60774-9 Shenkin, 1991, Information-theoretical entropy as a measure of sequence variability, Proteins, 11, 297, 10.1002/prot.340110408 Tonegawa, 1983, Somatic generation of antibody diversity, Nature (Lond.), 302, 575, 10.1038/302575a0 Vargas-Madrazo, 1994, A skew distribution of amino acids at recognition sites of the hypervariable regions of immunoglobulin, J. Mol. Evol., 38, 100, 10.1007/BF00175497 Vargas-Madrazo, 1995, Structural repertoire in VH pseudogenes of immunoglobulin: Comparison with human germline genes and human functional sequences, J. Mol. Biol., 10.1006/jmbi.1994.0067 Wu, 1970, An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity, J. Exp. Med., 132, 211, 10.1084/jem.132.2.211 Wysocki, 1989, Gene conversion and the generation of antibody diversity, Annu. Rev. Biochem., 58, 509, 10.1146/annurev.bi.58.070189.002453 Young, 1992, Analysis of sequence variation among legume lectins A ring of hypervariable residues forms the perimeter of the carbohydrate binding site, J. Mol. Biol., 228, 924, 10.1016/0022-2836(92)90875-K Zucherkandl, 1976, Evolutionary processes and evolutionary noise at molecular level, J. Mol. Evol., 7, 167, 10.1007/BF01731487