VH11 bias and normal V-D-J junctions in scid B lymphocytes rescued by neonatal T cell transfer

Bosma, 1983, A severe combined immunodeficiency mutation in the mouse, Nature, 301, 527, 10.1038/301527a0 Bosma, 1988, Evidence of functional lymphocytes in some (leaky) SCID mice, J. exp. Med., 167, 1016, 10.1084/jem.167.3.1016 Bosma, 1992, B and T cell leakiness in the scid mouse mutant, Immunodef. Rev., 3, 261 Carmack, 1990, Rearrangement and selection of VH11 in the Ly-1 B cell lineage, J. exp. Med., 172, 371, 10.1084/jem.172.1.371 Carroll, 1991, T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor δ gene recombination, Genes Develop., 5, 1357, 10.1101/gad.5.8.1357 Caroll, 1989, Occurrence of mature B (IgM+ B220+) and T(CD3+) lymphocytes in SCID mice, J. Immun., 143, 1087, 10.4049/jimmunol.143.4.1087 Clarke, 1982, Polymorphisms in antiphosphocholine antibodies reflecting evlution in immunoglobulin families, J. exp. Med, 157, 98, 10.1084/jem.157.1.98 Clarke, 1985, Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin, J. exp. Med., 161, 687, 10.1084/jem.161.4.687 Conger, 1989, Diversity in the available repertoire of murine antibodies reactive with bromelain-treated isologous erythrocytes, J. Immun., 143, 4044, 10.4049/jimmunol.143.12.4044 Crews, 1981, A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody, Cell, 25, 59, 10.1016/0092-8674(81)90231-2 Feeney, 1990, Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences, J. exp. Med., 172, 1377, 10.1084/jem.172.5.1377 Feeney, 1992, Predominance of Vh-D-Jh junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies, J. Immun., 149, 222, 10.4049/jimmunol.149.1.222 Feeney, 1988, Specific H chain junctional diversity may be required for non-T15 antibodies to bind phosphorylcholine, J. Immun., 141, 1267, 10.4049/jimmunol.141.4.1267 Feeney, 1989, Sequence and fine specificity analysis of primary 511 anti-phosphorylcholine antibodies, J. Immun., 143, 4061, 10.4049/jimmunol.143.12.4061 Ferrier, 1990, Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from SCID mice, J. exp. Med., 171, 1909, 10.1084/jem.171.6.1909 Fulop, 1990, The scid mutation in mice causes a general defect in DNA repair, Nature, 347, 479, 10.1038/347479a0 Gu, 1990, Sequence homologies, N sequence insertion and Jh gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation, Eur. molec. Biol. Org. J., 9, 2133, 10.1002/j.1460-2075.1990.tb07382.x Habu, 1987, Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level in scid mice, Eur. J. Immun., 17, 1467, 10.1002/eji.1830171013 Hardy, 1989, A single VH gene is utilized predominately in anti-BrMRBC hybridomas derived from purified Ly-1 B cells. Definition of the VH11 family, J. Immun., 142, 3643, 10.4049/jimmunol.142.10.3643 Hendrickson, 1991, A link between double-strand break-related repair and V(D)J recombination: the scid mutation, 88, 4061 Kienker, 1991, T cell receptor γ and δ gene junctional sequences in SCID mice: excessive P nucleotide insertion, J. exp. Med., 174, 769, 10.1084/jem.174.4.769 Kotloff, 1993, V(D)J recombination in peritoneal B cells of leaky scid mice, J. exp. Med., 178, 1981, 10.1084/jem.178.6.1981 Lieber, 1991, Site-specific recombination in the immune system, FASEB J., 5, 2934, 10.1096/fasebj.5.14.1752360 Lieber, 1992, The mechanism of V(D)J recombination: a balance of diversity, specificity, and stability, Cell, 70, 873, 10.1016/0092-8674(92)90237-7 Lieber, 1988, The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination, Cell, 55, 7, 10.1016/0092-8674(88)90004-9 Malynn, 1988, The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism, Cell, 54, 453, 10.1016/0092-8674(88)90066-9 Perlmutter, 1985, Diversity in the germline antibody repertoire. Molecular evolution of the T15VH gene family, J. exp. Med., 162, 1998, 10.1084/jem.162.6.1998 Phillips, 1991, The scid mouse: mutation in a DNA repair gene creates recipients useful for studies on stem cells, lymphocyte development, and graft-versus-host disease, Immunol. Rev., 124, 63, 10.1111/j.1600-065X.1991.tb00616.x Poncet, 1990, All VH11 genes expressed in peritoneal lymphocytes encode anti-bromelain-treated mouse red blood cell autoantibodies but other Vh gene families contribute to this specificity, Eur. J. Immun., 20, 1583, 10.1002/eji.1830200726 Reininger, 1987, Novel V genes encode virtually identical variable genes of six murine monoclonal anti-bromelain-treated red blood cell autoantibodies, J. Immun., 138, 316, 10.4049/jimmunol.138.1.316 Riggs, 1992, CD4+CD8− thymocytes from neonatal mice induce IgM production in SCID mice, J. Immun., 148, 1389, 10.4049/jimmunol.148.5.1389 Riggs, 1991, Adoptive transfer of neonatal T lymphocytes rescues immunoglobulin production in mice with severe combined immune deficiency, J. exp. Med., 173, 265, 10.1084/jem.173.1.265 Roth, 1992, V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes, Cell, 70, 983, 10.1016/0092-8674(92)90248-B Schuler, 1991, Coding joint formation of endogeneous T cell receptor genes in lymphoid cells from SCID mice: unusual P-nucleotide additions in VJ-coding joints, Eur. J. Immun., 21, 589, 10.1002/eji.1830210309 Schuler, 1986, Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency, Cell, 46, 963, 10.1016/0092-8674(86)90695-1 Sedgwick, 1983, A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells, J. immunol. Meth., 57, 301, 10.1016/0022-1759(83)90091-1 Weaver, 1989, The scid mutation disrupts gene rearrangement at the rejoining of coding strands, Curr. Top. Micro. Immun., 152, 77