Utility of a genetic risk score to predict recurrent cardiovascular events 1 year after an acute coronary syndrome: A pooled analysis of the RISCA, PRAXY, and TRIUMPH cohorts

Atherosclerosis - Tập 242 - Trang 261-267 - 2015
Christopher Labos1, Sara C. Martinez2, Rui Hao Leo Wang3, Petra A. Lenzini4, Louise Pilote5, Peter Bogaty6, James M. Brophy1,5, James C. Engert5,7, Sharon Cresci2,4, George Thanassoulis5
1Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
2Department of Medicine, Washington University, St. Louis, MO, USA
3Department of Biochemistry, McGill University, Montreal, QC, Canada
4Department of Genetics, Washington University, St. Louis, MO, USA
5Department of Medicine, McGill University, Montreal, QC, Canada
6Institut Universitaire de Cardiologie et de Pneumologie, Laval University, Quebec City, QC, Canada
7Department of Human Genetics, McGill University, Montreal, QC, Canada

Tài liệu tham khảo

Lloyd-Jones, 2010, American heart association statistics C, stroke statistics S. heart disease and stroke statistics–2010 update: a report from the American heart association, Circulation, 121, e46 Mulders, 2011, Patients with premature cardiovascular disease and a positive family history for cardiovascular disease are prone to recurrent events, Int. J. Cardiol., 153, 64, 10.1016/j.ijcard.2010.08.040 Burton, 2007, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls, Nature, 447, 661, 10.1038/nature05911 Erdmann, 2009, New susceptibility locus for coronary artery disease on chromosome 3q22.3, Nat. Genet., 41, 280, 10.1038/ng.307 Gudbjartsson, 2009, Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction, Nat. Genet., 41, 342, 10.1038/ng.323 Helgadottir, 2007, A common variant on chromosome 9p21 affects the risk of myocardial infarction, Science, 316, 1491, 10.1126/science.1142842 Kathiresan, 2009, Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants, Nat. Genet., 41, 334, 10.1038/ng.327 McPherson, 2007, A common allele on chromosome 9 associated with coronary heart disease, Science, 316, 1488, 10.1126/science.1142447 Samani, 2007, Genomewide association analysis of coronary artery disease, N. Engl. J. Med., 357, 443, 10.1056/NEJMoa072366 Trégouët, 2009, Genome-wide haplotype association study identifies the slc22a3-lpal2-lpa gene cluster as a risk locus for coronary artery disease, Nat. Genet., 41, 283, 10.1038/ng.314 Schunkert, 2011, Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease, Nat. Genet., 43, 333, 10.1038/ng.784 Consortium CADCDG, 2011, A genome-wide association study in europeans and south asians identifies five new loci for coronary artery disease, Nat. Genet., 43, 339, 10.1038/ng.782 Brautbar, 2009, Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the atherosclerosis risk in communities study, Circ. Cardiovasc. Genet., 2, 279, 10.1161/CIRCGENETICS.108.817338 Humphries, 2007, Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy uk men, Clin. Chem., 53, 8, 10.1373/clinchem.2006.074591 Junyent, 2010, A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the boston puerto rican health study, Nutr. Metabolism Cardiovasc. Dis., 20, 157, 10.1016/j.numecd.2009.03.016 Kathiresan, 2008, Polymorphisms associated with cholesterol and risk of cardiovascular events, N. Engl. J. Med., 358, 1240, 10.1056/NEJMoa0706728 Morrison, 2007, Prediction of coronary heart disease risk using a genetic risk score: the atherosclerosis risk in communities study, Am. J. Epidemiol., 166, 28, 10.1093/aje/kwm060 Paynter, 2009, Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3, Ann. Intern. Med., 150, 65, 10.7326/0003-4819-150-2-200901200-00003 Paynter, 2010, Association between a literature-based genetic risk score and cardiovascular events in women, JAMA:J. Am. Med. Assoc., 303, 631, 10.1001/jama.2010.119 Talmud, 2008, Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of chd in healthy middle-aged men, Clin. Chem., 54, 467, 10.1373/clinchem.2007.095489 Trichopoulou, 2008, Genetic predisposition, nongenetic risk factors, and coronary infarct, Archives Intern. Med., 168, 891, 10.1001/archinte.168.8.891 Yamada, 2002, Prediction of the risk of myocardial infarction from polymorphisms in candidate genes, N. Engl. J. Med., 347, 1916, 10.1056/NEJMoa021445 Buysschaert, 2010, A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the grace genetics study, Eur. heart J., 31, 1132, 10.1093/eurheartj/ehq053 Wauters, 2013, Influence of 23 coronary artery disease variants on recurrent myocardial infarction or cardiac death: the grace genetics study, Eur. heart J., 34, 993, 10.1093/eurheartj/ehs389 Mega, 2015, Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials, Lancet, 385, 2264, 10.1016/S0140-6736(14)61730-X Bogaty, 2008, Clinical utility of c-reactive protein measured at admission, hospital discharge, and 1 month later to predict outcome in patients with acute coronary disease. The risca (recurrence and inflammation in the acute coronary syndromes) study, J. Am. Coll. Cardiol., 51, 2339, 10.1016/j.jacc.2008.03.019 Pilote, 2012, Genesis-praxy (gender and sex determinants of cardiovascular disease: from bench to beyond-premature acute coronary syndrome), Am. heart J., 163, 741, 10.1016/j.ahj.2012.01.022 Arnold, 2011, Consortium ftCOR. Translational research investigating underlying disparities in acute myocardial infarction patients' health status (triumph): design and rationale of a prospective multicenter registry, Circulation Cardiovasc. Qual. Outcomes, 4, 467, 10.1161/CIRCOUTCOMES.110.960468 Lanfear, 2011, Factors influencing patient willingness to participate in genetic research after a myocardial infarction, Genome Med., 3, 39, 10.1186/gm255 Alpert, 2000, Myocardial infarction redefined–a consensus document of the joint european society of cardiology/american college of cardiology committee for the redefinition of myocardial infarction, J. Am. Coll. Cardiol., 36, 959, 10.1016/S0735-1097(00)00804-4 Thanassoulis, 2012, A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the framingham heart study, Circ. Cardiovasc. Genet., 5, 113, 10.1161/CIRCGENETICS.111.961342 Center for Outcomes Research UoMMS. Methods and formulas used to calculate the grace risk scores for patients presenting to hospital with an acute coronary syndrome. 1998–2010:http://www.outcomes-umassmed.org/grace/files/GRACE_RiskModel_Coefficients.pdf. Sundström, 2011, Useful tests of usefulness of new risk factors: tools for assessing reclassification and discrimination, Scand. J. Public Health, 39, 439, 10.1177/1403494810396556 Pencina, 2011, Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers, Statistics Med., 30, 11, 10.1002/sim.4085 Patel, 2014, Genetic variants at chromosome 9p21 and risk of first versus subsequent coronary heart disease events: a systematic review and meta-analysis, J. Am. Coll. Cardiol., 63, 2234, 10.1016/j.jacc.2014.01.065 Tragante, 2013, The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk, Eur. heart J., 34, 2896, 10.1093/eurheartj/eht222 Weijmans, 2015, Incremental value of a genetic risk score for the prediction of new vascular events in patients with clinically manifest vascular disease, Atherosclerosis, 239, 451, 10.1016/j.atherosclerosis.2015.02.008 Tikkanen, 2013, Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease, Arteriosclerosis, Thrombosis, Vasc. Biol., 33, 2261, 10.1161/ATVBAHA.112.301120 Yang, 2012, Use of functional genomics to identify candidate genes underlying human genetic association studies of vascular diseases, Arteriosclerosis, thrombosis, Vasc. Biol., 32, 216, 10.1161/ATVBAHA.111.232702 Topol, 2001, Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction, Circulation, 104, 2641, 10.1161/hc4701.100910