Usage and limitations of liquid chromatography-tandem mass spectrometry (LC–MS/MS) in clinical routine laboratories

Christoph Seger1
1Institute of Medical and Chemical Laboratory Diagnostics (ZIMCL), University Hospital Innsbruck, Innsbruck, Austria

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Müller MM. Implementation of reference systems in laboratory medicine. Clin Chem. 2000;46:1907–9.

Panteghini M. Traceability as a unique tool to improve standardization in laboratory medicine. Clin Biochem. 2009;42:236–40.

Yalow RS. Radioimmunoassay: a probe for the fine structure of biologic systems. Science. 1978;200:1236–45.

Winter WE, Sokoll LJ, Jialal I, editors. Handbook of diagnostic endocrinology. Washington DC: AACC; 2008.

Fenn JB. Electrospray wings for molecular elephants (Nobel lecture). Angew Chem Int Ed Engl. 2003;42:3871–94.

Himmelsbach M. 10 years of MS instrumental developments—impact on LC-MS/MS in clinical chemistry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;883–4:3–17.

Chace DH. Mass spectrometry in newborn and metabolic screening: historical perspective and future directions. J Mass Spectrom. 2009;44:163–70.

Seger C, Vogeser M. Immunosuppressant drug monitoring—a routine undertaking? J Lab Med. 2010;34:117–28.

Vogeser M, Seger C. Pitfalls associated with the use of liquid chromatography-tandem mass spectrometry in the clinical laboratory. Clin Chem. 2010;56:1234–44.

Picard S, Titier K, Etienne G, Teilhet E, Ducint D, Bernard MA, et al. Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood. 2007;109:3496–9.

Adaway JE, Keevil BG. Therapeutic drug monitoring and LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;883–884:33–49.

Taylor PJ, Franklin ME, Tai CH, Pillans PI. Therapeutic drug monitoring of tacrolimus by liquid chromatography-tandem mass spectrometry: is it truly a routine test? J Chromatogr B Analyt Technol Biomed Life Sci. 2012;883–884:108–12.

Saar E, Beyer J, Gerostamoulos D, Drummer OH. The analysis of antipsychotic drugs in human matrices using LC-MS(/MS). Drug Test Anal. 2012;4:376–94.

Carvalho VM. The coming of age of liquid chromatography coupled to tandem mass spectrometry in the endocrinology laboratory. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;883–884:50–8.

Peters FT. Recent advances of liquid chromatography-(tandem) mass spectrometry in clinical and forensic toxicology. Clin Biochem. 2011;44:54–65.

Maurer HH. Perspectives of liquid chromatography coupled to low- and high-resolution mass spectrometry for screening, identification, and quantification of drugs in clinical and forensic toxicology. Ther Drug Monit. 2010;32:324–7.

Wissenbach DK, Meyer MR, Weber AA, Remane D, Ewald AH, Peters FT, et al. Towards a universal LC-MS screening procedure—can an LIT LC-MS(n) screening approach and reference library be used on a quadrupole-LIT hybrid instrument? J Mass Spectrom. 2012;47:66–71.

Dresen S, Ferreirós N, Gnann H, Zimmermann R, Weinmann W. Detection and identification of 700 drugs by multi-target screening with a 3200 Q TRAP LC-MS/MS system and library searching. Anal Bioanal Chem. 2010;396:2425–34.

Oberacher H, Pitterl F, Siapi E, Steele BR, Letzel T, Grosse S, et al. On the inter-instrument and the inter-laboratory transferability of a tandem mass spectral reference library. 3. Focus on ion trap and upfront CID. J Mass Spectrom. 2012;47:263–70.

Oberacher H, Weinmann W, Dresen S. Quality evaluation of tandem mass spectral libraries. Anal Bioanal Chem. 2011;400:2641–8.

Carter GD. 25-Hydroxyvitamin D assays: the quest for accuracy. Clin Chem. 2009;55:1300–2.

Yates AM, Bowron A, Calton L, Heynes J, Field H, Rainbow S, et al. Interlaboratory variation in 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 is significantly improved if common calibration material is used. Clin Chem. 2008;54:2082–4.

Carter GD, Jones JC. Use of a common standard improves the performance of liquid chromatography-tandem mass spectrometry methods for serum 25-hydroxyvitamin-D. Ann Clin Biochem. 2009;46:79–81.

Phinney KW, Bedner M, Tai SS, Vamathevan VV, Sander LC, Sharpless KE, et al. Development and certification of a standard reference material for vitamin D metabolites in human serum. Anal Chem. 2012;84:956–62.

Schleicher RL, Encisco SE, Chaudhary-Webb M, Paliakov E, McCoy LF, Pfeiffer CM. Isotope dilution ultra performance liquid chromatography-tandem mass spectrometry method for simultaneous measurement of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and 3-epi-25-hydroxyvitamin D3 in human serum. Clin Chim Acta. 2011;412:1594–9.

Stepman HC, Vanderroost A, Van Uytfanghe K, Thienpont LM. Candidate reference measurement procedures for serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 by using isotope-dilution liquid chromatography-tandem mass spectrometry. Clin Chem. 2011;57:441–8.

Seger C, Tentschert K, Stöggl W, Griesmacher A, Ramsay SL. A rapid HPLC-MS/MS method for the simultaneous quantification of cyclosporine A, tacrolimus, sirolimus and everolimus in human blood samples. Nat Protoc. 2009;4:526–34.

Vogeser M, Seger C. A decade of HPLC-MS/MS in the routine clinical laboratory—goals for further developments. Clin Biochem. 2008;41:649–62.

Yuan C, Kosewick J, He X, Kozak M, Wang S. Sensitive measurement of serum 1a,25-dihydroxyvitamin D by liquid chromatography/tandem mass spectrometry after removing interference with immunoaffinity extraction. Rapid Commun Mass Spectrom. 2011;25:1241–9.

Strathmann FG, Laha TJ, Hoofnagle AN. Quantification of 1a,25-dihydroxy vitamin D by immunoextraction and liquid chromatography-tandem mass spectrometry. Clin Chem. 2011;57:1279–85.

Casetta B, Jans I, Billen J, Vanderschueren D, Bouillon R. Development of a method for the quantification of 1alpha,25(OH)2-vitamin D3 in serum by liquid chromatography tandem mass spectrometry without derivatization. Eur J Mass Spectrom (Chichester, Eng). 2010;16:81–9.

Singh RJ, Taylor RL, Reddy GS, Grebe SK. C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status. J Clin Endocrinol Metab. 2006;91:3055–61.

Molnar F, Sigüeiro R, Sato Y, Araujo C, Schuster I, Antony P, et al. 1a,25(OH)2-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: its synthesis, biological activity and crystal structure with its receptor. PLoS One. 2011;6:e18124.

Strathmann FG, Sadilkova K, Laha TJ, LeSourd SE, Bornhorst JA, Hoofnagle AN, et al. 3-epi-25 hydroxyvitamin D concentrations are not correlated with age in a cohort of infants and adults. Clin Chim Acta. 2012;413:203–6.

Stepman HC, Vanderroost A, Stöckl D, Thienpont LM. Full-scan mass spectral evidence for 3-epi-25-hydroxyvitamin D3 in serum of infants and adults. Clin Chem Lab Med. 2011;49:253–6.

Lensmeyer G, Poquette M, Wiebe D, Binkley N. The C-3 epimer of 25-hydroxyvitamin D(3) is present in adult serum. J Clin Endocrinol Metab. 2012;97:163–8.

Keevil B. Does the presence of 3-epi-25OHD3 affect the routine measurement of vitamin D using liquid chromatography tandem mass spectrometry? Clin Chem Lab Med. 2011;50:181–3.

Vogeser M, Zachoval R, Spöhrer U, Jacob K. Potential lack of specificity using electrospray tandem-mass spectrometry for the analysis of mycophenolic acid in serum. Ther Drug Monit. 2001;23:722–4.

Vogeser M, Spöhrer U. Pitfall in the high-throughput quantification of whole blood cyclosporin A using liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med. 2005;43:400–2.

Rauh M. LC-MS/MS for protein and peptide quantification in clinical chemistry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;883–884:59–67.

Picotti P, Aebersold R. Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directions. Nat Methods. 2012;9:555–66.