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Cấu trúc quy định upstream của các gen lúa: Tóm tắt cơ sở cho phân tích so sánh quy định mạng lưới trên toàn bộ chi và khai thác alen
Tóm tắt
Việc phân tích cấu trúc quy định upstream của các gen lúa và các protein điều tiết tương ứng của chúng là cốt lõi của sinh học mạng lưới và các ứng dụng của nó trong sinh học chức năng so sánh. Với các nguồn tài nguyên sinh học so sánh về gen trong chi Oryza đang phát triển nhanh chóng, việc thiết lập một chú thích genome tham chiếu xác định các yếu tố cis và các yếu tố trans-acting khác nhau, kết nối mỗi locus gen với các tín hiệu bên trong và bên ngoài khác nhau cho sự phát triển, phát triển sinh sản và thích ứng là rất cần thiết để tạo điều kiện cho việc hiểu biết về biến thể phenotypic trong bối cảnh của các mạng lưới điều tiết. Thông tin như vậy cũng rất quan trọng để tạo nền tảng cho việc khai thác sự biến đổi trong chuỗi không mã hóa, xác định các alen và epialleles mới giữa sự đa dạng phenotypic khổng lồ có trong nguồn gen lúa. Bài đánh giá này trình bày một tổng hợp về tình trạng kiến thức và các xu hướng đồng thuận liên quan đến các thành phần cis-acting và trans-acting khác nhau, xác định sự điều chỉnh không gian-thời gian của các gen lúa dựa trên các ví dụ tiêu biểu từ cả các nghiên cứu nền tảng ở những cây mô hình và cây không mô hình khác, cũng như các nghiên cứu gần đây ở lúa. Mục tiêu là tóm tắt cơ sở cho việc chú thích trình tự upstream có hệ thống của các nguồn tài nguyên trình tự genome đang phát triển nhanh chóng trong Oryza nhằm chuẩn bị cho các nghiên cứu sinh học chức năng trên toàn chi. Các quan điểm về các ứng dụng tiềm năng của thông tin này trong việc phát hiện gen, kỹ thuật mạng lưới và giống lúa được hỗ trợ bởi genomics cũng được thảo luận.
Từ khóa
#cấu trúc quy định #gen lúa #sinh học mạng lưới #gen chức năng so sánh #nghiền alenTài liệu tham khảo
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