Uptake of synthetic naked RNA by skin-resident dendritic cells via macropinocytosis allows antigen expression and induction of T-cell responses in mice

Abderraouf Selmi1, Fulvia Vascotto2, Kordula Kautz-Neu3, Özlem Türeci4, Uğur Şahin1,5, Esther von Stebut3, Mustafa Diken2,5, Sebastian Kreiter2,5
1Research Center for Immunotherapy (FZI), University Medical Center of Johannes Gutenberg University, Mainz, Germany
2TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Mainz, Germany
3Department of Dermatology, University Medical Center of Johannes Gutenberg University, Mainz, Germany
4Cluster for Individualized Immune Intervention (CI3), Mainz, Germany
5BioNTech RNA Pharmaceuticals GmbH, Mainz, Germany

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