Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19

Lancet Respiratory Medicine,The - Tập 10 - Trang 700-714 - 2022
Jonathan D Casey1, Laura M Beskow2, Jeremy Brown3, Samuel M Brown4, Étienne Gayat5,6, Michelle Ng Gong7, Michael O Harhay8, Samir Jaber9, Jacob C Jentzer10, Pierre-François Laterre11, John C Marshall12, Michael A Matthay13, Todd W Rice1, Yves Rosenberg14, Alison E Turnbull15, Lorraine B Ware1, Wesley H Self16,17, Alexandre Mebazaa5,6, Sean P Collins16,18
1Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
2Vanderbilt Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, TN, USA
3Office of Emergency Care Research, National Institute of Neurological Disorders and Stroke, Division of Clinical Research, National Institutes of Health, Bethesda, MD, USA
4Division of Pulmonary and Critical Care Medicine, Intermountain Medical Center and University of Utah, Salt Lake City, UT, USA
5Department of Anesthesia, Burn and Critical Care, University Hospitals Saint-Louis-Lariboisière, AP-HP, Paris, France
6INSERM UMR-S 942, MASCOT, Université Paris Cité, Paris, France
7Division of Critical Care Medicine and Division of Pulmonary Medicine, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA
8Palliative and Advanced Illness Research (PAIR) Center Clinical Trials Methods and Outcomes Lab, and Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
9Saint Eloi Intensive Care Unit, Montpellier University Hospital, and PhyMedExp, INSERM, CNRS, Université de Montpellier, Montpellier, France
10Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA
11Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium
12Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health, Toronto, ON, Canada
13Cardiovascular Research Institute, University of California, San Francisco, CA, USA
14National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
15Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
16Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
17Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA
18Geriatric Research, Education and Clinical Center, Tennessee Valley Healthcare System, Nashville, TN, USA

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