Upregulated NLRP3 inflammasome activation is attenuated by anthocyanins in patients with nonalcoholic fatty liver disease: A case-control and an intervention study

Younossi, 2019, Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, Hepatology, 69, 2672, 10.1002/hep.30251 Younossi, 2018, Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, Hepatology, 68, 361, 10.1002/hep.29724 Kogiso, 2020, Long-term outcomes of non-alcoholic fatty liver disease and the risk factors for mortality and hepatocellular carcinoma in a Japanese population, J Gastroenterol Hepatol, 35, 1579, 10.1111/jgh.14989 Newsome, 2020, FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study, Lancet Gastroenterol Hepatol, 5, 362, 10.1016/S2468-1253(19)30383-8 Ekstedt, 2006, Long-term follow-up of patients with NAFLD and elevated liver enzymes, Hepatology, 44, 865, 10.1002/hep.21327 Colak, 2021, Pathogenetic mechanisms of nonalcoholic fatty liver disease and inhibition of the inflammasome as a new therapeutic target, Clin Res Hepatol Gastroenterol, 45, 10.1016/j.clinre.2021.101710 Henao-Mejia, 2012, Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity, Nature, 482, 179, 10.1038/nature10809 Xu, 2018, Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice, J Hepatol, 68, 773, 10.1016/j.jhep.2017.11.040 Wree, 2014, NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice, Hepatology, 59, 898, 10.1002/hep.26592 Wree, 2014, NLRP3 inflammasome activation is required for fibrosis development in NAFLD, J Mol Med (Berl), 92, 1069, 10.1007/s00109-014-1170-1 Mridha, 2017, NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice, J Hepatol, 66, 1037, 10.1016/j.jhep.2017.01.022 Qu, 2019, The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice, Int Immunopharmacol, 70, 147, 10.1016/j.intimp.2019.02.016 De Boer, 2016, Fish-oil-derived n-3 polyunsaturated fatty acids reduce NLRP3 inflammasome activity and obesity-related inflammatory cross-talk between adipocytes and CD11b(+) macrophages, J Nutr Biochem, 34, 61, 10.1016/j.jnutbio.2016.04.004 Zheng, 2021, Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome, Cell Mol Immunol, 18, 2422, 10.1038/s41423-020-00545-z Olcum, 2020, Inhibitory effects of phytochemicals on NLRP3 inflammasome activation: a review, Phytomedicine, 75, 10.1016/j.phymed.2020.153238 Gomes, 2019, Antiobesity effects of anthocyanins on mitochondrial biogenesis, inflammation, and oxidative stress: a systematic review, Nutrition, 66, 192, 10.1016/j.nut.2019.05.005 Zhou, 2020, Cyanidin-3-O-beta-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-kappaB signaling pathway, Free Radic Biol Med, 160, 334, 10.1016/j.freeradbiomed.2020.08.006 Zhu, 2018, Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice, J Nutr Biochem, 53, 96, 10.1016/j.jnutbio.2017.10.012 Zhang, 2015, A CONSORT-compliant, randomized, double-blind, placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease, Medicine (Baltimore), 94, e758, 10.1097/MD.0000000000000758 Ghanim, 2004, Circulating mononuclear cells in the obese are in a proinflammatory state, Circulation, 110, 1564, 10.1161/01.CIR.0000142055.53122.FA Jung, 2016, Differences in metabolic biomarkers in the blood and gene expression profiles of peripheral blood mononuclear cells among normal weight, mildly obese and moderately obese subjects, Br J Nutr, 116, 1022, 10.1017/S0007114516002993 Wang, 2015, ZJU index: a novel model for predicting nonalcoholic fatty liver disease in a Chinese population, Sci Rep, 5, 16494, 10.1038/srep16494 Wan, 2016, Role of NLRP3 inflammasome in the progression of NAFLD to NASH, Can J Gastroenterol Hepatol, 2016, 10.1155/2016/6489012 Lee, 2013, Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes, Diabetes, 62, 194, 10.2337/db12-0420 Zhu, 2019, NLRP3 inflammasome expression in peripheral blood monocytes of coronary heart disease patients and its modulation by rosuvastatin, Mol Med Rep, 20, 1826 Everett, 2020, Inhibition of interleukin-1beta and reduction in atherothrombotic cardiovascular events in the CANTOS Trial, J Am Coll Cardiol, 76, 1660, 10.1016/j.jacc.2020.08.011 Santamarina, 2020, Obesity-related inflammatory modulation by jucara berry (Euterpe edulis Mart.) supplementation in Brazilian adults: a double-blind randomized controlled trial, Eur J Nutr, 59, 1693, 10.1007/s00394-019-02024-2 Vugic, 2020, Anthocyanin supplementation inhibits secretion of pro-inflammatory cytokines in overweight and obese individuals, J Funct Foods, 64, 10.1016/j.jff.2019.103596 Speciale, 2020, Anthocyanins as modulators of cell redox-dependent pathways in non-communicable diseases, Curr Med Chem, 27, 1955, 10.2174/0929867325666181112093336 Smeriglio, 2016, Chemistry, pharmacology and health benefits of anthocyanins, Phytother Res, 30, 1265, 10.1002/ptr.5642 Kim, 2017, Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages, Nutr Res Pract, 11, 357, 10.4162/nrp.2017.11.5.357 Muscarà, 2019, Anthocyanins ameliorate palmitate-induced inflammation and insulin resistance in 3T3-L1 adipocytes, Phytother Res, 33, 1888, 10.1002/ptr.6379 Joo, 2018, Anthocyanin-rich extract from red chinese cabbage alleviates vascular inflammation in endothelial cells and Apo E(-/-) Mice, Int J Mol Sci, 19, 816, 10.3390/ijms19030816 Guo, 2020, A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: a randomized controlled trial, Nutrition, 74, 10.1016/j.nut.2020.110745 Zhang, 2020, Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia, Redox Biol, 32, 10.1016/j.redox.2020.101474 Yang, 2017, Role of purified anthocyanins in improving cardiometabolic risk factors in chinese men and women with prediabetes or early untreated diabetes-A randomized controlled trial, Nutrients, 9, 1104, 10.3390/nu9101104 Xu, 2021, Anthocyanin supplementation at different doses improves cholesterol efflux capacity in subjects with dyslipidemia-a randomized controlled trial, Eur J Clin Nutr, 75, 345, 10.1038/s41430-020-0609-4