Use of mobile phones for patient self-reporting adverse drug reactions: A pilot study at a tertiary hospital in Rwanda
Tóm tắt
The use of mobile phones may avail early detection of adverse drug reactions (ADRs) in pharmacovigilance activities. The study aimed to explore the feasibility of outpatients to self-report ADRs using mobile phone technology and to picture such ADRs and medications received. Outpatients taking medications at the Gitwe hospital pharmacy during the study period were eligible, provided they were using a mobile phone and could talk about side effects. Participants were requested to call the investigator after one week of treatment or to accept a call from the investigator and answer some questions. The investigator collected the phone number and the prescribed medications of every participant. The data collected were analyzed to list all types of ADRs reported and match them with the actual side effects documented on each medication received. Of 80 patients enrolled, we called 79(98.75%) but one (1.25%) who called himself the investigator. Ten (12.5%) persons did not respond to the call. Of 70 respondents who picked calls, 36(51.43%) said not having experienced any side effects, and 34(48.57%) participants did. Dry cough, headache, dizziness, and swelling were dominant with14-21%. Two cases of heartbeat and dizziness pushed patients to return to the hospital. All respondents carried a functional mobile phone and demonstrated interest in self-reporting ADRs. Facilitated toll-free- call service may be an effective means of extending the scope of ADRs tracking in addition to the Yellow Card Scheme, and enhance the involvement of pharmacists and consumers in the pharmacovigilance programs.
Tài liệu tham khảo
Bouvy JC, De Bruin ML, Koopmanschap MA. Epidemiology of adverse drug reactions in Europe: a review of recent observational studies. Drug Saf. 2015;38(5):437–53. https://doi.org/10.1007/s40264-015-0281-0.
Thao Doan. Pharmacovigilance: A Practical Approach, Editors: Thao Doan Cheryl, Renz Fabio, Lievano Mondira, Bhattacharya Linda, Scarazzini Imprint: Elsevier, 1st August 2018.p.228.
Wilson AM, Thabane L, Holbrook A. Application of data mining techniques in pharmacovigilance. Br J Clin Pharmacol. 2004;57(2):127–34. https://doi.org/10.1046/j.1365-2125.2003.01968.x.
Ulrich Vogel. Latest developments in pharmacovigilance, drug safety, and risk management. 21st & 22nd February 2018, Holiday Inn, Kensington High Street.
Ampadu HH, Hoekman J, de Bruin ML, Pal SN, Olsson S, Sartori D, et al. Adverse Drug Reaction Reporting in Africa and a Comparison of Individual Case Safety Report Characteristics Between Africa and the Rest of the World: Analyses of Spontaneous Reports in VigiBase®.Drug Saf. 2016; 39(4):335–45. https://doi.org/10.1007/s40264-015-0387-4.
Mouton JP, Mehta U, Parrish AG, Wilson DP, Stewart A, Njuguna CW, et al. Mortality from adverse drug reactions in adult medical inpatients at four hospitals in South Africa: a cross-sectional survey. Br J Clin Pharmacol. 2015;80(4):818–26. https://doi.org/10.1111/bcp.12567 . (Epub 2015 6th July)
MoH: Rwanda Ministry of Health, https://www.moh.gov.rw, 2009.
Ministry of Health. Guidelines for Pharmacovigilance and Medicine Information in Rwanda. https://www.moh.gov.rw/fileadmin/templates/policies/Pharmacy-Policy_Rwanda-2016.pdf Accessed 3rd June 2018.
Rutaganda E, Dusabejambo V, Nyirigira J. Singer DRJ Pharmacovigilance at the CHUK national referral hospital in Rwanda: patterns of suspected adverse drug reactions. Clinical therapeutics. 2015;37(8), S:e8-e9.
Drugs and Medications. https://www.webmd.com/drugs/2/index Accessed 8th December 2019
Joshi VD, Dahake AP, Suthar AP. Adverse effects associated with the use of antihypertensive drugs: An Overview. Int J PharmTech Res. 2010;2(1):10–3.
Granowitz EV, Brown RB. Antibiotic adverse reactions and drug interactions. Crit Care Clin. 2008;24(2):421–42, xi. doi: 10.1016/j.ccc.2007.12.011.
Medicine.Net-Medication. https://www.medicinenet.com/medications/alpha_a.htm Accessed 8th December 2019.
RxList. https://www.rxlist.com/script/main/hp.asp Accessed 12th May 2019.
Aker JC, Mbiti IM. Mobile phones and economic development. J Econ Perspect. 2010;24:207–32.
Hughes ML, Weiss M. Adverse drug reaction reporting by community pharmacists-The barriers and facilitators. Pharmacoepidemiol Drug Saf. 2019. https://doi.org/10.1002/pds.4800.
Zurovac D, Talisuna AO, Snow RW. Mobile phone text messaging: a tool for malaria control in Africa. PLoS Med. 2012;9(2):e1001176.
Adedeji AA, Sanusi B, Tella A, Akinsanya M, Ojo O, Akinwunmi MO, et al. Exposure to anti-malarial drugs and monitoring of adverse drug reactions using toll-free mobile phone calls in the private retail sector in Sagamu, Nigeria: implications for pharmacovigilance. Malaria Journal. 2011;10(1):230.
Adedeji AA, Babirye J, Nsooli O, Kamowa D, Tikare OA, Okoruwa AG, et al. Use of Mobile Phones for Monitoring Adverse Drug Reaction in Pharmacy and Drug Stores in Ishaka, Uganda- a Pilot Assessment of Willingness to Report. British Journal of Pharmaceutical Research. 2014;4(19): 2245–2260.
MoH https://www.moh.gov.rw/fileadmin/user_upload/HMIS/2016_Annual_Statistical_booklets_V9_08_03_2018.pdf Accessed 12th May 2019.
Basch E. The Missing Voice of Patients in Drug-Safety Reporting. N Engl J Med. 2010;362:865–9.
McGraw MJ. Principle of Good Clinical Practice: Pharmacy Business Administration. Gurnee, Illinois, USA: Pharmaceutical Press; 2010.
IM Noble 2018Anti-Thrombotic Drug Problems Cardiovasc Pharm. 2018,7:1. https://doi.org/10.4172/2329-6607.1000231
Reyad AA, Mishriky R. Cariprazine: pharmacology and clinical management of psychiatric disorders. Psychiatric Annals. 2019;49(3):129–34.