Use of urinary taurine and creatine as biomarkers of organ dysfunction and metabolic perturbations

Draper RP, Creasy DM, Timbrell JA (1994a) Urinary creatine as a marker of specific acute testicular damage: comparison with other markers and preliminary investigations into the route by which it enters the urine. Hum Exp Toxicol 13:635

Draper RP, Waterfield CJ, Mason H et al. (1994b) Study of the urinary excretion of taurine and creatine in workers exposed to solvents. Hum Exp Toxicol 13:643

Draper RP, Waterfield CJ, York MJ et al. (1994c) The effect of the muscle toxicant 2,3,5,6-tetramethyl p-phenylenediamine (TMPD) on urinary taurine and creatine. Arch Toxicol 69:111?117

Gray J, Nicholson JK, Creasy DM et al. (1990) Studies on the relationship between acute testicular damage and urinary plasma creatine concentration. Arch Toxicol 64:443?450

Moore NP, Timbrell JA, Gray TJB (1989) Isolated rate seminiferous tubules synthesize guanidoacetic acid and creatine from arginine. Biochem Soc Trans 17:520

Moore NP, Creasy DM, Gray TJB et al. (1992) Urinary creatine profiles after administration of cell specific testicular toxicants to the rat. Arch Toxicol 66:435?442

Nicholson JK, Higham DP, Timbrell JA et al. (1989) Quantitative high resolution1H-NMR urinalysis studies on the biochemical effects of cadmium in the rat. Mol Pharmacol 36:398?404

Rawcliffe L, Creasy D, Timbrell JA (1989) Urinary creatine as a possible marker for testicular damage: studies with the testicular toxic compound 2-methoxyethanol. Reprod Toxicol 3:269?274

Reader S, Shingles C, Stonard MD (1991) Acute testicular toxicity of 1,3-dinitrobenzene and ethylene glycol monomethyl ether in the rat. Evaluation of biochemical effect markers and hormonal responses. Fund Appl Toxicol 13:61?70

Sanins SM, Nicholson JK, Elcombe C et al. (1990) Hepatotoxininduced hypertaurinuria: a proton NMR study. Arch Toxicol 64:401?411

Timbrell JA, Draper RP, Waterfield CJ (1994) Biomarkers in toxicology. New uses for old molecules. Toxicol Ecotoxicol News 1:1?11

Walker JB (1979) Creatine: Biosynthesis, regulation and function. Adv Enzymol Rel Areas Mol Biol 50:177?242

Waterfield CJ (1994) Determination of taurine in biological samples and isolated hepatocytes by high-performance liquid chromatography with fluorimetric detection. J Chromatogr 657:37?45

Waterfield CJ, Turton JA, Scales DC, et al. (1991) Taurine, a possible urinary marker of liver damage: a study of taurine excretion in carbon tetrachloride treated rats. Arch Toxicol 65:548?555

Waterfield CJ, Turton JA, Scales DC et al. (1993a) Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats. Arch Toxicol 67:244?254

Waterfield CJ, Turton JA, Scales DC et al. (1993b) Effect of various non-hepatotoxic compounds on urinary and liver taurine levels in rats. Arch Toxicol 67:538?546

Waterfield CJ, Jairath M, Asker D et al. (1995) The biochemical effects of clenbuterol: with particular reference to taurine and muscle damage. Eur J Pharmacol 293:141?149