Using Animal Models to Determine the Role of Gustatory Neural Input in the Control of Ingestive Behavior and the Maintenance of Body Weight
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Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000) A novel family of mammalian taste receptors. Cell 100:693–702
Ahima R, Antwi D (2008) Brain regulation of appetite and satiety. Endocrinol Metab Clin N Am 37:811–823
Akiba Y, Watanabe C, Mizumori M, Kaunitz JD (2009) Luminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. Am J Physiol Gastrointest Liver Physiol 297:G781–G791
Allen AL, McGeary JE, Hayes JE (2014) Polymorphisms in TRPV1 and TAS2Rs associate with sensations from sampled ethanol. Alcohol Clin Exp Res 38:2550–2560
Allison D, Fontaine K, Heshka S, Mentore J, Heymsfield S (2001) Alternative treatments for weight loss: a critical review. Crit Rev Food Sci Nutr 41:1–28, discussion 39-40
Ames B, Profet M, Gold L (1990) Dietary pesticides (99.99% all natural). Proc Natl Acad Sci U S A 87:7777–7781
Appel L et al (1997) A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 336:1117–1124
Bachmanov AA, Kiefer SW, Molina JC, Tordoff MG, Duffy VB, Bartoshuk LM, Mennella JA (2003) Chemosensory factors influencing alcohol perception, preferences, and consumption. Alcohol Clin Exp Res 27:220–231
Baharvand M, ShoalehSaadi N, Barakian R, Moghaddam EJ (2013) Taste alteration and impact on quality of life after head and neck radiotherapy. J Oral Pathol Med 42:106–112
Bartoshuk LM (1988) Taste. In: Stevens SS, Atkinson RC (eds) Stevens’ handbook of experimental psychology, vol 2. Wiley, New York, pp 461–499
Bartoshuk LM, Catalanotto F, Hoffman H, Logan H, Snyder DJ (2012) Taste damage (otitis media, tonsillectomy and head and neck cancer), oral sensations and BMI. Physiol Behav 107:516–526
Bartoshuk LM, Duffy VB, Hayes JE, Moskowitz HR, Snyder DJ (2006) Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives. Philos Trans R Soc Lond B Biol Sci 361:1137–1148
Basson M, Bartoshuk L, Dichello S, Panzini L, Weiffenbach J, Duffy V (2005) Association between 6-n-propylthiouracil (PROP) bitterness and colonic neoplasms. Dig Dis Sci 50:483–489
Batchelor DJ et al (2011) Sodium/glucose cotransporter-1, sweet receptor, and disaccharidase expression in the intestine of the domestic dog and cat: two species of different dietary habit. Am J Physiol Regul Integr Comp Physiol 300:R67–R75
Beckett EL, Martin C, Yates Z, Veysey M, Duesing K, Lucock M (2014) Bitter taste genetics—the relationship to tasting, liking, consumption and health. Food Funct 5:3040–3054
Behrens M, Meyerhof W (2006) Bitter taste receptors and human bitter taste perception. Cell Mol Life Sci 63:1501–1509
Behrens M, Meyerhof W (2010) Oral and extraoral bitter taste receptors. Results Probl Cell Differ 52:87–99
Behrens M, Meyerhof W (2011) Gustatory and extragustatory functions of mammalian taste receptors. Physiol Behav 105:4–13
Bell K, Tepper B (2006) Short-term vegetable intake by young children classified by 6-n-propylthoiuracil bitter-taste phenotype. Am J Clin Nutr 84:245–251
Bertoli S et al (2014) Taste sensitivity, nutritional status and metabolic syndrome: implication in weight loss dietary interventions. World J Diabetes 5:717–723
Bezencon C, le Coutre J, Damak S (2006) Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chemical senses
Bezencon C, le Coutre J, Damak S (2007) Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses 32:41–49
Blednov YA, Walker D, Martinez M, Levine M, Damak S, Margolskee RF (2008) Perception of sweet taste is important for voluntary alcohol consumption in mice. Genes Brain Behav 7:1–13
Blizard DA (2007) Sweet and bitter taste of ethanol in C57BL/6J and DBA2/J mouse strains. Behav Genet 37:146–159
Boesveldt S, Lindau ST, McClintock MK, Hummel T, Lundstrom JN (2011) Gustatory and olfactory dysfunction in older adults: a national probability study. Rhinology 49:324–330
Boggiano MM, Artiga AI, Pritchett CE, Chandler-Laney PC, Smith ML, Eldridge AJ (2007) High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating. Int J Obes 31:1357–1367
Boltong A, Keast R (2012) The influence of chemotherapy on taste perception and food hedonics: a systematic review. Cancer Treat Rev 38:152–163
Bouthoorn SH et al (2014) Genetic taste blindness to bitter and body composition in childhood: a Mendelian randomization design. Int J Obes (Lond) 38:1005–1010
Bradley RM, Mistretta CM, Bates CA, Killackey HP (1985) Transganglionic transport of HRP from the circumvallate papilla of the rat. Brain Res 361:154–161
Brasser SM, Norman MB, Lemon CH (2010) T1r3 taste receptor involvement in gustatory neural responses to ethanol and oral ethanol preference. Physiol Genomics 41:232–243
Brasser SM, Silbaugh BC, Ketchum MJ, Olney JJ, Lemon CH (2012) Chemosensory responsiveness to ethanol and its individual sensory components in alcohol-preferring, alcohol-nonpreferring and genetically heterogeneous rats. Addict Biol 17:423–436
Brinkworth G, Noakes M, Buckley J, Keogh J, Clifton P (2009) Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo. Am J Clin Nutr 90:23–32
Bueter M, Ashrafian H, Frankel AH, Tam FW, Unwin RJ, le Roux CW (2011) Sodium and water handling after gastric bypass surgery in a rat model. Surg Obes Relat Dis 7:68–73
Burd C, Senerat A, Chambers E, Keller KL (2013) PROP taster status interacts with the built environment to influence children's food acceptance and body weight status. Obesity (Silver Spring) 21:786–794
Burton-Freeman B, Gietzen DW, Schneeman BO (1997) Meal pattern analysis to investigate the satiating potential of fat, carbohydrate, and protein in rats. Am J Physiol Regul Integr Comp Physiol 273:R1916–R1922
Cai H, Maudsley S, Martin B (2014) What is the role of metabolic hormones in taste buds of the tongue. Front Horm Res 42:134–146
Caldas AS, Facundes VL, Cunha DA, Balata PM, Leal LB, da Silva HJ (2013) Gustatory and olfactory dysfunction in laryngectomized patients. Braz J Otorhinolaryngol 79:546–554
Cartoni C et al (2010) Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci 30:8376–8382
Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJ, Zuker CS (2010) The cells and peripheral representation of sodium taste in mice. Nature 464:297–301
Chen CC, Schilling LS, Lyder CH (2001) A concept analysis of malnutrition in the elderly. J Adv Nurs 36:131–142
Chevrot M et al (2013) Obesity alters the gustatory perception of lipids in the mouse: plausible involvement of lingual CD36. J Lipid Res 54:2485–2494
Choi SE (2014) Racial differences between African Americans and Asian Americans in the effect of 6-n-propylthiouracil taste intensity and food liking on body mass index. J Acad Nutr Diet 114:938–944
Choi SE, Chan J (2014) Relationship of 6-n-propylthiouracil taste intensity and chili pepper use with body mass index, energy intake, and fat intake within an ethnically diverse population. Journal of the Academy of Nutrition and Dietetics
Clayton JA, Collins FS (2014) Policy: NIH to balance sex in cell and animal studies. Nature 509:282–283
Cockayne DA et al (2005) P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol 567:621–639
Cohen J, Laing DG, Wilkes FJ, Chan A, Gabriel M, Cohn RJ (2014) Taste and smell dysfunction in childhood cancer survivors. Appetite 75:135–140
Cohn ZJ, Kim A, Huang L, Brand J, Wang H (2010) Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells. BMC Neurosci 11:72
Collier GH (1980) An ecological analysis of motivation. In: Toates FM, Halliday T (eds) Analysis of motivational processes. Academic Press, London, New York, pp 125–151
Comeau TB, Epstein JB, Migas C (2001) Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge. Support Care Cancer 9:575–580
Contreras RJ, Gomez MM, Norgren R (1980) Central origins of cranial nerve parasympathetic neurons in the rat. J Comp Neurol 190:373–394
Cooke D, Bloom S (2006) The obesity pipeline: current strategies in the development of anti-obesity drugs. Nat Rev Drug Discov 5:919–931
Cooper SJ, Al-Naser HA, Clifton PG (2006) The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats. Eur J Pharmacol 532:253–257
Cowart BJ (1989) Relationships between taste and smell across the adult life span. Ann N Y Acad Sci 561:39–55
Daly K, Al-Rammahi M, Arora DK, Moran AW, Proudman CJ, Ninomiya Y, Shirazi-Beechey SP (2012) Expression of sweet receptor components in equine small intestine: relevance to intestinal glucose transport. Am J Physiol Regul Integr Comp Physiol 303:R199–R208
Daly K, Al-Rammahi M, Moran A, Marcello M, Ninomiya Y, Shirazi-Beechey SP (2013) Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion. Am J Physiol Gastrointest Liver Physiol 304:G271–G282
Damak S, le Coutre J, Bezençon C (2013) Deletion or inhibition of Trpm5 decreases the gain in body weight and fat mass in mice. Chem Senses 38:A272
Dauchet L et al (2007) Dietary patterns and blood pressure change over 5-y follow-up in the SU.VI.MAX cohort. Am J Clin Nutr 85:1650–1656
Davis JD (1989) The microstructure of ingestive behavior. Ann N Y Acad Sci 575:106–119, discussion 120-101
Davis JD, Campbell CS (1973) Peripheral control of meal size in the rat. Effect of sham feeding on meal size and drinking rate. J Comp Physiol Psychol 83:379–387
Davoodi N, Kalinichev M, Korneev SA, Clifton PG (2009) Hyperphagia and increased meal size are responsible for weight gain in rats treated sub-chronically with olanzapine. Psychopharmacology 203:693–702
de Castro JM, de Castro ES (1989) Spontaneous meal patterns of humans—influence of the presence of other people. Am J Clin Nutr 50:237–247
Degrace-Passilly P, Besnard P (2012) CD36 and taste of fat. Curr Opin Clin Nutr Metab Care 15:107–111
Delay RJ, Kinnamon JC, Roper SD (1986) Ultrastructure of mouse vallate taste buds: II. Cell types and cell lineage. J Comp Neurol 253:242–252
Deshpande DA et al (2010) Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med 16:1299–1304
Dinehart M, Hayes J, Bartoshuk L, Lanier S, Duffy V (2006) Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol Behav 87:304–313
Ding E, Mozaffarian D (2006) Optimal dietary habits for the prevention of stroke. Semin Neurol 26:11–23
Donaldson L, Bennett L, Baic S, Melichar J (2009) Taste and weight: is there a link? Am J Clin Nutr 90:800S–803S
Dotson C, Vigues S, Steinle N, Munger S (2010) T1R and T2R receptors: the modulation of incretin hormones and potential targets for the treatment of type 2 diabetes mellitus. Curr Opin Investig Drugs 11:447–454
Dotson CD, Babich J, Steinle NI (2012a) Genetic predisposition and taste preference: impact on food intake and risk of chronic disease. Curr Nutr Rep 1:175–183
Dotson CD, Colbert CL, Garcea M, Smith JC, Spector AC (2012b) The consequences of gustatory deafferentation on body mass and feeding patterns in the rat. Am J Physiol Regul Integr Comp Physiol 303:R611–R623
Dotson CD, Geraedts MC, Munger SD (2013) Peptide regulators of peripheral taste function. Semin Cell Dev Biol 24:232–239
Dotson CD, Wallace MR, Bartoshuk LM, Logan HL (2012c) Variation in the gene TAS2R13 is associated with differences in alcohol consumption in patients with head and neck cancer. Chem Senses 37:737–744
Drewnowski A, Brunzell J, Sande K, Iverius P, Greenwood M (1985) Sweet tooth reconsidered: taste responsiveness in human obesity. Physiol Behav 35:617–622
Drewnowski A, Gomez-Carneros C (2000) Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr 72:1424–1435
Drewnowski A, Henderson S, Cockroft J (2007) Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women. J Am Diet Assoc 107:1340–1348
Drewnowski A, Henderson S, Hann C, Berg W, Ruffin M (2000) Genetic taste markers and preferences for vegetables and fruit of female breast care patients. J Am Diet Assoc 100:191–197
Drewnowski A, Henderson S, Levine A, Hann C (1999) Taste and food preferences as predictors of dietary practices in young women. Public Health Nutr 2:513–519
Drewnowski A, Henderson S, Shore A (1997) Taste responses to naringin, a flavonoid, and the acceptance of grapefruit juice are related to genetic sensitivity to 6-n-propylthiouracil. Am J Clin Nutr 66:391–397
Drewnowski A, Henderson S, Shore A, Barratt-Fornell A (1998) Sensory responses to 6-n-propylthiouracil (PROP) or sucrose solutions and food preferences in young women. Ann N Y Acad Sci 855:797–801
Du H, Feskens E (2010) Dietary determinants of obesity. Acta Cardiol 65:377–386
Duffy V, Bartoshuk L (2000) Food acceptance and genetic variation in taste. J Am Diet Assoc 100:647–655
Duffy V, Hayes J, Sullivan B, Faghri P (2009) Surveying food and beverage liking: a tool for epidemiological studies to connect chemosensation with health outcomes. Ann N Y Acad Sci 1170:558–568
Duffy VB (2004) Associations between oral sensation, dietary behaviors and risk of cardiovascular disease (CVD). Appetite 43:5–9
Duffy VB et al (2004a) Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res 28:1629–1637
Duffy VB, Hayes JE, Davidson AC, Kidd JR, Kidd KK, Bartoshuk LM (2010) Vegetable intake in college-aged adults is explained by oral sensory phenotypes and TAS2R38 genotype. Chemosens Percept 3:137–148
Duffy VB, Peterson JM, Bartoshuk LM (2004b) Associations between taste genetics, oral sensation and alcohol intake. Physiol Behav 82:435–445
Dutta TM, Josiah AF, Cronin CA, Wittenberg GF, Cole JW (2013) Altered taste and stroke: a case report and literature review. Top Stroke Rehabil 20:78–86
Dyer J, Daly K, Salmon KS, Arora DK, Kokrashvili Z, Margolskee RF, Shirazi-Beechey SP (2007) Intestinal glucose sensing and regulation of intestinal glucose absorption. Biochem Soc Trans 35:1191–1194
Dyer J, Salmon KS, Zibrik L, Shirazi-Beechey SP (2005) Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans 33:302–305
Elson AE, Dotson CD, Egan JM, Munger SD (2010) Glucagon signaling modulates sweet taste responsiveness. FASEB J 24:3960–3969
Epstein JB, Barasch A (2010) Taste disorders in cancer patients: pathogenesis, and approach to assessment and management. Oral Oncol 46:77–81
Eylam S, Spector AC (2002) The effect of amiloride on operantly conditioned performance in an NaCl taste detection task and NaCl preference in C57BL/6J mice. Behav Neurosci 116:149–159
Farley C, Cook JA, Spar BD, Austin TM, Kowalski TJ (2003) Meal pattern analysis of diet-induced obesity in susceptible and resistant rats. Obes Res 11:845–851
Feng P, Huang L, Wang H (2014) Taste bud homeostasis in health, disease, and aging. Chem Senses 39:3–16
Finger TE et al (2005) ATP signaling is crucial for communication from taste buds to gustatory nerves. Science 310:1495–1499
Finkelstein EA, Trogdon JG, Cohen JW, Dietz W (2009) Annual medical spending attributable to obesity: payer- and service-specific estimates. Health Aff 28:w822–w831
Finsterer J, Stollberger C, Kopsa W (2004) Weight reduction due to stroke-induced dysgeusia. Eur Neurol 51:47–49
Fischer ME et al (2014) The association of taste with change in adiposity-related health measures. J Acad Nutr Diet 114:1195–1202
Foster SR et al (2013) Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart. PLoS One 8:e64579
Frijters J, Rasmussen-Conrad E (1982) Sensory discrimination, intensity perception, and affective judgment of sucrose-sweetness in the overweight. J Gen Psychol 107:233–247
Fuchida S, Yamamoto T, Takiguchi T, Kandaudahewa G, Yuyama N, Hirata Y (2013) Association between underweight and taste sensitivity in middle- to old-aged nursing home residents in Sri Lanka: a cross-sectional study. J Oral Rehabil 40:854–863
Galindo MM et al (2012) G protein-coupled receptors in human fat taste perception. Chem Senses 37:123–139
Gilbertson TA, Liu L, York DA, Bray GA (1998) Dietary fat preferences are inversely correlated with peripheral gustatory fatty acid sensitivity. Ann N Y Acad Sci 855:165–168
Glanville EV, Kaplan AR (1965) Food preference and sensitivity of taste for bitter compounds. Nature 205:851–853
Goldstein GL, Daun H, Tepper BJ (2005) Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil. Obes Res 13:1017–1023
Gopalan P, Kumar M, Gupta D, Phillipps JJ (2005) A study of chorda tympani nerve injury and related symptoms following middle-ear surgery. J Laryngol Otol 119:189–192
Gray JT, Zolotukhin S (2011) Design and construction of functional AAV vectors. Methods Mol Biol 807:25–46
Green TL, McGregor LD, King KM (2008) Smell and taste dysfunction following minor stroke: a case report. Can J Neurosci Nurs 30:10–13
Grill HJ, Schwartz GJ (1992) The contribution of gustatory nerve input to oral motor behavior and intake-based preference. II. Effects of combined chorda tympani and glossopharyngeal nerve section in the rat. Brain Res 573:105–113
Guinand N, Just T, Stow NW, Van HC, Landis BN (2010) Cutting the chorda tympani: not just a matter of taste. J Laryngol Otol 124:999–1002
Hajnal A, Kovacs P, Ahmed T, Meirelles K, Lynch CJ, Cooney RN (2010) Gastric bypass surgery alters behavioral and neural taste functions for sweet taste in obese rats. Am J Physiol Gastrointest Liver Physiol 299:G967–G979
Hass N, Schwarzenbacher K, Breer H (2010) T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach. Cell Tissue Res 339:493–504
Hayes JE, Feeney EL, Allen AL (2013) Do polymorphisms in chemosensory genes matter for human ingestive behavior? Food Qual Prefer 30:202–216
Hayes JE, Wallace MR, Knopik VS, Herbstman DM, Bartoshuk LM, Duffy VB (2011) Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults. Chem Senses 36:311–319
Heald AE, Schiffman SS (1997) Taste and smell. Neglected senses that contribute to the malnutrition of AIDS. N C Med J 58:100–104
Hebert J et al (2008) Social desirability trait influences on self-reported dietary measures among diverse participants in a multicenter multiple risk factor trial. J Nutr 138:226S–234S
Heckmann JG, Stossel C, Lang CJ, Neundorfer B, Tomandl B, Hummel T (2005) Taste disorders in acute stroke: a prospective observational study on taste disorders in 102 stroke patients. Stroke 36:1690–1694
Heft MW, Robinson ME (2010) Age differences in orofacial sensory thresholds. J Dent Res 89:1102–1105
Hellekant G, Schmolling J, Marambaud P, Rose-Hellekant TA (2015) CALHM1 deletion in mice affects glossopharyngeal taste responses, food intake, body weight, and life span. Chem Senses
Herder C et al (2009) Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study. Diabetologia 52:433–442
Hinrichs AL et al (2006) Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Am J Hum Genet 78:103–111
Hirsch J, Hudgins L, Leibel R, Rosenbaum M (1998) Diet composition and energy balance in humans. Am J Clin Nutr 67:551S–555S
Hofbauer K, Nicholson J, Boss O (2007) The obesity epidemic: current and future pharmacological treatments. Annu Rev Pharmacol Toxicol 47:565–592
Hoon MA, Adler E, Lindemeier J, Battey JF, Ryba NJ, Zuker CS (1999) Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 96:541–551
Hoppu U, Laitinen K, Jaakkola J, Sandell M (2015) The hTAS2R38 genotype is associated with sugar and candy consumption in preschool boys. J Hum Nutr Diet 28(Suppl 1):45–51
Hu F, Manson J, Stampfer M, Colditz G, Liu S, Solomon C, Willett W (2001) Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 345:790–797
Huang CC, Lin CD, Wang CY, Chen JH, Shiao YT, Tsai MH (2012) Gustatory changes in patients with chronic otitis media, before and after middle-ear surgery. J Laryngol Otol 126:470–474
Huang YA, Maruyama Y, Stimac R, Roper SD (2008) Presynaptic (type III) cells in mouse taste buds sense sour (acid) taste. J Physiol 586:2903–2912
Hutton JL, Baracos VE, Wismer WV (2007) Chemosensory dysfunction is a primary factor in the evolution of declining nutritional status and quality of life in patients with advanced cancer. J Pain Symptom Manag 33:156–165
Imoscopi A, Inelmen EM, Sergi G, Miotto F, Manzato E (2012) Taste loss in the elderly: epidemiology, causes and consequences. Aging Clin Exp Res 24:570–579
Jacquin MF, Zeigler HP (1983) Trigeminal orosensation and ingestive behavior in the rat. Behav Neurosci 97:62–97
Jang HJ et al (2007) Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 104:15069–15074
Janssen S, Depoortere I (2013) Nutrient sensing in the gut: new roads to therapeutics? Trends Endocrinol Metab 24:92–100
Janssen S, Laermans J, Verhulst PJ, Thijs T, Tack J, Depoortere I (2011) Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. Proc Natl Acad Sci U S A 108:2094–2099
Jeon TI, Seo YK, Osborne TF (2011) Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK. Biochem J 438:33–37
Jerzsa-Latta M, Krondl M, Coleman P (1990) Use and perceived attributes of cruciferous vegetables in terms of genetically-mediated taste sensitivity. Appetite 15:127–134
Jiang H, Kuang Y, Wu Y, Xie W, Simon MI, Wu D (1997) Roles of phospholipase C beta2 in chemoattractant-elicited responses. Proc Natl Acad Sci U S A 94:7971–7975
Jinkins JR (2000) Atlas of neuroradiologic embryology, anatomy, and variants. Lippincott Williams & Wilkins, Philadelphia
Kabasawa C et al (2013) Taste disorders in myasthenia gravis: a multicenter cooperative study. Eur J Neurol 20:205–207
Kaji I, Karaki S, Fukami Y, Terasaki M, Kuwahara A (2009) Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine. Am J Physiol Gastrointest Liver Physiol 296:G971–G981
Kaminski L, Henderson S, Drewnowski A (2000) Young women’s food preferences and taste responsiveness to 6-n-propylthiouracil (PROP). Physiol Behav 68:691–697
Kamphuis MM, Westerterp-Plantenga MS (2003) PROP sensitivity affects macronutrient selection. Physiol Behav 79:167–172
Kampov-Polevoy A, Lange L, Bobashev G, Eggleston B, Root T, Garbutt JC (2014) Sweet-liking is associated with transformation of heavy drinking into alcohol-related problems in young adults with high novelty seeking. Alcohol Clin Exp Res 38:2119–2126
Kampov-Polevoy AB, Garbutt JC, Davis CE, Janowsky DS (1998) Preference for higher sugar concentrations and Tridimensional Personality Questionnaire scores in alcoholic and nonalcoholic men. Alcohol Clin Exp Res 22:610–614
Kataoka S, Yang R, Ishimaru Y, Matsunami H, Sévigny J, Kinnamon JC, Finger TE (2008) The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse. Chem Senses 33:243–254
Keast RS, Azzopardi KM, Newman LP, Haryono RY (2014) Impaired oral fatty acid chemoreception is associated with acute excess energy consumption. Appetite 80:1–6
Keller KL et al (2014) Bitter taste phenotype and body weight predict children’s selection of sweet and savory foods at a palatable test-meal. Appetite 77:113–121
Kim M, Chiego DJ, Bradley RM (2004) Morphology of parasympathetic neurons innervating rat lingual salivary glands. Auton Neurosci 111:27–36
Kinnamon SC, Cummings TA (1992) Chemosensory transduction mechanisms in taste. Annu Rev Physiol 54:715–731
Kitagawa M, Kusakabe Y, Miura H, Ninomiya Y, Hino A (2001) Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem Biophys Res Commun 283:236–242
Kiuchi S, Yamada T, Kiyokawa N, Saito T, Fujimoto J, Yasue H (2006) Genomic structure of swine taste receptor family 1 member 3, TAS1R3, and its expression in tissues. Cytogenet Genome Res 115:51–61
Klimacka-Nawrot E, Musialik J, Suchecka W, Petelenz M, Hartman M, Lichtanski P, Blonska-Fajfrowska B (2010) Taste disturbances during therapy with pegylated interferon-alpha 2b and ribavirin in patients with chronic hepatitis C. Wiad Lek 63:289–299
Kojima I, Nakagawa Y, Ohtsu Y, Medina A, Nagasawa M (2014) Sweet taste-sensing receptors expressed in pancreatic beta-cells: sweet molecules act as biased agonists. Endocrinol Metab 29:12–19
Kokrashvili Z, Mosinger B, Margolskee RF (2009a) T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1. Ann N Y Acad Sci 1170:91–94
Kokrashvili Z, Mosinger B, Margolskee RF (2009b) Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. Am J Clin Nutr 90:822S–825S
Kris-Etherton P, Etherton T, Carlson J, Gardner C (2002) Recent discoveries in inclusive food-based approaches and dietary patterns for reduction in risk for cardiovascular disease. Curr Opin Lipidol 13:397–407
Kyriazis GA, Smith KR, Tyrberg B, Hussain T, Pratley RE (2014) Sweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice. Endocrinology 155:2112–2121
Kyriazis GA, Soundarapandian MM, Tyrberg B (2012) Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A 109:E524–E532
La Sala MS et al (2013) Modulation of taste responsiveness by the satiation hormone peptide YY. FASEB J
Landis BN, Beutner D, Frasnelli J, Huttenbrink KB, Hummel T (2005) Gustatory function in chronic inflammatory middle ear diseases. Laryngoscope 115:1124–1127
Lange LA, Kampov-Polevoy AB, Garbutt JC (2010) Sweet liking and high novelty seeking: independent phenotypes associated with alcohol-related problems. Alcohol Alcohol 45:431–436
Lanier SA, Hayes JE, Duffy VB (2005) Sweet and bitter tastes of alcoholic beverages mediate alcohol intake in of-age undergraduates. Physiol Behav 83:821–831
Larue-Achagiotis C, Le Magnen J (1980) Changes of meal patterns induced by food-deprivation—metabolic correlates. Neurosci Biobehav Rev 4:25–27
Lauerma H, Paalassalo P (1995) The need for excessive dietary sodium chloride following tympanoplasty. J Laryngol Otol 109:324–325
Laugerette F, Passilly-Degrace P, Patris B, Niot I, Febbraio M, Montmayeur JP, Besnard P (2005) CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest 115:3177–3184
Le Roux CW et al (2011) Gastric bypass reduces fat intake and preference. Am J Physiol Regul Integr Comp Physiol 301:R1057–R1066
Lee RJ et al (2014) Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest 124:1393–1405
Leibowitz SF, Alexander JT, Cheung WK, Weiss GF (1993) Effects of serotonin and the serotonin blocker metergoline on meal patterns and macronutrient selection. Pharmacol Biochem Behav 45:185–194
Levitsky DA (1970) Feeding patterns of rats in response to fasts and changes in environmental conditions. Physiol Behav 5:291
Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E (2002) Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 99:4692–4696
Lindström J, Peltonen M, Eriksson J, Louheranta A, Fogelholm M, Uusitupa M, Tuomilehto J (2006) High-fibre, low-fat diet predicts long-term weight loss and decreased type 2 diabetes risk: the Finnish Diabetes Prevention Study. Diabetologia 49:912–920
Lundy RF Jr, Norgren R (2004) Gustatory system. In: Paxinos G (ed) The rat nervous system, 3rd edn. Academic Press, San Diego, pp 891–921
Lutz TA, Geary N, Szabady MM, Delprete E, Scharrer E (1995) Amylin decreases meal size in rats. Physiol Behav 58:1197–1202
Mace OJ et al (2009) An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine. J Physiol 587:195–210
Mahmoud FA, Aktas A, Walsh D, Hullihen B (2011) A pilot study of taste changes among hospice inpatients with advanced cancer. Am J Hosp Palliat Care 28:487–492
Malaty J, Malaty IA (2013) Smell and taste disorders in primary care. Am Fam Physician 88:852–859
Malki A, Fiedler J, Fricke K, Ballweg I, Pfaffl MW, Krautwurst D (2015) Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes. J Leukoc Biol
Margolskee RF et al (2007) T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U S A 104:15075–15080
Masubuchi Y et al (2013) A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. PLoS One 8:e54500
Mathus-Vliegen EM, de Groot GH (2013) Fasting and meal-induced CCK and PP secretion following intragastric balloon treatment for obesity. Obes Surg 23:622–633
Matsumura S, Eguchi A, Mizushige T, Kitabayashi N, Tsuzuki S, Inoue K, Fushiki T (2009) Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice. Neurosci Lett 450:186–190
Matsumura S, Mizushige T, Yoneda T, Iwanaga T, Tsuzuki S, Inoue K, Fushiki T (2007) GPR expression in the rat taste bud relating to fatty acid sensing. Biomed Res 28:49–55
Mattes R, Labov J (1989) Bitter taste responses to phenylthiocarbamide are not related to dietary goitrogen intake in human beings. J Am Diet Assoc 89:692–694
Mattes RD (2003) Nutritional implications of taste and smell. In: Doty RL (ed). Vol 42, 2nd Revised edition edn. Marcel Dekker Inc, pp 881-903
Mattes RD, Cowart BJ (1994) Dietary assessment of patients with chemosensory disorders. J Am Diet Assoc 94:50–56
Mattes-Kulig DA, Henkin RI (1985) Energy and nutrient consumption of patients with dysgeusia. J Am Diet Assoc 85:822–826
Mattsson T, Arvidson K, Heimdahl A, Ljungman P, Dahllof G, Ringden O (1992) Alterations in taste acuity associated with allogeneic bone marrow transplantation. J Oral Pathol Med 21:33–37
Max M et al (2001) Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet 28:58–63
Mbiene JP, Roberts JD (2003) Distribution of keratin 8-containing cell clusters in mouse embryonic tongue: evidence for a prepattern for taste bud development. J Comp Neurol 457:111–122
McCarron D, Reusser M (2001) Reducing cardiovascular disease risk with diet. Obes Res 9(Suppl 4):335S–340S
McManus LJ, Dawes PJ, Stringer MD (2011) Clinical anatomy of the chorda tympani: a systematic review. J Laryngol Otol 125:1101–1108
McManus LJ, Stringer MD, Dawes PJ (2012) Iatrogenic injury of the chorda tympani: a systematic review. J Laryngol Otol 126:8–14
Medina A et al (2014) Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states. Endocr J 61:797–805
Meguid MM, Laviano A, Rossi-Fanelli F (1998) Food intake equals meal size times mean number. Appetite 31:404
Meguid MM, Yang ZJ, Gleason JR (1996) The gut-brain brain-gut axis in anorexia: toward an understanding of food intake regulation. Nutrition 12:S57–S62
Meguid MM, Yang ZJ, Laviano A (1997) Meal size and number: relationship to dopamine levels in the ventromedial hypothalamic nucleus. Am J Physiol 272:R1925–R1930
Melhorn SJ, Krause EG, Scott KA, Mooney MR, Johnson JD, Woods SC, Sakai RR (2010) Acute exposure to a high-fat diet alters meal patterns and body composition. Physiol Behav 99:33–39
Meyer D et al (2012) Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca(2)(+) and cAMP concentrations in spermatozoa. PLoS One 7:e32354
Michael P, Raut V (2007) Chorda tympani injury: operative findings and postoperative symptoms. Otolaryngol Head Neck Surg 136:978–981
Miller IJ Jr (1977) Gustatory receptors of the palate. In: Katsuki Y, Sato M, Takagi S, Oomura Y (eds) Food intake and chemical senses. University of Tokyo Press, Tokyo, pp 173–186
Miller MG, Teates JF (1986) The role of taste in dietary self-selection in rats. Behav Neurosci 100:399–409
Minaya DM (2014) The role of TRPM5 in dietary fat preference, intake, and body composition. All graduate theses and dissertations paper 2173. http://digitalcommonsusuedu/etd/2173
Miura H, Scott JK, Harada S, Barlow LA (2014) Sonic hedgehog-expressing basal cells are general post-mitotic precursors of functional taste receptor cells. Dev Dyn 243:1286–1297
Mojet J, Christ-Hazelhof E, Heidema J (2001) Taste perception with age: generic or specific losses in threshold sensitivity to the five basic tastes? Chem Senses 26:845–860
Montmayeur J-P, Le Coutre J (2010) Fat detection: taste, texture, and post ingestive effects. Frontiers in neuroscience. CRC Press/Taylor & Francis, Boca Raton
Moran AW, Al-Rammahi M, Zhang C, Bravo D, Calsamiglia S, Shirazi-Beechey SP (2014) Sweet taste receptor expression in ruminant intestine and its activation by artificial sweeteners to regulate glucose absorption. J Dairy Sci 97:4955–4972
Moran AW et al (2010) Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners. Br J Nutr 104:637–646
Morgan CM et al (2002) Loss of control over eating, adiposity, and psychopathology in overweight children. Int J Eat Disord 31:430–441
Mosinger B et al (2013) Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility. Proc Natl Acad Sci U S A 110:12319–12324
Mowe M, Bohmer T (2002) Reduced appetite. A predictor for undernutrition in aged people. J Nutr Health Aging 6:81–83
Mowe M, Bohmer T, Kindt E (1994) Reduced nutritional status in an elderly population (>70 y) is probable before disease and possibly contributes to the development of disease. Am J Clin Nutr 59:317–324
Murphy C (1993) Nutrition and chemosensory perception in the elderly. Crit Rev Food Sci Nutr 33:3–15
Murray RG (1973) The ultrastructure of taste buds. In: Friedmann I (ed) The ultrastructure of sensory organs, vol 1973. North-Holland, Amsterdam, pp 1-81. doi: 10.1093/chemse/bjh110
Musialik J, Suchecka W, Klimacka-Nawrot E, Petelenz M, Hartman M, Blonska-Fajfrowska B (2012) Taste and appetite disorders of chronic hepatitis C patients. Eur J Gastroenterol Hepatol 24:1400–1405
Nakagawa Y et al (2009) Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One 4:e5106
Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS (2002) An amino-acid taste receptor. Nature 416:199–202
Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS (2001) Mammalian sweet taste receptors. Cell 106:381–390
Niewind A, Krondl M, Shrott M (1988) Genetic influences on the selection of brassica vegetables by elderly individuals. Nutr Res 8:13–20
Nissenbaum JW, Sclafani A (1987) Sham-feeding response of rats to Polycose and sucrose. Neurosci Biobehav Rev 11:215–222
Nissenbaum JW, Sclafani A (1988) A comparison of the effects of atropine on real-feeding and sham-feeding of sucrose in rats. Pharmacol Biochem Behav 29:231–238
Ogden CL, Carroll MD, Kit BK, Flegal KM (2014) Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA 311:806–814
Oh S, Kim KS, Chung YS, Shong M, Park SB (2009) Anti-obesity agents: a focused review on the structural classification of therapeutic entities. Current topics in medicinal Chemistry 9:466–481
Peracchio HL, Henebery KE, Sharafi M, Hayes JE, Duffy VB (2012) Otitis media exposure associates with dietary preference and adiposity: a community-based observational study of at-risk preschoolers. Physiol Behav 106:264–271
Peregrin T (2006) Improving taste sensation in patients who have undergone chemotherapy or radiation therapy. J Am Diet Assoc 106:1536–1540
Picciotto MR (1999) Knock-out mouse models used to study neurobiological systems. Crit Rev Neurobiol 13:103–149
Rajkumar P, Aisenberg WH, Acres OW, Protzko RJ, Pluznick JL (2014) Identification and characterization of novel renal sensory receptors. PLoS One 9:e111053
Ren X, Zhou L, Terwilliger R, Newton SS, de Araujo IE (2009) Sweet taste signaling functions as a hypothalamic glucose sensor. Front Integr Neurosci 3:12
Richard CD, Tolle V, Low MJ (2011) Meal pattern analysis in neural-specific proopiomelanocortin-deficient mice. Eur J Pharmacol 660:131–138
Rouse I, Beilin L, Armstrong B, Vandongen R (1983) Blood-pressure-lowering effect of a vegetarian diet: controlled trial in normotensive subjects. Lancet 1:5–10
Rozengurt N, Wu SV, Chen MC, Huang C, Sternini C, Rozengurt E (2006) Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol 291:G792–G802
Sacerdote C et al (2007) Lactase persistence and bitter taste response: instrumental variables and mendelian randomization in epidemiologic studies of dietary factors and cancer risk. Am J Epidemiol 166:576–581
Saito T et al (2001) Long-term follow-up results of electrogustometry and subjective taste disorder after middle ear surgery. Laryngoscope 111:2064–2070
Salbe A, DelParigi A, Pratley R, Drewnowski A, Tataranni P (2004) Taste preferences and body weight changes in an obesity-prone population. Am J Clin Nutr 79:372–378
Sánchez-Lara K, Sosa-Sánchez R, Green-Renner D, Rodríguez C, Laviano A, Motola-Kuba D, Arrieta O (2010) Influence of taste disorders on dietary behaviors in cancer patients under chemotherapy. Nutr J 9:15
Sandell M et al (2014) Genetic variation in the hTAS2R38 taste receptor and food consumption among Finnish adults. Genes Nutr 9:433
Santollo J, Eckel LA (2008) Estradiol decreases the orexigenic effect of neuropeptide Y, but not agouti-related protein, in ovariectomized rats. Behav Brain Res 191:173–177
Saper C, Chou T, Elmquist J (2002) The need to feed: homeostatic and hedonic control of eating. Neuron 36:199–211
Schiffman SS, Graham BG (2000) Taste and smell perception affect appetite and immunity in the elderly. Eur J Clin Nutr 54(Suppl 3):S54–S63
Schiffman SS, Wedral E (1996) Contribution of taste and smell losses to the wasting syndrome. Age Nutr 7:106–120
Sclafani A, Nissenbaum JW (1987) Oral versus postingestive origin of polysaccharide appetite in the rat. Neurosci Biobehav Rev 11:169–172
Shafaie Y, Koelliker Y, Hoffman DJ, Tepper BJ (2013) Energy intake and diet selection during buffet consumption in women classified by the 6-n-propylthiouracil bitter taste phenotype. Am J Clin Nutr 98:1583–1591
Shah AS, Ben-Shahar Y, Moninger TO, Kline JN, Welsh MJ (2009) Motile cilia of human airway epithelia are chemosensory. Science 325:1131–1134
Shin AC, Zheng H, Townsend RL, Sigalet DL, Berthoud HR (2010a) Meal-induced hormone responses in a rat model of Roux-en-Y gastric bypass surgery. Endocrinology 151:1588–1597
Shin YJ, Park JH, Choi JS, Chun MH, Moon YW, Lee MY (2010b) Enhanced expression of the sweet taste receptors and alpha-gustducin in reactive astrocytes of the rat hippocampus following ischemic injury. Neurochem Res 35:1628–1634
Ship JA, Duffy V, Jones JA, Langmore S (1996) Geriatric oral health and its impact on eating. J Am Geriatr Soc 44:456–464
Simon BR et al (2013) Artificial sweeteners stimulate adipogenesis and suppress lipolysis independent of sweet taste receptors. J Biol Chem
Simons PJ, Kummer JA, Luiken JJ, Boon L (2011) Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae. Acta Histochem 113:839–843
Skrandies W, Zschieschang R (2015) Olfactory and gustatory function and its relation to body weight. Physiol Behav
Small DM, Prescott J (2005) Odor/taste integration and the perception of flavor. Exp Brain Res 166:345–357
Smith GP (2000a) The controls of eating: a shift from nutritional homeostasis to behavioral neuroscience. Nutrition 16:814–820
Smith J (2000c) Microstructure of the rat’s intake of food, sucrose and saccharin in 24-hour tests. Neurosci Biobehav Rev 24:199–212
Smith JJ, Breathnach CS (1990) Functions of the seventh cranial nerve. Ear Nose Throat J 69(688-691):694–685
Solemdal K, Sandvik L, Willumsen T, Mowe M (2014) Taste ability in hospitalised older people compared with healthy, age-matched controls. Gerodontology 31:42–48
Spector AC (2000) Linking gustatory neurobiology to behavior in vertebrates. Neurosci Biobehav Rev 24:391–416
Spector AC (2003) The functional organization of the peripheral gustatory system: lessons from behavior. In: Fluharty SJ, Grill HJ (eds) Progress in psychobiology and physiological psychology, vol 18. Academic Press, New York, pp 101–161
Spector AC, Glendinning JI (2009) Linking peripheral taste processes to behavior. Curr Opin Neurobiol 19:370–377
Sprous D, Palmer K (2010) The T1R2/T1R3 sweet receptor and TRPM5 ion channel taste targets with therapeutic potential. Prog Mol Biol Transl Sci 91:151–208
Sternini C (2007) Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing. Am J Physiol Gastrointest Liver Physiol 292:G457–G461
Stevens JC (1996) Detection of tastes in mixture with other tastes: issues of masking and aging. Chem Senses 21:211–221
Stone LM, Wilcox CL, Kinnamon SC (2002) Virus-mediated transfer of foreign DNA into taste receptor cells. Chem Senses 27:779–787
Swain J, McCarron P, Hamilton E, Sacks F, Appel L (2008) Characteristics of the diet patterns tested in the optimal macronutrient intake trial to prevent heart disease (OmniHeart): options for a heart-healthy diet. J Am Diet Assoc 108:257–265
Swartz TD, Duca FA, de Wouters T, Sakar Y, Covasa M (2012) Up-regulation of intestinal type 1 taste receptor 3 and sodium glucose luminal transporter-1 expression and increased sucrose intake in mice lacking gut microbiota. Br J Nutr 107:621–630
Tabarin A et al (2007) Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis. Eur J Neurosci 26:2303–2314
Tanaka T, Reed DR, Ordovas JM (2007) Taste as the gatekeeper of personalized nutrition. In: Kok F, Bouwman L, Desiere F (eds). Vol 10. CRC Press, pp 115-132.
Taniguchi K (2004) Expression of the sweet receptor protein, T1R3, in the human liver and pancreas. J Vet Med Sci 66:1311–1314
Taruno A et al (2013) CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 495:223–226
Teal C, Baham D, Gor B, Jones L (2007) Is the MEDFICTS rapid dietary fat screener valid for premenopausal African-American women? J Am Diet Assoc 107:773–781
Tempel DL, Shorposner G, Dwyer D, Leibowitz SF (1989) Nocturnal patterns of macronutrient intake in freely feeding and food-deprived rats. Am J Physiol 256:R541–R548
Tepper B (1999) Does genetic taste sensitivity to PROP influence food preferences and body weight? Appetite 32:422
Tepper B (2008) Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes. Annu Rev Nutr 28:367–388
Tepper B et al (2008) Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. Obesity (Silver Spring) 16:2289–2295
Tepper B, Williams T, Burgess J, Antalis C, Mattes R (2009) Genetic variation in bitter taste and plasma markers of anti-oxidant status in college women. Int J Food Sci Nutr 60(Suppl 2):35–45
Tepper BJ, Ullrich NV (2002) Influence of genetic taste sensitivity to 6-n-propylthiouracil (PROP), dietary restraint and disinhibition on body mass index in middle-aged women. Physiol Behav 75:305–312
Tizzano M, Cristofoletti M, Sbarbati A, Finger TE (2011) Expression of taste receptors in solitary chemosensory cells of rodent airways. BMC Pulm Med 11:3
Toffanello ED et al (2013) Taste loss in hospitalized multimorbid elderly subjects. Clin Interv Aging 8:167–174
Tordoff MG, Downing A, Voznesenskaya A (2014) Macronutrient selection by seven inbred mouse strains and three taste-related knockout strains. Physiol Behav 135:49–54
Toyono T, Seta Y, Kataoka S, Toyoshima K (2007) CCAAT/Enhancer-binding protein beta regulates expression of human T1R3 taste receptor gene in the bile duct carcinoma cell line, HuCCT1. Biochim Biophys Acta 1769:641–648
Unciti-Broceta A, Moggio L, Dhaliwal K, Pidgeon L, Finlayson K, Haslett C, Bradley M (2011) Safe and efficient in vitro and in vivo gene delivery: tripodal cationic lipids with programmed biodegradability. J Mater Chem 21:2154–2158
van der Wielen N et al (2014) Cross-species comparison of genes related to nutrient sensing mechanisms expressed along the intestine. PLoS One 9:e107531
Vandenbeuch A, Clapp TR, Kinnamon SC (2008) Amiloride-sensitive channels in type I fungiform taste cells in mouse. BMC Neurosci 9:1
Varma M, Chai JK, Meguid MM, Gleason JR, Yang ZJ (1999) Effect of operative stress on food intake and feeding pattern in female rats. Nutrition 15:365–372
Vigorito M, Sclafani A, Jacquin MF (1987) Effects of gustatory deafferentation on Polycose and sucrose appetite in the rat. Neurosci Biobehav Rev 11:201–209
Vingtdeux V et al (2011) Generation and characterization of a CALHM1 knockout mouse model: relevance for Alzheimer’s disease. Alzheimers Dement 7:S506
Voigt A, Hubner S, Lossow K, Hermans-Borgmeyer I, Boehm U, Meyerhof W (2012) Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in mice. Chem Senses 37:897–911
Wang J et al (2007) Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. Alcohol Clin Exp Res 31:209–215
Wauson EM, Zaganjor E, Cobb MH (2013) Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3. Autophagy 9:418–419
Wauson EM et al (2012) The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol Cell 47:851–862
Widmayer P, Breer H, Hass N (2011) Candidate chemosensory cells in the porcine stomach. Histochem Cell Biol 136:37–45
Widmayer P, Kuper M, Kramer M, Konigsrainer A, Breer H (2012) Altered expression of gustatory-signaling elements in gastric tissue of morbidly obese patients. Int J Obes 36:1353–1359
Wooding S (2006) Phenylthiocarbamide: a 75-year adventure in genetics and natural selection. Genetics 172:2015–2023
Yackinous C, Guinard J (2002) Relation between PROP (6-n-propylthiouracil) taster status, taste anatomy and dietary intake measures for young men and women. Appetite 38:201–209
Yarmolinsky DA, Zuker CS, Ryba NJ (2009) Common sense about taste: from mammals to insects. Cell 139:234–244
Yoshida R, Horio N, Murata Y, Yasumatsu K, Shigemura N, Ninomiya Y (2009) NaCl responsive taste cells in the mouse fungiform taste buds. Neuroscience 159:795–803
Young RL, Sutherland K, Pezos N, Brierley SM, Horowitz M, Rayner CK, Blackshaw LA (2009) Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut 58:337–346
Zhang Y et al (2003) Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112:293–301
Zhang Y, Satterlee A, Huang L (2012) In vivo gene delivery by nonviral vectors: overcoming hurdles? Mol Ther 20:1298–1304
Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, Zuker CS (2003) The receptors for mammalian sweet and umami taste. Cell 115:255–266
Zheng C, Baum BJ (2008) Evaluation of promoters for use in tissue-specific gene delivery. Methods Mol Biol 434:205–219
Zheng D et al (2012) Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation. Proc Natl Acad Sci U S A 109:11975–11980
Zheng H, Lenard N, Shin A, Berthoud H (2009) Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals. Int J Obes (Lond) 33(Suppl 2):S8–S13