Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression

Springer Science and Business Media LLC - Tập 36 - Trang 113-120 - 2015
Lei Chen1,2, Zong-yang Li2, Sui-yi Xu2, Xie-jun Zhang2, Yuan Zhang2, Kun Luo3, Wei-ping Li1,2
1Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
2Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People’s Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen, China
3School of Medicine, Shandong University, Jinan, China

Tóm tắt

MicroRNAs can function as oncogenes or tumor suppressors in glioma. Previously, we showed that miR-107 inhibits glioma cell proliferation, migration, and invasion. Since tumor growth and invasion are closely related to angiogenesis, we further examined the role of miR-107 in glioma angiogenesis. In a co-culture of glioma cells and human brain microvascular endothelial cells (HBMVEC), overexpression of miR-107 in glioma cells led to the inhibition of HBMVEC proliferation, migration, and tube formation ability. ELISA, RT-PCR, and western blot assays revealed that upregulation of miR-107 in glioma cells inhibits VEGF expression. Our findings collectively support the critical involvement of miR-107 in glioma cell angiogenesis and highlight its potential as a therapeutic target for glioma.

Tài liệu tham khảo

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