Cập nhật về các liệu pháp kết hợp trong bệnh Parkinson: một bài tổng quan dựa trên chứng cứ

Current Neurology and Neuroscience Reports - Tập 23 - Trang 717-726 - 2023
Sushma Kola1, Indu Subramanian2,3
1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, USA
2Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, USA
3SW PADRECC, Veterans Affairs, Los Angeles, USA

Tóm tắt

Bài tổng quan này tóm tắt các liệu pháp kết hợp dựa trên chứng cứ gần đây cho bệnh Parkinson (PD) có thể cải thiện triệu chứng vận động và không vận động, nâng cao chất lượng cuộc sống, và thay đổi tiến triển của bệnh. Các nghiên cứu hình ảnh đã chứng minh rằng tập thể dục nhịp điệu thay đổi cấu trúc và chức năng não, trong khi tập luyện sức mạnh cải thiện tư thế và sự cân bằng. Cảm giác cô đơn liên quan đến mức độ nặng của bệnh PD xấu đi, tuy nhiên, việc kê toa xã hội và liệu pháp hành vi nhận thức có thể hiệu quả trong việc tạo ra kết nối. Các phương pháp y học Ayurvedic và y học cổ truyền Trung Quốc bao gồm yoga, thiền, thái cực quyền và châm cứu có thể giúp cải thiện khả năng di động, tâm trạng, giấc ngủ và chất lượng cuộc sống. Liệu pháp nghệ thuật nâng cao kỹ năng hình không gian, trong khi liệu pháp âm nhạc và khiêu vũ có thể giảm hiện tượng đóng băng khi đi bộ. Một vài nghiên cứu cho thấy sự sử dụng thành công của những chiến lược tích hợp này qua mạng, qua đó cải thiện khả năng tiếp cận và tham gia của bệnh nhân. Quản lý bệnh PD đã được mở rộng để bao gồm những cách tiếp cận tích hợp kết hợp liệu pháp thông thường và bổ sung. Lợi ích tiềm năng của vận động, dinh dưỡng, giấc ngủ, giao tiếp xã hội và thực hành liên kết tâm trí - cơ thể đã được xác nhận bởi một vài nghiên cứu thử nghiệm ngẫu nhiên có đối chứng gần đây.

Từ khóa

#bệnh Parkinson #liệu pháp kết hợp #tập thể dục nhịp điệu #sức mạnh #chất lượng cuộc sống #liệu pháp hành vi nhận thức #y học cổ truyền

Tài liệu tham khảo

Wang Y, et al. Epidemiology of complementary and alternative medicine use in patients with Parkinson's disease. J Clin Neurosci. 2013;20(8):1062–7. Ring M, et al. Developing and implementing core competencies for integrative medicine fellowships. Acad Med. 2014;89(3):421–8. Organization, W.H., Constitution of the World Health Organization, Signed on July 22, 1946, in New York City. International Organization, 1947. 1(1): p. 225-239. Weintraub D, et al. The neuropsychiatry of Parkinson's disease: Advances and challenges. Lancet Neurol. 2022;21(1):89–102. van der Eijk M, et al. Moving from physician-centered care towards patient-centered care for Parkinson's disease patients. Parkinsonism Relat Disord. 2013;19(11):923–7. Johansson ME, et al. Aerobic exercise alters brain function and structure in parkinson's disease: A randomized controlled trial. Ann Neurol. 2022;91(2):203–16. This study proves aerobic exercise actually changes brain structure and function, suggesting disease modification. Sacheli MA, et al. Exercise increases caudate dopamine release and ventral striatal activation in Parkinson's disease. Mov Disord. 2019;34(12):1891–900. The authors show that exercise alters the basal ganglia, in addition to providing symptomatic benefit. Jansen AE, et al. High intensity aerobic exercise improves bimanual coordination of grasping forces in Parkinson's disease. Parkinsonism Relat Disord. 2021;87:13–9. Amara AW, et al. Randomized, controlled trial of exercise on objective and subjective sleep in Parkinson's disease. Mov Disord. 2020;35(6):947–58. van der Kolk NM, et al. Effectiveness of home-based and remotely supervised aerobic exercise in Parkinson's disease: a double-blind, randomised controlled trial. Lancet Neurol. 2019;18(11):998–1008. Handlery R, et al. Physical activity in De Novo Parkinson disease: daily step recommendation and effects of treadmill exercise on physical activity. Phys Ther. 2021;101(10). Alberts JL, et al. Effectiveness of a long-term, home-based aerobic exercise intervention on slowing the progression of parkinson disease: design of the cyclical lower extremity exercise for parkinson disease II (CYCLE-II) study. Phys Ther. 2021;101(11). Çoban F, Belgen Kaygısız B, Selcuk F. Effect of clinical Pilates training on balance and postural control in patients with Parkinson's disease: a randomized controlled trial. J Comp Eff Res. 2021;10(18):1373–83. Cabrera-Martos I, et al. Effects of a core stabilization training program on balance ability in persons with Parkinson's disease: a randomized controlled trial. Clin Rehabil. 2020;34(6):764–72. Gandolfi M, et al. Four-week trunk-specific exercise program decreases forward trunk flexion in Parkinson's disease: A single-blinded, randomized controlled trial. Parkinsonism Relat Disord. 2019;64:268–74. Silva-Batista C, et al. A randomized, controlled trial of exercise for Parkinsonian individuals with freezing of gait. Mov Disord. 2020;35(9):1607–17. This trial demonstrates that exercise improves freezing of gait. Ferreira RM, et al. The effect of resistance training on the anxiety symptoms and quality of life in elderly people with Parkinson's disease: a randomized controlled trial. Arq Neuropsiquiatr. 2018;76(8):499–506. Choi Y, Kim D. Effects of task-based LSVT-BIG intervention on hand function, activity of daily living, psychological function, and quality of life in Parkinson's disease: A randomized control trial. Occup Ther Int. 2022;2022:1700306. Pazzaglia C, et al. Comparison of virtual reality rehabilitation and conventional rehabilitation in Parkinson's disease: a randomised controlled trial. Physiotherapy. 2020;106:36–42. Kashif M, et al. Combined effects of virtual reality techniques and motor imagery on balance, motor function and activities of daily living in patients with Parkinson's disease: A randomized controlled trial. BMC Geriatr. 2022;22(1):381. Feng H, et al. Virtual reality rehabilitation versus conventional physical therapy for improving balance and gait in Parkinson's disease patients: A randomized controlled trial. Med Sci Monit. 2019;25:4186–92. Maraki MI, et al. Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease. Mov Disord. 2019;34(1):48–57. The authors discuss that the Mediterranean diet reduces risk of PD. Alcalay RN, et al. The association between Mediterranean diet adherence and Parkinson's disease. Mov Disord. 2012;27(6):771–4. Paknahad Z, et al. The effect of the Mediterranean diet on cognitive function in patients with Parkinson's disease: A randomized clinical controlled trial. Complement Ther Med. 2020;50:102366. Paknahad Z, et al. The effects of Mediterranean diet on severity of disease and serum Total Antioxidant Capacity (TAC) in patients with Parkinson's disease: a single center, randomized controlled trial. Nutr Neurosci. 2022;25(2):313–20. Rusch C, et al. Effect of a Mediterranean diet intervention on gastrointestinal function in Parkinson's disease (the MEDI-PD study): study protocol for a randomised controlled trial. BMJ Open. 2021;11(9):e053336. Phillips MCL, et al. Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial. Mov Disord. 2018;33(8):1306–14. Knight E, et al. The role of diet and dietary patterns in Parkinson's disease. Nutrients. 2022;14(21). Metcalfe-Roach A, et al. MIND and mediterranean diets associated with later onset of Parkinson's disease. Mov Disord. 2021;36(4):977–84. This study demonstrates that plant-based diets can delay PD onset. Cersosimo MG, et al. Gastrointestinal manifestations in Parkinson's disease: prevalence and occurrence before motor symptoms. J Neurol. 2013;260(5):1332–8. Ibrahim A, et al. Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson's disease: A randomised controlled trial. PLoS One. 2020;15(12):e0244680. Du Y, et al. Probiotics for constipation and gut microbiota in Parkinson's disease. Parkinsonism Relat Disord. 2022;103:92–7. This RCT found that probiotics improve PD motor and non-motor symptoms. Tan AH, et al. Probiotics for constipation in Parkinson disease: A randomized placebo-controlled study. Neurology. 2021;96(5):e772–82. Tamtaji OR, et al. Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 2019;38(3):1031–5. Sun H, et al. Probiotics synergized with conventional regimen in managing Parkinson's disease. NPJ Parkinsons Dis. 2022;8(1):62. Park JM, et al. Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson's disease: a meta-analysis of randomized controlled trials. Gut Pathog. 2023;15(1):9. This review paper is a good summary of the evidence for probiotics in PwP. Bohnen NI, Hu MTM. Sleep disturbance as potential risk and progression factor for Parkinson's disease. J Parkinsons Dis. 2019;9(3):603–14. Vodovotz Y, et al. Prioritized research for the prevention, treatment, and reversal of chronic disease: recommendations from the lifestyle medicine research summit. Front Med (Lausanne). 2020;7:585744. This paper is a culmination of the Lifestyle Medicine Research Summit and provides the official lifestyle guidelines. Videnovic A, et al. 'The clocks that time us'--circadian rhythms in neurodegenerative disorders. Nat Rev Neurol. 2014;10(12):683–93. Baglioni C, et al. Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. 2011;135(1-3):10–9. Buysse DJ. Sleep health: can we define it? Does it matter? Sleep. 2014;37(1):9–17. Videnovic A, et al. Timed light therapy for sleep and daytime sleepiness associated with parkinson disease: A randomized clinical trial. JAMA Neurol. 2017;74(4):411–8. Rutten S, et al. Bright light therapy for depression in Parkinson disease: A randomized controlled trial. Neurology. 2019;92(11):e1145–56. Raymackers JM, et al. Bright light therapy with a head-mounted device for anxiety, depression, sleepiness and fatigue in patients with Parkinson's disease. Acta Neurol Belg. 2019;119(4):607–13. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540–5. Antonini A, et al. Outcome of Parkinson's disease patients affected by COVID-19. Mov Disord. 2020;35(6):905–8. Brooks SK, Weston D, Greenberg N. Social and psychological impact of the COVID-19 pandemic on people with Parkinson's disease: a scoping review. Public Health. 2021;199:77–86. Subramanian I, Farahnik J, Mischley LK. Synergy of pandemics-social isolation is associated with worsened Parkinson severity and quality of life. NPJ Parkinsons Dis. 2020;6:28. The authors show that loneliness directly worsens PD and quality of life and offer recommendations to combat isolation. Hermanowicz N, et al. Impact of isolation during the COVID-19 pandemic on the patient burden of parkinson's disease: A PMD alliance survey. Neuropsychiatr Dis Treat. 2022;18:633–43. Matthews KA, et al. Collecting psychosocial “vital signs” in electronic health records: Why now? What are they? What’s new for psychology? Am Psychol. 2016;71(6):497–504. Institute of Medicine Capturing Social and Behavioral Domains in Electronic Health Records: Phase 1. Washington. DC: The National Academies Press; 2014. p. 136. Roland M, Everington S, Marshall M. Social prescribing — transforming the relationship between physicians and their patients. New England Journal of Medicine (NEJM). 2020;383(2):97–9. The authors explain social prescribing as a tool to include in an integrative management plan. Hawkley LC, et al. From social structural factors to perceptions of relationship quality and loneliness: the chicago health, aging, and social relations study. J Gerontol Series B. 2008;63(6):S375–84. Hickin N, et al. The effectiveness of psychological interventions for loneliness: A systematic review and meta-analysis. Clin Psychol Rev. 2021;88:102066. Käll A, et al. A common elements approach to the development of a modular cognitive behavioral theory for chronic loneliness. J Consult Clin Psychol. 2020;88(3):269–82. Käll A, et al. Lonesome no more? A two-year follow-up of internet-administered cognitive behavioral therapy for loneliness. Internet Interv. 2020;19:100301. Interian A, et al. A pilot study of telehealth mindfulness-based cognitive therapy for depression in Parkinson's disease. J Geriatr Psychiatry Neurol. 2023;36(2):143–54. Bogosian A, et al. Acceptability and feasibility of a mindfulness intervention delivered via videoconferencing for people with Parkinson's. J Geriatr Psychiatry Neurol. 2022;35(1):155–67. Katiyar CK, Mukherjee PK. Some excerpts from Charaka Samhita - An ancient treatise on Ayurveda & healthy living. J Ethnopharmacol. 2017;197:3–9. Mukherjee PK, et al. Development of Ayurveda - Tradition to trend. J Ethnopharmacol. 2017;197:10–24. Kwok JYY, et al. Effects of mindfulness yoga versus conventional physical exercises on symptom experiences and health-related quality of life in people with Parkinson's disease: the potential mediating roles of anxiety and depression. Ann Behav Med. 2022;56(10):1068–81. Kwok JYY, et al. Effects of mindfulness yoga vs stretching and resistance training exercises on anxiety and depression for people with Parkinson disease: a randomized clinical trial. JAMA Neurol. 2019;76(7):755–63. This study found mindfulness yoga to be superior to conventional exercise for mood disorders. Hawkins BL, et al. Perceived activities and participation outcomes of a yoga intervention for individuals with Parkinson's disease: A mixed methods study. Int J Yoga Therap. 2018;28(1):51–61. Cherup NP, et al. Yoga meditation enhances proprioception and balance in individuals diagnosed with Parkinson's disease. Percept Mot Skills. 2021;128(1):304–23. Mitarnun W, et al. Home-based walking meditation decreases disease severity in Parkinson's disease: A randomized controlled trial. J Integr Complement Med. 2022;28(3):227-33. The authors demonstrate that a movement meditation can reduce PD severity, which may be useful for PwP who struggle with sedentary meditation. Cilia R, et al. Mucuna pruriens in Parkinson disease: A double-blind, randomized, controlled, crossover study. Neurology. 2017;89(5):432–8. Cilia R, et al. Daily intake of Mucuna pruriens in advanced Parkinson's disease: A 16-week, noninferiority, randomized, crossover, pilot study. Parkinsonism Relat Disord. 2018;49:60–6. Pereira CR, et al. Effectiveness of acupuncture in parkinson's disease symptoms-a systematic review. Healthcare (Basel). 2022;10(11) This review paper provides a good summary of the evidence for acupuncture in PD. Zhao Y, et al. Acupuncture for Parkinson's disease: Efficacy evaluation and mechanisms in the dopaminergic neural circuit. Neural Plast. 2021;2021:9926445. Fan JQ, et al. Effectiveness of acupuncture for anxiety among patients with Parkinson disease: A randomized clinical trial. JAMA Netw Open. 2022;5(9):e2232133. Aroxa FH, et al. Acupuncture as adjuvant therapy for sleep disorders in Parkinson's disease. J Acupunct Meridian Stud. 2017;10(1):33–8. Wu MX, et al. Acupuncture adjuvant treatment for dysphagia in patients with Parkinson's disease: a randomized controlled trial. Zhongguo Zhen Jiu. 2021;41(5):485–8. Kluger BM, et al. Randomized, controlled trial of acupuncture for fatigue in Parkinson's disease. Mov Disord. 2016;31(7):1027–32. Li F, et al. Tai chi and postural stability in patients with Parkinson's disease. N Engl J Med. 2012;366(6):511–9. This seminal trial proves that tai chi improves balance and reduces falls in PD. Scianni A. Tai Chi improves balance and prevents falls in people with Parkinson's disease. J Physiother. 2015;61(1):44. Deuel LM, Seeberger LC. Complementary therapies in parkinson disease: A review of acupuncture, Tai Chi, Qi Gong, Yoga, and Cannabis. Neurotherapeutics. 2020;17(4):1434–55. Song R, et al. The impact of Tai Chi and Qigong mind-body exercises on motor and non-motor function and quality of life in Parkinson's disease: A systematic review and meta-analysis. Parkinsonism Relat Disord. 2017;41:3–13. Xiao CM, Zhuang YC. Effect of health Baduanjin Qigong for mild to moderate Parkinson's disease. Geriatr Gerontol Int. 2016;16(8):911–9. Moon S, et al. Qigong exercise may reduce serum TNF-α levels and improve sleep in people with Parkinson's disease: A pilot study. Medicines (Basel). 2017;4(2). Kamieniarz A, et al. Tai Chi and Qi Gong therapies as a complementary treatment in Parkinson's disease - a systematic review. Complement Ther Med. 2021;56:102589. Redvers N, Blondin B. Traditional indigenous medicine in North America: A scoping review. PLoS One. 2020;15(8):e0237531. Celidwen Y, et al. Ethical principles of traditional Indigenous medicine to guide western psychedelic research and practice. Lancet Reg Health Am. 2023;18:100410. Jones D, et al. Complementary and alternative medicine use in minority and medically underserved oncology patients: Assessment and implications. Integr Cancer Ther. 2018;17(2):371–9. Uc EY, et al. Visual dysfunction in Parkinson disease without dementia. Neurology. 2005;65(12):1907–13. Ettinger T, et al. Art therapy as a comprehensive complementary treatment for Parkinson's disease. Front Hum Neurosci. 2023;17:1110531. Cucca A, et al. Art therapy for Parkinson's disease. Parkinsonism Relat Disord. 2021;84:148–54. The authors demonstrate that art therapy improves visuospatial processking in PwP. Bega D, et al. A review of the clinical evidence for complementary and alternative therapies in Parkinson’s disease. Current Treatment Options in Neurology. 2014;16(10):314. Calabrò RS, et al. Walking to your right music: a randomized controlled trial on the novel use of treadmill plus music in Parkinson's disease. J Neuroeng Rehabil. 2019;16(1):68. Thaut MH, et al. Rhythmic auditory stimulation for reduction of falls in Parkinson's disease: a randomized controlled study. Clin Rehabil. 2019;33(1):34–43. Park JK, Kim SJ. dual-task-based drum playing with rhythmic cueing on motor and attention control in patients with Parkinson's disease: A preliminary randomized study. Int J Environ Res Public Health. 2021;18(19). Pohl P, et al. Group-based music intervention in Parkinson's disease - findings from a mixed-methods study. Clin Rehabil. 2020;34(4):533–44. This study shows that group music therapy can improve motor and non-motor symptoms. Docu Axelerad A, et al. Benefits of tango therapy in alleviating the motor and non-motor symptoms of Parkinson's disease patients-a narrative review. Brain Sci. 2022;12(4). Poier D, et al. A randomized controlled trial to investigate the impact of tango argentino versus tai chi on quality of life in patients with parkinson disease: A short report. Complement Med Res. 2019;26(6):398–403. Moratelli JA, et al. Dance rhythms improve motor symptoms in individuals with parkinson's disease: A randomized clinical trial. J Dance Med Sci. 2022;26(1):1–6. This RCT proves that dance therapy improves motor symptoms in PD. Feenstra W, et al. Dance classes improve self-esteem and quality of life in persons with Parkinson's disease. J Neurol. 2022;269(11):5843–7. Frisaldi E, et al. Effectiveness of a dance-physiotherapy combined intervention in Parkinson's disease: a randomized controlled pilot trial. Neurol Sci. 2021;42(12):5045–53. The authors discuss that dance therapy combined with PT is more effective than PT alone in reducing motor dysfunction.