Use of hypoallergenic formula in the prevention of atopic disease among Asian children

Journal of Paediatrics and Child Health - Tập 38 Số 1 - Trang 84-88 - 2002
Yih‐Chih Chan1, Lynette Pei‐Chi Shek1, Marion M. Aw1, Seng Hock Quak1, BW Lee1
1Department of Paediatrics, National University Hospital, Singapore

Tóm tắt

Objective: To determine the effect of a partially hydrolysed formula on genetically predisposed children, with respect to the development of atopic clinical manifestations and in vitro testing of serum IgE levels (total and milk‐specific). Methods: One hundred and ten infants were randomly assigned to receive either partially hydrolysed formula or standard infant formula, and were prospectively monitored from birth for clinical atopic symptoms and serum IgE levels. Results: Eczema occurred less frequently in infants receiving partially hydrolysed formula. This was significant (P < 0.05) at 3, 6, 9, 12, 18 and 24 months. However, the significance decreased with time, although it almost reached statistical significance at 30 months by the Kaplan–Meier survival function (log–rank statistic, 3.46; P = 0.063). Although wheezing occurred less frequently in infants receiving partially hydrolysed formula, compared to those receiving standard infant formula, the difference did not reach statistical significance (P > 0.05). Conclusions: Exclusive feeding of hypoallergenic milk formula in the first 4 months of life has a protective effect in terms of the development of atopic dermatitis in the first 2 years of life, compared to feeding with cow’s milk formula.

Từ khóa


Tài liệu tham khảo

10.1016/0091-6749(84)90442-1

10.1016/0091-6749(83)90464-5

10.1111/j.1365-2222.1988.tb02863.x

Grullet G, 1992, Natural history of sensitisations in atopic dermatitis: a 3‐year follow‐up in 250 children: Food allergy and high risk of respiratory symptoms., Arch. Dermatol., 28, 187

Chandra RK, 1991, Cumulative incidence of atopic disorders in high‐risk infants fed whey hydrolysate, soy and conventional cow’s milk formulas., Ann. Allergy, 67, 129

Vandenplas Y, 1992, The effect of feeding a whey hydrolysate formula on the long term prophylaxis of atopic disease in high‐risk infants., Ann. Allergy, 68, 419

10.1016/0091-6749(89)90181-4

10.1016/S0022-3476(05)81413-1

10.1111/j.1365-2222.1979.tb02492.x

Chandra RK, 1989, Effect of feeding whey hydrolysate, soy and conventional cow’s milk formulas on incidence of atopic disease in high risk infants., Ann. Allergy, 63, 102

Willems R., 1993, Influence of hypoallergenic milk formula on the incidence of early allergic manifestations in infants predisposed to atopic diseases., Ann. Allergy, 71, 147

10.1111/j.1365-2222.1979.tb02493.x

10.1111/j.1398-9995.1982.tb02329.x

10.1034/j.1398-9995.2001.056008749.x

10.1136/adc.57.5.364

Casimir G, 1983, Neonatal IgE concentration as predictor of atopy., Lancet, 1, 413

10.1111/j.1651-2227.1976.tb04915.x

10.1177/000992289603501003

10.1111/j.1365-2222.1992.tb03100.x

Arschad SH, 1992, Effect of allergen avoidance on development of allergic disorders., Lancet, 339, 1494

Vandenplas Y., 1992, Prevention of atopic disease in children., Lancet, 121, 95

10.1016/S0022-3476(05)81415-5

10.1046/j.1365-2222.1996.1024365.x

10.1111/j.1365-2222.1996.tb00584.x

10.1016/S0091-6749(95)70074-9

10.1136/adc.75.5.392

Thông tin
Thông tin xuất bản

Journal of Paediatrics and Child Health

Tập 38 Số 1

84-88

Thông tin tác giả