Updates on the Management of Non-Melanoma Skin Cancer (NMSC)

Healthcare - Tập 5 Số 4 - Trang 82
Artur Fahradyan1,2, Anna C. Howell2, Erik M. Wolfswinkel2, Michaela Tsuha1, Parthiv Sheth3, Alex K. Wong2
1Division of Plastic and Maxillofacial Surgery, Children's Hospital of Los Angeles, Los Angeles, CA 90027, USA;
2Division of Plastic and Reconstructive Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA;
3Keck School of Medicine of University of Southern California, Los Angeles, CA 91001, USA;

Tóm tắt

Non-melanoma skin cancers (NMSCs) are the most common malignancy worldwide, of which 99% are basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of skin. NMSCs are generally considered a curable diseases, yet they currently pose an increasing global healthcare problem due to rising incidence. This has led to a shift in emphasis on prevention of NMSCs with development of various skin cancer prevention programs worldwide. This article aims to summarize the most recent changes and advances made in NMSC management with a focus on prevention, screening, diagnosis, and staging.

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Tài liệu tham khảo

Lomas, 2012, A systematic review of worldwide incidence of nonmelanoma skin cancer, Br. J. Dermatol., 166, 1069, 10.1111/j.1365-2133.2012.10830.x

Rogers, 2010, Incidence estimate of nonmelanoma skin cancer in the United States, 2006, Arch. Dermatol., 146, 283, 10.1001/archdermatol.2010.19

Leiter, 2014, Epidemiology of skin cancer, Adv. Exp. Med. Biol., 810, 120

Apalla, 2017, Epidemiological trends in skin cancer, Dermatol. Pract. Concept., 7, 1, 10.5826/dpc.0702a01

Katalinic, 2003, Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: Incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer), Br. J. Dermatol., 149, 1200, 10.1111/j.1365-2133.2003.05554.x

Losquadro, 2017, Anatomy of the Skin and the Pathogenesis of Nonmelanoma Skin Cancer, Facial Plast. Surg. Clin. N. Am., 25, 283, 10.1016/j.fsc.2017.03.001

Rigel, D.S., Robinson, J.K., Ross, M., Friedman, R.J., Cockerell, C.J., Lim, H.W., Stockfleth, E., and Kirkwood, J.M. (2011). Epidemiology of skin cancer. Cancer of the Skin, Elsevier. [2nd ed.].

Wollina, 2017, Carcinosarcoma of skin (sarcomatoid carcinoma)—A rare non-melanoma skin cancer (Case Review), Georgian Med. News, 263, 7

Barton, 2017, Nonmelanoma skin cancer and risk of all-cause and cancer-related mortality: A systematic review, Arch. Dermatol. Res., 309, 243, 10.1007/s00403-017-1724-5

Lewis, 2004, Nonmelanoma Skin Cancer Mortality (1988–2000), Arch. Dermatol., 140, 837, 10.1001/archderm.140.7.837

Guy, 2015, Prevalence and Costs of Skin Cancer Treatment in the U.S., 2002−2006 and 2007−2011, Am. J. Prev. Med., 48, 183, 10.1016/j.amepre.2014.08.036

Urbach, 1976, Cutaneous photobiology: Past, present and future, J. Investig. Dermatol., 67, 209, 10.1111/1523-1747.ep12513042

Fears, 1977, Mathematical models of age and ultraviolet effects on the incidence of skin cancer among whites in the United States, Am. J. Epidemiol., 105, 420, 10.1093/oxfordjournals.aje.a112400

Fears, 1978, The Authors Reply, Am. J. Epidemiol., 107, 260, 10.1093/oxfordjournals.aje.a112535

Armstrong, 2017, Sun exposure and skin cancer, and the puzzle of cutaneous melanoma, Cancer Epidemiol., 48, 147, 10.1016/j.canep.2017.04.004

Hampras, S., Locke, F., Chavez, J., Patel, P.S., Giuliano, A.R., Miller, K., Gheit, T., Tommasino, M., and Rollison, D.E. (2017). Prevalence of cutaneous viral infections in incident cutaneous squamous cell carcinoma detected among chronic lymphocytic leukemia and hematopoietic stem cell transplant patients. Leuk. Lymphoma, 1–7.

Hiesse, 1997, Malignancy after renal transplantation: Analysis of incidence and risk factors in 1700 patients followed during a 25-year period, Transplant. Proc., 29, 831, 10.1016/S0041-1345(96)00153-4

Greenberg, 2011, Management of Skin Cancer in Solid-organ Transplant Recipients: A Multidisciplinary Approach, Dermatol. Clin., 29, 231, 10.1016/j.det.2011.02.004

Penn, 2000, Post-transplant malignancy: The role of immunosuppression, Drug Saf., 23, 101, 10.2165/00002018-200023020-00002

Pollard, 2000, Head and neck cancer in cardiothoracic transplant recipients, Laryngoscope, 110, 1257, 10.1097/00005537-200008000-00006

Marzuka, 2015, Basal cell carcinoma: Pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management, Yale J. Biol. Med., 88, 167

Fogel, 2017, Genetic diseases associated with an increased risk of skin cancer development in childhood, Curr. Opin. Pediatr., 29, 426, 10.1097/MOP.0000000000000514

Amaral, 2017, Non-melanoma skin cancer: New and future synthetic drug treatments, Exp. Opin. Pharmacother., 18, 689, 10.1080/14656566.2017.1316372

Perkins, 2005, Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: A report from the childhood cancer survivor study, J. Clin. Oncol., 23, 3733, 10.1200/JCO.2005.06.237

Karagas, 2007, Squamous cell and basal cell carcinoma of the skin in relation to radiation therapy and potential modification of risk by sun exposure, Epidemiol. Camb. Mass, 18, 776, 10.1097/EDE.0b013e3181567ebe

Watt, 2012, Radiation-related risk of basal cell carcinoma: A report from the Childhood Cancer Survivor Study, J. Natl. Cancer Inst., 104, 1240, 10.1093/jnci/djs298

Schwartz, 2009, Basal cell skin cancer after total-body irradiation and hematopoietic cell transplantation, Radiat. Res., 171, 155, 10.1667/RR1469.1

Khalesi, 2013, A meta-analysis of pigmentary characteristics, sun sensitivity, freckling and melanocytic nevi and risk of basal cell carcinoma of the skin, Cancer Epidemiol., 37, 534, 10.1016/j.canep.2013.05.008

Vilata, 2013, Risk factors for non-melanoma skin cancer in kidney transplant patients in a Spanish population in the Mediterranean region, Acta Derm. Venereol., 93, 422, 10.2340/00015555-1525

Zilinska, 2017, Occurrence of malignancies after kidney transplantation in adults: Slovak multicenter experience, Neoplasma, 64, 311, 10.4149/neo_2017_220

Parren, 2011, Hereditary tumour syndromes featuring basal cell carcinomas, Br. J. Dermatol., 165, 30, 10.1111/j.1365-2133.2011.10334.x

Karagas, 2006, Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin, J. Natl. Cancer Inst., 98, 389, 10.1093/jnci/djj092

Patel, 2008, Exposure profiles and human papillomavirus infection in skin cancer: An analysis of 25 genus beta-types in a population-based study, J. Investig. Dermatol., 128, 2888, 10.1038/jid.2008.162

Nikolaou, 2012, Hereditary nonmelanoma skin cancer, Semin. Cutan. Med. Surg., 31, 204, 10.1016/j.sder.2012.08.005

2017, Squamous Cell Carcinoma of the Peristomal Skin of a Gastrostomy, J. Wound Ostomy Cont. Nurs., 44, 384, 10.1097/WON.0000000000000345

Oh, 2011, Primary squamous cell carcinoma arising at a gastrostomy tube site, J. Pediatr. Surg., 46, 756, 10.1016/j.jpedsurg.2011.01.018

Arons, 1965, Scar tissue carcinoma, part I: A clinical study with special reference to burn scar carcinoma, Ann. Surg., 161, 170, 10.1097/00000658-196502000-00003

Ramanujam, 2002, An unusual case of squamous cell carcinoma arising at the stomal site: Case report and review of the literature, J. Gastrointest. Surg., 6, 630, 10.1016/S1091-255X(01)00007-5

Losanoff, 2011, Squamous cell carcinoma complicating chronic suppurative hydradenitis, Am. Surg., 77, 1449, 10.1177/000313481107701131

Lavogiez, 2010, Clinicopathological study of 13 cases of squamous cell carcinoma complicating hidradenitis suppurativa, Dermatology, 220, 147, 10.1159/000269836

Cruickshank, 1963, Jean-Nicolas Marjolin: Destined to be forgotten?, Med. Hist., 7, 383, 10.1017/S0025727300028854

Metwally, 2017, Epidemiology and predictors of recurrence of Marjolin’s ulcer: Experience from Mansoura Universityxs, Ann. R. Coll. Surg. Engl., 99, 245, 10.1308/rcsann.2016.0309

Bartos, 2017, Basal Cell Carcinoma Multiplicity–A Retrospective Analysis of 899 Biopsy-proven Patients from a Single Institute, Klinicka Onkol., 30, 197, 10.14735/amko2017197

Ramachandran, 2001, Cutaneous basal cell carcinomas: Distinct host factors are associated with the development of tumors on the trunk and on the head and neck, Cancer, 92, 354, 10.1002/1097-0142(20010715)92:2<354::AID-CNCR1330>3.0.CO;2-F

Mukhtar, H. (1995). Unresolved issues in the epidemiology of basal cell and squamous cell skin cancer. Skin Cancer: Mechanisms and Human Relevance, CRC Press.

Kiiski, 2010, Risk factors for single and multiple basal cell carcinomas, Arch. Dermatol., 146, 848, 10.1001/archdermatol.2010.155

Flohil, 2011, Cumulative risks and rates of subsequent basal cell carcinomas in Netherlands, Br. J. Dermatol., 165, 874, 10.1111/j.1365-2133.2011.10488.x

Lovatt, 2005, Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors, J. Am. Acad. Dermatol., 52, 468, 10.1016/j.jaad.2004.08.060

Weistenhofer, 2017, Retrospective evaluation of exposure to natural UV radiation: Experiences with the online UV history tool in a field study, JDDG J. Dtsch. Dermatol. Ges., 15, 610, 10.1111/ddg.13250

Schaart, 1993, Disappearance of the ozone layer and skin cancer: Attempt at risk assessment, Hautarzt, 44, 63

Silverberg, 2013, HIV infection status, immunodeficiency, and the incidence of non-melanoma skin cancer, J. Natl. Cancer Inst., 105, 350, 10.1093/jnci/djs529

Asgari, 2017, Association of Multiple Primary Skin Cancers with Human Immunodeficiency Virus Infection, CD4 Count, and Viral Load, JAMA Dermatol., 153, 892, 10.1001/jamadermatol.2017.1716

Moloney, 2006, A population-based study of skin cancer incidence and prevalence in renal transplant recipients, Br. J. Dermatol., 154, 498, 10.1111/j.1365-2133.2005.07021.x

Lindelof, 2000, Incidence of skin cancer in 5356 patients following organ transplantation, Br. J. Dermatol., 143, 513

Buell, 2002, Immunosuppression and merkel cell cancer, Transpl. Proc., 34, 1780, 10.1016/S0041-1345(02)03065-8

Vakharia, P., Nardone, B., Schlosser, B., Lee, D., Serrano, L., and West, D. (2017). Chronic exposure to tetracyclines and subsequent diagnosis for non-melanoma skin cancer in a large Midwestern U.S. patient population. J. Eur. Acad. Dermatol. Venereol.

FDA (2017, July 24). Tattoos & Permanent Makeup: Fact Sheet, Available online: https://www.fda.gov/cosmetics/productsingredients/products/ucm108530.htm.

Junqueira, 2017, Squamous neoplasms arising within tattoos: Clinical presentation, histopathology and management, Clin. Exp. Dermatol., 42, 601, 10.1111/ced.13183

Burton, 2016, Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease, Am. J. Clin. Dermatol., 17, 491, 10.1007/s40257-016-0207-3

Ting, 2005, Metastatic basal cell carcinoma: Report of two cases and literature review, J. Cutan. Med. Surg., 9, 10, 10.1177/120347540500900104

Toll, 2015, Active nuclear IKK correlates with metastatic risk in cutaneous squamous cell carcinoma, Arch. Dermatol. Res., 307, 721, 10.1007/s00403-015-1579-6

Karia, 2014, Evaluation of American Joint Committee on Cancer, International Union Against Cancer, and Brigham and Women’s Hospital Tumor Staging for Cutaneous Squamous Cell Carcinoma, J. Clin. Oncol., 32, 327, 10.1200/JCO.2012.48.5326

Motaparthi, 2017, Cutaneous Squamous Cell Carcinoma, Adv. Anatomic Pathol., 24, 171, 10.1097/PAP.0000000000000157

Edge, S.B., Byrd, D.R., Compton, C.C., Fritz, A.G., Greene, F.L., and Trotti, A. (2010). Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas American Joint Committee on Cancer. AJCC Cancer Staging Handbook, Springer. [7th ed.]. Chapter 29.

Califano, J.A., Lydiatt, W.M., Nehal, K.S., O’Sullivan, B., Schmults, C., Seethala, R.R., Weber, R.S., and Shah, J.P. (2017). Chapter 15: Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC Cancer Staging Manual, Springer. [8th ed.].

McCormack, 1997, Differences in age and body site distribution of the histological subtypes of basal cell carcinoma. A possible indicator of differing causes, Arch. Dermatol., 133, 593, 10.1001/archderm.1997.03890410049006

Muzic, 2017, Incidence and Trends of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma, Mayo Clin. Proc., 92, 890, 10.1016/j.mayocp.2017.02.015

Verkouteren, 2017, Epidemiology of basal cell carcinoma: Scholarly review, Br. J. Dermatol., 177, 359, 10.1111/bjd.15321

Olson, 2008, The impact of an appearance-based educational intervention on adolescent intention to use sunscreen, Health Educ. Res., 23, 763, 10.1093/her/cym005

Reeder, 2012, Sun protection policies and practices in New Zealand primary schools, N. Z. Med. J., 125, 70

Doran, C.M., Ling, R., Byrnes, J., Crane, M., Shakeshaft, A.P., Searles, A., and Perez, D. (2016). Benefit Cost Analysis of Three Skin Cancer Public Education Mass-Media Campaigns Implemented in New South Wales, Australia. PLoS ONE, 11.

Robinson, 2009, The duty to inspect the skin and counsel those at risk to develop melanoma, JAMA, 301, 1702, 10.1001/jama.2009.542

Reichrath, 2017, Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond, Mol. Cell. Endocrinol., 453, 96, 10.1016/j.mce.2017.05.001

Chen, 2015, A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention, N. Engl. J. Med., 373, 1618, 10.1056/NEJMoa1506197

Minocha, R., Damian, D., and Halliday, G. (2017). Melanoma and non-melanoma skin cancer chemoprevention: A role for nicotinamide?. Photodermatol. Photoimmunol. Photomed.

Drago, 2017, Prevention of non-melanoma skin cancers with nicotinamide in transplant recipients: A case-control study, Eur. J. Dermatol., 27, 382, 10.1684/ejd.2017.3025

Cummings, 1997, Approaches to the prevention and control of skin cancer, Cancer Metastasis Rev., 16, 309, 10.1023/A:1005804328268

Malvehy, J., and Pellacani, G. (2017). Dermoscopy, Confocal Microscopy and other Non-invasive Tools for the Diagnosis of Non-Melanoma Skin Cancers and Other Skin Conditions. Acta Derm. Venereol.

Werner, 2015, Evidence- and consensus-based (S3) Guidelines for the treatment of actinic keratosis–International League of Dermatological Societies in cooperation with the European Dermatology Forum–short version, J. Eur. Acad. Dermatol. Venereol., 29, 2069, 10.1111/jdv.13180

Dourmishev, 2013, Clinical variants, stages, and management of basal cell carcinoma, Indian Dermatol. Online J., 4, 12, 10.4103/2229-5178.105456

Walling, 2004, Aggressive basal cell carcinoma: Presentation, pathogenesis, and management, Cancer Metastasis Rev., 23, 389, 10.1023/B:CANC.0000031775.04618.30

Rubin, 2005, Basal-cell carcinoma, N. Engl. J. Med., 353, 2262, 10.1056/NEJMra044151

Duarte, 2017, A prospective evaluation of the candle wax sign: A visual clue to diagnose aggressive basal cell carcinoma, J. Am. Acad. Dermatol., 77, 163, 10.1016/j.jaad.2017.02.043

Murzaku, 2014, Methods and rates of dermoscopy usage: A cross-sectional survey of US dermatologists stratified by years in practice, J. Am. Acad. Dermatol., 71, 393, 10.1016/j.jaad.2014.03.048

Katz, 2010, Dermoscopy and its impact on skin cancer diagnostics, J. Drugs Dermatol., 9, 129

Felder, 2006, Dermoscopic differentiation of a superficial basal cell carcinoma and squamous cell carcinoma in situ, Dermatol. Surg., 32, 423

Amjadi, 2010, Non-Invasive Tools for Improving Diagnosis of Non-Melanoma Skin Cancer: A Review, Int. J. Plast. Surg., 7, 1

Mu, 2016, Use of Digitally Stained Multimodal Confocal Mosaic Images to Screen for Nonmelanoma Skin Cancer, JAMA Dermatol., 152, 1335, 10.1001/jamadermatol.2016.2997

Que, 2016, Basics of Confocal Microscopy and the Complexity of Diagnosing Skin Tumors, Dermatol. Clin., 34, 367, 10.1016/j.det.2016.05.001

Russell, 1999, Basal cell carcinoma: A comparison of shave biopsy versus punch biopsy techniques in subtype diagnosis, J. Am. Acad. Dermatol., 41, 69, 10.1016/S0190-9622(99)70409-3

Gurunluoglu, 2015, Nonpersistence of Basal Cell Carcinoma after Diagnostic Shave Biopsy, Ann. Plast. Surg., 74, 695, 10.1097/01.SAP.0000462324.61391.04

Alcalay, 2004, Residual skin cancer after preoperative biopsy: Evaluation by Mohs micrographic surgery, Int. J. Dermatol., 43, 456, 10.1111/j.1365-4632.2004.02129.x

Alcalay, 2010, Histological evaluation of residual basal cell carcinoma after shave biopsy prior to Mohs micrographic surgery, J. Eur. Acad. Dermatol. Venereol., 25, 839, 10.1111/j.1468-3083.2010.03881.x

Grelck, 2013, Incidence of Residual Nonmelanoma Skin Cancer in Excisions after Shave Biopsy, Dermatol. Surg., 39, 374, 10.1111/dsu.12056

Goldberg, 2005, Accuracy of serial transverse cross-sections in detecting residual basal cell carcinoma at the surgical margins of an elliptical excision specimen, J. Am. Acad. Dermatol., 53, 468, 10.1016/j.jaad.2005.02.049

Roozeboom, 2012, Agreement between histological subtype on punch biopsy and surgical excision in primary basal cell carcinoma, J. Eur. Acad. Dermatol. Venereol., 27, 894, 10.1111/j.1468-3083.2012.04608.x

Schnebelen, 2016, Margin Status in Shave Biopsies of Nonmelanoma Skin Cancers: Is It Worth Reporting?, Arch. Pathol. Lab. Med., 140, 678, 10.5858/arpa.2015-0313-OA

Sun, 2015, Accuracy of Biopsy in Subtyping Periocular Basal Cell Carcinoma, Ophthalmic Plast. Reconstr. Surg., 31, 449, 10.1097/IOP.0000000000000372

Kadouch, 2017, Diagnostic accuracy of confocal microscopy imaging versus punch biopsy for diagnosing and subtyping basal cell carcinoma, J. Eur. Acad. Dermatol. Venereol., 31, 1641, 10.1111/jdv.14253

Que, 2016, Application of Handheld Confocal Microscopy for Skin Cancer Diagnosis, Dermatol. Clin., 34, 469, 10.1016/j.det.2016.05.009

Cinotti, 2014, Laser photodynamic treatment for in situ squamous cell carcinoma of the glans monitored by reflectance confocal microscopy, Australas. J. Dermatol., 55, 72, 10.1111/ajd.12052

Kai, 2016, Five-year recurrence rate of lentigo maligna after treatment with imiquimod, Br. J. Dermatol., 174, 165, 10.1111/bjd.14311

Chen, 2014, Confocal microscopy-guided laser ablation for superficial and early nodular basal cell carcinoma: A promising surgical alternative for superficial skin cancers, JAMA Dermatol., 150, 994, 10.1001/jamadermatol.2013.10225

Phelps, 2014, Biopsy Techniques, JAMA Dermatol., 150, 12, 10.1001/jamadermatol.2013.7226

American Academy of Dermatology|Association (2017, July 20). Clinical Guidelines. Available online: https://www.aad.org/practicecenter/quality/clinical-guidelines#undefined.

(2017, July 18). National Comprehensive Cancer Network. Available online: https://www.nccn.org/professionals/physician_gls/pdf/nmsc_blocks.pdf.

Humphreys, 2017, The role of imaging in the management of patients with nonmelanoma skin cancer: When is Imaging Necessary?, J. Am. Acad. Dermatol., 76, 591, 10.1016/j.jaad.2015.10.009

MacFarlane, 2017, The role of imaging in the management of patients with nonmelanoma skin cancer: Diagnostic Modalities and Applications, J. Am. Acad. Dermatol., 76, 579, 10.1016/j.jaad.2015.10.010

Lv, 2017, A Network Meta-Analysis of Non-Melanoma Skin Cancer (NMSC) Treatments: Efficacy and Safety Assessment, J. Cell. Biochem., 118, 3686, 10.1002/jcb.26015

Griffin, L., and Lear, J. (2016). Photodynamic Therapy and Non-Melanoma Skin Cancer. Cancers, 8.

Cohen, D., and Lee, P. (2016). Photodynamic Therapy for Non-Melanoma Skin Cancers. Cancers, 8.

Hamdan, 2017, Microneedle-assisted photodynamic therapy: Delivery of a NIR photosensitiser for the treatment of skin cancers, Photodiagnosis Photodyn. Ther., 17, A63, 10.1016/j.pdpdt.2017.01.141

Cheraghi, 2017, Radiation Therapy in Dermatology: Non-Melanoma Skin Cancer, J. Drugs Dermatol., 16, 464

Abramson, 2013, Tangential Shave Removal of Basal Cell Carcinoma, Dermatol. Surg., 39, 387, 10.1111/dsu.12106

Taheri, 2013, Tangential Shave Removal of Basal Cell Carcinoma, Dermatol. Surg., 39, 1945, 10.1111/dsu.12330

Stewart, 2014, Surgical Excision of Non–Melanoma Skin Cancer in an Elderly Veteran’s Affairs Population, Plast. Reconstr. Surg. Glob. Open, 2, e277, 10.1097/GOX.0000000000000234

Gonzalez, 2016, Resistance of Nonmelanoma Skin Cancer to Nonsurgical Treatments. Part I: Topical Treatments, Actas Dermo-Sifiliogr., 107, 730

Salazar, 2016, Resistance of Nonmelanoma Skin Cancer to Nonsurgical Treatments. Part II: Photodynamic Therapy, Vismodegib, Cetuximab, Intralesional Methotrexate, and Radiotherapy, Actas Dermo-Sifiliogr., 107, 740, 10.1016/j.ad.2016.04.020

Telfer, 2008, Guidelines for the management of basal cell carcinoma, Br. J. Dermatol., 159, 35, 10.1111/j.1365-2133.2008.08666.x

Motley, 2002, Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma, Br. J. Dermatol., 146, 18, 10.1046/j.0007-0963.2001.04615.x

Bath-Hextall, F.J., Perkins, W., Bong, J., and Williams, H.C. (2007). Interventions for basal cell carcinoma of the skin. Cochrane Database Syst. Rev.

Smeets, 2004, Surgical excision vs. Mohs’ micrographic surgery for basal-cell carcinoma of the face: Randomised controlled trial, Lancet, 364, 1766, 10.1016/S0140-6736(04)17399-6

Lansbury, 2013, Interventions for nonmetastatic squamous cell carcinoma of the skin: Systematic review and pooled analysis of observational studies, BMJ, 347, f6153, 10.1136/bmj.f6153

Ghareeb, 2016, Underutilization of Mohs Micrographic Surgery for Less Common Cutaneous Malignancies in the United States, Dermatol. Surg., 42, 653, 10.1097/DSS.0000000000000705

Moncrieff, 2015, False-negative rate of intraoperative frozen section margin analysis for complex head and neck nonmelanoma skin cancer excisions, Clin. Exp. Dermatol., 40, 834, 10.1111/ced.12743

Walker, 2017, Rapid visualization of nonmelanoma skin cancer, J. Am. Acad. Dermatol., 76, 209, 10.1016/j.jaad.2016.09.008

Schell, 2013, Suggested Excisional Margins for Cutaneous Malignant Lesions Based on Mohs Micrographic Surgery, JAMA Facial Plast. Surg., 15, 337, 10.1001/jamafacial.2013.1011

McDaniel, 1983, Therapy for basal cell epitheliomas by curettage only: Further study, Arch. Dermatol., 119, 901, 10.1001/archderm.1983.01650350029009

Reymann, 1985, 15 years’ experience with treatment of basal cell carcinomas of the skin with curettage, Acta Derm. Venereol. Suppl. Stockh, 120, 56

Barlow, 2006, Treatment of basal cell carcinoma with curettage alone, J. Am. Acad. Dermatol., 54, 1039, 10.1016/j.jaad.2006.01.041

Kauvar, 2015, Consensus for Nonmelanoma Skin Cancer Treatment; basal cell carcinoma, including a cost analysis of treatment methods, Dermatol. Surg., 41, 550, 10.1097/DSS.0000000000000296

Kauvar, 2015, Consensus for Nonmelanoma Skin Cancer Treatment, Part II; Squamous Cell Carcinoma, Including a Cost Analysis of Treatment Methods, Dermatol. Surg., 41, 1214, 10.1097/DSS.0000000000000478

Blixt, 2013, Recurrence rates of aggressive histologic types of basal cell carcinoma after treatment with electrodesiccation and curettage alone, Dermatol. Surg., 39, 719, 10.1111/dsu.12122

Silverman, 1991, Recurrence rates of treated basal cell carcinomas. Part 2: Curettage-electrodesiccation, J. Dermatol. Surg. Oncol., 17, 720, 10.1111/j.1524-4725.1991.tb03425.x

Rowe, 1989, Mohs surgery is the treatment of choice for recurrent (previously treated) basal cell carcinoma, J. Dermatol. Surg. Oncol., 15, 424, 10.1111/j.1524-4725.1989.tb03249.x

Rowe, 1989, Long-term recurrence rates in previously untreated (primary) basal cell carcinoma: Implications for patient follow-up, J. Dermatol. Surg. Oncol., 15, 315, 10.1111/j.1524-4725.1989.tb03166.x

Kennedy, 1990, Photodynamic therapy with endogenous protoporphyrin IX: Basic principles and present clinical experience, J. Photochem. Photobiol. B Biol., 6, 143, 10.1016/1011-1344(90)85083-9

Grant, 1993, Photodynamic therapy of malignant and premalignant lesions in patients with ‘field cancerization’ of the oral cavity, J. Laryngol. Otol., 107, 1140, 10.1017/S0022215100125496

Grant, 1997, Photodynamic therapy: An effective, but non-selective treatment for superficial cancers of the oral cavity, Int. J. Cancer, 71, 937, 10.1002/(SICI)1097-0215(19970611)71:6<937::AID-IJC4>3.0.CO;2-Z

Lou, 2004, Interstitial photodynamic therapy as salvage treatment for recurrent head and neck cancer, Br. J. Cancer, 91, 441, 10.1038/sj.bjc.6601993

Jager, 2005, MR imaging-guided interstitial photodynamic laser therapy for advanced head and neck tumors, AJNR Am. J. Neuroradiol., 26, 1193

Jerjes, 2007, The application of photodynamic therapy in the head and neck, Dent. Update Lond., 34, 478, 10.12968/denu.2007.34.8.478

Wennberg, 2006, Results from a 15-month update of a multicentre study of methyl aminolaevulinate photodynamic therapy in immunocompromised organ transplant recipients with nonmelanoma skin cancer, Br. J. Dermatol., 155, 57

Jain, 2016, 5-Aminolevulinic acid coated microneedles for photodynamic therapy of skin tumors, J. Control. Release, 239, 72, 10.1016/j.jconrel.2016.08.015

2016, Penetration of 630 nm laser and 5-aminolevulinic acid in tissue with intralesional photodynamic therapy, Photodiagnosis Photodyn. Ther., 16, 166, 10.1016/j.pdpdt.2016.09.006

Anand, 2017, Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death, Mol. Cancer Ther., 16, 1092, 10.1158/1535-7163.MCT-16-0608

Peng, 2017, A Clinical Trial Using Attrition Combined with 5-Aminolevulinic Acids Based Photodynamic Therapy in Treating Squamous Cell Carcinoma, Med. Sci. Monit., 23, 1347, 10.12659/MSM.900420

Patel, 2016, Highly Effective Dual-Function Near-Infrared (NIR) Photosensitizer for Fluorescence Imaging and Photodynamic Therapy (PDT) of Cancer, J. Med. Chem., 59, 9774, 10.1021/acs.jmedchem.6b00890

Sotiriou, E., Apalla, Z., Vrani, F., Lazaridou, E., Vakirlis, E., Lallas, A., and Ionnides, D. (2017). Daylight photodynamic therapy vs. Conventional photodynamic therapy as skin cancer preventive treatment in patients with faces and scalp cancerization: An intra-individual comparison study. J. Eur. Acad. Dermatol. Venereol.

Apalla, 2010, Skin cancer: Preventive photodynamic therapy in patients with face and scalp cancerization. A randomized placebo-controlled study, Br. J. Dermatol., 162, 171, 10.1111/j.1365-2133.2009.09492.x

Grigalavicius, 2017, The influence of photodynamic therapy with 5-aminolevulinic acid on senescent skin cancer cells, Photodiagnosis Photodyn. Ther., 17, 29, 10.1016/j.pdpdt.2016.10.008

Orbuch, 2016, The Photodynamic Therapy Experience of a High Volume Laser and Dermatologic Surgery Center, J. Drugs Dermatol., 15, 1420

Blanco, 2017, A Multicenter Clinical Study of Expected and Unexpected Side Reactions during and after Skin Cancer Treatment by Photodynamic Therapy, Skinmed, 15, 113

Anderson, 2013, Lasers for Dermatology and Skin Biology, J. Investig. Dermatol., 133, E21, 10.1038/skinbio.2013.181

Jalian, 2013, Combined 585 nm pulsed-dye and 1064 nm Nd:YAG lasers for the treatment of basal cell carcinoma, Lasers Surg. Med., 46, 1, 10.1002/lsm.22201

Anderson, 1983, Selective photothermolysis: Precise microsurgery by selective absorption of pulsed radiation, Science, 220, 524, 10.1126/science.6836297

Mirza, F., and Khatri, K. (2017). The use of lasers in the treatment of skin cancer: A review. J. Cosmet. Laser Ther.

Soleymani, 2017, An Analysis of Laser Therapy for the Treatment of Nonmelanoma Skin Cancer, Dermatol. Surg., 43, 615, 10.1097/DSS.0000000000001048

Bolognia, J.L., Jorizzo, J.L., and Schaffer, J.V. (2012). Laser therapy. Dermatology, Mosby. [3rd ed.].

Omi, 2014, The role of the CO2 laser and fractional CO2 laser in dermatology, Laser Ther., 23, 49, 10.5978/islsm.14-RE-01

Humphreys, 1998, Treatment of superficial basal cell carcinoma and squamous cell carcinoma in situ with a high-energy pulsed carbon dioxide laser, Arch. Dermatol., 134, 1247, 10.1001/archderm.134.10.1247

Trelles, 1996, Penetration depth of ultrapulsed carbon dioxide laser in human skin, Dermatol. Surg., 22, 863, 10.1111/j.1524-4725.1996.tb00589.x

Adams, 1979, Treatment of basal-cell carcinomas with a carbon-dioxide laser, J. Dermatol. Surg. Oncol., 5, 803, 10.1111/j.1524-4725.1979.tb00756.x

Pozo, 2008, Bowen’s disease treated by carbon dioxide laser. A series of 44 patients, J. Dermatol. Treat., 19, 293, 10.1080/09546630701870772

Choi, 2017, Effect of Methyl Aminolevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients with Microinvasive Squamous Cell Carcinoma, JAMA Dermatol., 153, 289, 10.1001/jamadermatol.2016.4463

Smucler, 2008, Combination of Er:YAG laser and photodynamic therapy in the treatment of nodular basal cell carcinoma, Lasers Surg. Med., 40, 153, 10.1002/lsm.20606

Ko, 2014, A randomized trial comparing methyl aminolaevulinate photodynamic therapy with and without Er:YAG ablative fractional laser treatment in Asian patients with lower extremity Bowen disease: Results from a 12-month follow-up, Br. J. Dermatol., 170, 165, 10.1111/bjd.12627

Smucler, 2012, Ultrasound guided ablative-laser assisted photodynamic therapy of basal cell carcinoma (US-aL-PDT), Photomed. Laser Surg., 30, 200, 10.1089/pho.2011.3107

Choi, 2016, Er:YAG ablative fractional laser-primed photodynamic therapy with methyl aminolevulinate as an alternative treatment option for patients with thin nodular basal cell carcinoma: 12-month follow-up results of a randomized, prospective, comparative trial, J. Eur. Acad. Dermatol. Venereol., 30, 783, 10.1111/jdv.13453

Carija, 2016, Single treatment of low-risk basal cell carcinomas with pulsed dye laser-mediated photodynamic therapy (PDL-PDT) compared with photodynamic therapy (PDT): A controlled, investigator-blinded, intra-individual prospective study, Photodiagnosis Photodyn. Ther., 16, 60, 10.1016/j.pdpdt.2016.08.003

Kwan, 2004, Radiotherapy for locally advanced basal cell and squamous cell carcinomas of the skin, Int. J. Radiat. Oncol. Biol. Phys., 60, 406e411, 10.1016/j.ijrobp.2004.03.006

Locke, 2001, Radiotherapy for epithelial skin cancer, Int. J. Radiat. Oncol. Biol. Phys., 51, 748, 10.1016/S0360-3016(01)01656-X

Schulte, 2005, Soft X-ray therapy for cutaneous basal cell and squamous cell carcinomas, J. Am. Acad. Dermatol., 53, 993, 10.1016/j.jaad.2005.07.045

Creutzberg, 2010, Efficacy of a hypofractionated schedule in electron beam radiotherapy for epithelial skin cancer: Analysis of 434 cases, Radiother. Oncol., 95, 245, 10.1016/j.radonc.2010.02.024

Guix, 2000, Treatment of skin carcinomas of the face by high-dose-rate brachytherapy and custom-made surface molds, Int. J. Radiat. Oncol. Biol. Phys., 47, 95, 10.1016/S0360-3016(99)00547-7

Likhacheva, 2017, Skin surface brachytherapy: A survey of contemporary practice patterns, Brachytherapy, 16, 223, 10.1016/j.brachy.2016.10.006

Goyal, 2015, A pilot study of ultrasound-guided electronic brachytherapy for skin cancer, J. Contemp. Brachyther., 5, 374, 10.5114/jcb.2015.55538

Mendenhall, 2009, Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck, Laryngoscope, 119, 1994, 10.1002/lary.20608

Lovett, 1990, External Irradiation of epithelial skin cancer, Int. J. Radiat. Oncol. Biol. Phys., 19, 235, 10.1016/0360-3016(90)90529-S

Cognetta, 2012, Superficial X-ray in the treatment of basal and squamous cell carcinomas: A viable option in select patients, J. Am. Acad. Dermatol., 67, 1235, 10.1016/j.jaad.2012.06.001

Miller, 1982, Electron beam therapy for difficult cutaneous basal and squamous cell carcinoma, Br. J. Dermatol., 106, 429, 10.1111/j.1365-2133.1982.tb04536.x

Mareco, 2015, Interstitial high-dose-rate brachytherapy in eyelid cancer, Brachytherapy, 14, 554, 10.1016/j.brachy.2015.03.005

Cho, 2014, Utility of radiotherapy for treatment of basal cell carcinoma: A review, Br. J. Dermatol., 171, 968, 10.1111/bjd.13253

Pfeiffer, 1990, Systemic cytotoxic therapy of basal cell carcinoma. A review of the literature, Eur. J. Cancer, 26, 73, 10.1016/0277-5379(90)90262-R

Carneiro, 2006, Metastatic basal cell carcinoma: Complete response to chemotherapy and associated pure red cell aplasia, Cancer Investig., 24, 396, 10.1080/07357900600705474

Khandekar, 1990, Complete response of metastatic basal cell carcinoma to cisplatin chemotherapy: A report on two patients, Arch. Dermatol., 126, 1660, 10.1001/archderm.1990.01670360128037

Wysong, 2013, Update on metastatic basal cell carcinoma: A summary of published cases from 1981 through 2011, JAMA Dermatol., 149, 615, 10.1001/jamadermatol.2013.3064

Espeli, 2016, Weekly multi-agent chemotherapy (CMF-b) for advanced non-melanoma skin cancer, Anticancer Res., 36, 2359

Sadek, 1990, Treatment of advanced squamous cell carcinoma of the skin with cisplatin, 5-fluorouracil, and bleomycin, Cancer, 66, 1692, 10.1002/1097-0142(19901015)66:8<1692::AID-CNCR2820660807>3.0.CO;2-Y

Krahn, 2001, Coexpression patterns of EGFR, HER2, HER3 and HER4 in non-melanoma skin cancer, Eur. J. Cancer, 37, 251, 10.1016/S0959-8049(00)00364-6

Maubec, 2011, Phase II study of cetuximab as first-line single-drug therapy in patients with unresectable squamous cell carcinoma of the skin, J. Clin. Oncol., 29, 3419, 10.1200/JCO.2010.34.1735

Reigneau, 2015, Efficacy of neoadjuvant cetuximab alone or with platinum salt for the treatment of unresectable advanced nonmetastatic cutaneous squamous cell carcinomas, Br. J. Dermatol., 173, 527, 10.1111/bjd.13741

Mesia, 2015, Chemoradiotherapy with or without panitumumab in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-1): A randomised, controlled, open-label phase 2 trial, Lancet Oncol., 16, 208, 10.1016/S1470-2045(14)71198-2

Giralt, 2015, Panitumumab plus radiotherapy versus chemoradiotherapy in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-2): A randomized, controlled, open-label phase 2 trial, Lancet Oncol., 16, 221, 10.1016/S1470-2045(14)71200-8

Kim, 2014, Open-label, exploratory Phase II trial of oral itraconazole for the treatment of basal cell carcinoma, J. Clin. Oncol., 32, 745, 10.1200/JCO.2013.49.9525

Bakshi, A., Chaudhary, S., Rana, M., Elmets, C., and Athar, M. (2017). Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond. Mol. Carcinog.

Alarcon, 2016, Tumor regrowth and development of keratinocytic neoplasms in patients under smoothened inhibition: In vivo assessment with reflectance confocal microscopy, Skin Res. Technol., 23, 283, 10.1111/srt.12332

Gjersvik, 2016, Study on the risk of cutaneous squamous cell carcinoma after vismodegib therapy for Basal cell carcinoma, JAMA Dermatol., 152, 1172, 10.1001/jamadermatol.2016.2427

Zargari, 2017, Inoperable infiltrative basal cell carcinoma successfully treated with vismodegib, Dermatol. Ther., 30, e12509, 10.1111/dth.12509

Odom, 2017, A Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma, J. Skin Cancer, 2017, 1, 10.1155/2017/6121760

Micali, 2014, Topical pharmacotherapy for skin cancer: Part II. Clinical applications, J. Am. Acad. Dermatol., 70, 979.e1, 10.1016/j.jaad.2013.12.037

Micali, 2014, Topical pharmacotherapy for skin cancer: Part I. Pharmacology, J. Am. Acad. Dermatol., 70, 965.e1, 10.1016/j.jaad.2013.12.045

Bargman, 2003, Topical treatment of Bowen’s disease with 5-fluorouracil, J. Cutan. Med. Surg., 7, 101, 10.1177/120347540300700201

Salim, 2003, Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen’s disease, Br. J. Dermatol., 148, 539, 10.1046/j.1365-2133.2003.05033.x

Gross, 2007, 5% 5-Fluorouracil cream for the treatment of small superficial basal cell carcinoma: Efficacy, tolerability, cosmetic outcome, and patient satisfaction, Dermatol. Surg., 33, 433

Ishioka, 2015, Evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: Preliminary study, An. Bras Dermatol., 90, 426, 10.1590/abd1806-4841.20153437

Kwon, 2011, Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma: Clinical experience and review of literature, World J. Surg. Oncol., 9, 80, 10.1186/1477-7819-9-80

Alam, 2001, Cutaneous squamous-cell carcinoma, N. Engl. J. Med., 344, 975, 10.1056/NEJM200103293441306

Ross, 2006, Sentinel lymph node biopsy in cutaneous squamous cell carcinoma: A systematic review of the English literature, Dermatol. Surg., 32, 1309

Dona, 2003, Metastatic cutaneous squamous cell carcinoma to the parotid: The role of surgery and adjuvant radiotherapy to achieve best outcome, ANZ J. Surg., 73, 692, 10.1046/j.1445-2197.2003.02737.x

Reschly, 2003, Utility of sentinel lymphadenectomy in the management of patients with high-risk cutaneous squamous cell carcinoma, Dermatol. Surg., 29, 135

Martinez, 2007, High-risk cutaneous squamous cell carcinoma without palpable lymphadenopathy: Is there a therapeutic role for elective neck dissection, Dermatol. Surg., 33, 410

Olbricht, 2008, Cutaneous squamous cell carcinoma, Adv. Dermatol., 24, 33, 10.1016/j.yadr.2008.09.007

Kyrgidis, 2010, Cutaneous squamous cell carcinoma (SCC) of the head and neck: Risk factors of overall and recurrence-free survival, Eur. J. Cancer, 46, 1563, 10.1016/j.ejca.2010.02.046

Samsanavicius, 2016, Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma: Analysis of recurrence-free survival, Medicina, 52, 276, 10.1016/j.medici.2016.09.002

Durham, 2016, Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma on the Head and Neck, JAMA Otolaryngol. Head Neck Surg., 142, 1171, 10.1001/jamaoto.2016.1927

Ahadiat, 2017, SLNB in cutaneous SCC: A review of the current state of literature and the direction for the future, J. Surg. Oncol., 116, 344, 10.1002/jso.24675

Veness, 2015, High-risk cutaneous squamous cell carcinoma and the emerging role of sentinel lymph node biopsy: A literature review, J. Am. Acad. Dermatol., 73, 127, 10.1016/j.jaad.2015.03.039

Gore, 2015, Prospective study of sentinel node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck, Head Neck, 38, E884

Maruyama, 2016, Availability of sentinel lymph node biopsy for cutaneous squamous cell carcinoma, J. Dermatol., 44, 431, 10.1111/1346-8138.13577

Silberstein, 2015, Lymph Node Metastasis in Cutaneous Head and Neck Squamous Cell Carcinoma, Dermatol. Surg., 41, 1126, 10.1097/DSS.0000000000000488

Martinez, 2007, High-Risk Cutaneous Squamous Cell Carcinoma without Palpable Lymphadenopathy: Is There a Therapeutic Role for Elective Neck Dissection?, Dermatol. Surg., 33, 410